Click here to switch to the map view.

The map label for this gene is cysG [H]

Identifier: 119776024

GI number: 119776024

Start: 3434479

End: 3435288

Strand: Reverse

Name: cysG [H]

Synonym: Sama_2892

Alternate gene names: 119776024

Gene position: 3435288-3434479 (Counterclockwise)

Preceding gene: 119776027

Following gene: 119776023

Centisome position: 79.78

GC content: 60.62

Gene sequence:

>810_bases
ATGGACGTTGTAACGTTGCCGGGCCAAGGGCCCAACGGCAAGGTGTGGTTGGTGGGTGCCGGTCCGGGAGATGTGGAACT
CCTGACCCTGAAGGCTGCCCGTATCCTGGCCAGCGCCGACGCCGTGCTCTACGACGCACTTGTCAGTGATGACATTCTCG
CCCTCATTCCTGAACACGCCGAGAAGATTGCCGTTGGCAAGCGCGCTGGCGCCCACAGTGCCCGTCAGGAAGACATTAAC
CAACTGCTGGTAACCAAGGCATTTACCCGTAAAAACGTGGTGCGCCTCAAGGGCGGCGACCCCTTTATTTTCGGCCGTGG
TGGTGAAGAGTTGCAAACCCTGGTCGAAGCCGGTGTGGCCTTTGAGGTGGTACCGGGCATTACGGCTGCAAGCGGCACCT
CTGCCTATGCCGGCATTCCGCTTACCCACAGAGACTTTGCCCAGGGCGTCACCTTTATTACCGGCCATTGCCAGCTCGAG
AGCCGTCCCATGGACTGGCAGGGCTATGCCAATCCGGCCAACACCCTGGTGGTGTACATGGGCATTCTCAACGCCGGACT
CATCCAGCGCGAGCTGACCAAACATGGCCGCAGCGCCGCCACACCGGTAGCCATTGTCTCCCGCGCCACCACCGCCCACC
AGCAGCGGGTGATTGGCACCCTGGGCGAGCTTGAAACCCTCGCCAAAGATGCGCGGGTGGTGATGCCGGCATTGATGATA
GTCGGGGAAGTGGTGAGTCTCGCCGACACACTCAACTGGTTTGAACCCGCCCAAGTGGCCGAGGTTCTGCCCAAACAGAA
TACGAATTGA

Upstream 100 bases:

>100_bases
TCTGCATATTCATTTTGGTTATAAAAACTAACTATTTACTATTTTTTAAGGAATATAAGGCCCGTTATATTGGCTTCCAA
TCTGGTAAGTGGGGGTGTGT

Downstream 100 bases:

>100_bases
TGCTGCCACGGCAGCCTTCTCAAATATAAGACTCGGAGAAACAAGATGTCAGGGCCTGTGTTAAGTCACCTTGAGCAACT
GGAAGCGGAAAGCATCCAGA

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MDVVTLPGQGPNGKVWLVGAGPGDVELLTLKAARILASADAVLYDALVSDDILALIPEHAEKIAVGKRAGAHSARQEDIN
QLLVTKAFTRKNVVRLKGGDPFIFGRGGEELQTLVEAGVAFEVVPGITAASGTSAYAGIPLTHRDFAQGVTFITGHCQLE
SRPMDWQGYANPANTLVVYMGILNAGLIQRELTKHGRSAATPVAIVSRATTAHQQRVIGTLGELETLAKDARVVMPALMI
VGEVVSLADTLNWFEPAQVAEVLPKQNTN

Sequences:

>Translated_269_residues
MDVVTLPGQGPNGKVWLVGAGPGDVELLTLKAARILASADAVLYDALVSDDILALIPEHAEKIAVGKRAGAHSARQEDIN
QLLVTKAFTRKNVVRLKGGDPFIFGRGGEELQTLVEAGVAFEVVPGITAASGTSAYAGIPLTHRDFAQGVTFITGHCQLE
SRPMDWQGYANPANTLVVYMGILNAGLIQRELTKHGRSAATPVAIVSRATTAHQQRVIGTLGELETLAKDARVVMPALMI
VGEVVSLADTLNWFEPAQVAEVLPKQNTN
>Mature_269_residues
MDVVTLPGQGPNGKVWLVGAGPGDVELLTLKAARILASADAVLYDALVSDDILALIPEHAEKIAVGKRAGAHSARQEDIN
QLLVTKAFTRKNVVRLKGGDPFIFGRGGEELQTLVEAGVAFEVVPGITAASGTSAYAGIPLTHRDFAQGVTFITGHCQLE
SRPMDWQGYANPANTLVVYMGILNAGLIQRELTKHGRSAATPVAIVSRATTAHQQRVIGTLGELETLAKDARVVMPALMI
VGEVVSLADTLNWFEPAQVAEVLPKQNTN

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=242, Percent_Identity=55.7851239669422, Blast_Score=259, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6322922, Length=253, Percent_Identity=35.1778656126482, Blast_Score=118, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 28503; Mature: 28503

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVVTLPGQGPNGKVWLVGAGPGDVELLTLKAARILASADAVLYDALVSDDILALIPEHA
CCEEECCCCCCCCEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
EKIAVGKRAGAHSARQEDINQLLVTKAFTRKNVVRLKGGDPFIFGRGGEELQTLVEAGVA
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEECCCHHHHHHHHHCCCE
FEVVPGITAASGTSAYAGIPLTHRDFAQGVTFITGHCQLESRPMDWQGYANPANTLVVYM
EEECCCCEECCCCCCCCCCCCCHHHHHCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHH
GILNAGLIQRELTKHGRSAATPVAIVSRATTAHQQRVIGTLGELETLAKDARVVMPALMI
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGEVVSLADTLNWFEPAQVAEVLPKQNTN
HHHHHHHHHHHCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure
MDVVTLPGQGPNGKVWLVGAGPGDVELLTLKAARILASADAVLYDALVSDDILALIPEHA
CCEEECCCCCCCCEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
EKIAVGKRAGAHSARQEDINQLLVTKAFTRKNVVRLKGGDPFIFGRGGEELQTLVEAGVA
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEECCCHHHHHHHHHCCCE
FEVVPGITAASGTSAYAGIPLTHRDFAQGVTFITGHCQLESRPMDWQGYANPANTLVVYM
EEECCCCEECCCCCCCCCCCCCHHHHHCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHH
GILNAGLIQRELTKHGRSAATPVAIVSRATTAHQQRVIGTLGELETLAKDARVVMPALMI
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGEVVSLADTLNWFEPAQVAEVLPKQNTN
HHHHHHHHHHHCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA