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The map label for this gene is devR [H]

Identifier: 119715235

GI number: 119715235

Start: 1041802

End: 1042458

Strand: Direct

Name: devR [H]

Synonym: Noca_0992

Alternate gene names: 119715235

Gene position: 1041802-1042458 (Clockwise)

Preceding gene: 119715231

Following gene: 119715237

Centisome position: 20.9

GC content: 70.32

Gene sequence:

>657_bases
ATGGAGGACCACGGCACGAGCGGGAAGATCACCGTCTACCTGCTCGACGACCACGAGTTGGTGCGCCGGGGCATCCGGGA
GCTGCTGGAGAGCGAGGGCGACATCGTCGTCATCGGCGAGTCCGGCCTGGCTGCCGAGGCCGCGCGGCGCATCCCCGCCC
TCCGCCCCGACGTCGCCATCCTCGACGGTCGGCTGCCCGATGGCTCCGGCATCGACGTGTGCCGCGACGTGCGCTCGGTC
GACCCGGGCATCGCGGCGCTGATCCTCACGTCGTACGACGACGACGAGGCGCTGTTCTCCGCGATCATGGCCGGTGCCGC
CGGCTACATCCTCAAGCAGGTCAAGGGCACCGACTTCGTCGAGACGGTCCGTCGGGTGGCCGCCGGCCAGTCGATGCTGG
ACCCGGCGGTGACCGCCCACGTCCTCGACCGGCTGCGCGCCGGGCCGCGGATGGACCCCTCGATCGAGCAGCTGACCGCC
CAGGAGCAGCGCATCCTCGAGCTGATCGGCCAGGGCATGACGAACCGGCAGATCGCCGCCCACCTGTGCCTCGCCGAGAA
GACCGTCAAGAACTACGTCTCCTCGATGCTCGCCAAGCTCGGCCTCGAGAGCCGCACCCAGGCGGCCATCTTCGCCACCA
AGCACCTCGGGGTCTGA

Upstream 100 bases:

>100_bases
GCCTCCGGTGTGCGGGGCTGCGGACCCAGGGACAAAGGTCCCCCGGACCGGGGGCCATCGACAGGCAACATCGAACGCCG
CGCCACCTAGGTTGAAGAAC

Downstream 100 bases:

>100_bases
CCCGGCGGGAGGGTCGCGGGTCGACGCCGGCGGGTCAGGTGCCGTGGGCGCCGTAGAGGCGCCGGCCACTGACCTCGTGG
ACGTCGACGCGGACGAACAG

Product: regulatory protein LuxR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MEDHGTSGKITVYLLDDHELVRRGIRELLESEGDIVVIGESGLAAEAARRIPALRPDVAILDGRLPDGSGIDVCRDVRSV
DPGIAALILTSYDDDEALFSAIMAGAAGYILKQVKGTDFVETVRRVAAGQSMLDPAVTAHVLDRLRAGPRMDPSIEQLTA
QEQRILELIGQGMTNRQIAAHLCLAEKTVKNYVSSMLAKLGLESRTQAAIFATKHLGV

Sequences:

>Translated_218_residues
MEDHGTSGKITVYLLDDHELVRRGIRELLESEGDIVVIGESGLAAEAARRIPALRPDVAILDGRLPDGSGIDVCRDVRSV
DPGIAALILTSYDDDEALFSAIMAGAAGYILKQVKGTDFVETVRRVAAGQSMLDPAVTAHVLDRLRAGPRMDPSIEQLTA
QEQRILELIGQGMTNRQIAAHLCLAEKTVKNYVSSMLAKLGLESRTQAAIFATKHLGV
>Mature_218_residues
MEDHGTSGKITVYLLDDHELVRRGIRELLESEGDIVVIGESGLAAEAARRIPALRPDVAILDGRLPDGSGIDVCRDVRSV
DPGIAALILTSYDDDEALFSAIMAGAAGYILKQVKGTDFVETVRRVAAGQSMLDPAVTAHVLDRLRAGPRMDPSIEQLTA
QEQRILELIGQGMTNRQIAAHLCLAEKTVKNYVSSMLAKLGLESRTQAAIFATKHLGV

Specific function: Member of the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. When phosphorylated binds the promoter of at least its own and Acr (hspX) gene in response to hypoxia. Activates its own transcription under hy

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=208, Percent_Identity=34.1346153846154, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1790102, Length=200, Percent_Identity=33, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1787473, Length=202, Percent_Identity=32.6732673267327, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1788222, Length=206, Percent_Identity=27.6699029126214, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1788546, Length=201, Percent_Identity=27.363184079602, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786747, Length=199, Percent_Identity=25.1256281407035, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1788712, Length=202, Percent_Identity=25.2475247524752, Blast_Score=68, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR011990
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23455; Mature: 23455

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDHGTSGKITVYLLDDHELVRRGIRELLESEGDIVVIGESGLAAEAARRIPALRPDVAI
CCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHCCCCCCCCEE
LDGRLPDGSGIDVCRDVRSVDPGIAALILTSYDDDEALFSAIMAGAAGYILKQVKGTDFV
ECCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHH
ETVRRVAAGQSMLDPAVTAHVLDRLRAGPRMDPSIEQLTAQEQRILELIGQGMTNRQIAA
HHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHH
HLCLAEKTVKNYVSSMLAKLGLESRTQAAIFATKHLGV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MEDHGTSGKITVYLLDDHELVRRGIRELLESEGDIVVIGESGLAAEAARRIPALRPDVAI
CCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHCCCCCCCCEE
LDGRLPDGSGIDVCRDVRSVDPGIAALILTSYDDDEALFSAIMAGAAGYILKQVKGTDFV
ECCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHH
ETVRRVAAGQSMLDPAVTAHVLDRLRAGPRMDPSIEQLTAQEQRILELIGQGMTNRQIAA
HHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHH
HLCLAEKTVKNYVSSMLAKLGLESRTQAAIFATKHLGV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]