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The map label for this gene is pdhR [H]

Identifier: 119773515

GI number: 119773515

Start: 452998

End: 453750

Strand: Direct

Name: pdhR [H]

Synonym: Sama_0374

Alternate gene names: 119773515

Gene position: 452998-453750 (Clockwise)

Preceding gene: 119773514

Following gene: 119773516

Centisome position: 10.52

GC content: 55.64

Gene sequence:

>753_bases
ATGGCATATAGCAAAATAAACCAGCCGAAGATCTCCGATGTGATCATGCAGCAACTCGAGCGCATGATCCTTGAAGGCAG
TCTCAAGCCCGGCCAAAAACTGCCCCCTGAGCGGGAGTTGGCCATTCAATTTGAAGTTTCCCGTCCTTCCCTGCGCGAAG
CCATCCAGAAACTGGAGGCCAAAGGCCTGCTGATGCGTCGCCAGGGCGGTGGTACCTACGTGAAAGAGCAGCTGTGGCAA
AGCATGGCCGACCCTATCGTAGAGCTCATGCAGAGCGACACCGAGAGCCAGTACGACCTGCTTGAATTCCGTCATGCCAC
CGAAGGCATGATGGCGTACTTTGCCGCGCTGCGCGGTACAGATGCCGACATGAATAACATCCAAAAAATGATTTTGGAAG
TGGAAGAGGCCCAAACTATCGAAAGTAAGGCCGATGCCATCGTGCGTTTTTATCGCGCCGTGGCCGAAGCCTCCCACAAT
GTGGCCATGTTACATCTGGTTTTAAGTTTAACTCCGGTGCTGCACAAGAATGTGGCACAAAACCTGGAGCTTCTGAGCCG
CCGCGAAGATGCCTCCAGAATGGCGAACGAACACCGCCGGGCACTGCTCGCCGCTATAGTTCGCCGCGATCCCGAAGCGG
CCCGCGAAGCCTCGAATGAGCACTTGAGCTACATCGAAGAGGTGATGTTGGCGGTCAGGGAAGAAGATAGCCGGTTGCAG
CGCAGCCTGCGCCGATTAAAGAGTGGCGCCTGA

Upstream 100 bases:

>100_bases
TGATATGGATCACTGTATGGACTTTAAAACCGTGATTTGATAAAGTGCGCTCACTCGCATAAATTGGTAAGACCAATTTA
CAATGGAGCTGAGGGCCCAC

Downstream 100 bases:

>100_bases
TGGCCGGGATGGTGTTTACCAGTACCTTGCAAGCCACTTTTCCCATAAATATGTATATATAAGGACAGTCTCATGTCTGA
ACCTATGCAAATGCTACAAG

Product: transcriptional regulator PdhR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MAYSKINQPKISDVIMQQLERMILEGSLKPGQKLPPERELAIQFEVSRPSLREAIQKLEAKGLLMRRQGGGTYVKEQLWQ
SMADPIVELMQSDTESQYDLLEFRHATEGMMAYFAALRGTDADMNNIQKMILEVEEAQTIESKADAIVRFYRAVAEASHN
VAMLHLVLSLTPVLHKNVAQNLELLSRREDASRMANEHRRALLAAIVRRDPEAAREASNEHLSYIEEVMLAVREEDSRLQ
RSLRRLKSGA

Sequences:

>Translated_250_residues
MAYSKINQPKISDVIMQQLERMILEGSLKPGQKLPPERELAIQFEVSRPSLREAIQKLEAKGLLMRRQGGGTYVKEQLWQ
SMADPIVELMQSDTESQYDLLEFRHATEGMMAYFAALRGTDADMNNIQKMILEVEEAQTIESKADAIVRFYRAVAEASHN
VAMLHLVLSLTPVLHKNVAQNLELLSRREDASRMANEHRRALLAAIVRRDPEAAREASNEHLSYIEEVMLAVREEDSRLQ
RSLRRLKSGA
>Mature_249_residues
AYSKINQPKISDVIMQQLERMILEGSLKPGQKLPPERELAIQFEVSRPSLREAIQKLEAKGLLMRRQGGGTYVKEQLWQS
MADPIVELMQSDTESQYDLLEFRHATEGMMAYFAALRGTDADMNNIQKMILEVEEAQTIESKADAIVRFYRAVAEASHNV
AMLHLVLSLTPVLHKNVAQNLELLSRREDASRMANEHRRALLAAIVRRDPEAAREASNEHLSYIEEVMLAVREEDSRLQR
SLRRLKSGA

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=233, Percent_Identity=57.5107296137339, Blast_Score=272, Evalue=2e-74,
Organism=Escherichia coli, GI1790032, Length=241, Percent_Identity=36.0995850622407, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1789353, Length=238, Percent_Identity=28.9915966386555, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1790780, Length=222, Percent_Identity=30.1801801801802, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI48994955, Length=215, Percent_Identity=28.3720930232558, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082208, Length=209, Percent_Identity=30.622009569378, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1789621, Length=240, Percent_Identity=29.1666666666667, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 28483; Mature: 28352

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYSKINQPKISDVIMQQLERMILEGSLKPGQKLPPERELAIQFEVSRPSLREAIQKLEA
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
KGLLMRRQGGGTYVKEQLWQSMADPIVELMQSDTESQYDLLEFRHATEGMMAYFAALRGT
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
DADMNNIQKMILEVEEAQTIESKADAIVRFYRAVAEASHNVAMLHLVLSLTPVLHKNVAQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
NLELLSRREDASRMANEHRRALLAAIVRRDPEAAREASNEHLSYIEEVMLAVREEDSRLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
RSLRRLKSGA
HHHHHHHCCC
>Mature Secondary Structure 
AYSKINQPKISDVIMQQLERMILEGSLKPGQKLPPERELAIQFEVSRPSLREAIQKLEA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
KGLLMRRQGGGTYVKEQLWQSMADPIVELMQSDTESQYDLLEFRHATEGMMAYFAALRGT
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
DADMNNIQKMILEVEEAQTIESKADAIVRFYRAVAEASHNVAMLHLVLSLTPVLHKNVAQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
NLELLSRREDASRMANEHRRALLAAIVRRDPEAAREASNEHLSYIEEVMLAVREEDSRLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
RSLRRLKSGA
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]