Click here to switch to the map view.

The map label for this gene is atoC [H]

Identifier: 119775993

GI number: 119775993

Start: 3398749

End: 3400263

Strand: Reverse

Name: atoC [H]

Synonym: Sama_2861

Alternate gene names: 119775993

Gene position: 3400263-3398749 (Counterclockwise)

Preceding gene: 119775994

Following gene: 119775992

Centisome position: 78.96

GC content: 56.17

Gene sequence:

>1515_bases
GTGTCTAATGGTGTAACCCATCGAGGGCTCGCAAATGGCGGGCCCTTACGTTATCGTGTAGTGGCTGAATTAACCAAGAT
GAATCAAATGGATAAGATATTAATCGTCGACGACAATCTGGATGTTTGCCAGGCACTTTCACTGATGCTTGAACTGAACG
GTTACAAAAGCCATTGCGTGCAGAGTCCTGAAATGGCGCTCGATGCCATTGAGAAGCACGAGTTTTCGCTGGTGATCCAG
GACATGAATTTCACCCGCGATACCACCAGCGGTGAGGAAGGCCGGGAACTGTTTCATGCTCTGCGTGAGTGTCGTCCGGG
GATCCCCATCATACTTCTGACTGCCTGGACCGAGCTTGAAATGGCCGTGGAGCTGATGAAAGCCGGTGCCGCCGATTATT
TGGGTAAGCCCTGGGACGATGCCAAGTTGCTCACCAGCATTGGCAACCTGATTTCGCTGCACAAACTGTCACGGGAAAAC
GGCGAACTGAAGCGCCAGAAGGCCGAGCGCACCGCGGTTATTCACGAGGCAAACCTCTGTGGCCTGGTGTTTGGCAGCAC
GGCCATGGAGCGTTGCGTGGATCTGGCGCTGCAACTGGCCAAATCGGACGTATCCGTGCTGATCACTGGTCCCAACGGCG
CAGGTAAAGATCGCCTGGCCGACATTCTCCATGCCAATTCGCCATTAAAAGACAAACCCTTTATCAAGGTGAATGTGGGC
GCCTTGCCCATGGAGCTGATGGAGGCCGAACTCTTTGGCGCCGAGGCTGGCGCCTTTACCGGCGCCACCAAGTCCCGTAT
CGGCCGCTTTGAAGCCGCCAATGGTGGCACCCTGTTTTTGGACGAGATTGGCAATCTGCCTTTGAGCGGCCAGGTGAAAT
TGCTGCGGGTGCTGCAAACCGGAGAATTTGAACGCCTTGGCAGCCACCAGACCCGTAAATGTAAGGTCAGGGTGCTCAGC
GCCACCAATGCCGATTTGCGTCAGGATATTCAGACTGGGCGCTTTCGTGAAGATCTTTTCTACCGCCTGAACGTGGTGGA
GCTGGCATTGCCGCCCCTGTGCGAGCGTCGCGATGATGTGCTGCCCCTGGTGCAACACTTTACCCGGGGACGGGCATTGG
ATGCCTCTGCCAAGGCGGCGCTGCTGGCCCATTCCTGGCCGGGCAATGTGCGTGAGTTGGAGAACGCCTGTAAGCGGGCG
GATATCCTGGCCAGAGGCGAGATGCTGAGTGCGGTGGATTTTGGTTTGATGCCGACACAAACGCCGCAACCCGCGGTAAA
TCAGTCCGGGATTTCTTCGAATGAGGCGCATCATAACGAGCCCTTTAACACTCTTCTTCCCGAGTCAGAACCGGTTAACA
CAGCGCCAAACCGAAGCGAGATAGAGGCCGCCATTACCGCCCACAATGGGGTGATTGCCAGGGTGGCCAAATCCTTTGGA
CTCAGCCGTCAGGCGCTGTATCGCCGCATGGAGAAGTTCGGCATTGAGGTGAAGTCCTCCAAGGCCGAAGGATAA

Upstream 100 bases:

>100_bases
CCCGCCGTGACCGTGGCGCTGCTGTTTGTGGTGACGACCATAGCGGTGATTATTCCCGCCAGACGCGCGGCGGCGATTTC
CCCCTCTATTGCCACCCGCA

Downstream 100 bases:

>100_bases
GCCCATGGGGACAGGTTTTATTCCAAGCCTCAGAAACAGGCTCCTGCTGGTGGTACTGGTGAGCTGGCTTATCGGCGGCA
CCCTGGCCTATTGGCTCGGT

Product: response regulator receiver protein

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MSNGVTHRGLANGGPLRYRVVAELTKMNQMDKILIVDDNLDVCQALSLMLELNGYKSHCVQSPEMALDAIEKHEFSLVIQ
DMNFTRDTTSGEEGRELFHALRECRPGIPIILLTAWTELEMAVELMKAGAADYLGKPWDDAKLLTSIGNLISLHKLSREN
GELKRQKAERTAVIHEANLCGLVFGSTAMERCVDLALQLAKSDVSVLITGPNGAGKDRLADILHANSPLKDKPFIKVNVG
ALPMELMEAELFGAEAGAFTGATKSRIGRFEAANGGTLFLDEIGNLPLSGQVKLLRVLQTGEFERLGSHQTRKCKVRVLS
ATNADLRQDIQTGRFREDLFYRLNVVELALPPLCERRDDVLPLVQHFTRGRALDASAKAALLAHSWPGNVRELENACKRA
DILARGEMLSAVDFGLMPTQTPQPAVNQSGISSNEAHHNEPFNTLLPESEPVNTAPNRSEIEAAITAHNGVIARVAKSFG
LSRQALYRRMEKFGIEVKSSKAEG

Sequences:

>Translated_504_residues
MSNGVTHRGLANGGPLRYRVVAELTKMNQMDKILIVDDNLDVCQALSLMLELNGYKSHCVQSPEMALDAIEKHEFSLVIQ
DMNFTRDTTSGEEGRELFHALRECRPGIPIILLTAWTELEMAVELMKAGAADYLGKPWDDAKLLTSIGNLISLHKLSREN
GELKRQKAERTAVIHEANLCGLVFGSTAMERCVDLALQLAKSDVSVLITGPNGAGKDRLADILHANSPLKDKPFIKVNVG
ALPMELMEAELFGAEAGAFTGATKSRIGRFEAANGGTLFLDEIGNLPLSGQVKLLRVLQTGEFERLGSHQTRKCKVRVLS
ATNADLRQDIQTGRFREDLFYRLNVVELALPPLCERRDDVLPLVQHFTRGRALDASAKAALLAHSWPGNVRELENACKRA
DILARGEMLSAVDFGLMPTQTPQPAVNQSGISSNEAHHNEPFNTLLPESEPVNTAPNRSEIEAAITAHNGVIARVAKSFG
LSRQALYRRMEKFGIEVKSSKAEG
>Mature_503_residues
SNGVTHRGLANGGPLRYRVVAELTKMNQMDKILIVDDNLDVCQALSLMLELNGYKSHCVQSPEMALDAIEKHEFSLVIQD
MNFTRDTTSGEEGRELFHALRECRPGIPIILLTAWTELEMAVELMKAGAADYLGKPWDDAKLLTSIGNLISLHKLSRENG
ELKRQKAERTAVIHEANLCGLVFGSTAMERCVDLALQLAKSDVSVLITGPNGAGKDRLADILHANSPLKDKPFIKVNVGA
LPMELMEAELFGAEAGAFTGATKSRIGRFEAANGGTLFLDEIGNLPLSGQVKLLRVLQTGEFERLGSHQTRKCKVRVLSA
TNADLRQDIQTGRFREDLFYRLNVVELALPPLCERRDDVLPLVQHFTRGRALDASAKAALLAHSWPGNVRELENACKRAD
ILARGEMLSAVDFGLMPTQTPQPAVNQSGISSNEAHHNEPFNTLLPESEPVNTAPNRSEIEAAITAHNGVIARVAKSFGL
SRQALYRRMEKFGIEVKSSKAEG

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=479, Percent_Identity=37.5782881002088, Blast_Score=291, Evalue=7e-80,
Organism=Escherichia coli, GI1790299, Length=487, Percent_Identity=34.7022587268994, Blast_Score=262, Evalue=5e-71,
Organism=Escherichia coli, GI1790437, Length=401, Percent_Identity=38.6533665835411, Blast_Score=261, Evalue=8e-71,
Organism=Escherichia coli, GI87082117, Length=359, Percent_Identity=41.7827298050139, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1788905, Length=387, Percent_Identity=38.7596899224806, Blast_Score=239, Evalue=4e-64,
Organism=Escherichia coli, GI1789087, Length=331, Percent_Identity=39.8791540785499, Blast_Score=207, Evalue=2e-54,
Organism=Escherichia coli, GI87082152, Length=268, Percent_Identity=44.4029850746269, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1786524, Length=349, Percent_Identity=39.2550143266476, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1789233, Length=334, Percent_Identity=37.7245508982036, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI87081872, Length=213, Percent_Identity=44.6009389671362, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1787583, Length=373, Percent_Identity=30.8310991957105, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1789828, Length=268, Percent_Identity=32.4626865671642, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI87081858, Length=326, Percent_Identity=28.5276073619632, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 55245; Mature: 55114

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNGVTHRGLANGGPLRYRVVAELTKMNQMDKILIVDDNLDVCQALSLMLELNGYKSHCV
CCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCHHHHC
QSPEMALDAIEKHEFSLVIQDMNFTRDTTSGEEGRELFHALRECRPGIPIILLTAWTELE
CCHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECHHHHH
MAVELMKAGAADYLGKPWDDAKLLTSIGNLISLHKLSRENGELKRQKAERTAVIHEANLC
HHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCC
GLVFGSTAMERCVDLALQLAKSDVSVLITGPNGAGKDRLADILHANSPLKDKPFIKVNVG
EEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEEECC
ALPMELMEAELFGAEAGAFTGATKSRIGRFEAANGGTLFLDEIGNLPLSGQVKLLRVLQT
CCCHHHHHHHHHCCCCCCCCCCHHHHCCCEECCCCCEEEEHHHCCCCCCCCHHHHHHHHC
GEFERLGSHQTRKCKVRVLSATNADLRQDIQTGRFREDLFYRLNVVELALPPLCERRDDV
CCHHHHCCCCCCEEEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHCCCCCH
LPLVQHFTRGRALDASAKAALLAHSWPGNVRELENACKRADILARGEMLSAVDFGLMPTQ
HHHHHHHHCCCCCCCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCC
TPQPAVNQSGISSNEAHHNEPFNTLLPESEPVNTAPNRSEIEAAITAHNGVIARVAKSFG
CCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCHHHHHEEEECCCCHHHHHHHHHC
LSRQALYRRMEKFGIEVKSSKAEG
CCHHHHHHHHHHHCCEEECCCCCC
>Mature Secondary Structure 
SNGVTHRGLANGGPLRYRVVAELTKMNQMDKILIVDDNLDVCQALSLMLELNGYKSHCV
CCCCCCCCCCCCCCEEHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCHHHHC
QSPEMALDAIEKHEFSLVIQDMNFTRDTTSGEEGRELFHALRECRPGIPIILLTAWTELE
CCHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECHHHHH
MAVELMKAGAADYLGKPWDDAKLLTSIGNLISLHKLSRENGELKRQKAERTAVIHEANLC
HHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCC
GLVFGSTAMERCVDLALQLAKSDVSVLITGPNGAGKDRLADILHANSPLKDKPFIKVNVG
EEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEEECC
ALPMELMEAELFGAEAGAFTGATKSRIGRFEAANGGTLFLDEIGNLPLSGQVKLLRVLQT
CCCHHHHHHHHHCCCCCCCCCCHHHHCCCEECCCCCEEEEHHHCCCCCCCCHHHHHHHHC
GEFERLGSHQTRKCKVRVLSATNADLRQDIQTGRFREDLFYRLNVVELALPPLCERRDDV
CCHHHHCCCCCCEEEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHCCCCCH
LPLVQHFTRGRALDASAKAALLAHSWPGNVRELENACKRADILARGEMLSAVDFGLMPTQ
HHHHHHHHCCCCCCCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCC
TPQPAVNQSGISSNEAHHNEPFNTLLPESEPVNTAPNRSEIEAAITAHNGVIARVAKSFG
CCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCHHHHHEEEECCCCHHHHHHHHHC
LSRQALYRRMEKFGIEVKSSKAEG
CCHHHHHHHHHHHCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]