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The map label for this gene is hflK [H]

Identifier: 119386378

GI number: 119386378

Start: 818872

End: 820071

Strand: Direct

Name: hflK [H]

Synonym: Pden_3670

Alternate gene names: 119386378

Gene position: 818872-820071 (Clockwise)

Preceding gene: 119386377

Following gene: 119386379

Centisome position: 47.33

GC content: 69.83

Gene sequence:

>1200_bases
ATGGCAGGACAAGGCCCCTGGGGCGGCGGCGGAGATGATGACAAGGGCGGCAGGCAGCCACCGCAGGGCGGCGGCCAGCG
CCCCTGGGGCAGCCCGGGGGGCGGCAAGGACGACAAGCCGCAGGGGCCGCGCCGCGGCGACCAGATCCCCGAGATCGAGG
AACTGGTGCGCAAGGGCCAGGACCGGCTGCGCGTGCTGATGGGCGGCAAGGGGCCGGGCGGCGGCAACCGCGGCGGCGGC
CCGCGCCGGCCGCAGGGTCCGCAATTCCAGATGAGCCGCGGCACCTGGGGCATCGCCATCCTCGCCGTGGTGGCGGTCTG
GGCCTTTTCCAGCTTCTATACCGTCAAGCCCGAGGAACGCGCGGTCGAGCTTTTGTTCGGCAAGCCCGTGGGCACGGGCG
AGCCGGGCCTGAACTTCGCGCCCTGGCCCGTCGTCACCGCCGAGGTGGTGCAGGTCTCGGGCGAGCGGACAACGGAAATC
GGCACCGGCCGCGCCGGGCCGATGGATTCGGGGCTGATGCTGACCCGCGACCAGAACATCGTCGACATGGCTTATCAGGT
GGTCTGGAACATCTCGGACCCCGAGAAATTCCTGTTCAACCTGGCCGATCCCGACGACACGATCCGCGCCGTCTCGGAAT
CCGCCATGCGCGACATCGTGGCGCGCTCCGAACTGGCGCCGATCCTGAACCGCGATCGCGGCGCCATCGCCGACGACCTG
AAGCTGGCGGTGCAGAACACGCTGAACGATTACGAGGCGGGGATCAACGTGCTGCGCGTCAACCTCGACCGCGCCGACCC
GCCGCGTGAGGTGATCGACAGCTTCCGCGAGGTGCAGGCCGCCCAGCAGGAACGCGACCGGCTGGAGAAAGAGGCCGACG
CCTATGCGAACCGCGTGCTGGCCAGCGCCCGGGGCGAGGCCGCCGCCGTGATCGAACGCGCCGAAGCCTATCGCGCCGAG
GCCGTGAACACCGCCGAGGGCGAGGCCGCGCGCTTCAACTCGGTCTATGACGAATATGTCAAGGCGCCGGAGGTGACACG
CCGCCGGATGTATCTGGAAACCATGGAAAAGGTTCTGGGCGGGGTGAACAAGGTCATCCTCGACGGCGAGGCCGGGCAGG
GCGTCGTGCCCTATCTGCCGCTGGATCAGCTGCGCAGCGGGGCTGCGGGCGCTCGCAACACCGAGGGGGGGAACCAGTGA

Upstream 100 bases:

>100_bases
GTGGGGGCGGCAAATCTGGACAAACCCGTCGCATCGGCTTGATTTTCCGGCCGAAGGCACCAGTTTCAACCACACAGACG
TAAAGCGAGGCACGAGATTT

Downstream 100 bases:

>100_bases
TGAACCGTGTAATCTCGCTTCTGGCGCTGCCCTTCCTGGTCGTGGTGGCGGTCCTGGTGGTCTCGGCGCTCTATATCGTC
GACGTGCGTGAAAAGGCCCT

Product: HflK protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MAGQGPWGGGGDDDKGGRQPPQGGGQRPWGSPGGGKDDKPQGPRRGDQIPEIEELVRKGQDRLRVLMGGKGPGGGNRGGG
PRRPQGPQFQMSRGTWGIAILAVVAVWAFSSFYTVKPEERAVELLFGKPVGTGEPGLNFAPWPVVTAEVVQVSGERTTEI
GTGRAGPMDSGLMLTRDQNIVDMAYQVVWNISDPEKFLFNLADPDDTIRAVSESAMRDIVARSELAPILNRDRGAIADDL
KLAVQNTLNDYEAGINVLRVNLDRADPPREVIDSFREVQAAQQERDRLEKEADAYANRVLASARGEAAAVIERAEAYRAE
AVNTAEGEAARFNSVYDEYVKAPEVTRRRMYLETMEKVLGGVNKVILDGEAGQGVVPYLPLDQLRSGAAGARNTEGGNQ

