Click here to switch to the map view.

The map label for this gene is yngE [H]

Identifier: 119386345

GI number: 119386345

Start: 787177

End: 788781

Strand: Direct

Name: yngE [H]

Synonym: Pden_3637

Alternate gene names: 119386345

Gene position: 787177-788781 (Clockwise)

Preceding gene: 119386343

Following gene: 119386346

Centisome position: 45.5

GC content: 69.72

Gene sequence:

>1605_bases
ATGAAGCTTGGCACCTCGGCCCTGCCGTCCTCGGAGGCGTTCCGCGCCAACCGCACGGCGCATCTCGCCATGCTGGAGAC
GGTGCGCGAGGCGGCGCTGGCCGCGGCGTCGGGCGGCGGCCCCAAGGCTGTCGAGCGCCATGTCGCGCGCGGCAAGATGC
CGCCGCGCGAACGGGTGGCGAACCTGCTCGACCCCGGCTCGCCCTTCCTGGAGATCGGCGCCACGGCGGCGCATGGCATG
TATGGCGCCGCCGCGCCCTGCGCCGGGGTGATCGCCGGCATCGGCCGCGTGCACGGGCAAGAGGTGATGGTCGTGGCCAA
CGACGCGACCGTCAAGGGCGGCACCTATTACCCGATGACGGTGAAAAAGCACCTGCGCGCGCAGGAGATCGCCGAGGAAT
GCCAGCTGCCCTGCGTCTATCTGGTCGATTCGGGCGGCGCGAACCTGCCCAACCAGGACGAGGTCTTTCCCGACCGCGAC
CATTTCGGCCGCATCTTCTACAACCAGGCGCGGATGTCGGCCAAGGGCATCGCGCAGATCGCCGTGGTCATGGGCTCCTG
CACGGCGGGCGGCGCCTATGTGCCGGCCATGTCCGACGTGACCATCATCGTCCGCAACCAGGGCACGATCTTCCTGGCCG
GCCCTCCCTTGGTGCGCGCCGCCACCGGCGAGGTGGTCTCGGCCGAGGATCTGGGCGGCGGCGACGTCCACACCCGGCTT
TCGGGCGTGGCCGACTACCTGGCCGAGGACGACGCCCATGCGCTGGCCCTTGCCCGCCGCGCCATCGGGAACCTCAACCG
CAGCCTGCCGGCGACCGTGCAATGGCAATCCCCCGAGCCTCCGGCCCATGACCCGGAAGACATCCTGGGCATCGTCCCCG
CCGACCTGAAGATCCCCTACGACATCCGCGAGGTCATCGCGCGCGTCGTGGACGGCTCGCGCTTCGACGAGTTCAAGGCC
CGCTTCGGCGAGACGCTGGTGACGGGCTTCGCCCATCTCGAAGGCTGCCCCATCGGCATCGTCGCGAATAACGGCGTGAT
CTTCTCGGAGGCTGCGCAGAAGGGCGCGCATTTCATCGAACTCTGCTCGATGCGGGGCATCCCGCTGGTCTTCCTGCAGA
ACGTCACCGGCTTCATGGTGGGCCGCAAATACGAGAACGAGGGCATCGCGCGGCACGGCGCCAAGATGGTGACGGCGGTG
GCGACGACCAGCGTGCCCAAGATCACCATGCTGGTCGGCGGCAGCTTCGGCGCCGGCAATTACGGCATGGCCGGCCGCGC
CTACGGGCCGCGCTTCCTCTGGACCTGGCCCAATTCCCGCATCTCGGTGATGGGCGGCGAACAGGCGGCCGGCGTGCTCG
CCACCGTGCGCCGCGAGGGGATCGAGCGCCAGGGCGGCACCTGGACCGCCGAGGAGGAGGCCGAGTTCAAGCGTCCCACC
ATCGAGATGTTCGAGCGCCAGTCGCACCCGCTCTACGCCTCGGCCCGGCTCTGGGACGACGGCATCATCGACCCCAGGAA
GACCCGCGACGTGCTGGCGCTGAGCCTGCGCGCCAGCCTCAACGCGCCGGTCGAGCCGACCCGCTTCGGCATCTTCAGGA
TGTGA

Upstream 100 bases:

