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The map label for this gene is dosT [H]

Identifier: 119715191

GI number: 119715191

Start: 994910

End: 996520

Strand: Reverse

Name: dosT [H]

Synonym: Noca_0946

Alternate gene names: 119715191

Gene position: 996520-994910 (Counterclockwise)

Preceding gene: 119715192

Following gene: 119715183

Centisome position: 19.99

GC content: 74.3

Gene sequence:

>1611_bases
GTGATCGATCCGGGGGCGGCACGGCAGACTGGAGCCGTGACGTCCGAGCACGACGGGGCGCTGAGCGCCTCGACGCAAGC
CCTGCTGGACGCCGTCGCCGCGATCTCCTCCGACCTGGACCTCCGCGCGGTGCTGACCAGGATCGTCGAGGCCGCGTCCC
GGCTCACCGGCGCGGAGTACGGCGCCCTCGGCGTGGTCGGCAGCGGCTCCCTGCTCGTCGAGTTCGTGACGACCGGGATC
GACGACACCCGACGCGACCTGATCGGTGACCCGCCCCACGGGCACGGGATCCTCGGGCTGCTGATCCGCGACCCCGAACC
GCTGCGGCTCGACGACCTGACCCAGCACTCGCAGTCGGTCGGGTTCCCGCCGCACCACCCGCCGATGCGCTCCTTCCTCG
GGGTGCCGGTCCGGATCCGGGGCACGGTCTTCGGCAACCTCTACCTGACCGAGAAGTCCGGCGGCGGCGCGTTCACCGCG
GAGGACCAGCTGTTGGTCGAGTCGCTCGCCAGCACGGCCGGGTTCGTGATCGACAACGCCCGTGCCTACGGGCTGAGCGA
GCGCCGCCGCCAGTGGCTCGAGGCGTCCGCGGAGCTCACCGAGATGCTGCAGCCGCCGATCGAGCTCGGCCGGGCACTGA
GCCAGGTCGCCCGCTCCGCCCGCTCGATGAGCGGTGCCGTCGCCGCGTCGGTGCTCCGGCTGGACAACGGCACCCCCGTC
CACACGACGGCCGTCGACCCCGCCGACGCCGACCGGGTCGGCGGCGCGCTGGAACTGCTCGGGGACGAGGTGTGGCCGCG
CGGCGACGTCTCTCCGGTCGGCCGGACCATCGGCGGCCTCGAGGCGCTCCTGGTGCCGCTTCGCACCCACCTGGTCGGCA
GCGGCCTGTTGGTGCTGCTCTTCGAGGGGGGCACCCCGCCACCGGCCTTCGACGAGCGCGCGCTGCTCGCCTCCTTCGCC
GACCAGGCGGGCCTCGCCCTGGACCGGGCCCAGGCGATCGAGGACCGCGCGGAGCTGGCCGTCACCTCCGACCGGGAGCG
GATCGCGCGCGACCTGCACGACCTGGTGATCCAGCGGCTCTTCGCCACCGGGCTGCAGCTCCAGGGGGCCGGCTCGATGG
CGACCAGCCCGGAGCTGGCCGCGCGGATCGACGAGGCCGTGGTCGCGCTCGACATGACCATCAAGGACATCCGCGGCACC
ATCTTCGAGCTCCAGCACCGCGGGCACGCGCCGTCGCTCCGGGCCGACCTGCGCCAGCTCGCGCGGGAGTACGCGCCGCT
GCTGAAGTTCGACCCCACCGTGACGACCGTCGGACCGGTGGACACCGCCGTGCCGACCGAGGTCCGCGAGCAGCTGCTGC
CCGTGCTGCGCGAGGCGCTGTCGAACCTGGCCCGGCACGCCGCCGCCGACCACGCCGAGATCGAGCTGGCCGTCGACGCG
CGCGAGGTGCGCCTCACCGTCTTGGACAACGGGGTCGGCCTGGGCACGCTCAGCGCCGAGAGCGGGCTGCGCAACGCCCG
CCGTCGGGCGACCACCCTCGGCGGCTCCTTCGAGCTCGGCCCACGCCAGCCGCGCGGCACCTCGTTCGTGTGGCGGGTGC
CGCTGCGCTGA

Upstream 100 bases:

>100_bases
CCCGGAGCCTGCACCTGCGGCTGCGGTGGACCGAGATCTCCGGCCGGCAGATCGGCTCCGGGTGGGACGTGGAGGCGGCG
CTGCCCGTGCGGCGCTCGGT

Downstream 100 bases:

>100_bases
GCGCGATCCGCTGAGCGCCGGAGGGGGTCAGTTGCCGAGCAGCTTGCTGGCGAGCACCGCGGCCTGGGTGCGGCGCTCCA
GGCCGAGCTTCGCGAGGATG

Product: GAF domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 536; Mature: 536

Protein sequence:

>536_residues
MIDPGAARQTGAVTSEHDGALSASTQALLDAVAAISSDLDLRAVLTRIVEAASRLTGAEYGALGVVGSGSLLVEFVTTGI
DDTRRDLIGDPPHGHGILGLLIRDPEPLRLDDLTQHSQSVGFPPHHPPMRSFLGVPVRIRGTVFGNLYLTEKSGGGAFTA
EDQLLVESLASTAGFVIDNARAYGLSERRRQWLEASAELTEMLQPPIELGRALSQVARSARSMSGAVAASVLRLDNGTPV
HTTAVDPADADRVGGALELLGDEVWPRGDVSPVGRTIGGLEALLVPLRTHLVGSGLLVLLFEGGTPPPAFDERALLASFA
DQAGLALDRAQAIEDRAELAVTSDRERIARDLHDLVIQRLFATGLQLQGAGSMATSPELAARIDEAVVALDMTIKDIRGT
IFELQHRGHAPSLRADLRQLAREYAPLLKFDPTVTTVGPVDTAVPTEVREQLLPVLREALSNLARHAAADHAEIELAVDA
REVRLTVLDNGVGLGTLSAESGLRNARRRATTLGGSFELGPRQPRGTSFVWRVPLR

Sequences:

>Translated_536_residues
MIDPGAARQTGAVTSEHDGALSASTQALLDAVAAISSDLDLRAVLTRIVEAASRLTGAEYGALGVVGSGSLLVEFVTTGI
DDTRRDLIGDPPHGHGILGLLIRDPEPLRLDDLTQHSQSVGFPPHHPPMRSFLGVPVRIRGTVFGNLYLTEKSGGGAFTA
EDQLLVESLASTAGFVIDNARAYGLSERRRQWLEASAELTEMLQPPIELGRALSQVARSARSMSGAVAASVLRLDNGTPV
HTTAVDPADADRVGGALELLGDEVWPRGDVSPVGRTIGGLEALLVPLRTHLVGSGLLVLLFEGGTPPPAFDERALLASFA
DQAGLALDRAQAIEDRAELAVTSDRERIARDLHDLVIQRLFATGLQLQGAGSMATSPELAARIDEAVVALDMTIKDIRGT
IFELQHRGHAPSLRADLRQLAREYAPLLKFDPTVTTVGPVDTAVPTEVREQLLPVLREALSNLARHAAADHAEIELAVDA
REVRLTVLDNGVGLGTLSAESGLRNARRRATTLGGSFELGPRQPRGTSFVWRVPLR
>Mature_536_residues
MIDPGAARQTGAVTSEHDGALSASTQALLDAVAAISSDLDLRAVLTRIVEAASRLTGAEYGALGVVGSGSLLVEFVTTGI
DDTRRDLIGDPPHGHGILGLLIRDPEPLRLDDLTQHSQSVGFPPHHPPMRSFLGVPVRIRGTVFGNLYLTEKSGGGAFTA
EDQLLVESLASTAGFVIDNARAYGLSERRRQWLEASAELTEMLQPPIELGRALSQVARSARSMSGAVAASVLRLDNGTPV
HTTAVDPADADRVGGALELLGDEVWPRGDVSPVGRTIGGLEALLVPLRTHLVGSGLLVLLFEGGTPPPAFDERALLASFA
DQAGLALDRAQAIEDRAELAVTSDRERIARDLHDLVIQRLFATGLQLQGAGSMATSPELAARIDEAVVALDMTIKDIRGT
IFELQHRGHAPSLRADLRQLAREYAPLLKFDPTVTTVGPVDTAVPTEVREQLLPVLREALSNLARHAAADHAEIELAVDA
REVRLTVLDNGVGLGTLSAESGLRNARRRATTLGGSFELGPRQPRGTSFVWRVPLR

Specific function: Interacts with the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. May act as a direct hypoxia sensor (rather than a redox sensor); the normal state is the oxygenated form, while the deoxy form is probably

COG id: COG2203

COG function: function code T; FOG: GAF domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=280, Percent_Identity=31.4285714285714, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR011712 [H]

Pfam domain/function: PF01590 GAF; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: 2.7.3.- [C]

Molecular weight: Translated: 56963; Mature: 56963

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDPGAARQTGAVTSEHDGALSASTQALLDAVAAISSDLDLRAVLTRIVEAASRLTGAEY
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
GALGVVGSGSLLVEFVTTGIDDTRRDLIGDPPHGHGILGLLIRDPEPLRLDDLTQHSQSV
CCEEEECCCHHHHHHHHCCCCHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCC
GFPPHHPPMRSFLGVPVRIRGTVFGNLYLTEKSGGGAFTAEDQLLVESLASTAGFVIDNA
CCCCCCCCHHHHCCCCEEEEEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCEEEECC
RAYGLSERRRQWLEASAELTEMLQPPIELGRALSQVARSARSMSGAVAASVLRLDNGTPV
HHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
HTTAVDPADADRVGGALELLGDEVWPRGDVSPVGRTIGGLEALLVPLRTHLVGSGLLVLL
EEECCCCCCHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
FEGGTPPPAFDERALLASFADQAGLALDRAQAIEDRAELAVTSDRERIARDLHDLVIQRL
ECCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHH
FATGLQLQGAGSMATSPELAARIDEAVVALDMTIKDIRGTIFELQHRGHAPSLRADLRQL
HHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AREYAPLLKFDPTVTTVGPVDTAVPTEVREQLLPVLREALSNLARHAAADHAEIELAVDA
HHHHCCCEECCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEH
REVRLTVLDNGVGLGTLSAESGLRNARRRATTLGGSFELGPRQPRGTSFVWRVPLR
EEEEEEEEECCCCCEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCC
>Mature Secondary Structure
MIDPGAARQTGAVTSEHDGALSASTQALLDAVAAISSDLDLRAVLTRIVEAASRLTGAEY
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
GALGVVGSGSLLVEFVTTGIDDTRRDLIGDPPHGHGILGLLIRDPEPLRLDDLTQHSQSV
CCEEEECCCHHHHHHHHCCCCHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCC
GFPPHHPPMRSFLGVPVRIRGTVFGNLYLTEKSGGGAFTAEDQLLVESLASTAGFVIDNA
CCCCCCCCHHHHCCCCEEEEEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCEEEECC
RAYGLSERRRQWLEASAELTEMLQPPIELGRALSQVARSARSMSGAVAASVLRLDNGTPV
HHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
HTTAVDPADADRVGGALELLGDEVWPRGDVSPVGRTIGGLEALLVPLRTHLVGSGLLVLL
EEECCCCCCHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
FEGGTPPPAFDERALLASFADQAGLALDRAQAIEDRAELAVTSDRERIARDLHDLVIQRL
ECCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHH
FATGLQLQGAGSMATSPELAARIDEAVVALDMTIKDIRGTIFELQHRGHAPSLRADLRQL
HHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AREYAPLLKFDPTVTTVGPVDTAVPTEVREQLLPVLREALSNLARHAAADHAEIELAVDA
HHHHCCCEECCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEH
REVRLTVLDNGVGLGTLSAESGLRNARRRATTLGGSFELGPRQPRGTSFVWRVPLR
EEEEEEEEECCCCCEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups; Phosphotransferases with a nitrogenous group as acceptor [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]