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The map label for this gene is acsA [H]

Identifier: 119715105

GI number: 119715105

Start: 897773

End: 899398

Strand: Direct

Name: acsA [H]

Synonym: Noca_0860

Alternate gene names: 119715105

Gene position: 897773-899398 (Clockwise)

Preceding gene: 119715104

Following gene: 119715106

Centisome position: 18.01

GC content: 72.2

Gene sequence:

>1626_bases
ATGACCGGCCTCGCCTCCATCAAGGCCCCGCAGGTGGGCAGCTGGGAGGCCGCCCGGGACGCGTTCCGCTGGCCGGCGCT
CGCCGACTACAACATCGCGACCGACTGTCTGTCGGCCCCCGCGGGGCGCCCGGCACTCGTCGTGGTCGCTCCTGACCGGA
CCACCGAGGTCTCCTTCGGCCGGCTCGACGACCTCTCCAGCCGACTCGCCGGCGTGCTCCGGGGCCTGGGCGTCGGCGTC
GGCGATCGGGTCGCGGTGAAGCTCCCCCAGAGTGCCGAGATGGCGATCGCGGTCCTCGCCACGCTCAAGCTCGGCGCCGT
CGTCGTGACCGTGTCCAACGTCCTCGGGGTCGACGCGGTCGCGCACCGCCTCGAGGACAGCGGCGCCCTGGTGCTCGTCT
GCGCGGGAGGGATCGGGGAGCGCGAGCTGGCCGAGCGCACCGGCGCCACCCTGCTCGTCACCGGCGACGAGGGCTGGCTC
GGGGGCGCCCTCGACGGGCACGAGCCGCTCACGTCCTTCGCCTCGTCCGGAGCCGACGACCCGGCACTCCTCCTCTACAC
CTCGGGCACGACCGGCTCGTCCAAAGGGGTGCTGCACGGTCACCGGGTGCTGCTCGGCCATCACGCGATCGACCTCGCGT
GGGACCACGTCCGTGAGGGCGACGTGGCCTACAGCCCCGTCGACTGGTCCTGGGCCGGCGGCCTGATGCTGGGCCTGCTC
GTGCCGCTCGCCTATGGAATCACCGTGGTGGCCTACCGCGAGCCTCGGTTCGACGCCGAGCGCACGGTCGCCATCATGCG
GGACACCGGCGTGAGTGTGGGGCTCTTCCCGCCCACGGCGCTCCGGGTGCTGCAACGCTCGGGCGCCCTCACCAAGGAGA
CGATGGCCACTCTCCGGCTGCGGGTACTGATCAGCGGCGCCGAGGCGGTCGAGTCCGAGCTGGCCTCCTGGGCTCGCGAC
GAGCTCGGCCTGAGTGTGAACAACGCCTTCGGCCAGACCGAGGCCAACGCGTTGATCGGTCACGCGAACGTGCTCGGTGA
GCTCGACCCGCGATGCCTCGGACGCCCGTACCCCGGTCACGAGGTCGCCATCCTCGACGCACGCCAGCAGCCGGTCGGGC
CGGGCGTCGTGGGCGAGATCGCGGTACGCGCGGACGACCCGGTGTGCATGCTGCGCTACTGGAATGCGCCCGAGGCGACG
GCCGCCAAGTTCCGCAACGGCTGGCTCCTGACGGGAGACTCCGCACACGCGGACGCCGACGGGAACCTGTACTTCCACGG
ACGGGCCGACGACATCATCAAGAGCGGTGGCTATCGACTGGGCCCGGCCGAGATCGAGGGCGCGATCCTGGCGCACCCGG
ACGTCGCCGAGTGCGCCGTCGTCGGGCTGCCCGATCCCCAGCGGGGCCAGGAGGTCACCGCCTTCGTGGTCCTGGGCGCG
GACGTGGTTCCCAGCCCCGAGCTGACCACCGAGCTGCAGTCGCGGGTGCGCGCCGAGGTCGGGGCCCATGCCTATCCGCG
ACACATCGAGTACGTCGACGGGCTCGCGAAGAGCAGCACCGGCAAGGTCGATCGAGCATCGCTCCGTCGCGCGTACGGCC
CCGTGACCGACGAGGCCAGCCGATGA

Upstream 100 bases:

>100_bases
CCGGTCTCGGCGAGCACACCGCCGAGATCCTCGCCGAGCTCGGCTTCGACGACGCGTTCGTCGAAGCGATCGTCGACCGG
CCCGAGAAGGGGGCACTCCG

Downstream 100 bases:

>100_bases
GCACGTCGATGGTGGTCGTGGGTGGGGGCACGATGGGCCGTGGCATCGCGATCGCAGCACTCGCCACGGGCTTCGAGGTG
ACGTTGGTGGACGTCGCCGA

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acetyl-CoA synthase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MTGLASIKAPQVGSWEAARDAFRWPALADYNIATDCLSAPAGRPALVVVAPDRTTEVSFGRLDDLSSRLAGVLRGLGVGV
GDRVAVKLPQSAEMAIAVLATLKLGAVVVTVSNVLGVDAVAHRLEDSGALVLVCAGGIGERELAERTGATLLVTGDEGWL
GGALDGHEPLTSFASSGADDPALLLYTSGTTGSSKGVLHGHRVLLGHHAIDLAWDHVREGDVAYSPVDWSWAGGLMLGLL
VPLAYGITVVAYREPRFDAERTVAIMRDTGVSVGLFPPTALRVLQRSGALTKETMATLRLRVLISGAEAVESELASWARD
ELGLSVNNAFGQTEANALIGHANVLGELDPRCLGRPYPGHEVAILDARQQPVGPGVVGEIAVRADDPVCMLRYWNAPEAT
AAKFRNGWLLTGDSAHADADGNLYFHGRADDIIKSGGYRLGPAEIEGAILAHPDVAECAVVGLPDPQRGQEVTAFVVLGA
DVVPSPELTTELQSRVRAEVGAHAYPRHIEYVDGLAKSSTGKVDRASLRRAYGPVTDEASR

Sequences:

>Translated_541_residues
MTGLASIKAPQVGSWEAARDAFRWPALADYNIATDCLSAPAGRPALVVVAPDRTTEVSFGRLDDLSSRLAGVLRGLGVGV
GDRVAVKLPQSAEMAIAVLATLKLGAVVVTVSNVLGVDAVAHRLEDSGALVLVCAGGIGERELAERTGATLLVTGDEGWL
GGALDGHEPLTSFASSGADDPALLLYTSGTTGSSKGVLHGHRVLLGHHAIDLAWDHVREGDVAYSPVDWSWAGGLMLGLL
VPLAYGITVVAYREPRFDAERTVAIMRDTGVSVGLFPPTALRVLQRSGALTKETMATLRLRVLISGAEAVESELASWARD
ELGLSVNNAFGQTEANALIGHANVLGELDPRCLGRPYPGHEVAILDARQQPVGPGVVGEIAVRADDPVCMLRYWNAPEAT
AAKFRNGWLLTGDSAHADADGNLYFHGRADDIIKSGGYRLGPAEIEGAILAHPDVAECAVVGLPDPQRGQEVTAFVVLGA
DVVPSPELTTELQSRVRAEVGAHAYPRHIEYVDGLAKSSTGKVDRASLRRAYGPVTDEASR
>Mature_540_residues
TGLASIKAPQVGSWEAARDAFRWPALADYNIATDCLSAPAGRPALVVVAPDRTTEVSFGRLDDLSSRLAGVLRGLGVGVG
DRVAVKLPQSAEMAIAVLATLKLGAVVVTVSNVLGVDAVAHRLEDSGALVLVCAGGIGERELAERTGATLLVTGDEGWLG
GALDGHEPLTSFASSGADDPALLLYTSGTTGSSKGVLHGHRVLLGHHAIDLAWDHVREGDVAYSPVDWSWAGGLMLGLLV
PLAYGITVVAYREPRFDAERTVAIMRDTGVSVGLFPPTALRVLQRSGALTKETMATLRLRVLISGAEAVESELASWARDE
LGLSVNNAFGQTEANALIGHANVLGELDPRCLGRPYPGHEVAILDARQQPVGPGVVGEIAVRADDPVCMLRYWNAPEATA
AKFRNGWLLTGDSAHADADGNLYFHGRADDIIKSGGYRLGPAEIEGAILAHPDVAECAVVGLPDPQRGQEVTAFVVLGAD
VVPSPELTTELQSRVRAEVGAHAYPRHIEYVDGLAKSSTGKVDRASLRRAYGPVTDEASR

