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The map label for this gene is livH [H]

Identifier: 119386284

GI number: 119386284

Start: 725984

End: 726859

Strand: Direct

Name: livH [H]

Synonym: Pden_3575

Alternate gene names: 119386284

Gene position: 725984-726859 (Clockwise)

Preceding gene: 119386283

Following gene: 119386285

Centisome position: 41.96

GC content: 63.81

Gene sequence:

>876_bases
ATGACATTGGTCTTTCTTTCGCAGCTTCTGAACGGGTTGCTCGACGGCTTCTATTACATGCTGATCGCGCTGGGGCTGTC
GCTGATCTTCTCGCTCGGGGGGATCGTCAACCTTGCGCATGGGGCGTTCTTCACGCTTGGCGCCTATCTGGCGCTGGTGC
TGACGCCGCATATCGGCTTTTTCGGGGCGCTGATCGTCGGCCCGCTGATCGCGGCGGGCGTCGCGATGGTGGTCGAGCGC
ACGCTGTTCACGCGCTTCTATCGCGAGGATCCGCTTTATTCGCTGCTGCTGACCTTTGGCCTTGCCATGATCATCGAGCA
GAGCCTGCGCTGGTATTTCGGCGCCTCTCCCCGCGCCTATTCCATGCCGAACGAGCTGCGCGGGCAGGTCTTCATGGGCG
ATTTCGTCTATTCGCGCTATCGCTTCTTCCTGATCGGCATCGCCGTCGCGACGGTGGCGGCGGTCTGGGTGCTGCTGAAC
AGGACCGCCTTCGGGCGGATCGTGCGGGCGGGCATCCAGAATCCCGACATCCTCGGCACGCTGGGGATTTCCCTGCGGCC
CTACCTGTCGGCGGTCGTCGCCATCGCCATCGCCATCGCGGCCCTTGCGGGCGTGCTGATGGCCCCCTTGCAGCCCGTCC
ACCCGATGATGGGGGTCGAGGTCGGGACGGCGGCCTTCGTCGTTGTGGTGATCGGAGGGCTGGGCTCGTTCTGGGGCGTG
GTCGTCGCCGCGCTGCTGGTCGGGCTGGTCAAGGGGCTGATGATCGGCATCGGCTATACGCAATATTCGATGCTGGCCAT
CTATCTGCTGATGTTCGTGGTGTTGTTCCTGCGGCCGCGCGGGCTGTTCGGCGAACGCATCACCCGCTTTGAATAG

Upstream 100 bases:

>100_bases
GGTCGGCGGCGACTGCACGTTCTGATCCCGAAGAACCCGCAAGGGCAGGGCGCGTCCCGGCGACGCGCCCGATCATCTCT
CATGCCATTGGGGATGCCTC

Downstream 100 bases:

>100_bases
GTTTCAGATGAATACCCAAAAACGTGCGGCGATGAGGAATCTGCTGATCGTGGCGGCAGGGCTGGTGCTGCTGCCGGTCT
TGCTGGGCCGGATCGGGCTG

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MTLVFLSQLLNGLLDGFYYMLIALGLSLIFSLGGIVNLAHGAFFTLGAYLALVLTPHIGFFGALIVGPLIAAGVAMVVER
TLFTRFYREDPLYSLLLTFGLAMIIEQSLRWYFGASPRAYSMPNELRGQVFMGDFVYSRYRFFLIGIAVATVAAVWVLLN
RTAFGRIVRAGIQNPDILGTLGISLRPYLSAVVAIAIAIAALAGVLMAPLQPVHPMMGVEVGTAAFVVVVIGGLGSFWGV
VVAALLVGLVKGLMIGIGYTQYSMLAIYLLMFVVLFLRPRGLFGERITRFE

Sequences:

>Translated_291_residues
MTLVFLSQLLNGLLDGFYYMLIALGLSLIFSLGGIVNLAHGAFFTLGAYLALVLTPHIGFFGALIVGPLIAAGVAMVVER
TLFTRFYREDPLYSLLLTFGLAMIIEQSLRWYFGASPRAYSMPNELRGQVFMGDFVYSRYRFFLIGIAVATVAAVWVLLN
RTAFGRIVRAGIQNPDILGTLGISLRPYLSAVVAIAIAIAALAGVLMAPLQPVHPMMGVEVGTAAFVVVVIGGLGSFWGV
VVAALLVGLVKGLMIGIGYTQYSMLAIYLLMFVVLFLRPRGLFGERITRFE
>Mature_290_residues
TLVFLSQLLNGLLDGFYYMLIALGLSLIFSLGGIVNLAHGAFFTLGAYLALVLTPHIGFFGALIVGPLIAAGVAMVVERT
LFTRFYREDPLYSLLLTFGLAMIIEQSLRWYFGASPRAYSMPNELRGQVFMGDFVYSRYRFFLIGIAVATVAAVWVLLNR
TAFGRIVRAGIQNPDILGTLGISLRPYLSAVVAIAIAIAALAGVLMAPLQPVHPMMGVEVGTAAFVVVVIGGLGSFWGVV
VAALLVGLVKGLMIGIGYTQYSMLAIYLLMFVVLFLRPRGLFGERITRFE

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=309, Percent_Identity=25.2427184466019, Blast_Score=81, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 31547; Mature: 31415

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCC
>Mature Secondary Structure 
TLVFLSQLLNGLLDGFYYMLIALGLSLIFSLGGIVNLAHGAFFTLGAYLALVLTPHIGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGALIVGPLIAAGVAMVVERTLFTRFYREDPLYSLLLTFGLAMIIEQSLRWYFGASPRAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SMPNELRGQVFMGDFVYSRYRFFLIGIAVATVAAVWVLLNRTAFGRIVRAGIQNPDILGT
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
LGISLRPYLSAVVAIAIAIAALAGVLMAPLQPVHPMMGVEVGTAAFVVVVIGGLGSFWGV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHH
VVAALLVGLVKGLMIGIGYTQYSMLAIYLLMFVVLFLRPRGLFGERITRFE
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]