>100_bases
CGGGCTTCGACGTTGATCTGGATCAAGATTTTCCCGCCTTTGGCAGGGATGCGACAAACTGGCGCAGCAGCGCCGGCACT
TCGACCGAAAGGATGATGCG

Downstream 100 bases:

>100_bases
CGGCCATGCGCATCTCCACCCGGCAAGGCGACATCACCCGGCTCGCCGTCGATGCCATCGTCAATGCGGCCAATCGCACG
CTGCTGGGCGGCGGCGGCGT

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 534; Mature: 534

Protein sequence:

>534_residues
MKLGTSALPSSEAFRANRTAHLAMLETVREAALAAASGGGPKAVERHVARGKMPPRERVANLLDPGSPFLEIGATAAHGM
YGAAAPCAGVIAGIGRVHGQEVMVVANDATVKGGTYYPMTVKKHLRAQEIAEECQLPCVYLVDSGGANLPNQDEVFPDRD
HFGRIFYNQARMSAKGIAQIAVVMGSCTAGGAYVPAMSDVTIIVRNQGTIFLAGPPLVRAATGEVVSAEDLGGGDVHTRL
SGVADYLAEDDAHALALARRAIGNLNRSLPATVQWQSPEPPAHDPEDILGIVPADLKIPYDIREVIARVVDGSRFDEFKA
RFGETLVTGFAHLEGCPIGIVANNGVIFSEAAQKGAHFIELCSMRGIPLVFLQNVTGFMVGRKYENEGIARHGAKMVTAV
ATTSVPKITMLVGGSFGAGNYGMAGRAYGPRFLWTWPNSRISVMGGEQAAGVLATVRREGIERQGGTWTAEEEAEFKRPT
IEMFERQSHPLYASARLWDDGIIDPRKTRDVLALSLRASLNAPVEPTRFGIFRM

Sequences:

>Translated_534_residues
MKLGTSALPSSEAFRANRTAHLAMLETVREAALAAASGGGPKAVERHVARGKMPPRERVANLLDPGSPFLEIGATAAHGM
YGAAAPCAGVIAGIGRVHGQEVMVVANDATVKGGTYYPMTVKKHLRAQEIAEECQLPCVYLVDSGGANLPNQDEVFPDRD
HFGRIFYNQARMSAKGIAQIAVVMGSCTAGGAYVPAMSDVTIIVRNQGTIFLAGPPLVRAATGEVVSAEDLGGGDVHTRL
SGVADYLAEDDAHALALARRAIGNLNRSLPATVQWQSPEPPAHDPEDILGIVPADLKIPYDIREVIARVVDGSRFDEFKA
RFGETLVTGFAHLEGCPIGIVANNGVIFSEAAQKGAHFIELCSMRGIPLVFLQNVTGFMVGRKYENEGIARHGAKMVTAV
ATTSVPKITMLVGGSFGAGNYGMAGRAYGPRFLWTWPNSRISVMGGEQAAGVLATVRREGIERQGGTWTAEEEAEFKRPT
IEMFERQSHPLYASARLWDDGIIDPRKTRDVLALSLRASLNAPVEPTRFGIFRM
>Mature_534_residues
MKLGTSALPSSEAFRANRTAHLAMLETVREAALAAASGGGPKAVERHVARGKMPPRERVANLLDPGSPFLEIGATAAHGM
YGAAAPCAGVIAGIGRVHGQEVMVVANDATVKGGTYYPMTVKKHLRAQEIAEECQLPCVYLVDSGGANLPNQDEVFPDRD
HFGRIFYNQARMSAKGIAQIAVVMGSCTAGGAYVPAMSDVTIIVRNQGTIFLAGPPLVRAATGEVVSAEDLGGGDVHTRL
SGVADYLAEDDAHALALARRAIGNLNRSLPATVQWQSPEPPAHDPEDILGIVPADLKIPYDIREVIARVVDGSRFDEFKA
RFGETLVTGFAHLEGCPIGIVANNGVIFSEAAQKGAHFIELCSMRGIPLVFLQNVTGFMVGRKYENEGIARHGAKMVTAV
ATTSVPKITMLVGGSFGAGNYGMAGRAYGPRFLWTWPNSRISVMGGEQAAGVLATVRREGIERQGGTWTAEEEAEFKRPT
IEMFERQSHPLYASARLWDDGIIDPRKTRDVLALSLRASLNAPVEPTRFGIFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=533, Percent_Identity=62.1013133208255, Blast_Score=665, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=509, Percent_Identity=32.0235756385069, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI295821216, Length=529, Percent_Identity=31.0018903591682, Blast_Score=222, Evalue=7e-58,
Organism=Homo sapiens, GI310133460, Length=143, Percent_Identity=50.3496503496504, Blast_Score=126, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17552936, Length=537, Percent_Identity=59.2178770949721, Blast_Score=655, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=508, Percent_Identity=33.4645669291339, Blast_Score=235, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI25147359, Length=508, Percent_Identity=33.4645669291339, Blast_Score=235, Evalue=5e-62,
Organism=Drosophila melanogaster, GI24586065, Length=541, Percent_Identity=60.2587800369686, Blast_Score=670, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 57055; Mature: 57055

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLGTSALPSSEAFRANRTAHLAMLETVREAALAAASGGGPKAVERHVARGKMPPRERVA
CCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHH
NLLDPGSPFLEIGATAAHGMYGAAAPCAGVIAGIGRVHGQEVMVVANDATVKGGTYYPMT
HHHCCCCCCEEECCHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCEECCCEECCHH
VKKHLRAQEIAEECQLPCVYLVDSGGANLPNQDEVFPDRDHFGRIFYNQARMSAKGIAQI
HHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AVVMGSCTAGGAYVPAMSDVTIIVRNQGTIFLAGPPLVRAATGEVVSAEDLGGGDVHTRL
HHHHHCCCCCCEECCCCCCEEEEEECCCEEEEECCCEEEECCCCEEECCCCCCCHHHHHH
SGVADYLAEDDAHALALARRAIGNLNRSLPATVQWQSPEPPAHDPEDILGIVPADLKIPY
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHEECCCCCCCCH
DIREVIARVVDGSRFDEFKARFGETLVTGFAHLEGCPIGIVANNGVIFSEAAQKGAHFIE
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEHHHHCCHHHHH
LCSMRGIPLVFLQNVTGFMVGRKYENEGIARHGAKMVTAVATTSVPKITMLVGGSFGAGN
HHHCCCCCEEEECCCHHHHCCCEECCCCHHHHCHHHEEHHHHCCCCEEEEEEECCCCCCC
YGMAGRAYGPRFLWTWPNSRISVMGGEQAAGVLATVRREGIERQGGTWTAEEEAEFKRPT
CCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCH
IEMFERQSHPLYASARLWDDGIIDPRKTRDVLALSLRASLNAPVEPTRFGIFRM
HHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHEEEEHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKLGTSALPSSEAFRANRTAHLAMLETVREAALAAASGGGPKAVERHVARGKMPPRERVA
CCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHH
NLLDPGSPFLEIGATAAHGMYGAAAPCAGVIAGIGRVHGQEVMVVANDATVKGGTYYPMT
HHHCCCCCCEEECCHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCEECCCEECCHH
VKKHLRAQEIAEECQLPCVYLVDSGGANLPNQDEVFPDRDHFGRIFYNQARMSAKGIAQI
HHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AVVMGSCTAGGAYVPAMSDVTIIVRNQGTIFLAGPPLVRAATGEVVSAEDLGGGDVHTRL
HHHHHCCCCCCEECCCCCCEEEEEECCCEEEEECCCEEEECCCCEEECCCCCCCHHHHHH
SGVADYLAEDDAHALALARRAIGNLNRSLPATVQWQSPEPPAHDPEDILGIVPADLKIPY
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHEECCCCCCCCH
DIREVIARVVDGSRFDEFKARFGETLVTGFAHLEGCPIGIVANNGVIFSEAAQKGAHFIE
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEHHHHCCHHHHH
LCSMRGIPLVFLQNVTGFMVGRKYENEGIARHGAKMVTAVATTSVPKITMLVGGSFGAGN
HHHCCCCCEEEECCCHHHHCCCEECCCCHHHHCHHHEEHHHHCCCCEEEEEEECCCCCCC
YGMAGRAYGPRFLWTWPNSRISVMGGEQAAGVLATVRREGIERQGGTWTAEEEAEFKRPT
CCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCH
IEMFERQSHPLYASARLWDDGIIDPRKTRDVLALSLRASLNAPVEPTRFGIFRM
HHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHEEEEHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]