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The map label for this gene is acdA [H]

Identifier: 119774514

GI number: 119774514

Start: 1668615

End: 1669772

Strand: Direct

Name: acdA [H]

Synonym: Sama_1377

Alternate gene names: 119774514

Gene position: 1668615-1669772 (Clockwise)

Preceding gene: 119774513

Following gene: 119774515

Centisome position: 38.75

GC content: 57.69

Gene sequence:

>1158_bases
ATGGATTTCAATTTCAACGAAGATCAACGTCAGTTTGCCGACCTGGCACGCCAGTTTGCCGCGGATGAGCTGACCCCCTT
TGCCGCCAAGTGGGACGAAGAGCATCATTTCCCCAAAGATGTGATTCAAAAGGCCGGTGAGCTGGGTTTCTGTTCACTCT
ATTCCCCTGAATCAGAAGGCGGCATGGGCCTGTCGCGCCTGGATGCCTCGATTATCTTTGAAGAGCTGTCAAAGGGCTGT
ACCGCCACTACCGCGATGCTGACGATCCACAATATGGCCACCTGGATGGTGACGACCTGGGGCACTGAGGCGTTTCGCGC
CGAATGGTCTGAGGCCCTCACAACGGGTGCCAAGTTGGCCTCATACTGCCTGACCGAGCCCGGTGCCGGCAGTGATGCCG
CGTCACTCACCACCAAGGCTGTGCGTGAAGGCGATGAGTACGTGATTAACGGCAGCAAAATGTTTATTTCAGGCGCCGGT
GCCACCGAGCTTTTGGTGGTGATGTGCCGCACCGGAGAAGCCGGTCCCAAAGGTATTTCTGCCATTGCCATCCCCGCCGA
TGCCGAGGGTGTCATTTACGGCAAGGCCGAAGACAAGATGGGCTGGAACGCCCAGCCAACCCGCCTTATCACGTTTGAAA
ACGTGCGCGTACCGGTGCAAAACCTGCTGGGTGAAGAAGGCCAGGGCTTTACCTTCGCCATGAAGGGCCTCGATGGCGGC
CGTATCAATATCGCCACCTGCTCCGTAGGTACCGCACAGGCTGCCCTGGAGCGCTCAATCGCGTACATGAACGAGCGTAA
GCAGTTTGGCAAGCCGCTGGCGGCCTTCCAGGCGCTGCAATTCAAGCTCGCCGACATGGCCACTGAGCTGGTGGCTGCGC
GTCAGATGGTACGTCTTGCGGCCTTTAAACTGGATAGCCAGGACCCGGAAGCCACGGCCTACTGCGCCATGGCCAAACGT
TTTGCCACCGACATCGGCTTTGCCGTGTGCGACGCTGCACTGCAAATTCATGGTGGCTATGGTTATATCCGTGAGTATCC
GCTGGAGCGTCATTTCCGTGACGTGCGGGTACACCAGATCCTGGAAGGCACCAACGAAATCATGCGTCTCATCATTTCCC
GTCGTCTGCTGGACGAAAACGCCAACGACATCCTCTGA

Upstream 100 bases:

>100_bases
GGTGCTTAACCTGGCGAGGCCGTAAACCAAAACCACCTTCAAGGCCGGCATTATGCCGGCCATCACATGAAGTGACCCCA
GAGTCACGGGAGCAGTCAAG

Downstream 100 bases:

>100_bases
TTTGCCAGTGATTTCGATTGAATAGAGACTTCGACAGAAAAGGAATAACAGCCATGGCATTTTTGATTGAACGTATCGAA
GGCAATACCGCCATCCTCAC

Product: butyryl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MDFNFNEDQRQFADLARQFAADELTPFAAKWDEEHHFPKDVIQKAGELGFCSLYSPESEGGMGLSRLDASIIFEELSKGC
TATTAMLTIHNMATWMVTTWGTEAFRAEWSEALTTGAKLASYCLTEPGAGSDAASLTTKAVREGDEYVINGSKMFISGAG
ATELLVVMCRTGEAGPKGISAIAIPADAEGVIYGKAEDKMGWNAQPTRLITFENVRVPVQNLLGEEGQGFTFAMKGLDGG
RINIATCSVGTAQAALERSIAYMNERKQFGKPLAAFQALQFKLADMATELVAARQMVRLAAFKLDSQDPEATAYCAMAKR
FATDIGFAVCDAALQIHGGYGYIREYPLERHFRDVRVHQILEGTNEIMRLIISRRLLDENANDIL

Sequences:

>Translated_385_residues
MDFNFNEDQRQFADLARQFAADELTPFAAKWDEEHHFPKDVIQKAGELGFCSLYSPESEGGMGLSRLDASIIFEELSKGC
TATTAMLTIHNMATWMVTTWGTEAFRAEWSEALTTGAKLASYCLTEPGAGSDAASLTTKAVREGDEYVINGSKMFISGAG
ATELLVVMCRTGEAGPKGISAIAIPADAEGVIYGKAEDKMGWNAQPTRLITFENVRVPVQNLLGEEGQGFTFAMKGLDGG
RINIATCSVGTAQAALERSIAYMNERKQFGKPLAAFQALQFKLADMATELVAARQMVRLAAFKLDSQDPEATAYCAMAKR
FATDIGFAVCDAALQIHGGYGYIREYPLERHFRDVRVHQILEGTNEIMRLIISRRLLDENANDIL
>Mature_385_residues
MDFNFNEDQRQFADLARQFAADELTPFAAKWDEEHHFPKDVIQKAGELGFCSLYSPESEGGMGLSRLDASIIFEELSKGC
TATTAMLTIHNMATWMVTTWGTEAFRAEWSEALTTGAKLASYCLTEPGAGSDAASLTTKAVREGDEYVINGSKMFISGAG
ATELLVVMCRTGEAGPKGISAIAIPADAEGVIYGKAEDKMGWNAQPTRLITFENVRVPVQNLLGEEGQGFTFAMKGLDGG
RINIATCSVGTAQAALERSIAYMNERKQFGKPLAAFQALQFKLADMATELVAARQMVRLAAFKLDSQDPEATAYCAMAKR
FATDIGFAVCDAALQIHGGYGYIREYPLERHFRDVRVHQILEGTNEIMRLIISRRLLDENANDIL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7656849, Length=375, Percent_Identity=56.2666666666667, Blast_Score=448, Evalue=1e-126,
Organism=Homo sapiens, GI4557233, Length=373, Percent_Identity=41.0187667560322, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI4557231, Length=385, Percent_Identity=38.7012987012987, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI187960098, Length=385, Percent_Identity=38.7012987012987, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=36.6310160427808, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI21361497, Length=371, Percent_Identity=35.3099730458221, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI4501857, Length=378, Percent_Identity=32.2751322751323, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=31.3829787234043, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI226958414, Length=336, Percent_Identity=32.1428571428571, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI76496475, Length=387, Percent_Identity=32.2997416020672, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI4557235, Length=387, Percent_Identity=32.2997416020672, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI48976061, Length=369, Percent_Identity=29.2682926829268, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI211971008, Length=369, Percent_Identity=29.2682926829268, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI4503943, Length=378, Percent_Identity=26.4550264550265, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI38505218, Length=355, Percent_Identity=29.8591549295775, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI7669494, Length=355, Percent_Identity=26.1971830985915, Blast_Score=112, Evalue=7e-25,
Organism=Escherichia coli, GI1786223, Length=388, Percent_Identity=30.4123711340206, Blast_Score=171, Evalue=6e-44,
Organism=Escherichia coli, GI87081958, Length=391, Percent_Identity=31.7135549872123, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI87082384, Length=296, Percent_Identity=27.027027027027, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17533517, Length=367, Percent_Identity=53.9509536784741, Blast_Score=414, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17534899, Length=389, Percent_Identity=40.1028277634961, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17569725, Length=388, Percent_Identity=38.9175257731959, Blast_Score=271, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=36.4829396325459, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17506239, Length=377, Percent_Identity=35.2785145888594, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17508101, Length=377, Percent_Identity=33.1564986737401, Blast_Score=217, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI71985184, Length=353, Percent_Identity=33.9943342776204, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17538396, Length=384, Percent_Identity=30.9895833333333, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17505929, Length=367, Percent_Identity=31.8801089918256, Blast_Score=174, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI71990804, Length=285, Percent_Identity=36.140350877193, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI32563615, Length=229, Percent_Identity=37.9912663755458, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17551932, Length=362, Percent_Identity=30.1104972375691, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71982178, Length=275, Percent_Identity=29.4545454545455, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI71985192, Length=301, Percent_Identity=31.5614617940199, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17534353, Length=381, Percent_Identity=26.509186351706, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17562446, Length=392, Percent_Identity=27.8061224489796, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17531909, Length=245, Percent_Identity=28.1632653061224, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24660351, Length=380, Percent_Identity=38.9473684210526, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI21356377, Length=380, Percent_Identity=38.4210526315789, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=37.7659574468085, Blast_Score=232, Evalue=4e-61,
Organism=Drosophila melanogaster, GI24666513, Length=372, Percent_Identity=35.2150537634409, Blast_Score=222, Evalue=4e-58,
Organism=Drosophila melanogaster, GI21355753, Length=383, Percent_Identity=34.2036553524804, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI281363737, Length=341, Percent_Identity=33.7243401759531, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI19920834, Length=379, Percent_Identity=26.9129287598945, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42092; Mature: 42092

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFNFNEDQRQFADLARQFAADELTPFAAKWDEEHHFPKDVIQKAGELGFCSLYSPESEG
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHCCCCCEEEECCCCCCC
GMGLSRLDASIIFEELSKGCTATTAMLTIHNMATWMVTTWGTEAFRAEWSEALTTGAKLA
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHH
SYCLTEPGAGSDAASLTTKAVREGDEYVINGSKMFISGAGATELLVVMCRTGEAGPKGIS
HHHHCCCCCCCCHHHHHHHHHHCCCCEEEECCEEEEECCCHHHEEEEEECCCCCCCCCCE
AIAIPADAEGVIYGKAEDKMGWNAQPTRLITFENVRVPVQNLLGEEGQGFTFAMKGLDGG
EEEECCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCHHHHCCCCCCCEEEEEECCCCC
RINIATCSVGTAQAALERSIAYMNERKQFGKPLAAFQALQFKLADMATELVAARQMVRLA
EEEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFKLDSQDPEATAYCAMAKRFATDIGFAVCDAALQIHGGYGYIREYPLERHFRDVRVHQI
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHCCCHHHHHHHHHHHHH
LEGTNEIMRLIISRRLLDENANDIL
HHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDFNFNEDQRQFADLARQFAADELTPFAAKWDEEHHFPKDVIQKAGELGFCSLYSPESEG
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHCCCCCEEEECCCCCCC
GMGLSRLDASIIFEELSKGCTATTAMLTIHNMATWMVTTWGTEAFRAEWSEALTTGAKLA
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHH
SYCLTEPGAGSDAASLTTKAVREGDEYVINGSKMFISGAGATELLVVMCRTGEAGPKGIS
HHHHCCCCCCCCHHHHHHHHHHCCCCEEEECCEEEEECCCHHHEEEEEECCCCCCCCCCE
AIAIPADAEGVIYGKAEDKMGWNAQPTRLITFENVRVPVQNLLGEEGQGFTFAMKGLDGG
EEEECCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCHHHHCCCCCCCEEEEEECCCCC
RINIATCSVGTAQAALERSIAYMNERKQFGKPLAAFQALQFKLADMATELVAARQMVRLA
EEEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFKLDSQDPEATAYCAMAKRFATDIGFAVCDAALQIHGGYGYIREYPLERHFRDVRVHQI
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHCCCHHHHHHHHHHHHH
LEGTNEIMRLIISRRLLDENANDIL
HHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]