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The map label for this gene is hemC

Identifier: 119386338

GI number: 119386338

Start: 781573

End: 782514

Strand: Direct

Name: hemC

Synonym: Pden_3630

Alternate gene names: 119386338

Gene position: 781573-782514 (Clockwise)

Preceding gene: 119386335

Following gene: 119386341

Centisome position: 45.18

GC content: 70.28

Gene sequence:

>942_bases
ATGACCCAGATGCCCGACCCCCAGAACCCCATCCGCATCGGCACCCGAGGCTCGGCCCTGGCGCTGGCGCAGGCGCATGA
AACCCGCGACCGGCTGATGGCCGCGCATGGCCTTGCCGCCGACGCCTTCCGGATCGTGGTGATCAAGACCACCGGCGACC
GCGTGCTGGACCGGCCGCTGAAAGAGATCGGCGGCAAGGGTCTGTTCACCCGCGAGATCGAGGATGCGCTGCTGGCGCAC
GAGATCGACATCGCCGTGCATTCCATGAAGGACATGCCGACGATCCAGCCCGAGGGGTTGGTGATCGACTGCTACCTGCC
GCGCGAGGATGTGCGCGACGCCTTTGTCAGCGCGCAGTTCGCGGCGATTTCCGAGCTTCCCCAAGGGGCTGTCGTCGGTT
CCTCGAGCTTGCGGCGGCGGGCGCAACTGGCGGCGCGGCGGCCCGACCTGAAGCTTGTGGAGTTTCGAGGAAACGTGCAG
ACGCGCCTGAAAAAGCTGGAAGACGGCGTTGCTGTAGCGACCTTCCTGGCCATGGCCGGGCTGACGCGGCTGGGCATGCT
GCATGTCGCGCGCGGCGCGGTCGAACCCGACGAGATGCTGCCTGCCGTGGCGCAAGGCTGCATCGGGGTCGAGCGGCGCG
CCGACGATGCGCGCACCGCCTCGCTACTGGCCGCGATTTCGGACCGGGACAGCGCGCTGCGGGTGACGGCCGAGCGGGCC
TTCCTGGCGCGGCTCGACGGTTCCTGCCAGACGCCCATCGCCGGGCTGGCGGAACTGCAGGGCGACCGGCTGCGGCTGCG
CGGCGAGATCCTGCGCCCCGACGGCAGCGAGGTCATCGCGGCCGAGCGCGTCGGTCCGGCCGCGGACGGCGCGGCCATGG
GCACCGATCTGGCCGAGGAATTGCGCGGCCGGGCGCCTGCCGACTTCTTCGACTGGTCCTAA

Upstream 100 bases:

>100_bases
CGCGCAGGATGGTTTTTTCGGACATAATTCACCTCTCGCCCCTTTCATGGCGCGCGCGTCCCCGTTGTCAAGGCCGAGGG
GGGGCGCTAAGCCCTGTGTC

Downstream 100 bases:

>100_bases
AGCGCCAGCCCCAGCGCCAGCCCAAGTCCCAGCAGAACCATTGCCCGGCGATAAAGCGCCAGCCCGTGCAGCAGATCCTG
CGCCAGAGGGTCGCGGGCGC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MTQMPDPQNPIRIGTRGSALALAQAHETRDRLMAAHGLAADAFRIVVIKTTGDRVLDRPLKEIGGKGLFTREIEDALLAH
EIDIAVHSMKDMPTIQPEGLVIDCYLPREDVRDAFVSAQFAAISELPQGAVVGSSSLRRRAQLAARRPDLKLVEFRGNVQ
TRLKKLEDGVAVATFLAMAGLTRLGMLHVARGAVEPDEMLPAVAQGCIGVERRADDARTASLLAAISDRDSALRVTAERA
FLARLDGSCQTPIAGLAELQGDRLRLRGEILRPDGSEVIAAERVGPAADGAAMGTDLAEELRGRAPADFFDWS

Sequences:

