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The map label for this gene is gor [H]

Identifier: 119386377

GI number: 119386377

Start: 817413

End: 818813

Strand: Direct

Name: gor [H]

Synonym: Pden_3669

Alternate gene names: 119386377

Gene position: 817413-818813 (Clockwise)

Preceding gene: 119386376

Following gene: 119386378

Centisome position: 47.25

GC content: 69.31

Gene sequence:

>1401_bases
ATGAAATTCGACTACGACCTTTTCGTCATCGGCGGCGGCTCGGGCGGGGTGCGCGCGGCGCGGATCGCGGCCAGCGAATA
CGGCGCCCGCGTCGGCCTGGCCGAGGAAAGCCGGATGGGCGGCACCTGCGTCATCCGCGGCTGCGTGCCCAAGAAGCTGA
TGATCTTTGCCTCGCAGGCCGGGGCGGCGGCCGCCGAATCGCGCGGCTACGGCTGGCAGGGGGCCGGCGAGGGCCGCTTC
GACTGGGCCGAGTTCCACGGCAAACTGGGGCGCGAACTCGACCGGTTGGAGGGTGCCTATACCTCGGGTCTGGTCAATGC
CGGGGTCGAGGTCCACATGCAGCGCGCCCGGCTGCACGACGCCCATACGGTCGAGCTGGCGGACGGCCAGCGCCTGACGG
CCAAGCATATCCTGATCGCCATCGGCGGGCGGCCGCAGCGGCCCGACATTCCGGGCAAGGAACTGGGGCTGATCTCGGAC
GACCTGTTCACGCTGGAGAAACTGCCCGGTCGGGTGCTGGTGGTGGGCGGCGGCTTCATCGCCTGCGAATTCGCCACCAT
CCTGCAGGGGCTGGGCAGCGCCACGGTGCTGGCCTATCGCGGCGACGCGGTGCTGCGCGGCTTCGACGGCGAGATGCGCC
GCCATGTCACCGAGCAGTTGCGCGCCATCGGCGTCGACGTGCGGCTGGGCACCAATCCGGCGCGGCTGGACCGCGAGGGT
GCGGGGGTCCGCGTCACCTTCGAGGACGACAGCAGCGAGATCTTCGACGCGGTGATGTTCGCCACCGGGCGCGTGCCCTA
TACCAAGGGGCTGGGGCTCGAGGATGCCGGCGTCAAGCTGGGCCGCAAGGGCGAGATCGTGGTGGACGAATGGTCGCAAA
GCTCGGTCCCCTCGATCTTTGCCGTGGGCGACGTGACCGACCGGGTGAACCTGACGCCGGTCGCGATCCGCGAGGGGCAC
AGCTTCGCCGACACCGTCTTCGGCGCCCGGCCGCGCAAGGTCGATCATCGGCTGGTGGCCAGCGCCGTCTATACCCGCCC
GCATGAACTGGCCACCATCGGCCTGACCGAGGAAGAGGCCGATGCCTGCGGTCCCGCCGATGTCTATGTCGCCAGCTTCC
GGCCCATGCGCTCGCTTTTCGCCGGCTCGGATGCGCGGGCGGTGATGAAGCTGATCGTGGATGCGCAGACCGACAAGGTG
CTGGGTTGCCACATCTTCGGCCCCGAGGCGGGCGAGATGATCCAGATGATCGCCGTGCCCATGGGCATGGGCGCGACCAA
GGCCGATTTCGACGCCGCCATCGCCGTGCACCCGACGCTGGCCGAGGAGCTTGTGACCATGCGCAAGCCTTCGCGCCGGG
TGGGGGCGGCAAATCTGGACAAACCCGTCGCATCGGCTTGA

Upstream 100 bases:

>100_bases
CCGGGGTGGTTGAACATGGGCTGTTCCTGAATATCTGCGAACTTGCGATCATCGGCTGCCCGGACGGCTCGGTGGTCGAG
TTGCGGCGCGAGGACATGGC

Downstream 100 bases:

