Click here to switch to the map view.

The map label for this gene is wecC [H]

Identifier: 119717219

GI number: 119717219

Start: 3185143

End: 3186342

Strand: Reverse

Name: wecC [H]

Synonym: Noca_2995

Alternate gene names: 119717219

Gene position: 3186342-3185143 (Counterclockwise)

Preceding gene: 119717222

Following gene: 119717218

Centisome position: 63.91

GC content: 71.92

Gene sequence:

>1200_bases
GTGGCAGATCAGTTCGACTTCGACGTCTGCGTCGTGGGTGGCGGCGGGCACGTCGGGTTCCCGTTGGCGGTCGCGTTCGC
CTCCCGGGGGCTCCGGGTGGCGGTCTACGACGTGAACGCGGCGGTCGTCGCGACCATCGCCTCCGGACGCGCCCCGTTCC
TCGAGCCCGGGGTCCACGCACCGCTCGCCGACGCGATCGCGTCGGACCGTCTGGTCGCGACGACCGAGCGCGAGGTCGTC
CGCCGGGCCGAGCACGTCGTGATCGTGGTCGGCACCCCGGTCGACCAGTACCTCAGCCCCGACCCCGAGGCCGTGCCGCG
GGTGGTCGGGGAGCTGGAGGACCTGCTCGTGGCCGGACAGCTGGTCGTGCTCAGGAGCACCGTCTTCCCCGGGGTGACCC
GCCGGGTCGAGCAGCTGCTCGCCGGCAGCCACCCCGACGTCGACCTGGCCTTCTGCCCCGAGCGGATCGCCGAGGGCCGG
GCCATGACCGAGCTCTTCACGCTGCCGCAGCTGGTGGCTGCGCGCAGCGACCGGCCGATGCAGCGTGCAGCGGCCCTGTT
CGGCAAGCTCACCGACACCGTCATCGAGCTGGCGCCCGAGGAGGCGGAGCTCGCGAAGCTGTTCACCAACTCCTGGCGCT
ACATCAAGTTCGCGGCCGCCAACCAGTACTACATGATCGCCAACGACCTCGGTCTCGACTTCGCCCGGATCCGCGACGCC
ATGACCACGGACTACCCCCGCTCCGCGGACCTGCCGGGCGCGGGGTTCGCCGCCGGCCCCTGCCTGTTCAAGGACACCAT
GCAGCTCGCCTCGGTCACCGGGGGCGCCTTCGCGCTCGGCCACTCCGCGATGCTCGTCAACGAGGGCCTCCCCGACTACC
TCGTCCGCGGGATGGAGCAACGCCACGACCTCCCGGCGCTCACTGTCGGGATCCTCGGCATGGCGTTCAAGGCCGAGAGC
GACGACCGGCGCTCCAGCCTGTCCTACCGGCTCAAGCGGGTGCTGTCCTTCCGCGCCGGCCGCGTCCTGACCACCGACCC
CTACGTCGCGGACGACTCCGACCTCCTGCCCCTCGAGCGGGTGCTGTCCGAGGCCGACCTGCTCGTGATCGGGGCGCCGC
ACGCGGTCTACCGGGACCTCGAGCCGGCGGTCCCGGTCGTCGACGTGTGGAACCTGCTCGGAATGGGGTCGGCCCTGTGA

Upstream 100 bases:

>100_bases
CACCGATGACCCCGGAACCGGGCTGCCCGGCCGCTCCGTCGCGGTAGTTTGGGCGAGACCTCTCGACCCGAGCCGACCGA
CCCGACGGAGCAGCAGCAGC

Downstream 100 bases:

>100_bases
CGCCCACCGCCGTGTCCGTGATCGTCCCGGCCTACCACGAGGATCAGGGCATCGGACGGGTGCTCGACCGGCTGATCGAC
GCCATCACTCTCGACTTCGA

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MADQFDFDVCVVGGGGHVGFPLAVAFASRGLRVAVYDVNAAVVATIASGRAPFLEPGVHAPLADAIASDRLVATTEREVV
RRAEHVVIVVGTPVDQYLSPDPEAVPRVVGELEDLLVAGQLVVLRSTVFPGVTRRVEQLLAGSHPDVDLAFCPERIAEGR
AMTELFTLPQLVAARSDRPMQRAAALFGKLTDTVIELAPEEAELAKLFTNSWRYIKFAAANQYYMIANDLGLDFARIRDA
MTTDYPRSADLPGAGFAAGPCLFKDTMQLASVTGGAFALGHSAMLVNEGLPDYLVRGMEQRHDLPALTVGILGMAFKAES
DDRRSSLSYRLKRVLSFRAGRVLTTDPYVADDSDLLPLERVLSEADLLVIGAPHAVYRDLEPAVPVVDVWNLLGMGSAL

Sequences:

>Translated_399_residues
MADQFDFDVCVVGGGGHVGFPLAVAFASRGLRVAVYDVNAAVVATIASGRAPFLEPGVHAPLADAIASDRLVATTEREVV
RRAEHVVIVVGTPVDQYLSPDPEAVPRVVGELEDLLVAGQLVVLRSTVFPGVTRRVEQLLAGSHPDVDLAFCPERIAEGR
AMTELFTLPQLVAARSDRPMQRAAALFGKLTDTVIELAPEEAELAKLFTNSWRYIKFAAANQYYMIANDLGLDFARIRDA
MTTDYPRSADLPGAGFAAGPCLFKDTMQLASVTGGAFALGHSAMLVNEGLPDYLVRGMEQRHDLPALTVGILGMAFKAES
DDRRSSLSYRLKRVLSFRAGRVLTTDPYVADDSDLLPLERVLSEADLLVIGAPHAVYRDLEPAVPVVDVWNLLGMGSAL
>Mature_398_residues
ADQFDFDVCVVGGGGHVGFPLAVAFASRGLRVAVYDVNAAVVATIASGRAPFLEPGVHAPLADAIASDRLVATTEREVVR
RAEHVVIVVGTPVDQYLSPDPEAVPRVVGELEDLLVAGQLVVLRSTVFPGVTRRVEQLLAGSHPDVDLAFCPERIAEGRA
MTELFTLPQLVAARSDRPMQRAAALFGKLTDTVIELAPEEAELAKLFTNSWRYIKFAAANQYYMIANDLGLDFARIRDAM
TTDYPRSADLPGAGFAAGPCLFKDTMQLASVTGGAFALGHSAMLVNEGLPDYLVRGMEQRHDLPALTVGILGMAFKAESD
DRRSSLSYRLKRVLSFRAGRVLTTDPYVADDSDLLPLERVLSEADLLVIGAPHAVYRDLEPAVPVVDVWNLLGMGSAL

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI48994968, Length=406, Percent_Identity=26.8472906403941, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1788340, Length=400, Percent_Identity=26.25, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 42942; Mature: 42811

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADQFDFDVCVVGGGGHVGFPLAVAFASRGLRVAVYDVNAAVVATIASGRAPFLEPGVHA
CCCCCCCCEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCCCCCCCCC
PLADAIASDRLVATTEREVVRRAEHVVIVVGTPVDQYLSPDPEAVPRVVGELEDLLVAGQ
CHHHHHHCCCEEEHHHHHHHHHCCEEEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHHH
LVVLRSTVFPGVTRRVEQLLAGSHPDVDLAFCPERIAEGRAMTELFTLPQLVAARSDRPM
HHHHHHHHCHHHHHHHHHHHCCCCCCCCCEECCHHHHCCHHHHHHHHHHHHHHHCCCCHH
QRAAALFGKLTDTVIELAPEEAELAKLFTNSWRYIKFAAANQYYMIANDLGLDFARIRDA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCEEEEECCCCCHHHHHHHH
MTTDYPRSADLPGAGFAAGPCLFKDTMQLASVTGGAFALGHSAMLVNEGLPDYLVRGMEQ
HCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCEEEECCCCHHHHHHHHHH
RHDLPALTVGILGMAFKAESDDRRSSLSYRLKRVLSFRAGRVLTTDPYVADDSDLLPLER
HCCCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHH
VLSEADLLVIGAPHAVYRDLEPAVPVVDVWNLLGMGSAL
HHCCCCEEEEECCHHHHHCCCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure 
ADQFDFDVCVVGGGGHVGFPLAVAFASRGLRVAVYDVNAAVVATIASGRAPFLEPGVHA
CCCCCCCEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCCCCCCCCC
PLADAIASDRLVATTEREVVRRAEHVVIVVGTPVDQYLSPDPEAVPRVVGELEDLLVAGQ
CHHHHHHCCCEEEHHHHHHHHHCCEEEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHHH
LVVLRSTVFPGVTRRVEQLLAGSHPDVDLAFCPERIAEGRAMTELFTLPQLVAARSDRPM
HHHHHHHHCHHHHHHHHHHHCCCCCCCCCEECCHHHHCCHHHHHHHHHHHHHHHCCCCHH
QRAAALFGKLTDTVIELAPEEAELAKLFTNSWRYIKFAAANQYYMIANDLGLDFARIRDA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCEEEEECCCCCHHHHHHHH
MTTDYPRSADLPGAGFAAGPCLFKDTMQLASVTGGAFALGHSAMLVNEGLPDYLVRGMEQ
HCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCEEEECCCCHHHHHHHHHH
RHDLPALTVGILGMAFKAESDDRRSSLSYRLKRVLSFRAGRVLTTDPYVADDSDLLPLER
HCCCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHH
VLSEADLLVIGAPHAVYRDLEPAVPVVDVWNLLGMGSAL
HHCCCCEEEEECCHHHHHCCCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]