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The map label for this gene is argH

Identifier: 119773401

GI number: 119773401

Start: 298127

End: 299497

Strand: Direct

Name: argH

Synonym: Sama_0260

Alternate gene names: 119773401

Gene position: 298127-299497 (Clockwise)

Preceding gene: 119773400

Following gene: 119773408

Centisome position: 6.92

GC content: 59.59

Gene sequence:

>1371_bases
ATGGCCTTGTGGGGCGGCAGATTTCAGGGGCAAGCCAGTGCCCTGTTCCAACTCTTTAACGATTCACTGCCGGTAGATTA
CCGACTGTTCGTCCAGGACGTGGAAGGCTCCATCGCCTGGGCCGATGCCATCGCCAGCGTGGGCATTTTGAATGCCGATG
AATGCAGCCGCCTCAAGGCAGCCCTGACGGAGCTGCTTGAGGAAGTGGGCGAGGATGAGTCGGCCATCATCGGCAGCGGC
GCCGAAGACATTCACAGCTTTGTGGAAACCAAACTGATTGAAAAAGTGGGCGATCTCGGTAAAAAGCTGCACACCGGCCG
TTCCCGTAACGACCAGGTGGCCACCGACCTCAAGCTATGGTGCAAGGCATCGGGCGGCCTGCTGGAAACCAAGCTTACTG
CCGTGATTCAGGCACTGCTGGCACTGGCAAGCCGTGAGCTGGATGCCGTGATGCCCGGCTACACCCACCTGCAGCGGGCA
CAGCCTGTGACCTTTGGTCACTGGTGCCTGGCCTATGTGGAAATGCTGGAGCGTGACCTGTCCCGTCTTGCCGATGCTTT
GAAGCGCCTTAACACCTGTCCACTGGGCTCGGGTGCGCTGGCGGGCACTGCCTATGCTATCGACCGCCATGAGTTGGCCG
CCGCGCTGGGTTTTGGCGGACCGACCCTCAACAGTCTGGATTCCGTCTCCGACCGTGACCATGTGGTGGAGCTCTGCGCC
GCTGCCTCTGTGTCTATGATGCATCTGTCGCGGATGGCGGAAGACCTGATTTTCTTCAACACGGGTGAAGCGGCTTTTGT
GGAGCTGGCCGATAACGTGACTTCGGGTTCTTCGCTGATGCCCCAGAAGAAAAACCCCGATGCGCTGGAACTGATCCGCG
GTAAAACTGGCCGTGTTTACGGCAATCTCGTGGGCATTCTCACCACCATGAAGGCACTGCCGCTGGCCTACAACAAGGAC
ATGCAGGAAGACAAAGAAGGTCTGTTCGACACCCTCGACAGCTGGGGCATTTGCCTGGATATGGCAGCACTGGTGCTGGA
GGGGGTGAAGGTAAACCGTGACAACACCAAGCAGGCGGCCCAGGCGGGTTATGCCAACGCCACCGAGCTTGCCGACTATC
TGGTTGCCAAGGGCATGCCGTTCCGGGAAGCACACCATGTGGTGGGTGAAGTGGTGCTGCATGCCATCAGCAAGGGACAG
GCGCTGGAAGCCTTGCCGCTGGCCTCGCTGCAATCCTTTGCCGCCGTGATTGGCGACGATGTCTACCCGCACCTCAGCCT
GGATGAATGTCTGGCGAAGCGGGATGTGCTGGGCGGCACTGCCATCAAGCAGGTGACAGCTGCACTGGCGGCCAAACAGC
AGCAATACTGA

Upstream 100 bases:

>100_bases
GCGCTTACAACACCAAGTAAGCCGCCTTGTCAGTCAGGGGGCCAATTTGGCCCCCATTCATTTTTAGTTCCGGGCACGCC
CGGGCAGAAGGAGAATTGCT

Downstream 100 bases:

>100_bases
GCCTGCTCAGCAGGCAATAAAAAAGCTCGCCATCCGGCGAGCTTTTTCGTTTAAAGAGTGGATTAAATCTCGTCTTCCCA
CACCACCTTGGCACCACGAA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MALWGGRFQGQASALFQLFNDSLPVDYRLFVQDVEGSIAWADAIASVGILNADECSRLKAALTELLEEVGEDESAIIGSG
AEDIHSFVETKLIEKVGDLGKKLHTGRSRNDQVATDLKLWCKASGGLLETKLTAVIQALLALASRELDAVMPGYTHLQRA
QPVTFGHWCLAYVEMLERDLSRLADALKRLNTCPLGSGALAGTAYAIDRHELAAALGFGGPTLNSLDSVSDRDHVVELCA
AASVSMMHLSRMAEDLIFFNTGEAAFVELADNVTSGSSLMPQKKNPDALELIRGKTGRVYGNLVGILTTMKALPLAYNKD
MQEDKEGLFDTLDSWGICLDMAALVLEGVKVNRDNTKQAAQAGYANATELADYLVAKGMPFREAHHVVGEVVLHAISKGQ
ALEALPLASLQSFAAVIGDDVYPHLSLDECLAKRDVLGGTAIKQVTAALAAKQQQY

Sequences:

>Translated_456_residues
MALWGGRFQGQASALFQLFNDSLPVDYRLFVQDVEGSIAWADAIASVGILNADECSRLKAALTELLEEVGEDESAIIGSG
AEDIHSFVETKLIEKVGDLGKKLHTGRSRNDQVATDLKLWCKASGGLLETKLTAVIQALLALASRELDAVMPGYTHLQRA
QPVTFGHWCLAYVEMLERDLSRLADALKRLNTCPLGSGALAGTAYAIDRHELAAALGFGGPTLNSLDSVSDRDHVVELCA
AASVSMMHLSRMAEDLIFFNTGEAAFVELADNVTSGSSLMPQKKNPDALELIRGKTGRVYGNLVGILTTMKALPLAYNKD
MQEDKEGLFDTLDSWGICLDMAALVLEGVKVNRDNTKQAAQAGYANATELADYLVAKGMPFREAHHVVGEVVLHAISKGQ
ALEALPLASLQSFAAVIGDDVYPHLSLDECLAKRDVLGGTAIKQVTAALAAKQQQY
>Mature_455_residues
ALWGGRFQGQASALFQLFNDSLPVDYRLFVQDVEGSIAWADAIASVGILNADECSRLKAALTELLEEVGEDESAIIGSGA
EDIHSFVETKLIEKVGDLGKKLHTGRSRNDQVATDLKLWCKASGGLLETKLTAVIQALLALASRELDAVMPGYTHLQRAQ
PVTFGHWCLAYVEMLERDLSRLADALKRLNTCPLGSGALAGTAYAIDRHELAAALGFGGPTLNSLDSVSDRDHVVELCAA
ASVSMMHLSRMAEDLIFFNTGEAAFVELADNVTSGSSLMPQKKNPDALELIRGKTGRVYGNLVGILTTMKALPLAYNKDM
QEDKEGLFDTLDSWGICLDMAALVLEGVKVNRDNTKQAAQAGYANATELADYLVAKGMPFREAHHVVGEVVLHAISKGQA
LEALPLASLQSFAAVIGDDVYPHLSLDECLAKRDVLGGTAIKQVTAALAAKQQQY

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=458, Percent_Identity=44.9781659388646, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI68303542, Length=458, Percent_Identity=44.9781659388646, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI68303549, Length=458, Percent_Identity=42.5764192139738, Blast_Score=345, Evalue=6e-95,
Organism=Homo sapiens, GI68303547, Length=458, Percent_Identity=42.5764192139738, Blast_Score=344, Evalue=9e-95,
Organism=Escherichia coli, GI1790398, Length=453, Percent_Identity=67.1081677704194, Blast_Score=609, Evalue=1e-175,
Organism=Saccharomyces cerevisiae, GI6321806, Length=456, Percent_Identity=43.640350877193, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI221473854, Length=448, Percent_Identity=44.1964285714286, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI78706858, Length=448, Percent_Identity=44.1964285714286, Blast_Score=364, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_SHEAM (A1S265)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_926141.1
- ProteinModelPortal:   A1S265
- SMR:   A1S265
- STRING:   A1S265
- GeneID:   4602516
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_0260
- NMPDR:   fig|326297.7.peg.250
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- PhylomeDB:   A1S265
- ProtClustDB:   PRK04833
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 48944; Mature: 48813

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALWGGRFQGQASALFQLFNDSLPVDYRLFVQDVEGSIAWADAIASVGILNADECSRLKA
CCCCCCCCCCHHHHHHHHHCCCCCCCHHHHEECCCCCHHHHHHHHHHCCCCHHHHHHHHH
ALTELLEEVGEDESAIIGSGAEDIHSFVETKLIEKVGDLGKKLHTGRSRNDQVATDLKLW
HHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
CKASGGLLETKLTAVIQALLALASRELDAVMPGYTHLQRAQPVTFGHWCLAYVEMLERDL
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHH
SRLADALKRLNTCPLGSGALAGTAYAIDRHELAAALGFGGPTLNSLDSVSDRDHVVELCA
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHH
AASVSMMHLSRMAEDLIFFNTGEAAFVELADNVTSGSSLMPQKKNPDALELIRGKTGRVY
HHHHHHHHHHHHHHHHEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCCCHH
GNLVGILTTMKALPLAYNKDMQEDKEGLFDTLDSWGICLDMAALVLEGVKVNRDNTKQAA
HHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
QAGYANATELADYLVAKGMPFREAHHVVGEVVLHAISKGQALEALPLASLQSFAAVIGDD
HCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
VYPHLSLDECLAKRDVLGGTAIKQVTAALAAKQQQY
CCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ALWGGRFQGQASALFQLFNDSLPVDYRLFVQDVEGSIAWADAIASVGILNADECSRLKA
CCCCCCCCCHHHHHHHHHCCCCCCCHHHHEECCCCCHHHHHHHHHHCCCCHHHHHHHHH
ALTELLEEVGEDESAIIGSGAEDIHSFVETKLIEKVGDLGKKLHTGRSRNDQVATDLKLW
HHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
CKASGGLLETKLTAVIQALLALASRELDAVMPGYTHLQRAQPVTFGHWCLAYVEMLERDL
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHH
SRLADALKRLNTCPLGSGALAGTAYAIDRHELAAALGFGGPTLNSLDSVSDRDHVVELCA
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHH
AASVSMMHLSRMAEDLIFFNTGEAAFVELADNVTSGSSLMPQKKNPDALELIRGKTGRVY
HHHHHHHHHHHHHHHHEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCCCHH
GNLVGILTTMKALPLAYNKDMQEDKEGLFDTLDSWGICLDMAALVLEGVKVNRDNTKQAA
HHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
QAGYANATELADYLVAKGMPFREAHHVVGEVVLHAISKGQALEALPLASLQSFAAVIGDD
HCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
VYPHLSLDECLAKRDVLGGTAIKQVTAALAAKQQQY
CCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA