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The map label for this gene is cobB [H]

Identifier: 119715028

GI number: 119715028

Start: 824884

End: 825714

Strand: Reverse

Name: cobB [H]

Synonym: Noca_0781

Alternate gene names: 119715028

Gene position: 825714-824884 (Counterclockwise)

Preceding gene: 119715029

Following gene: 119715025

Centisome position: 16.56

GC content: 76.53

Gene sequence:

>831_bases
ATGACCAGCCTGCTCGCCGGGTCCCCGGCGGCCGCCGCCCTCGACCTGCTCGCCGCGCGTCCCCTGGTCGTGCTCACCGG
CGCCGGGCTCTCGACCGACTCGGGGATCCCCGACTACCGCGGTCCGGGCTCGCCGGCGCGGACCCCGATGACCTACCAGG
AGTTCGTCTCGGGCCCGGCCGCGCGACAGCGGTACTGGGCGCGCAGCCACCTCGGGTGGGGCCGGATGCGCCTCGCCGAC
CCGAACGCCGGCCACCGCGCCCTCGCGCGGATCGCCCCCGAGCTGCTGATCACCCAGAACGTCGACGGGCTGCACGAGCG
GGCCGGCACCCCGCGCCTGGTCGCGCTGCACGGCCGGATCGCGGACGTCGTCTGCCTGGGCTGCCGGGCGGCCTCGGCGC
GCGCGGCGCTCCAGGAGCGCCTGACCGAGCTGAACCCCGGGTTCGCCGAGCGGCACGCGGCGGTCGCCGTACGCCCGGAC
GGCGACGTCGAGCTCGACGAGACCGGCGACTTCGTGGTCCCGGGGTGCGAGCGCTGCGGCGGCATCCTCAAGCCGGACGT
GGTCTTCTTCGGCGAGAACGTGCCGGCGTCTCGCGTGGAGCGCTGCTACGCCGCAGTCGACGCGCTCGCCGACGCCGGCG
GCGTGCTGCTGGTCGCCGGCTCCAGCCTGACCGTGATGTCCGGGTTCCGCTTCGTCCGCCGGGCCGCCGGCGCGGGCGTT
CCGGTCGTGATCGTCAACCGGGGTGCGACCCGCGGCGACGCGCACGCGGCGTATGCGATCGACGCCGGCTGCAGCGAGTT
CCTCGAGGACCTGGCGGCCCGGCGCGGCTGA

Upstream 100 bases:

>100_bases
CCGAGCACCTGCTCGACGAGCTGGTCACGACGGCACCTCCGAAGAACCGGGAGGCCGAGGCGGCGAAGGCCAAGGCGCGC
GCCGAGCTCCGCTACGCCCG

Downstream 100 bases:

>100_bases
GCTACACCCGGGGGCCGGAGCCCGTCAGTCGGGGTCCTCGTCCTGGGGCCGGGCCAGCTCGCCGAGCAGGTCGATGATCT
CGTGGAGGGCCAGGTCGTGC

Product: silent information regulator protein Sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MTSLLAGSPAAAALDLLAARPLVVLTGAGLSTDSGIPDYRGPGSPARTPMTYQEFVSGPAARQRYWARSHLGWGRMRLAD
PNAGHRALARIAPELLITQNVDGLHERAGTPRLVALHGRIADVVCLGCRAASARAALQERLTELNPGFAERHAAVAVRPD
GDVELDETGDFVVPGCERCGGILKPDVVFFGENVPASRVERCYAAVDALADAGGVLLVAGSSLTVMSGFRFVRRAAGAGV
PVVIVNRGATRGDAHAAYAIDAGCSEFLEDLAARRG

Sequences:

>Translated_276_residues
MTSLLAGSPAAAALDLLAARPLVVLTGAGLSTDSGIPDYRGPGSPARTPMTYQEFVSGPAARQRYWARSHLGWGRMRLAD
PNAGHRALARIAPELLITQNVDGLHERAGTPRLVALHGRIADVVCLGCRAASARAALQERLTELNPGFAERHAAVAVRPD
GDVELDETGDFVVPGCERCGGILKPDVVFFGENVPASRVERCYAAVDALADAGGVLLVAGSSLTVMSGFRFVRRAAGAGV
PVVIVNRGATRGDAHAAYAIDAGCSEFLEDLAARRG
>Mature_275_residues
TSLLAGSPAAAALDLLAARPLVVLTGAGLSTDSGIPDYRGPGSPARTPMTYQEFVSGPAARQRYWARSHLGWGRMRLADP
NAGHRALARIAPELLITQNVDGLHERAGTPRLVALHGRIADVVCLGCRAASARAALQERLTELNPGFAERHAAVAVRPDG
DVELDETGDFVVPGCERCGGILKPDVVFFGENVPASRVERCYAAVDALADAGGVLLVAGSSLTVMSGFRFVRRAAGAGVP
VVIVNRGATRGDAHAAYAIDAGCSEFLEDLAARRG

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI6912662, Length=261, Percent_Identity=44.4444444444444, Blast_Score=197, Evalue=9e-51,
Organism=Homo sapiens, GI6912664, Length=270, Percent_Identity=29.6296296296296, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI13787215, Length=250, Percent_Identity=31.2, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI300795542, Length=270, Percent_Identity=28.8888888888889, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71990482, Length=263, Percent_Identity=42.2053231939163, Blast_Score=205, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71990487, Length=265, Percent_Identity=41.8867924528302, Blast_Score=200, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17567771, Length=263, Percent_Identity=39.5437262357414, Blast_Score=194, Evalue=4e-50,
Organism=Drosophila melanogaster, GI28571445, Length=274, Percent_Identity=43.7956204379562, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI28571443, Length=229, Percent_Identity=42.3580786026201, Blast_Score=154, Evalue=5e-38,
Organism=Drosophila melanogaster, GI28571441, Length=229, Percent_Identity=42.3580786026201, Blast_Score=154, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 28801; Mature: 28670

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLLAGSPAAAALDLLAARPLVVLTGAGLSTDSGIPDYRGPGSPARTPMTYQEFVSGPA
CCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCHH
ARQRYWARSHLGWGRMRLADPNAGHRALARIAPELLITQNVDGLHERAGTPRLVALHGRI
HHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHEEECCCCHHHHHCCCCEEEEECCHH
ADVVCLGCRAASARAALQERLTELNPGFAERHAAVAVRPDGDVELDETGDFVVPGCERCG
HHHHHHHCCHHHHHHHHHHHHHHCCCCHHHCCEEEEECCCCCEEECCCCCEECCCHHHCC
GILKPDVVFFGENVPASRVERCYAAVDALADAGGVLLVAGSSLTVMSGFRFVRRAAGAGV
CCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCC
PVVIVNRGATRGDAHAAYAIDAGCSEFLEDLAARRG
CEEEEECCCCCCCCCEEEEEHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSLLAGSPAAAALDLLAARPLVVLTGAGLSTDSGIPDYRGPGSPARTPMTYQEFVSGPA
CCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCHH
ARQRYWARSHLGWGRMRLADPNAGHRALARIAPELLITQNVDGLHERAGTPRLVALHGRI
HHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHEEECCCCHHHHHCCCCEEEEECCHH
ADVVCLGCRAASARAALQERLTELNPGFAERHAAVAVRPDGDVELDETGDFVVPGCERCG
HHHHHHHCCHHHHHHHHHHHHHHCCCCHHHCCEEEEECCCCCEEECCCCCEECCCHHHCC
GILKPDVVFFGENVPASRVERCYAAVDALADAGGVLLVAGSSLTVMSGFRFVRRAAGAGV
CCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCC
PVVIVNRGATRGDAHAAYAIDAGCSEFLEDLAARRG
CEEEEECCCCCCCCCEEEEEHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA