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The map label for this gene is mvaB [H]

Identifier: 119386349

GI number: 119386349

Start: 791932

End: 792801

Strand: Direct

Name: mvaB [H]

Synonym: Pden_3641

Alternate gene names: 119386349

Gene position: 791932-792801 (Clockwise)

Preceding gene: 119386348

Following gene: 119386350

Centisome position: 45.77

GC content: 69.77

Gene sequence:

>870_bases
ATGTCCCGGGTTGAGATCTTCGAGGTCGGGCCGCGCGACGGCCTGCAGAACGAAAAGCGCCTGATCCCGGCGGCGGAAAA
GGTCGCGCTGGTCGACCTGCTGTCGCAGGCCGGCTTCCGGCGCATCGAGGTGACCAGCTTCGTGCCGCCGAAATGGGTGC
CGCAGATGGCGGATGCCGCCGAGGTCATGGCCGGCATCACCCGGCATGCCGGCATCCGCTATGCGGTGCTGACCCCCAAC
CTCAGGGGCTACGAGGCCGCGAAGGCGGCCGGCGCGGACGAGGTGGCGATCTTCGCCTCGGCCTCGGAGGGGTTTTCCAG
GGCGAACCTGAACGCGACCATCGCCGAAAGCCTGGAACGCTTCGCCCCGGTGGCCGAGGCGGCGCGGGCCGACGGCATTC
CGTTGCGCGGCTATGTCTCGGTGGTGACGGATTGCCCCTTCGACGGGCCGGTGCCGCCCGCGAACGTCGCCCGGGTGACC
GCCGCGCTTCGCGACATGGGTTGCTATGAGGTCAGCCTGGGCGACACCATCGGCCAGGGCCGGCCCGAGACCATCGACGC
CATGCTCTCTGCCGTGCTGGAGGAACTGCCGCCCGAAAACCTCGCCGGCCATTACCACGATACCGCAGGCCGGGCGCTGG
AGAATGTCGATGCAAGCCTTTCGCGCGGCTTGCGGGTCTTCGACGCCGCTGTCGGCGGGCTGGGCGGTTGCCCCTATGCA
CCGGGCGCGGCGGGCAATGTCGCGACCGAAAAACTTGCCGCGCATCTGGCCGCGCACGGCCACGACACCGGGCTGGACAT
GGCGGTGATCGAACAGGCCGCCGCCATGGCCCGCACCATGAGGGCCCGCACCATGAGGGGAGGAGCATGA

Upstream 100 bases:

>100_bases
GCCTATCGCGACCGCATGACGGTGCGGCCGGCCTATCGCCGTGCCTTGGCCCGCGCCGGGGGCGATGCGATCTATGAACG
CGATTTCTATGAGGTGCCGG

Downstream 100 bases:

>100_bases
TGGAAACGATCCGCATCGACACCGACGCCCGCGGCGTGGCGCATCTGTGGCTCGCGCGCCCCGAGAAGCACAATGCGCTT
TCGGCGCAGATGATCCGCGA

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MSRVEIFEVGPRDGLQNEKRLIPAAEKVALVDLLSQAGFRRIEVTSFVPPKWVPQMADAAEVMAGITRHAGIRYAVLTPN
LRGYEAAKAAGADEVAIFASASEGFSRANLNATIAESLERFAPVAEAARADGIPLRGYVSVVTDCPFDGPVPPANVARVT
AALRDMGCYEVSLGDTIGQGRPETIDAMLSAVLEELPPENLAGHYHDTAGRALENVDASLSRGLRVFDAAVGGLGGCPYA
PGAAGNVATEKLAAHLAAHGHDTGLDMAVIEQAAAMARTMRARTMRGGA

Sequences:

>Translated_289_residues
MSRVEIFEVGPRDGLQNEKRLIPAAEKVALVDLLSQAGFRRIEVTSFVPPKWVPQMADAAEVMAGITRHAGIRYAVLTPN
LRGYEAAKAAGADEVAIFASASEGFSRANLNATIAESLERFAPVAEAARADGIPLRGYVSVVTDCPFDGPVPPANVARVT
AALRDMGCYEVSLGDTIGQGRPETIDAMLSAVLEELPPENLAGHYHDTAGRALENVDASLSRGLRVFDAAVGGLGGCPYA
PGAAGNVATEKLAAHLAAHGHDTGLDMAVIEQAAAMARTMRARTMRGGA
>Mature_288_residues
SRVEIFEVGPRDGLQNEKRLIPAAEKVALVDLLSQAGFRRIEVTSFVPPKWVPQMADAAEVMAGITRHAGIRYAVLTPNL
RGYEAAKAAGADEVAIFASASEGFSRANLNATIAESLERFAPVAEAARADGIPLRGYVSVVTDCPFDGPVPPANVARVTA
ALRDMGCYEVSLGDTIGQGRPETIDAMLSAVLEELPPENLAGHYHDTAGRALENVDASLSRGLRVFDAAVGGLGGCPYAP
GAAGNVATEKLAAHLAAHGHDTGLDMAVIEQAAAMARTMRARTMRGGA

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=271, Percent_Identity=53.8745387453875, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI109150422, Length=270, Percent_Identity=52.5925925925926, Blast_Score=300, Evalue=9e-82,
Organism=Homo sapiens, GI109150427, Length=270, Percent_Identity=52.5925925925926, Blast_Score=300, Evalue=9e-82,
Organism=Homo sapiens, GI260654708, Length=85, Percent_Identity=62.3529411764706, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17510563, Length=275, Percent_Identity=48.7272727272727, Blast_Score=275, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24582381, Length=283, Percent_Identity=53.7102473498233, Blast_Score=310, Evalue=6e-85,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000138
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 30215; Mature: 30083

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVEIFEVGPRDGLQNEKRLIPAAEKVALVDLLSQAGFRRIEVTSFVPPKWVPQMADAA
CCCEEEEECCCCCCCCCHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHH
EVMAGITRHAGIRYAVLTPNLRGYEAAKAAGADEVAIFASASEGFSRANLNATIAESLER
HHHHHHHHHCCCEEEEECCCCCCCHHHHHCCCCCEEEEEECCCCCHHCCCCHHHHHHHHH
FAPVAEAARADGIPLRGYVSVVTDCPFDGPVPPANVARVTAALRDMGCYEVSLGDTIGQG
HHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCC
RPETIDAMLSAVLEELPPENLAGHYHDTAGRALENVDASLSRGLRVFDAAVGGLGGCPYA
CCHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCC
PGAAGNVATEKLAAHLAAHGHDTGLDMAVIEQAAAMARTMRARTMRGGA
CCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SRVEIFEVGPRDGLQNEKRLIPAAEKVALVDLLSQAGFRRIEVTSFVPPKWVPQMADAA
CCEEEEECCCCCCCCCHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHH
EVMAGITRHAGIRYAVLTPNLRGYEAAKAAGADEVAIFASASEGFSRANLNATIAESLER
HHHHHHHHHCCCEEEEECCCCCCCHHHHHCCCCCEEEEEECCCCCHHCCCCHHHHHHHHH
FAPVAEAARADGIPLRGYVSVVTDCPFDGPVPPANVARVTAALRDMGCYEVSLGDTIGQG
HHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCC
RPETIDAMLSAVLEELPPENLAGHYHDTAGRALENVDASLSRGLRVFDAAVGGLGGCPYA
CCHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCC
PGAAGNVATEKLAAHLAAHGHDTGLDMAVIEQAAAMARTMRARTMRGGA
CCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2687236; 2656635; 1637819 [H]