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The map label for this gene is hbd [H]

Identifier: 119715106

GI number: 119715106

Start: 899395

End: 900222

Strand: Direct

Name: hbd [H]

Synonym: Noca_0861

Alternate gene names: 119715106

Gene position: 899395-900222 (Clockwise)

Preceding gene: 119715105

Following gene: 119715107

Centisome position: 18.04

GC content: 69.57

Gene sequence:

>828_bases
ATGAGCACGTCGATGGTGGTCGTGGGTGGGGGCACGATGGGCCGTGGCATCGCGATCGCAGCACTCGCCACGGGCTTCGA
GGTGACGTTGGTGGACGTCGCCGAGGACGTGCTCGACCGTGCTCAGGCACGGGTGTCGGAGCACTTCGCCCGACACCCGC
AGCCGGATCGGGGGGTCTTGCACACGACCACGTCACTGGCCGGCTCCCTCGAGACGGCCGAGGTCGTCATCGAGGCGGTG
CCGGAGATCCTCCCGCTCAAGACGCAGATCTTCCAGCAGCTGCGCGGCGCGCCACCCGGCACGCTGCTCGTCAGCAACAC
CTCGACGATGAGCATCAGCGCGCTCGCCGAGGCGTGCGGCGGGTCGTCCCGTGTGGTGGGGATGCACTTCTTCAACCCGG
CCCACCGGATGCCTCTGGTCGAGGTCGTCGTCGGCACACGGACGAGCGACGACGCCCGGGACCGGGCGGTGGCGCTCGCG
GTCCGCCTCGGCAAGGACCCGATCGTGGTGCGAGACCTCCCGGGCTTCGTGACCAGCCGACTGGGCTTGATCCTCGGGAC
CGAGGCCATGCGCATGGTCGAGGAGCAGGTCGCCAACGCCGCCGACATCGACAAGGCGTTGAGGCTGGGCTACGGACATC
CCATGGGACCGCTGGAGCTCGCCGACCTGGTCGGGCTCGACGCCCGCCTGAACAACTTGCGCAGCATGTTCGAGCGCTCC
GGGGACGCGGCGTACGAACCGCCCGCGGTGCTGGTCGACCTCGTCGCCGCCGGGCACCTCGGCAAGAAGTCCGGTCGTGG
CTTCTACGACTACGAGGCGCAGTCGTGA

Upstream 100 bases:

>100_bases
ACATCGAGTACGTCGACGGGCTCGCGAAGAGCAGCACCGGCAAGGTCGATCGAGCATCGCTCCGTCGCGCGTACGGCCCC
GTGACCGACGAGGCCAGCCG

Downstream 100 bases:

>100_bases
GTGGCCTGCTCCGGGTCGGGACCCGGCAGGGCTTCGACACCCTGGAGATCGACTCGCCCACGAACCGCAACGCTCTCTCG
GTCGAGCTGCTCACCGCGCT

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MSTSMVVVGGGTMGRGIAIAALATGFEVTLVDVAEDVLDRAQARVSEHFARHPQPDRGVLHTTTSLAGSLETAEVVIEAV
PEILPLKTQIFQQLRGAPPGTLLVSNTSTMSISALAEACGGSSRVVGMHFFNPAHRMPLVEVVVGTRTSDDARDRAVALA
VRLGKDPIVVRDLPGFVTSRLGLILGTEAMRMVEEQVANAADIDKALRLGYGHPMGPLELADLVGLDARLNNLRSMFERS
GDAAYEPPAVLVDLVAAGHLGKKSGRGFYDYEAQS

Sequences:

>Translated_275_residues
MSTSMVVVGGGTMGRGIAIAALATGFEVTLVDVAEDVLDRAQARVSEHFARHPQPDRGVLHTTTSLAGSLETAEVVIEAV
PEILPLKTQIFQQLRGAPPGTLLVSNTSTMSISALAEACGGSSRVVGMHFFNPAHRMPLVEVVVGTRTSDDARDRAVALA
VRLGKDPIVVRDLPGFVTSRLGLILGTEAMRMVEEQVANAADIDKALRLGYGHPMGPLELADLVGLDARLNNLRSMFERS
GDAAYEPPAVLVDLVAAGHLGKKSGRGFYDYEAQS
>Mature_274_residues
STSMVVVGGGTMGRGIAIAALATGFEVTLVDVAEDVLDRAQARVSEHFARHPQPDRGVLHTTTSLAGSLETAEVVIEAVP
EILPLKTQIFQQLRGAPPGTLLVSNTSTMSISALAEACGGSSRVVGMHFFNPAHRMPLVEVVVGTRTSDDARDRAVALAV
RLGKDPIVVRDLPGFVTSRLGLILGTEAMRMVEEQVANAADIDKALRLGYGHPMGPLELADLVGLDARLNNLRSMFERSG
DAAYEPPAVLVDLVAAGHLGKKSGRGFYDYEAQS

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=285, Percent_Identity=38.5964912280702, Blast_Score=182, Evalue=2e-46,
Organism=Homo sapiens, GI296179427, Length=302, Percent_Identity=36.4238410596026, Blast_Score=174, Evalue=8e-44,
Organism=Homo sapiens, GI20127408, Length=284, Percent_Identity=33.8028169014084, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI68989263, Length=291, Percent_Identity=30.2405498281787, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI261878539, Length=291, Percent_Identity=30.2405498281787, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI115430219, Length=244, Percent_Identity=29.9180327868852, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1787661, Length=282, Percent_Identity=40.4255319148936, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1790281, Length=223, Percent_Identity=36.7713004484305, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1788682, Length=199, Percent_Identity=36.1809045226131, Blast_Score=114, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17553560, Length=291, Percent_Identity=34.7079037800687, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17549919, Length=289, Percent_Identity=33.5640138408304, Blast_Score=165, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17563036, Length=285, Percent_Identity=34.3859649122807, Blast_Score=161, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71985923, Length=283, Percent_Identity=29.3286219081272, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17558304, Length=280, Percent_Identity=32.8571428571429, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI25144276, Length=283, Percent_Identity=32.8621908127208, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17508951, Length=283, Percent_Identity=32.8621908127208, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17508953, Length=283, Percent_Identity=32.8621908127208, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71985930, Length=283, Percent_Identity=26.8551236749117, Blast_Score=117, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI193203623, Length=153, Percent_Identity=31.3725490196078, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115533614, Length=153, Percent_Identity=31.3725490196078, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24583077, Length=283, Percent_Identity=32.1554770318021, Blast_Score=131, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24583079, Length=283, Percent_Identity=32.1554770318021, Blast_Score=131, Evalue=4e-31,
Organism=Drosophila melanogaster, GI19921000, Length=283, Percent_Identity=32.1554770318021, Blast_Score=131, Evalue=4e-31,
Organism=Drosophila melanogaster, GI20129993, Length=248, Percent_Identity=30.6451612903226, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45549573, Length=263, Percent_Identity=27.7566539923954, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 29094; Mature: 28963

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSMVVVGGGTMGRGIAIAALATGFEVTLVDVAEDVLDRAQARVSEHFARHPQPDRGVL
CCCCEEEECCCCCCCHHEEEHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
HTTTSLAGSLETAEVVIEAVPEILPLKTQIFQQLRGAPPGTLLVSNTSTMSISALAEACG
EEHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCC
GSSRVVGMHFFNPAHRMPLVEVVVGTRTSDDARDRAVALAVRLGKDPIVVRDLPGFVTSR
CCCEEEEEEECCHHHHCCEEEHEECCCCCCHHHHHHHHEEEEECCCCEEEECCCHHHHHH
LGLILGTEAMRMVEEQVANAADIDKALRLGYGHPMGPLELADLVGLDARLNNLRSMFERS
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GDAAYEPPAVLVDLVAAGHLGKKSGRGFYDYEAQS
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
STSMVVVGGGTMGRGIAIAALATGFEVTLVDVAEDVLDRAQARVSEHFARHPQPDRGVL
CCCEEEECCCCCCCHHEEEHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
HTTTSLAGSLETAEVVIEAVPEILPLKTQIFQQLRGAPPGTLLVSNTSTMSISALAEACG
EEHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCC
GSSRVVGMHFFNPAHRMPLVEVVVGTRTSDDARDRAVALAVRLGKDPIVVRDLPGFVTSR
CCCEEEEEEECCHHHHCCEEEHEECCCCCCHHHHHHHHEEEEECCCCEEEECCCHHHHHH
LGLILGTEAMRMVEEQVANAADIDKALRLGYGHPMGPLELADLVGLDARLNNLRSMFERS
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GDAAYEPPAVLVDLVAAGHLGKKSGRGFYDYEAQS
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]