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The map label for this gene is adk

Identifier: 119774452

GI number: 119774452

Start: 1599152

End: 1599796

Strand: Direct

Name: adk

Synonym: Sama_1315

Alternate gene names: 119774452

Gene position: 1599152-1599796 (Clockwise)

Preceding gene: 119774451

Following gene: 119774453

Centisome position: 37.14

GC content: 54.88

Gene sequence:

>645_bases
ATGCGCATTATCCTATTGGGCGCCCCAGGTGCCGGTAAAGGTACCCAGGCTCAGTTCATCATGGAACACTACGGAATCCC
CCAGATTTCTACCGGCGACATGCTGCGTGCAGCGGTCAAAGCCGGTACGCCCCTGGGTTTGGAAGCCAAGAAAGTGATGG
ACGCAGGTCAGCTGGTTTCTGATGAACTGATCATCGGTCTGGTGAAGGAGCGCATTGCTCAGGACGACTGCGCCAACGGT
TTCCTGCTGGACGGTTTCCCACGCACCATTCCTCAGGCCGATGCCATGGCTGCCAATGGCATCAGCATCGATCACGTGAT
TGAAATTGACGTGCCTGATGAAGAAATTGTGAACCGCATGAGCGGTCGCCGCGTACATCCAGGCTCAGGCCGTGTTTATC
ACGTTGTGTTCAATCCACCCAAGGTGGAAGGCAAGGATGACGTGACCGGTGAAGATCTGGTTATCCGTCCGGATGATGAA
GAGAGCACAGTGCGTAAGCGTCTGGGTATTTACCACGAGCAAACCAAGCCATTGGTTGATTACTATGGCAAGGTTGCCGC
CGAAGGTAACACCAAGTACACCAAGTTTGACGGTACCCAGAGCGTGGCCGAGGTCAGCAAGTTGATCCAGGCTGCCCTGA
GCTGA

Upstream 100 bases:

>100_bases
GAGGCTAAAGTCGAAAGAGCAGGCCTTCTAAAGCGCGGGTTTATGTGCGAAGATCGCCGCCCTAAGAAGAATATCGATGC
GAATTTAAGAGGACTCCCCG

Downstream 100 bases:

>100_bases
TAGCCAGAGATCGCACTTTGTAGAAAAGCCTGTGAAAACAGGCTTTTTTGTTTTTTGGCCTATGATAGGCTAAACCAAAG
TTTGCCAATTTGAGGTGAGA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MRIILLGAPGAGKGTQAQFIMEHYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDELIIGLVKERIAQDDCANG
FLLDGFPRTIPQADAMAANGISIDHVIEIDVPDEEIVNRMSGRRVHPGSGRVYHVVFNPPKVEGKDDVTGEDLVIRPDDE
ESTVRKRLGIYHEQTKPLVDYYGKVAAEGNTKYTKFDGTQSVAEVSKLIQAALS

Sequences:

>Translated_214_residues
MRIILLGAPGAGKGTQAQFIMEHYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDELIIGLVKERIAQDDCANG
FLLDGFPRTIPQADAMAANGISIDHVIEIDVPDEEIVNRMSGRRVHPGSGRVYHVVFNPPKVEGKDDVTGEDLVIRPDDE
ESTVRKRLGIYHEQTKPLVDYYGKVAAEGNTKYTKFDGTQSVAEVSKLIQAALS
>Mature_214_residues
MRIILLGAPGAGKGTQAQFIMEHYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDELIIGLVKERIAQDDCANG
FLLDGFPRTIPQADAMAANGISIDHVIEIDVPDEEIVNRMSGRRVHPGSGRVYHVVFNPPKVEGKDDVTGEDLVIRPDDE
ESTVRKRLGIYHEQTKPLVDYYGKVAAEGNTKYTKFDGTQSVAEVSKLIQAALS

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=218, Percent_Identity=46.7889908256881, Blast_Score=201, Evalue=4e-52,
Organism=Homo sapiens, GI4502013, Length=218, Percent_Identity=46.7889908256881, Blast_Score=201, Evalue=5e-52,
Organism=Homo sapiens, GI19923437, Length=184, Percent_Identity=45.1086956521739, Blast_Score=170, Evalue=8e-43,
Organism=Homo sapiens, GI310110345, Length=182, Percent_Identity=41.7582417582418, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI53832003, Length=182, Percent_Identity=41.7582417582418, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI8051579, Length=182, Percent_Identity=41.7582417582418, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI53832001, Length=182, Percent_Identity=41.7582417582418, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI4502011, Length=195, Percent_Identity=30.7692307692308, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI22749187, Length=206, Percent_Identity=27.6699029126214, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI7706497, Length=213, Percent_Identity=29.5774647887324, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI28144899, Length=195, Percent_Identity=27.6923076923077, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI28144897, Length=195, Percent_Identity=27.6923076923077, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=26.6187050359712, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI237858799, Length=138, Percent_Identity=26.8115942028986, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1786680, Length=213, Percent_Identity=73.2394366197183, Blast_Score=320, Evalue=4e-89,
Organism=Caenorhabditis elegans, GI17552384, Length=188, Percent_Identity=47.8723404255319, Blast_Score=186, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI17537943, Length=213, Percent_Identity=33.3333333333333, Blast_Score=126, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17567503, Length=213, Percent_Identity=30.9859154929577, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17550688, Length=187, Percent_Identity=26.7379679144385, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=210, Percent_Identity=48.0952380952381, Blast_Score=207, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6321018, Length=188, Percent_Identity=43.6170212765958, Blast_Score=146, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6322828, Length=214, Percent_Identity=28.0373831775701, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI22026816, Length=184, Percent_Identity=51.6304347826087, Blast_Score=197, Evalue=4e-51,
Organism=Drosophila melanogaster, GI17737899, Length=184, Percent_Identity=44.5652173913043, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24645822, Length=184, Percent_Identity=44.5652173913043, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24663208, Length=181, Percent_Identity=29.8342541436464, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17647141, Length=181, Percent_Identity=29.8342541436464, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221459597, Length=207, Percent_Identity=25.1207729468599, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI21356893, Length=207, Percent_Identity=25.1207729468599, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_SHEAM (A1S566)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_927192.1
- ProteinModelPortal:   A1S566
- SMR:   A1S566
- STRING:   A1S566
- GeneID:   4603567
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_1315
- NMPDR:   fig|326297.7.peg.1242
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- PhylomeDB:   A1S566
- ProtClustDB:   PRK00279
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23155; Mature: 23155

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIILLGAPGAGKGTQAQFIMEHYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVS
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
DELIIGLVKERIAQDDCANGFLLDGFPRTIPQADAMAANGISIDHVIEIDVPDEEIVNRM
HHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHCCCCCEEEEEEEECCHHHHHHHH
SGRRVHPGSGRVYHVVFNPPKVEGKDDVTGEDLVIRPDDEESTVRKRLGIYHEQTKPLVD
CCCEECCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCHHHHHHHHHCCHHHCCCCHHH
YYGKVAAEGNTKYTKFDGTQSVAEVSKLIQAALS
HHHHEEECCCCEEEEECCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRIILLGAPGAGKGTQAQFIMEHYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVS
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
DELIIGLVKERIAQDDCANGFLLDGFPRTIPQADAMAANGISIDHVIEIDVPDEEIVNRM
HHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHCCCCCEEEEEEEECCHHHHHHHH
SGRRVHPGSGRVYHVVFNPPKVEGKDDVTGEDLVIRPDDEESTVRKRLGIYHEQTKPLVD
CCCEECCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCHHHHHHHHHCCHHHCCCCHHH
YYGKVAAEGNTKYTKFDGTQSVAEVSKLIQAALS
HHHHEEECCCCEEEEECCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA