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The map label for this gene is trpA [H]

Identifier: 119717249

GI number: 119717249

Start: 3225856

End: 3226680

Strand: Reverse

Name: trpA [H]

Synonym: Noca_3025

Alternate gene names: 119717249

Gene position: 3226680-3225856 (Counterclockwise)

Preceding gene: 119717250

Following gene: 119717248

Centisome position: 64.72

GC content: 75.64

Gene sequence:

>825_bases
ATGAGCACGCGGACCGCGTTCGACACGGCGAGGGCCGAGGGCCGGGCGGCGCTCGTGGGCTACCTGCCGGCGGGCTTCCC
GGACGTCGCCGGGGGCATCGACGCCATGCTGGCGATGGTCGACGCCGGGTGTGACGTGATCGAGGTCGGGCTGCCCTACA
GCGACCCGGTCATGGACGGGCCCACCATCCAGGCGGCCGCGCAGCAGGCCCTCGAGCGGGGCGTCCGCACCGCCGACGTC
CTGCGCACCGTCGAGGCGGTCGCGGCGACCGGCACGCCGACCGTCGTGATGACCTACTGGAACCCGGTCGAACGGTACGG
CGTCTCGCGGTTCGCCGCCGATCTCGCCAACGCCGGGGGAGCGGGTCTGATCACGCCCGACCTCACCCCCGACAGCGCGC
AGGAGTGGATCGCCGCCGCCGACGAGCACGACCTGGACAAGGTGTTCCTGGTCGCGCCGTCCTCGACCGAGGAGCGGCTC
GCGATGACGACGGCGGCGTGCCGCGGCTTCGTCTACGCCACCGCGGTGATGGGCGTGACCGGCGCCCGGGCGACGACCAG
CGACCTGGCCGGACCGCTCGTGGCGCGGGCCAGGAGCGCGATCGCGGCGGCCGGCGCGGACCTGCCGGTCGGCGTGGGCC
TCGGCGTCAGCACCGGCGACCAGGCCGCCGAGCTGGCTGCCAGGAACGGGATCGGCGCCGACGGCGTGATCGTGGGCTCG
GCGTTCGTGCGCACGCTCCTCGACCACCCGGACGACCCGGCCGCGGGCCTGCGCGCGCTCCGCGAGCTGACCGAGGACCT
CGCCGCCGGTGTCCGGCGTGCGTAG

Upstream 100 bases:

>100_bases
TGAGCGGGCGCGGCGACAAGGACATGGGCACCGCGATCGAGTACTTCGGCCTGGTCGACGGCCAGCACGCCGGAGGCCAC
GGAGCCGGGGAGCCGATCGG

Downstream 100 bases:

>100_bases
GCGGCTCGCGGGGATCGGCGCCCTGGTGCTGGCCGGGGCGCTGCTCGCCGGCTGCTCCACCAGCACGGCCGAGACCGACG
GCGGCTACCGCGCCGCCGTG

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MSTRTAFDTARAEGRAALVGYLPAGFPDVAGGIDAMLAMVDAGCDVIEVGLPYSDPVMDGPTIQAAAQQALERGVRTADV
LRTVEAVAATGTPTVVMTYWNPVERYGVSRFAADLANAGGAGLITPDLTPDSAQEWIAAADEHDLDKVFLVAPSSTEERL
AMTTAACRGFVYATAVMGVTGARATTSDLAGPLVARARSAIAAAGADLPVGVGLGVSTGDQAAELAARNGIGADGVIVGS
AFVRTLLDHPDDPAAGLRALRELTEDLAAGVRRA

Sequences:

>Translated_274_residues
MSTRTAFDTARAEGRAALVGYLPAGFPDVAGGIDAMLAMVDAGCDVIEVGLPYSDPVMDGPTIQAAAQQALERGVRTADV
LRTVEAVAATGTPTVVMTYWNPVERYGVSRFAADLANAGGAGLITPDLTPDSAQEWIAAADEHDLDKVFLVAPSSTEERL
AMTTAACRGFVYATAVMGVTGARATTSDLAGPLVARARSAIAAAGADLPVGVGLGVSTGDQAAELAARNGIGADGVIVGS
AFVRTLLDHPDDPAAGLRALRELTEDLAAGVRRA
>Mature_273_residues
STRTAFDTARAEGRAALVGYLPAGFPDVAGGIDAMLAMVDAGCDVIEVGLPYSDPVMDGPTIQAAAQQALERGVRTADVL
RTVEAVAATGTPTVVMTYWNPVERYGVSRFAADLANAGGAGLITPDLTPDSAQEWIAAADEHDLDKVFLVAPSSTEERLA
MTTAACRGFVYATAVMGVTGARATTSDLAGPLVARARSAIAAAGADLPVGVGLGVSTGDQAAELAARNGIGADGVIVGSA
FVRTLLDHPDDPAAGLRALRELTEDLAAGVRRA

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=265, Percent_Identity=28.6792452830189, Blast_Score=101, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6321412, Length=250, Percent_Identity=36.8, Blast_Score=161, Evalue=8e-41,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 27852; Mature: 27720

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRTAFDTARAEGRAALVGYLPAGFPDVAGGIDAMLAMVDAGCDVIEVGLPYSDPVMDG
CCCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCC
PTIQAAAQQALERGVRTADVLRTVEAVAATGTPTVVMTYWNPVERYGVSRFAADLANAGG
CHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCC
AGLITPDLTPDSAQEWIAAADEHDLDKVFLVAPSSTEERLAMTTAACRGFVYATAVMGVT
CCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCC
GARATTSDLAGPLVARARSAIAAAGADLPVGVGLGVSTGDQAAELAARNGIGADGVIVGS
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHHHCCCCCCCEEHHH
AFVRTLLDHPDDPAAGLRALRELTEDLAAGVRRA
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STRTAFDTARAEGRAALVGYLPAGFPDVAGGIDAMLAMVDAGCDVIEVGLPYSDPVMDG
CCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCC
PTIQAAAQQALERGVRTADVLRTVEAVAATGTPTVVMTYWNPVERYGVSRFAADLANAGG
CHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCC
AGLITPDLTPDSAQEWIAAADEHDLDKVFLVAPSSTEERLAMTTAACRGFVYATAVMGVT
CCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCC
GARATTSDLAGPLVARARSAIAAAGADLPVGVGLGVSTGDQAAELAARNGIGADGVIVGS
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHHHCCCCCCCEEHHH
AFVRTLLDHPDDPAAGLRALRELTEDLAAGVRRA
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA