Click here to switch to the map view.

The map label for this gene is glmS [H]

Identifier: 119715141

GI number: 119715141

Start: 935791

End: 937635

Strand: Direct

Name: glmS [H]

Synonym: Noca_0896

Alternate gene names: 119715141

Gene position: 935791-937635 (Clockwise)

Preceding gene: 119715139

Following gene: 119715142

Centisome position: 18.77

GC content: 71.44

Gene sequence:

>1845_bases
GTGTGCGGGATCGTCGGTTACGTGGGCCAGAAGGCGGCGCAGGACGTCGTGGTCGAGGGGCTCCGGAGGCTGGAGTACCG
CGGCTACGACTCGGCCGGGATCGCGCTGGTCGCGGACCGGGCGCTGGCCACCGACAAACGGGCCGGCAAGCTCGCGAACC
TGGAGAAGGCGATCGCCGACACGCCGCTCCCGCCGGCCACCACGGGCATCGGGCACACCCGCTGGGCCACCCACGGGGCA
CCCAACGACGTCAACGCGCACCCGCACACCGGCGAGCAGCGCCGCGTCGGCCTGGTGCACAACGGCATCATCGAGAACTT
CGCCGAGCTGCGCGCCGAGCTGGAGACCGCCGGTCACCGGCTGCTCTCGGAGACCGACACCGAGGTCGCGGCGCACCTGC
TGGAGGCGGAGGTGACCCGCGGCGCGGACCTGACCGCGGCGATGCAACGCGTCGTACGCCGGCTCGAGGGCGCGTTCACC
CTGGTCGCGGTCGACGCCCTCGACCCGTCGCGGGTGGTCGCCGCCCGGCGCAACTCGCCGCTGGTCGTCGGCCTCGGCGA
GGGCGAGAACTTCCTGGGGTCCGATGTCGCGGCGTTCATCGAGCACACCCGCGAGGCGCTGGAGCTCGGCCAGGACCAGG
TGGTCACGATCACCCGCGAGGCCGTGTCCGTGACCGGCTTCGACGGCACGCCGGCCGAGGGCCGCCGCTACCATGTCGAC
TGGGACCTGTCGGCCGCCGAGAAGGACGGCCACGACTGGTTCATGCGCAAGGAGATCTTCGAGCAGCCGCACGCGGTCGC
CGACTCGCTACTGGGCCGGCGTACTCCCGAGGGCCACCTGCACCTGGACGAGATGCGGCTCTCCGACCAGGAGCTGCGCG
ACGTCGACAAGATCATCATCATCGCGGCCGGCACGTCGTTCTACGCCGGGATGGTGGCGAAGTACGCGATCGAGCACTGG
TGCCGGATCCCCGTCGAGGTCGAGCTGTCCTCGGAGTTCCGCTACCGCGACCCGATCCTGGACTACTCCACGTTGGTCGT
GGCGATCAGCCAATCGGGGGAGACCGCCGACACGCTGCAGGCGATCCGGCACGCCCGGACCCAGCGGTCCAAGGTGCTCG
CGATCTGCAACACCAACGGCTCCACGATCCCGCGCGAGTCCGACGCGGTGATCTACACCCACGCCGGTCCCGAGATCGGC
GTCGCCTCGACCAAGGGGTTCCTGACCCAGCTGGTCGCGTGCTACCTGCTCGCGCTCTACCTGGCGCAGGTCAAGGGCAC
GAGGTACGGCGACGAGATCGACGAGGTGATGCGCCAGCTCGAGGCGATGCCCGCGCACGTCCAGCGGATGCTCGACGACG
CGGACGCCGTCTACGAGCTGGCCCGCCAGCACGTCGGGACCCGGTCGGTGCTGTTCCTCGGCCGCCACGCCGGCTACCCG
GTCGCCCTGGAGGGGGCGCTCAAGCTGAAGGAGCTGGCCTACCTGCACGCGGAGGGCTTCGCGGCCGGCGAGCTCAAGCA
CGGGCCGATCGCGCTCGTCGAAGACGGCCTGCCGGTGCTGTGCGTGGTGCCCCCGGCCGGCCGCGACCAGCTCCGCGACA
AGATGGTCAGCGGGATCCAGGAGGTGCGGGCCCGCGGCGCGCGGACCATCTGCCTGGTCGAGGACGGCGACGACGCGATC
GCGCCGTACGCCGACGTCGTCGTCCGCCTGCCCCAGGTGCCGGTGCTGCTGCAGCCACTGGTCGCGGTGGTGCCGCTCCA
GCTCTTCGCGTGCGAGCTCGCCACGGTGCTCGGCCACGACGTCGACCAGCCGCGCAACCTCGCCAAGTCGGTCACGGTCG
AATGA

Upstream 100 bases:

>100_bases
GACTCCCGGCCGGCGTCGGCGGGGGGCAGCTCGCCGTGGGACGGCCCTTGGGCAGGCATGGACGCGATTCTTGCAAAGCC
CCGCCGTTACAGTGACACCC

Downstream 100 bases:

>100_bases
GCCGCCCACGAGGGAACGCCCGGTGATCGTCGGGGTCGGGATCGACGTGGTCGACGTCGCGCGCTTCGGCGTCTCTCTGT
CACGGACCCCGGGCCTGACC

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MCGIVGYVGQKAAQDVVVEGLRRLEYRGYDSAGIALVADRALATDKRAGKLANLEKAIADTPLPPATTGIGHTRWATHGA
PNDVNAHPHTGEQRRVGLVHNGIIENFAELRAELETAGHRLLSETDTEVAAHLLEAEVTRGADLTAAMQRVVRRLEGAFT
LVAVDALDPSRVVAARRNSPLVVGLGEGENFLGSDVAAFIEHTREALELGQDQVVTITREAVSVTGFDGTPAEGRRYHVD
WDLSAAEKDGHDWFMRKEIFEQPHAVADSLLGRRTPEGHLHLDEMRLSDQELRDVDKIIIIAAGTSFYAGMVAKYAIEHW
CRIPVEVELSSEFRYRDPILDYSTLVVAISQSGETADTLQAIRHARTQRSKVLAICNTNGSTIPRESDAVIYTHAGPEIG
VASTKGFLTQLVACYLLALYLAQVKGTRYGDEIDEVMRQLEAMPAHVQRMLDDADAVYELARQHVGTRSVLFLGRHAGYP
VALEGALKLKELAYLHAEGFAAGELKHGPIALVEDGLPVLCVVPPAGRDQLRDKMVSGIQEVRARGARTICLVEDGDDAI
APYADVVVRLPQVPVLLQPLVAVVPLQLFACELATVLGHDVDQPRNLAKSVTVE

Sequences:

>Translated_614_residues
MCGIVGYVGQKAAQDVVVEGLRRLEYRGYDSAGIALVADRALATDKRAGKLANLEKAIADTPLPPATTGIGHTRWATHGA
PNDVNAHPHTGEQRRVGLVHNGIIENFAELRAELETAGHRLLSETDTEVAAHLLEAEVTRGADLTAAMQRVVRRLEGAFT
LVAVDALDPSRVVAARRNSPLVVGLGEGENFLGSDVAAFIEHTREALELGQDQVVTITREAVSVTGFDGTPAEGRRYHVD
WDLSAAEKDGHDWFMRKEIFEQPHAVADSLLGRRTPEGHLHLDEMRLSDQELRDVDKIIIIAAGTSFYAGMVAKYAIEHW
CRIPVEVELSSEFRYRDPILDYSTLVVAISQSGETADTLQAIRHARTQRSKVLAICNTNGSTIPRESDAVIYTHAGPEIG
VASTKGFLTQLVACYLLALYLAQVKGTRYGDEIDEVMRQLEAMPAHVQRMLDDADAVYELARQHVGTRSVLFLGRHAGYP
VALEGALKLKELAYLHAEGFAAGELKHGPIALVEDGLPVLCVVPPAGRDQLRDKMVSGIQEVRARGARTICLVEDGDDAI
APYADVVVRLPQVPVLLQPLVAVVPLQLFACELATVLGHDVDQPRNLAKSVTVE
>Mature_614_residues
MCGIVGYVGQKAAQDVVVEGLRRLEYRGYDSAGIALVADRALATDKRAGKLANLEKAIADTPLPPATTGIGHTRWATHGA
PNDVNAHPHTGEQRRVGLVHNGIIENFAELRAELETAGHRLLSETDTEVAAHLLEAEVTRGADLTAAMQRVVRRLEGAFT
LVAVDALDPSRVVAARRNSPLVVGLGEGENFLGSDVAAFIEHTREALELGQDQVVTITREAVSVTGFDGTPAEGRRYHVD
WDLSAAEKDGHDWFMRKEIFEQPHAVADSLLGRRTPEGHLHLDEMRLSDQELRDVDKIIIIAAGTSFYAGMVAKYAIEHW
CRIPVEVELSSEFRYRDPILDYSTLVVAISQSGETADTLQAIRHARTQRSKVLAICNTNGSTIPRESDAVIYTHAGPEIG
VASTKGFLTQLVACYLLALYLAQVKGTRYGDEIDEVMRQLEAMPAHVQRMLDDADAVYELARQHVGTRSVLFLGRHAGYP
VALEGALKLKELAYLHAEGFAAGELKHGPIALVEDGLPVLCVVPPAGRDQLRDKMVSGIQEVRARGARTICLVEDGDDAI
APYADVVVRLPQVPVLLQPLVAVVPLQLFACELATVLGHDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=686, Percent_Identity=34.2565597667638, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI205277386, Length=685, Percent_Identity=34.1605839416058, Blast_Score=373, Evalue=1e-103,
Organism=Escherichia coli, GI1790167, Length=619, Percent_Identity=45.0726978998384, Blast_Score=499, Evalue=1e-142,
Organism=Escherichia coli, GI1788651, Length=174, Percent_Identity=28.735632183908, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17532899, Length=721, Percent_Identity=32.7323162274619, Blast_Score=324, Evalue=9e-89,
Organism=Caenorhabditis elegans, GI17539970, Length=437, Percent_Identity=35.6979405034325, Blast_Score=271, Evalue=9e-73,
Organism=Caenorhabditis elegans, GI17532897, Length=436, Percent_Identity=36.0091743119266, Blast_Score=265, Evalue=4e-71,
Organism=Saccharomyces cerevisiae, GI6322745, Length=460, Percent_Identity=34.7826086956522, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6323731, Length=383, Percent_Identity=29.7650130548303, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=37.0731707317073, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21357745, Length=687, Percent_Identity=34.6433770014556, Blast_Score=385, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66763; Mature: 66763

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYVGQKAAQDVVVEGLRRLEYRGYDSAGIALVADRALATDKRAGKLANLEKAIAD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHCCHHCCHHHHHHHHHHC
TPLPPATTGIGHTRWATHGAPNDVNAHPHTGEQRRVGLVHNGIIENFAELRAELETAGHR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
LLSETDTEVAAHLLEAEVTRGADLTAAMQRVVRRLEGAFTLVAVDALDPSRVVAARRNSP
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHCCCCCC
LVVGLGEGENFLGSDVAAFIEHTREALELGQDQVVTITREAVSVTGFDGTPAEGRRYHVD
EEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHEEEECCCCCCCCCCEEEEE
WDLSAAEKDGHDWFMRKEIFEQPHAVADSLLGRRTPEGHLHLDEMRLSDQELRDVDKIII
CCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCCCCCCCEEHHHHHCCHHHHHCCCEEEE
IAAGTSFYAGMVAKYAIEHWCRIPVEVELSSEFRYRDPILDYSTLVVAISQSGETADTLQ
EEECCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEEEEEECCCCHHHHHH
AIRHARTQRSKVLAICNTNGSTIPRESDAVIYTHAGPEIGVASTKGFLTQLVACYLLALY
HHHHHHHHCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
LAQVKGTRYGDEIDEVMRQLEAMPAHVQRMLDDADAVYELARQHVGTRSVLFLGRHAGYP
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
VALEGALKLKELAYLHAEGFAAGELKHGPIALVEDGLPVLCVVPPAGRDQLRDKMVSGIQ
EEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHH
EVRARGARTICLVEDGDDAIAPYADVVVRLPQVPVLLQPLVAVVPLQLFACELATVLGHD
HHHHCCCCEEEEEECCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
VDQPRNLAKSVTVE
CCCHHHHHHHCCCC
>Mature Secondary Structure
MCGIVGYVGQKAAQDVVVEGLRRLEYRGYDSAGIALVADRALATDKRAGKLANLEKAIAD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHCCHHCCHHHHHHHHHHC
TPLPPATTGIGHTRWATHGAPNDVNAHPHTGEQRRVGLVHNGIIENFAELRAELETAGHR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
LLSETDTEVAAHLLEAEVTRGADLTAAMQRVVRRLEGAFTLVAVDALDPSRVVAARRNSP
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHCCCCCC
LVVGLGEGENFLGSDVAAFIEHTREALELGQDQVVTITREAVSVTGFDGTPAEGRRYHVD
EEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHEEEECCCCCCCCCCEEEEE
WDLSAAEKDGHDWFMRKEIFEQPHAVADSLLGRRTPEGHLHLDEMRLSDQELRDVDKIII
CCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCCCCCCCEEHHHHHCCHHHHHCCCEEEE
IAAGTSFYAGMVAKYAIEHWCRIPVEVELSSEFRYRDPILDYSTLVVAISQSGETADTLQ
EEECCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEEEEEECCCCHHHHHH
AIRHARTQRSKVLAICNTNGSTIPRESDAVIYTHAGPEIGVASTKGFLTQLVACYLLALY
HHHHHHHHCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
LAQVKGTRYGDEIDEVMRQLEAMPAHVQRMLDDADAVYELARQHVGTRSVLFLGRHAGYP
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
VALEGALKLKELAYLHAEGFAAGELKHGPIALVEDGLPVLCVVPPAGRDQLRDKMVSGIQ
EEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHH
EVRARGARTICLVEDGDDAIAPYADVVVRLPQVPVLLQPLVAVVPLQLFACELATVLGHD
HHHHCCCCEEEEEECCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
VDQPRNLAKSVTVE
CCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]