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The map label for this gene is zwf [H]

Identifier: 119716764

GI number: 119716764

Start: 2705595

End: 2707145

Strand: Reverse

Name: zwf [H]

Synonym: Noca_2538

Alternate gene names: 119716764

Gene position: 2707145-2705595 (Counterclockwise)

Preceding gene: 119716765

Following gene: 119716763

Centisome position: 54.3

GC content: 69.57

Gene sequence:

>1551_bases
GTGACGACGCCTCCGGGCTGGCACAACCCCCTCCGCGACCCGCGCGATCGTCGGCTGCCGCGGATCGCGGGGCCGAGCGG
GATGGTGCTCTTCGGCGTCACCGGCGACCTGTCCCGCAAGAAGATCATGCCGGCGATCTACGACCTCGCGAACCGCGGGC
TGCTGCCGCCGGGCTTCAGCCTGACCGGCTTCGCGCGCCGCGACTGGGCCGACCAGGACTTCGCGCAGATCGTCCACGAC
TCGGTCAAGACGCACGCCCGGACCGAGTTCCGCGAGGAGGTGTGGCGTCAGCTCGCGGAAGGCTTCCGCTTCGTGCCGGG
CAACTTCGACGACGACATGGCCTTCGAGCGGCTGCGCCGGACCATCGAGGAGCTCGACGAGGTGCGCGGCACCGGCGGCA
ACCACGCGTTCTACCTGGCCATCCCGCCGGGGTTCTTCGCCGATGTCGTGGGTCAGCTCCAGGAGCACGGGCTGACCGAG
GGCCGCGGCGACTCCTGGCGTCGGGTGGTCGTGGAGAAGCCCTTCGGTCACGACCTGGAGTCCGCGCAGCGGCTCAACTC
GGTGCTGGCCGAGGTGTTCCCCTCCGGCTCGATCTTCCGGATCGACCACTACCTCGGCAAGGAGACGGTGCAGAACATCC
TGGCGCTGCGGTTCGCCAACGAGATGTTCGAGCCGATCTGGAACTCCAACTACGTCGACCACGTCCAGATCACGATGGCC
GAGGACATCGGCATCGGCGGGCGCGCCGGCTACTACGACGGCATCGGCGCGGCACGGGACGTGATCCAGAACCACCTCCT
CCAGCTGATGGCGCTCGTGGCCATGGAGGAGCCGACGTCCTTCGACGCCGAGAGCCTGCGCATCGAGAAGCAGAAGGTCC
TCTCCAGCGTCGTGCTGCCGCGCCGGCTCGACCTGACCACCGCACGCGGTCAGTACGCCGCCGGCTGGGCGGGCGGCGAG
CAGGTGATCGGCTTCCTCGAGGAGGAGGGCATCAAGCGGACCTCCACCACCGAGACCTACGCCGCGGTGACCCTCCACGT
GGACACCCGGCGGTGGGCCGGCGTCCCGTTCTACCTCCGCACCGGCAAGCGGCTGGGCCGGCGGGTGACCGAAGTGGCCG
TGGTCTTCAGGCGGGCGCCGCACCTGCCGTTCGCCGCCTCCTCGACCGAGGAGCTCACCCAGAACGCCCTCGTGATCCGG
GTGCAGCCCGACGAGGGCGTGACGATGCGCTTCGGCTCGAAGGTGCCCGGCACCCAGATGGAGATCCGCGACGTCAACAT
GGACTTCGTGTACGGCGGGGCCTTCACCGAGTCCTCTCCCGAGGCCTACGAGCGCCTCATCCTCGACGTGCTCCTCGGCG
ACCCGCCGCTCTTCCCCCGCCACGAGGAGGTGGAGCTGTCCTGGAGGATCCTCGATCCGATCCTCGAGCACTGGGCCCGC
CAGGACGAGCAGCACAAGAGCAGGCCCGAGCAGTACGAGTCCGGTGGCTGGGGCCCGGAGTCCGCGAATGCGATGCTCGC
CCGCGACGGACGGGTGTGGAGACGACCATGA

Upstream 100 bases:

