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The map label for this gene is hemH [H]

Identifier: 119774453

GI number: 119774453

Start: 1599916

End: 1600899

Strand: Direct

Name: hemH [H]

Synonym: Sama_1316

Alternate gene names: 119774453

Gene position: 1599916-1600899 (Clockwise)

Preceding gene: 119774452

Following gene: 119774454

Centisome position: 37.15

GC content: 55.18

Gene sequence:

>984_bases
ATGTTTGGAGTACTCCTAGTCAATCTGGGCACCCCAGATGCCCCCGACGCCCCTTCTGTGCGCCGTTTTTTAAAGCAATT
TTTGAGCGACCCCAGGGTAGTGGATTTATCCCCCTGGATTTGGAAACCGATTCTGAATGGCATCATTCTTAATACCCGTC
CTGCCAAAGTCGCCAAACTGTATCAAAGCATCTGGTGGGATGAGGGCTCACCGCTGATGGTCATTAGCCAGCGTCAGCGG
GAGAAGCTTGCCATCGAACTGAGCAGCCTCTACGGCCATGAAGTCCCGGTTGAACTTGGGATGAGTTATGGCTCACCGTC
GCTGAGCCAGGGGTTGGAGCGCCTCAAAGCCCAGGGTATAGACCGTGTCGTGGTGTTGCCTTTGTATCCTCAGTATTCCT
GCTCTACGGTGGCCAGTGTGTTCGATGGGGTTGCCGGCGTGCTCAAATCCTGGCGACGCCTGCCAGACTGGCGCATGGTG
CGCGAGTATTACCGTCATCCGCTGTATATACGGGCGCTGGCTGATTCTGTTCGTCGTCTTTGGGACGCTGACGGTAAAGC
TGAACTCTTACTGATGTCGTTCCACGGCGTGCCGCTGAGGTACATAACCGAAGGTGATCCCTATCAGGCCCAGTGCCAGG
AAACCGCAAGGCTCGTTGCCAAAGACCTTGGCCTTGGCAATGACGAATGGCAGGTCTGTTTTCAGTCGCGCTTTGGCAAA
GAAGAGTGGCTGACTCCCTATACCGACGAGTTGCTCGAGAGCCTGCCGGGCAAGGGCGTTAAGAAGGTGGACATTATGTG
TCCTGCTTTTTCGGCAGATTGCCTGGAAACGCTCGAAGAGATTGCCGAAGGGGGTAAAGAGTCCTTCATCCACGCCGGTG
GCGAGCAATATAGAGTCATTCCCTGTCTGAACGACGACGATGGCCATATCCGATTGCTGGCTGAACTGGTCAGAGAGCAG
AGCCTCGGCTGGCAAGTTGGCTGA

Upstream 100 bases:

>100_bases
GTAGAAAAGCCTGTGAAAACAGGCTTTTTTGTTTTTTGGCCTATGATAGGCTAAACCAAAGTTTGCCAATTTGAGGTGAG
ATGTGAGCCAGGAAAAGCCA

Downstream 100 bases:

>100_bases
TGGCGCTGCGCTCATCACTGGTCAGTATCTTAAAATATGATAGAATCTGCCGCCTTTGAGCCAGGCGGCGGTATTTGCAG
CTTTCTTTTGCGTGGATCTC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase 1; Protoheme ferro-lyase 1 [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MFGVLLVNLGTPDAPDAPSVRRFLKQFLSDPRVVDLSPWIWKPILNGIILNTRPAKVAKLYQSIWWDEGSPLMVISQRQR
EKLAIELSSLYGHEVPVELGMSYGSPSLSQGLERLKAQGIDRVVVLPLYPQYSCSTVASVFDGVAGVLKSWRRLPDWRMV
REYYRHPLYIRALADSVRRLWDADGKAELLLMSFHGVPLRYITEGDPYQAQCQETARLVAKDLGLGNDEWQVCFQSRFGK
EEWLTPYTDELLESLPGKGVKKVDIMCPAFSADCLETLEEIAEGGKESFIHAGGEQYRVIPCLNDDDGHIRLLAELVREQ
SLGWQVG

Sequences:

>Translated_327_residues
MFGVLLVNLGTPDAPDAPSVRRFLKQFLSDPRVVDLSPWIWKPILNGIILNTRPAKVAKLYQSIWWDEGSPLMVISQRQR
EKLAIELSSLYGHEVPVELGMSYGSPSLSQGLERLKAQGIDRVVVLPLYPQYSCSTVASVFDGVAGVLKSWRRLPDWRMV
REYYRHPLYIRALADSVRRLWDADGKAELLLMSFHGVPLRYITEGDPYQAQCQETARLVAKDLGLGNDEWQVCFQSRFGK
EEWLTPYTDELLESLPGKGVKKVDIMCPAFSADCLETLEEIAEGGKESFIHAGGEQYRVIPCLNDDDGHIRLLAELVREQ
SLGWQVG
>Mature_327_residues
MFGVLLVNLGTPDAPDAPSVRRFLKQFLSDPRVVDLSPWIWKPILNGIILNTRPAKVAKLYQSIWWDEGSPLMVISQRQR
EKLAIELSSLYGHEVPVELGMSYGSPSLSQGLERLKAQGIDRVVVLPLYPQYSCSTVASVFDGVAGVLKSWRRLPDWRMV
REYYRHPLYIRALADSVRRLWDADGKAELLLMSFHGVPLRYITEGDPYQAQCQETARLVAKDLGLGNDEWQVCFQSRFGK
EEWLTPYTDELLESLPGKGVKKVDIMCPAFSADCLETLEEIAEGGKESFIHAGGEQYRVIPCLNDDDGHIRLLAELVREQ
SLGWQVG

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=331, Percent_Identity=27.190332326284, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI60499025, Length=331, Percent_Identity=27.190332326284, Blast_Score=111, Evalue=7e-25,
Organism=Escherichia coli, GI1786681, Length=315, Percent_Identity=52.3809523809524, Blast_Score=319, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6324750, Length=328, Percent_Identity=24.390243902439, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17864156, Length=334, Percent_Identity=25.748502994012, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24651774, Length=266, Percent_Identity=25.9398496240602, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI45552018, Length=169, Percent_Identity=26.0355029585799, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 36936; Mature: 36936

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGVLLVNLGTPDAPDAPSVRRFLKQFLSDPRVVDLSPWIWKPILNGIILNTRPAKVAKL
CCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEECCHHHHHHHHCCEEECCCHHHHHHH
YQSIWWDEGSPLMVISQRQREKLAIELSSLYGHEVPVELGMSYGSPSLSQGLERLKAQGI
HHHHHCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHCCC
DRVVVLPLYPQYSCSTVASVFDGVAGVLKSWRRLPDWRMVREYYRHPLYIRALADSVRRL
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHH
WDADGKAELLLMSFHGVPLRYITEGDPYQAQCQETARLVAKDLGLGNDEWQVCFQSRFGK
HCCCCCCEEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
EEWLTPYTDELLESLPGKGVKKVDIMCPAFSADCLETLEEIAEGGKESFIHAGGEQYRVI
CCCCCCHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHHEECCCCCEEEE
PCLNDDDGHIRLLAELVREQSLGWQVG
EECCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFGVLLVNLGTPDAPDAPSVRRFLKQFLSDPRVVDLSPWIWKPILNGIILNTRPAKVAKL
CCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEECCHHHHHHHHCCEEECCCHHHHHHH
YQSIWWDEGSPLMVISQRQREKLAIELSSLYGHEVPVELGMSYGSPSLSQGLERLKAQGI
HHHHHCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHCCC
DRVVVLPLYPQYSCSTVASVFDGVAGVLKSWRRLPDWRMVREYYRHPLYIRALADSVRRL
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHH
WDADGKAELLLMSFHGVPLRYITEGDPYQAQCQETARLVAKDLGLGNDEWQVCFQSRFGK
HCCCCCCEEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
EEWLTPYTDELLESLPGKGVKKVDIMCPAFSADCLETLEEIAEGGKESFIHAGGEQYRVI
CCCCCCHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHHEECCCCCEEEE
PCLNDDDGHIRLLAELVREQSLGWQVG
EECCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]