Specific function: Has a role in growth and sporulation on acetate [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42544132, Length=553, Percent_Identity=28.2097649186257, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI58082049, Length=527, Percent_Identity=30.7400379506641, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI122937307, Length=534, Percent_Identity=31.6479400749064, Blast_Score=212, Evalue=9e-55,
Organism=Homo sapiens, GI157311624, Length=528, Percent_Identity=29.7348484848485, Blast_Score=205, Evalue=9e-53,
Organism=Homo sapiens, GI157311622, Length=528, Percent_Identity=29.7348484848485, Blast_Score=205, Evalue=9e-53,
Organism=Homo sapiens, GI38505220, Length=488, Percent_Identity=30.7377049180328, Blast_Score=199, Evalue=6e-51,
Organism=Homo sapiens, GI115511026, Length=497, Percent_Identity=29.3762575452716, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI8923896, Length=543, Percent_Identity=27.6243093922652, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI13375727, Length=530, Percent_Identity=27.7358490566038, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI28416953, Length=553, Percent_Identity=27.4864376130199, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI253970489, Length=366, Percent_Identity=31.6939890710383, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI187761345, Length=390, Percent_Identity=28.7179487179487, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI187761343, Length=390, Percent_Identity=28.7179487179487, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI195947378, Length=406, Percent_Identity=25.1231527093596, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI156151445, Length=545, Percent_Identity=24.7706422018349, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI42544134, Length=415, Percent_Identity=22.1686746987952, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI38524616, Length=521, Percent_Identity=24.9520153550864, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI13325057, Length=375, Percent_Identity=25.6, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1790505, Length=554, Percent_Identity=28.158844765343, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1788107, Length=559, Percent_Identity=27.0125223613596, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI145693145, Length=545, Percent_Identity=25.8715596330275, Blast_Score=133, Evalue=4e-32,
Organism=Escherichia coli, GI1786529, Length=542, Percent_Identity=29.520295202952, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI221142682, Length=494, Percent_Identity=25.3036437246964, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786810, Length=520, Percent_Identity=26.5384615384615, Blast_Score=112, Evalue=9e-26,
Organism=Escherichia coli, GI1786801, Length=514, Percent_Identity=26.0700389105058, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789201, Length=397, Percent_Identity=24.4332493702771, Blast_Score=86, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71983001, Length=569, Percent_Identity=28.1195079086116, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71982997, Length=569, Percent_Identity=28.1195079086116, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17558820, Length=497, Percent_Identity=25.9557344064386, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI32563687, Length=490, Percent_Identity=25.9183673469388, Blast_Score=139, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17559526, Length=369, Percent_Identity=27.6422764227642, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17538037, Length=542, Percent_Identity=24.3542435424354, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17557194, Length=533, Percent_Identity=24.577861163227, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17531443, Length=372, Percent_Identity=27.6881720430108, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17560140, Length=363, Percent_Identity=26.7217630853994, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71994703, Length=509, Percent_Identity=23.7721021611002, Blast_Score=102, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI71994694, Length=509, Percent_Identity=23.7721021611002, Blast_Score=102, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI71994690, Length=509, Percent_Identity=23.7721021611002, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71985884, Length=415, Percent_Identity=26.0240963855422, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17560308, Length=308, Percent_Identity=27.9220779220779, Blast_Score=90, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323182, Length=559, Percent_Identity=30.4114490161002, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6319264, Length=538, Percent_Identity=29.368029739777, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6319699, Length=245, Percent_Identity=29.3877551020408, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI62472339, Length=531, Percent_Identity=27.8719397363465, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24667955, Length=531, Percent_Identity=27.8719397363465, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24667959, Length=495, Percent_Identity=27.6767676767677, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI18859661, Length=538, Percent_Identity=29.182156133829, Blast_Score=135, Evalue=9e-32,
Organism=Drosophila melanogaster, GI21355225, Length=527, Percent_Identity=27.8937381404175, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24648257, Length=374, Percent_Identity=29.144385026738, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24656500, Length=509, Percent_Identity=25.9332023575639, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21355181, Length=491, Percent_Identity=24.847250509165, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24648260, Length=516, Percent_Identity=24.8062015503876, Blast_Score=105, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24581924, Length=362, Percent_Identity=26.7955801104972, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI281365686, Length=484, Percent_Identity=22.3140495867769, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI19922652, Length=509, Percent_Identity=26.1296660117878, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21358303, Length=440, Percent_Identity=22.7272727272727, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI20130357, Length=369, Percent_Identity=26.5582655826558, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21356947, Length=497, Percent_Identity=22.7364185110664, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI21356441, Length=314, Percent_Identity=25.1592356687898, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24648253, Length=488, Percent_Identity=22.7459016393443, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24648255, Length=362, Percent_Identity=24.585635359116, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24653035, Length=498, Percent_Identity=23.4939759036145, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24648676, Length=398, Percent_Identity=27.1356783919598, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI161076582, Length=507, Percent_Identity=23.0769230769231, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 56810; Mature: 56679

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGLASIKAPQVGSWEAARDAFRWPALADYNIATDCLSAPAGRPALVVVAPDRTTEVSFG
CCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCCEECCC
RLDDLSSRLAGVLRGLGVGVGDRVAVKLPQSAEMAIAVLATLKLGAVVVTVSNVLGVDAV
CHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCEEEEEHHHHHHHHHH
AHRLEDSGALVLVCAGGIGERELAERTGATLLVTGDEGWLGGALDGHEPLTSFASSGADD
HHHHCCCCCEEEEEECCCCHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHCCCCC
PALLLYTSGTTGSSKGVLHGHRVLLGHHAIDLAWDHVREGDVAYSPVDWSWAGGLMLGLL
CEEEEEECCCCCCCCCCEECCEEEEECCEEEHHHHHCCCCCEEECCCCCCHHHHHHHHHH
VPLAYGITVVAYREPRFDAERTVAIMRDTGVSVGLFPPTALRVLQRSGALTKETMATLRL
HHHHHCEEEEEEECCCCCCCCEEEEEEECCCEEECCCHHHHHHHHHCCCCHHHHHHHHEE
RVLISGAEAVESELASWARDELGLSVNNAFGQTEANALIGHANVLGELDPRCLGRPYPGH
EEEECCHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHEEECHHHHCCCCHHHCCCCCCCC
EVAILDARQQPVGPGVVGEIAVRADDPVCMLRYWNAPEATAAKFRNGWLLTGDSAHADAD
EEEEEECCCCCCCCCCEEEEEEECCCCEEEEEECCCCCHHHHHHCCCEEEECCCCCCCCC
GNLYFHGRADDIIKSGGYRLGPAEIEGAILAHPDVAECAVVGLPDPQRGQEVTAFVVLGA
CCEEEECCHHHHHHCCCCEECHHHCCCEEEECCCHHHEEEEECCCCCCCCEEEEEEEECC
DVVPSPELTTELQSRVRAEVGAHAYPRHIEYVDGLAKSSTGKVDRASLRRAYGPVTDEAS
CCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCC
R
C
>Mature Secondary Structure 
TGLASIKAPQVGSWEAARDAFRWPALADYNIATDCLSAPAGRPALVVVAPDRTTEVSFG
CCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCCEECCC
RLDDLSSRLAGVLRGLGVGVGDRVAVKLPQSAEMAIAVLATLKLGAVVVTVSNVLGVDAV
CHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCEEEEEHHHHHHHHHH
AHRLEDSGALVLVCAGGIGERELAERTGATLLVTGDEGWLGGALDGHEPLTSFASSGADD
HHHHCCCCCEEEEEECCCCHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHCCCCC
PALLLYTSGTTGSSKGVLHGHRVLLGHHAIDLAWDHVREGDVAYSPVDWSWAGGLMLGLL
CEEEEEECCCCCCCCCCEECCEEEEECCEEEHHHHHCCCCCEEECCCCCCHHHHHHHHHH
VPLAYGITVVAYREPRFDAERTVAIMRDTGVSVGLFPPTALRVLQRSGALTKETMATLRL
HHHHHCEEEEEEECCCCCCCCEEEEEEECCCEEECCCHHHHHHHHHCCCCHHHHHHHHEE
RVLISGAEAVESELASWARDELGLSVNNAFGQTEANALIGHANVLGELDPRCLGRPYPGH
EEEECCHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHEEECHHHHCCCCHHHCCCCCCCC
EVAILDARQQPVGPGVVGEIAVRADDPVCMLRYWNAPEATAAKFRNGWLLTGDSAHADAD
EEEEEECCCCCCCCCCEEEEEEECCCCEEEEEECCCCCHHHHHHCCCEEEECCCCCCCCC
GNLYFHGRADDIIKSGGYRLGPAEIEGAILAHPDVAECAVVGLPDPQRGQEVTAFVVLGA
CCEEEECCHHHHHHCCCCEECHHHCCCEEEECCCHHHEEEEECCCCCCCCEEEEEEEECC
DVVPSPELTTELQSRVRAEVGAHAYPRHIEYVDGLAKSSTGKVDRASLRRAYGPVTDEAS
CCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934817; 9387221; 9384377 [H]