Sequences:

>Translated_399_residues
MAGQGPWGGGGDDDKGGRQPPQGGGQRPWGSPGGGKDDKPQGPRRGDQIPEIEELVRKGQDRLRVLMGGKGPGGGNRGGG
PRRPQGPQFQMSRGTWGIAILAVVAVWAFSSFYTVKPEERAVELLFGKPVGTGEPGLNFAPWPVVTAEVVQVSGERTTEI
GTGRAGPMDSGLMLTRDQNIVDMAYQVVWNISDPEKFLFNLADPDDTIRAVSESAMRDIVARSELAPILNRDRGAIADDL
KLAVQNTLNDYEAGINVLRVNLDRADPPREVIDSFREVQAAQQERDRLEKEADAYANRVLASARGEAAAVIERAEAYRAE
AVNTAEGEAARFNSVYDEYVKAPEVTRRRMYLETMEKVLGGVNKVILDGEAGQGVVPYLPLDQLRSGAAGARNTEGGNQ
>Mature_398_residues
AGQGPWGGGGDDDKGGRQPPQGGGQRPWGSPGGGKDDKPQGPRRGDQIPEIEELVRKGQDRLRVLMGGKGPGGGNRGGGP
RRPQGPQFQMSRGTWGIAILAVVAVWAFSSFYTVKPEERAVELLFGKPVGTGEPGLNFAPWPVVTAEVVQVSGERTTEIG
TGRAGPMDSGLMLTRDQNIVDMAYQVVWNISDPEKFLFNLADPDDTIRAVSESAMRDIVARSELAPILNRDRGAIADDLK
LAVQNTLNDYEAGINVLRVNLDRADPPREVIDSFREVQAAQQERDRLEKEADAYANRVLASARGEAAAVIERAEAYRAEA
VNTAEGEAARFNSVYDEYVKAPEVTRRRMYLETMEKVLGGVNKVILDGEAGQGVVPYLPLDQLRSGAAGARNTEGGNQ

Specific function: HflC and HflK govern the stability of phage lambda cII protein and have been proposed to encode or regulate a cII- specific protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=289, Percent_Identity=39.1003460207612, Blast_Score=198, Evalue=5e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 43019; Mature: 42887

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGQGPWGGGGDDDKGGRQPPQGGGQRPWGSPGGGKDDKPQGPRRGDQIPEIEELVRKGQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCH
DRLRVLMGGKGPGGGNRGGGPRRPQGPQFQMSRGTWGIAILAVVAVWAFSSFYTVKPEER
HHEEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCEEECCHHH
AVELLFGKPVGTGEPGLNFAPWPVVTAEVVQVSGERTTEIGTGRAGPMDSGLMLTRDQNI
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEECCCCCCCCCCCCEEEECCCHH
VDMAYQVVWNISDPEKFLFNLADPDDTIRAVSESAMRDIVARSELAPILNRDRGAIADDL
HHHHHHHHHCCCCHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
KLAVQNTLNDYEAGINVLRVNLDRADPPREVIDSFREVQAAQQERDRLEKEADAYANRVL
HHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASARGEAAAVIERAEAYRAEAVNTAEGEAARFNSVYDEYVKAPEVTRRRMYLETMEKVLG
HHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
GVNKVILDGEAGQGVVPYLPLDQLRSGAAGARNTEGGNQ
CCCEEEECCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
AGQGPWGGGGDDDKGGRQPPQGGGQRPWGSPGGGKDDKPQGPRRGDQIPEIEELVRKGQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCH
DRLRVLMGGKGPGGGNRGGGPRRPQGPQFQMSRGTWGIAILAVVAVWAFSSFYTVKPEER
HHEEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCEEECCHHH
AVELLFGKPVGTGEPGLNFAPWPVVTAEVVQVSGERTTEIGTGRAGPMDSGLMLTRDQNI
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEECCCCCCCCCCCCEEEECCCHH
VDMAYQVVWNISDPEKFLFNLADPDDTIRAVSESAMRDIVARSELAPILNRDRGAIADDL
HHHHHHHHHCCCCHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
KLAVQNTLNDYEAGINVLRVNLDRADPPREVIDSFREVQAAQQERDRLEKEADAYANRVL
HHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASARGEAAAVIERAEAYRAEAVNTAEGEAARFNSVYDEYVKAPEVTRRRMYLETMEKVLG
HHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
GVNKVILDGEAGQGVVPYLPLDQLRSGAAGARNTEGGNQ
CCCEEEECCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]