>100_bases
TTTTCCGGCCGAAGGCACCAGTTTCAACCACACAGACGTAAAGCGAGGCACGAGATTTATGGCAGGACAAGGCCCCTGGG
GCGGCGGCGGAGATGATGAC

Product: pyridine nucleotide-disulphide oxidoreductase dimerisation region

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MKFDYDLFVIGGGSGGVRAARIAASEYGARVGLAEESRMGGTCVIRGCVPKKLMIFASQAGAAAAESRGYGWQGAGEGRF
DWAEFHGKLGRELDRLEGAYTSGLVNAGVEVHMQRARLHDAHTVELADGQRLTAKHILIAIGGRPQRPDIPGKELGLISD
DLFTLEKLPGRVLVVGGGFIACEFATILQGLGSATVLAYRGDAVLRGFDGEMRRHVTEQLRAIGVDVRLGTNPARLDREG
AGVRVTFEDDSSEIFDAVMFATGRVPYTKGLGLEDAGVKLGRKGEIVVDEWSQSSVPSIFAVGDVTDRVNLTPVAIREGH
SFADTVFGARPRKVDHRLVASAVYTRPHELATIGLTEEEADACGPADVYVASFRPMRSLFAGSDARAVMKLIVDAQTDKV
LGCHIFGPEAGEMIQMIAVPMGMGATKADFDAAIAVHPTLAEELVTMRKPSRRVGAANLDKPVASA

Sequences:

>Translated_466_residues
MKFDYDLFVIGGGSGGVRAARIAASEYGARVGLAEESRMGGTCVIRGCVPKKLMIFASQAGAAAAESRGYGWQGAGEGRF
DWAEFHGKLGRELDRLEGAYTSGLVNAGVEVHMQRARLHDAHTVELADGQRLTAKHILIAIGGRPQRPDIPGKELGLISD
DLFTLEKLPGRVLVVGGGFIACEFATILQGLGSATVLAYRGDAVLRGFDGEMRRHVTEQLRAIGVDVRLGTNPARLDREG
AGVRVTFEDDSSEIFDAVMFATGRVPYTKGLGLEDAGVKLGRKGEIVVDEWSQSSVPSIFAVGDVTDRVNLTPVAIREGH
SFADTVFGARPRKVDHRLVASAVYTRPHELATIGLTEEEADACGPADVYVASFRPMRSLFAGSDARAVMKLIVDAQTDKV
LGCHIFGPEAGEMIQMIAVPMGMGATKADFDAAIAVHPTLAEELVTMRKPSRRVGAANLDKPVASA
>Mature_466_residues
MKFDYDLFVIGGGSGGVRAARIAASEYGARVGLAEESRMGGTCVIRGCVPKKLMIFASQAGAAAAESRGYGWQGAGEGRF
DWAEFHGKLGRELDRLEGAYTSGLVNAGVEVHMQRARLHDAHTVELADGQRLTAKHILIAIGGRPQRPDIPGKELGLISD
DLFTLEKLPGRVLVVGGGFIACEFATILQGLGSATVLAYRGDAVLRGFDGEMRRHVTEQLRAIGVDVRLGTNPARLDREG
AGVRVTFEDDSSEIFDAVMFATGRVPYTKGLGLEDAGVKLGRKGEIVVDEWSQSSVPSIFAVGDVTDRVNLTPVAIREGH
SFADTVFGARPRKVDHRLVASAVYTRPHELATIGLTEEEADACGPADVYVASFRPMRSLFAGSDARAVMKLIVDAQTDKV
LGCHIFGPEAGEMIQMIAVPMGMGATKADFDAAIAVHPTLAEELVTMRKPSRRVGAANLDKPVASA

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=463, Percent_Identity=39.7408207343413, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI22035672, Length=450, Percent_Identity=36.8888888888889, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI148277065, Length=460, Percent_Identity=33.4782608695652, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI33519430, Length=460, Percent_Identity=33.4782608695652, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI33519428, Length=460, Percent_Identity=33.4782608695652, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI33519426, Length=460, Percent_Identity=33.4782608695652, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI148277071, Length=460, Percent_Identity=33.4782608695652, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI291045266, Length=430, Percent_Identity=34.1860465116279, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI291045268, Length=427, Percent_Identity=32.0843091334895, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI91199540, Length=458, Percent_Identity=29.9126637554585, Blast_Score=152, Evalue=9e-37,
Organism=Escherichia coli, GI1789915, Length=431, Percent_Identity=39.2111368909513, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI1786307, Length=453, Percent_Identity=28.9183222958057, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI87081717, Length=450, Percent_Identity=27.7777777777778, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI87082354, Length=459, Percent_Identity=27.4509803921569, Blast_Score=138, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI71983419, Length=439, Percent_Identity=40.3189066059225, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI71983429, Length=439, Percent_Identity=40.3189066059225, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17557007, Length=474, Percent_Identity=34.5991561181435, Blast_Score=248, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=30.5613305613306, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=31.4533622559653, Blast_Score=168, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17559934, Length=196, Percent_Identity=27.5510204081633, Blast_Score=65, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6325166, Length=463, Percent_Identity=38.4449244060475, Blast_Score=277, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6321091, Length=461, Percent_Identity=27.9826464208243, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6325240, Length=498, Percent_Identity=25.5020080321285, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17737741, Length=479, Percent_Identity=36.3256784968685, Blast_Score=250, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24640553, Length=476, Percent_Identity=34.8739495798319, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24640551, Length=471, Percent_Identity=35.031847133758, Blast_Score=238, Evalue=5e-63,
Organism=Drosophila melanogaster, GI24640549, Length=476, Percent_Identity=34.8739495798319, Blast_Score=238, Evalue=7e-63,
Organism=Drosophila melanogaster, GI21358499, Length=459, Percent_Identity=31.1546840958606, Blast_Score=163, Evalue=3e-40,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49644; Mature: 49644

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFDYDLFVIGGGSGGVRAARIAASEYGARVGLAEESRMGGTCVIRGCVPKKLMIFASQA
CCEEEEEEEEECCCCCCEEEEEEHHHHCCEECCCHHCCCCCEEEEECCCCCEEEEEECCC
GAAAAESRGYGWQGAGEGRFDWAEFHGKLGRELDRLEGAYTSGLVNAGVEVHMQRARLHD
CCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCHHEEEHHHHCCC
AHTVELADGQRLTAKHILIAIGGRPQRPDIPGKELGLISDDLFTLEKLPGRVLVVGGGFI
CEEEEECCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEEECCCC
ACEFATILQGLGSATVLAYRGDAVLRGFDGEMRRHVTEQLRAIGVDVRLGTNPARLDREG
CHHHHHHHHCCCCEEEEEEECCEEEECCCHHHHHHHHHHHHHHEEEEEECCCHHHCCCCC
AGVRVTFEDDSSEIFDAVMFATGRVPYTKGLGLEDAGVKLGRKGEIVVDEWSQSSVPSIF
CCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEE
AVGDVTDRVNLTPVAIREGHSFADTVFGARPRKVDHRLVASAVYTRPHELATIGLTEEEA
EECCCCCCCCCEEEEEECCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHH
DACGPADVYVASFRPMRSLFAGSDARAVMKLIVDAQTDKVLGCHIFGPEAGEMIQMIAVP
CCCCCCCEEEECCHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHC
MGMGATKADFDAAIAVHPTLAEELVTMRKPSRRVGAANLDKPVASA
CCCCCCCCCCCEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKFDYDLFVIGGGSGGVRAARIAASEYGARVGLAEESRMGGTCVIRGCVPKKLMIFASQA
CCEEEEEEEEECCCCCCEEEEEEHHHHCCEECCCHHCCCCCEEEEECCCCCEEEEEECCC
GAAAAESRGYGWQGAGEGRFDWAEFHGKLGRELDRLEGAYTSGLVNAGVEVHMQRARLHD
CCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCHHEEEHHHHCCC
AHTVELADGQRLTAKHILIAIGGRPQRPDIPGKELGLISDDLFTLEKLPGRVLVVGGGFI
CEEEEECCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEEECCCC
ACEFATILQGLGSATVLAYRGDAVLRGFDGEMRRHVTEQLRAIGVDVRLGTNPARLDREG
CHHHHHHHHCCCCEEEEEEECCEEEECCCHHHHHHHHHHHHHHEEEEEECCCHHHCCCCC
AGVRVTFEDDSSEIFDAVMFATGRVPYTKGLGLEDAGVKLGRKGEIVVDEWSQSSVPSIF
CCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEE
AVGDVTDRVNLTPVAIREGHSFADTVFGARPRKVDHRLVASAVYTRPHELATIGLTEEEA
EECCCCCCCCCEEEEEECCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHH
DACGPADVYVASFRPMRSLFAGSDARAVMKLIVDAQTDKVLGCHIFGPEAGEMIQMIAVP
CCCCCCCEEEECCHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHC
MGMGATKADFDAAIAVHPTLAEELVTMRKPSRRVGAANLDKPVASA
CCCCCCCCCCCEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1849605; 10984043 [H]