>100_bases
CGGTCGGCGACGGCCAGGTCCTCGCAGCCAAGGGCCGGCCCGTGCTCCGCCTGCACCTGTCGTCACCGAGCGACCTGGAC
GCCGTGCTGGGAGCGCTCGG

Downstream 100 bases:

>100_bases
TCGAGCTGACAAACACCAACTCGTCGGGCATCGCCGCGGAGTTCCTCCGGGCCCGCACCCGCGCCGGCAGCCCGGCGATG
GGCATGGTGATGACGCTGGT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MTTPPGWHNPLRDPRDRRLPRIAGPSGMVLFGVTGDLSRKKIMPAIYDLANRGLLPPGFSLTGFARRDWADQDFAQIVHD
SVKTHARTEFREEVWRQLAEGFRFVPGNFDDDMAFERLRRTIEELDEVRGTGGNHAFYLAIPPGFFADVVGQLQEHGLTE
GRGDSWRRVVVEKPFGHDLESAQRLNSVLAEVFPSGSIFRIDHYLGKETVQNILALRFANEMFEPIWNSNYVDHVQITMA
EDIGIGGRAGYYDGIGAARDVIQNHLLQLMALVAMEEPTSFDAESLRIEKQKVLSSVVLPRRLDLTTARGQYAAGWAGGE
QVIGFLEEEGIKRTSTTETYAAVTLHVDTRRWAGVPFYLRTGKRLGRRVTEVAVVFRRAPHLPFAASSTEELTQNALVIR
VQPDEGVTMRFGSKVPGTQMEIRDVNMDFVYGGAFTESSPEAYERLILDVLLGDPPLFPRHEEVELSWRILDPILEHWAR
QDEQHKSRPEQYESGGWGPESANAMLARDGRVWRRP

Sequences:

>Translated_516_residues
MTTPPGWHNPLRDPRDRRLPRIAGPSGMVLFGVTGDLSRKKIMPAIYDLANRGLLPPGFSLTGFARRDWADQDFAQIVHD
SVKTHARTEFREEVWRQLAEGFRFVPGNFDDDMAFERLRRTIEELDEVRGTGGNHAFYLAIPPGFFADVVGQLQEHGLTE
GRGDSWRRVVVEKPFGHDLESAQRLNSVLAEVFPSGSIFRIDHYLGKETVQNILALRFANEMFEPIWNSNYVDHVQITMA
EDIGIGGRAGYYDGIGAARDVIQNHLLQLMALVAMEEPTSFDAESLRIEKQKVLSSVVLPRRLDLTTARGQYAAGWAGGE
QVIGFLEEEGIKRTSTTETYAAVTLHVDTRRWAGVPFYLRTGKRLGRRVTEVAVVFRRAPHLPFAASSTEELTQNALVIR
VQPDEGVTMRFGSKVPGTQMEIRDVNMDFVYGGAFTESSPEAYERLILDVLLGDPPLFPRHEEVELSWRILDPILEHWAR
QDEQHKSRPEQYESGGWGPESANAMLARDGRVWRRP
>Mature_515_residues
TTPPGWHNPLRDPRDRRLPRIAGPSGMVLFGVTGDLSRKKIMPAIYDLANRGLLPPGFSLTGFARRDWADQDFAQIVHDS
VKTHARTEFREEVWRQLAEGFRFVPGNFDDDMAFERLRRTIEELDEVRGTGGNHAFYLAIPPGFFADVVGQLQEHGLTEG
RGDSWRRVVVEKPFGHDLESAQRLNSVLAEVFPSGSIFRIDHYLGKETVQNILALRFANEMFEPIWNSNYVDHVQITMAE
DIGIGGRAGYYDGIGAARDVIQNHLLQLMALVAMEEPTSFDAESLRIEKQKVLSSVVLPRRLDLTTARGQYAAGWAGGEQ
VIGFLEEEGIKRTSTTETYAAVTLHVDTRRWAGVPFYLRTGKRLGRRVTEVAVVFRRAPHLPFAASSTEELTQNALVIRV
QPDEGVTMRFGSKVPGTQMEIRDVNMDFVYGGAFTESSPEAYERLILDVLLGDPPLFPRHEEVELSWRILDPILEHWARQ
DEQHKSRPEQYESGGWGPESANAMLARDGRVWRRP

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=485, Percent_Identity=38.5567010309278, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI109389365, Length=485, Percent_Identity=38.5567010309278, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI52145310, Length=494, Percent_Identity=29.3522267206478, Blast_Score=156, Evalue=4e-38,
Organism=Escherichia coli, GI1788158, Length=503, Percent_Identity=40.7554671968191, Blast_Score=392, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17538218, Length=507, Percent_Identity=37.4753451676529, Blast_Score=353, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6324088, Length=488, Percent_Identity=36.8852459016393, Blast_Score=314, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24643350, Length=484, Percent_Identity=37.396694214876, Blast_Score=306, Evalue=3e-83,
Organism=Drosophila melanogaster, GI24643352, Length=484, Percent_Identity=37.396694214876, Blast_Score=305, Evalue=4e-83,
Organism=Drosophila melanogaster, GI221513548, Length=495, Percent_Identity=29.6969696969697, Blast_Score=212, Evalue=6e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 58307; Mature: 58175

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPPGWHNPLRDPRDRRLPRIAGPSGMVLFGVTGDLSRKKIMPAIYDLANRGLLPPGFS
CCCCCCCCCCCCCCHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCC
LTGFARRDWADQDFAQIVHDSVKTHARTEFREEVWRQLAEGFRFVPGNFDDDMAFERLRR
CCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHHH
TIEELDEVRGTGGNHAFYLAIPPGFFADVVGQLQEHGLTEGRGDSWRRVVVEKPFGHDLE
HHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHH
SAQRLNSVLAEVFPSGSIFRIDHYLGKETVQNILALRFANEMFEPIWNSNYVDHVQITMA
HHHHHHHHHHHHCCCCCEEEEHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
EDIGIGGRAGYYDGIGAARDVIQNHLLQLMALVAMEEPTSFDAESLRIEKQKVLSSVVLP
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
RRLDLTTARGQYAAGWAGGEQVIGFLEEEGIKRTSTTETYAAVTLHVDTRRWAGVPFYLR
CCCCCEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECHHHCCCCHHHH
TGKRLGRRVTEVAVVFRRAPHLPFAASSTEELTQNALVIRVQPDEGVTMRFGSKVPGTQM
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCEEEEEEECCCCCEEEECCCCCCCCE
EIRDVNMDFVYGGAFTESSPEAYERLILDVLLGDPPLFPRHEEVELSWRILDPILEHWAR
EEEECCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHC
QDEQHKSRPEQYESGGWGPESANAMLARDGRVWRRP
CCHHHHCCCHHHHCCCCCCCCCCEEEECCCCCCCCC
>Mature Secondary Structure 
TTPPGWHNPLRDPRDRRLPRIAGPSGMVLFGVTGDLSRKKIMPAIYDLANRGLLPPGFS
CCCCCCCCCCCCCHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCC
LTGFARRDWADQDFAQIVHDSVKTHARTEFREEVWRQLAEGFRFVPGNFDDDMAFERLRR
CCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHHH
TIEELDEVRGTGGNHAFYLAIPPGFFADVVGQLQEHGLTEGRGDSWRRVVVEKPFGHDLE
HHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHH
SAQRLNSVLAEVFPSGSIFRIDHYLGKETVQNILALRFANEMFEPIWNSNYVDHVQITMA
HHHHHHHHHHHHCCCCCEEEEHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
EDIGIGGRAGYYDGIGAARDVIQNHLLQLMALVAMEEPTSFDAESLRIEKQKVLSSVVLP
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
RRLDLTTARGQYAAGWAGGEQVIGFLEEEGIKRTSTTETYAAVTLHVDTRRWAGVPFYLR
CCCCCEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECHHHCCCCHHHH
TGKRLGRRVTEVAVVFRRAPHLPFAASSTEELTQNALVIRVQPDEGVTMRFGSKVPGTQM
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCEEEEEEECCCCCEEEECCCCCCCCE
EIRDVNMDFVYGGAFTESSPEAYERLILDVLLGDPPLFPRHEEVELSWRILDPILEHWAR
EEEECCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHC
QDEQHKSRPEQYESGGWGPESANAMLARDGRVWRRP
CCHHHHCCCHHHHCCCCCCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]