>Translated_313_residues
MTQMPDPQNPIRIGTRGSALALAQAHETRDRLMAAHGLAADAFRIVVIKTTGDRVLDRPLKEIGGKGLFTREIEDALLAH
EIDIAVHSMKDMPTIQPEGLVIDCYLPREDVRDAFVSAQFAAISELPQGAVVGSSSLRRRAQLAARRPDLKLVEFRGNVQ
TRLKKLEDGVAVATFLAMAGLTRLGMLHVARGAVEPDEMLPAVAQGCIGVERRADDARTASLLAAISDRDSALRVTAERA
FLARLDGSCQTPIAGLAELQGDRLRLRGEILRPDGSEVIAAERVGPAADGAAMGTDLAEELRGRAPADFFDWS
>Mature_312_residues
TQMPDPQNPIRIGTRGSALALAQAHETRDRLMAAHGLAADAFRIVVIKTTGDRVLDRPLKEIGGKGLFTREIEDALLAHE
IDIAVHSMKDMPTIQPEGLVIDCYLPREDVRDAFVSAQFAAISELPQGAVVGSSSLRRRAQLAARRPDLKLVEFRGNVQT
RLKKLEDGVAVATFLAMAGLTRLGMLHVARGAVEPDEMLPAVAQGCIGVERRADDARTASLLAAISDRDSALRVTAERAF
LARLDGSCQTPIAGLAELQGDRLRLRGEILRPDGSEVIAAERVGPAADGAAMGTDLAEELRGRAPADFFDWS

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI20149500, Length=274, Percent_Identity=41.970802919708, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI66933009, Length=274, Percent_Identity=41.970802919708, Blast_Score=192, Evalue=3e-49,
Organism=Escherichia coli, GI48994974, Length=294, Percent_Identity=52.3809523809524, Blast_Score=276, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6319996, Length=283, Percent_Identity=34.2756183745583, Blast_Score=162, Evalue=5e-41,
Organism=Drosophila melanogaster, GI20130425, Length=299, Percent_Identity=39.1304347826087, Blast_Score=188, Evalue=4e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_PARDP (A1B853)

Other databases:

- EMBL:   CP000490
- RefSeq:   YP_917393.1
- ProteinModelPortal:   A1B853
- SMR:   A1B853
- STRING:   A1B853
- GeneID:   4582182
- GenomeReviews:   CP000490_GR
- KEGG:   pde:Pden_3630
- eggNOG:   COG0181
- HOGENOM:   HBG624842
- OMA:   SLHAVGQ
- PhylomeDB:   A1B853
- ProtClustDB:   PRK00072
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418
- Gene3D:   G3DSA:3.30.160.40
- PANTHER:   PTHR11557
- PIRSF:   PIRSF001438
- PRINTS:   PR00151
- TIGRFAMs:   TIGR00212

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 33670; Mature: 33539

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQMPDPQNPIRIGTRGSALALAQAHETRDRLMAAHGLAADAFRIVVIKTTGDRVLDRPL
CCCCCCCCCCEEECCCCCEEEHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHH
KEIGGKGLFTREIEDALLAHEIDIAVHSMKDMPTIQPEGLVIDCYLPREDVRDAFVSAQF
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHHH
AAISELPQGAVVGSSSLRRRAQLAARRPDLKLVEFRGNVQTRLKKLEDGVAVATFLAMAG
HHHHHCCCCCEECCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCHHHHHHHHHHH
LTRLGMLHVARGAVEPDEMLPAVAQGCIGVERRADDARTASLLAAISDRDSALRVTAERA
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHCCCCCCEEEHHHHH
FLARLDGSCQTPIAGLAELQGDRLRLRGEILRPDGSEVIAAERVGPAADGAAMGTDLAEE
HHHHCCCCCCCCHHHHHHCCCCEEEEEEEEECCCCCCEEEHHCCCCCCCCCHHHHHHHHH
LRGRAPADFFDWS
HCCCCCCCCCCCC
>Mature Secondary Structure 
TQMPDPQNPIRIGTRGSALALAQAHETRDRLMAAHGLAADAFRIVVIKTTGDRVLDRPL
CCCCCCCCCEEECCCCCEEEHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHH
KEIGGKGLFTREIEDALLAHEIDIAVHSMKDMPTIQPEGLVIDCYLPREDVRDAFVSAQF
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHHH
AAISELPQGAVVGSSSLRRRAQLAARRPDLKLVEFRGNVQTRLKKLEDGVAVATFLAMAG
HHHHHCCCCCEECCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCHHHHHHHHHHH
LTRLGMLHVARGAVEPDEMLPAVAQGCIGVERRADDARTASLLAAISDRDSALRVTAERA
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHCCCCCCEEEHHHHH
FLARLDGSCQTPIAGLAELQGDRLRLRGEILRPDGSEVIAAERVGPAADGAAMGTDLAEE
HHHHCCCCCCCCHHHHHHCCCCEEEEEEEEECCCCCCEEEHHCCCCCCCCCHHHHHHHHH
LRGRAPADFFDWS
HCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA