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The map label for this gene is rmlA1 [C]

Identifier: 119775946

GI number: 119775946

Start: 3351988

End: 3352668

Strand: Reverse

Name: rmlA1 [C]

Synonym: Sama_2814

Alternate gene names: 119775946

Gene position: 3352668-3351988 (Counterclockwise)

Preceding gene: 119775947

Following gene: 119775945

Centisome position: 77.86

GC content: 59.18

Gene sequence:

>681_bases
ATGAAAGCCATGATCCTCGCCGCGGGGCGGGGCGAGCGCTTGCGACCGCTCACAGACACAGTCCCCAAGCCGCTGGTGCA
AGCCGCTGGCAAACCCCTGATTGAATACCACCTCGAAAAGCTTGCGGCCATCGGGGTGCGGGAGGTGATCATCAATACCG
CCTGGCTCGGGCACAAGCTGGTGGAAACCCTTGAAGATGGCAGCCGATTTGGTCTGATGATTCAGTACAGCCACGAAGAT
GAGGCGCTGGAAACCGCTGGTGGAATTCTTAAGGCTTTGCCGCTGCTGGGGGATGAGCCTTTTCTGGTGATCAATGGTGA
TATTTATATTGATGCCTTGCCCGTCTTGTCACCAAGCCCTGAGCTGCTGTCGGGGGAGACCCTGGCGCATCTCTACCTGG
TGGACAACCCGCCACAGCATCCCCAGGGGGATTTTGCGCTGGAGCAGGGCATCCTCAGCGCCGAGGGGAAGCCAACGTTT
ACCTTCTCCGGGATAGGCATTTATCATCCGGCGCTCTTTCGCACGCTGGCACCCGGGCGTCATGCGCTGGGGCCGCTGCT
GCGGCAACACATGAACGATGGGCGCATTCGCGGCGAACATTTTGACCGGTATTGGTGCGATGTGGGCACACCCGAGAGGC
TCGATGCCCTCAATCAACGACTTATGGCGCTTGGAGTGTAA

Upstream 100 bases:

>100_bases
CCATGCACTATATCCGCGATGTGGCGGTGCGCTACAAGGAGCTTGGCGACTTTGCCCAGTTTATCATGAGGCGGGTCATG
CCGGCGCTGGAGGCTGGAGC

Downstream 100 bases:

>100_bases
CGTCCGTTTATGAAGTACAAAGGCAAGTTTTTTGGTTTTTTGATTGGCTTTATGTTCGGCAAGATTTTCGGCGCCTTGCT
TGGCCTCGTGGTTGGGCACT

Product: nucleotidyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MKAMILAAGRGERLRPLTDTVPKPLVQAAGKPLIEYHLEKLAAIGVREVIINTAWLGHKLVETLEDGSRFGLMIQYSHED
EALETAGGILKALPLLGDEPFLVINGDIYIDALPVLSPSPELLSGETLAHLYLVDNPPQHPQGDFALEQGILSAEGKPTF
TFSGIGIYHPALFRTLAPGRHALGPLLRQHMNDGRIRGEHFDRYWCDVGTPERLDALNQRLMALGV

Sequences:

>Translated_226_residues
MKAMILAAGRGERLRPLTDTVPKPLVQAAGKPLIEYHLEKLAAIGVREVIINTAWLGHKLVETLEDGSRFGLMIQYSHED
EALETAGGILKALPLLGDEPFLVINGDIYIDALPVLSPSPELLSGETLAHLYLVDNPPQHPQGDFALEQGILSAEGKPTF
TFSGIGIYHPALFRTLAPGRHALGPLLRQHMNDGRIRGEHFDRYWCDVGTPERLDALNQRLMALGV
>Mature_226_residues
MKAMILAAGRGERLRPLTDTVPKPLVQAAGKPLIEYHLEKLAAIGVREVIINTAWLGHKLVETLEDGSRFGLMIQYSHED
EALETAGGILKALPLLGDEPFLVINGDIYIDALPVLSPSPELLSGETLAHLYLVDNPPQHPQGDFALEQGILSAEGKPTF
TFSGIGIYHPALFRTLAPGRHALGPLLRQHMNDGRIRGEHFDRYWCDVGTPERLDALNQRLMALGV

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=114, Percent_Identity=42.9824561403509, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI11761619, Length=114, Percent_Identity=42.9824561403509, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1788351, Length=230, Percent_Identity=27.8260869565217, Blast_Score=64, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI133931050, Length=113, Percent_Identity=42.4778761061947, Blast_Score=84, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6320148, Length=114, Percent_Identity=40.3508771929825, Blast_Score=79, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21355443, Length=113, Percent_Identity=39.8230088495575, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24644084, Length=113, Percent_Identity=39.8230088495575, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 24777; Mature: 24777

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMILAAGRGERLRPLTDTVPKPLVQAAGKPLIEYHLEKLAAIGVREVIINTAWLGHKL
CCEEEEECCCCCCCCCCHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VETLEDGSRFGLMIQYSHEDEALETAGGILKALPLLGDEPFLVINGDIYIDALPVLSPSP
HHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCCCCCC
ELLSGETLAHLYLVDNPPQHPQGDFALEQGILSAEGKPTFTFSGIGIYHPALFRTLAPGR
CHHCCCEEEEEEEECCCCCCCCCCHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHCCCCH
HALGPLLRQHMNDGRIRGEHFDRYWCDVGTPERLDALNQRLMALGV
HHHHHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKAMILAAGRGERLRPLTDTVPKPLVQAAGKPLIEYHLEKLAAIGVREVIINTAWLGHKL
CCEEEEECCCCCCCCCCHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VETLEDGSRFGLMIQYSHEDEALETAGGILKALPLLGDEPFLVINGDIYIDALPVLSPSP
HHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCCCCCC
ELLSGETLAHLYLVDNPPQHPQGDFALEQGILSAEGKPTFTFSGIGIYHPALFRTLAPGR
CHHCCCEEEEEEEECCCCCCCCCCHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHCCCCH
HALGPLLRQHMNDGRIRGEHFDRYWCDVGTPERLDALNQRLMALGV
HHHHHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA