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The map label for this gene is ampR [H]

Identifier: 119386163

GI number: 119386163

Start: 595356

End: 596231

Strand: Direct

Name: ampR [H]

Synonym: Pden_3451

Alternate gene names: 119386163

Gene position: 595356-596231 (Clockwise)

Preceding gene: 119386161

Following gene: 119386164

Centisome position: 34.41

GC content: 68.61

Gene sequence:

>876_bases
ATGGATCGCCCGCAACTTCCCCTGAACGCCCTGCGCGCCTTCGAGGTCGCATCGCGCCACCTGAACCTGACCCGCGCCGC
CATCGAGCTTTGCGTGACGCAGGCGGCGCTGAGCCACCAGATCCGCGGGCTGGAGGAGCGCCTGGGGGTCACGCTGTTCC
GCCGCGTCCCGCGCGGGCTGGTGCTGACCGAAGAGGGGATCATGCTGGCCCCGGTCCTGACCCGGATCTTCGACGAGATG
TCCGGCACGCTGGATCGCTTTTCGGCCGGGCACTATCACGAGACGATCAACCTGGGCGTCGTCAACAGCTTCGCCACGGA
ATGGCTGATCCCGCGCCTTGCGGATTTCCAGCGGCTTCACCCCTCGATCGACCTGCGCATCCACACCAACAACAACCGCG
TCGACCTGGCCGGCGAAGGGCTGGACCTGGCGGTCCGGTTCGGCGACGGCAGTTGGCACGGCGTGGCGGCGACCAGGCTG
ATGAGCGGCGCGATGATGGTGGTGTGCAGCCCCGAACTGGCCGGGCGCCTGCGCAGGGTCGAGGATCTTCTGTCGGTGCC
CCTGCTGCGATCCTATCGCGCGAATGAATGGGAGCGATGGTTCGCCGGCCACGGGCTGCCGGCACCGCAGCTGCGCGGCC
CGGTCTTCGACACCTCGCTGGCCATCGCTGAAATGGCCGCCCGGTCCCATGGCCTGGGACTGGTGCCGGTTGCGCTGTTT
TCGTCCTGGACCCAGGCCGGACGGCTGGCCCGACCGTTCGAGGCCGTGCTTGCGGCGGGCGACTATTGGCTGACCCGCTT
GCACGCCAGTCCCGAAACCACCGGGCAGGGCGCATTGCGGGAATGGCTCGTGGCGCGTTGCGAGGATGTTGCGTGA

Upstream 100 bases:

>100_bases
GCTTGTCTGCGGCCGCCATGCGCCCAGTTAAAGCGACGCGGCAACGGGGCGCAAACGATCATATTTCACTTCTGCCATGA
GATAATCTAATTTCGGCGGC

Downstream 100 bases:

>100_bases
CGCGACCAATCAGGCCCGCTCCGACGGTTGTGCTGGATTCTTGCGCGCGGCTGCCTGATGGGTAGTGCCATCGGGAACGG
CATCCGGAAGGGCAGGAATG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MDRPQLPLNALRAFEVASRHLNLTRAAIELCVTQAALSHQIRGLEERLGVTLFRRVPRGLVLTEEGIMLAPVLTRIFDEM
SGTLDRFSAGHYHETINLGVVNSFATEWLIPRLADFQRLHPSIDLRIHTNNNRVDLAGEGLDLAVRFGDGSWHGVAATRL
MSGAMMVVCSPELAGRLRRVEDLLSVPLLRSYRANEWERWFAGHGLPAPQLRGPVFDTSLAIAEMAARSHGLGLVPVALF
SSWTQAGRLARPFEAVLAAGDYWLTRLHASPETTGQGALREWLVARCEDVA

Sequences:

>Translated_291_residues
MDRPQLPLNALRAFEVASRHLNLTRAAIELCVTQAALSHQIRGLEERLGVTLFRRVPRGLVLTEEGIMLAPVLTRIFDEM
SGTLDRFSAGHYHETINLGVVNSFATEWLIPRLADFQRLHPSIDLRIHTNNNRVDLAGEGLDLAVRFGDGSWHGVAATRL
MSGAMMVVCSPELAGRLRRVEDLLSVPLLRSYRANEWERWFAGHGLPAPQLRGPVFDTSLAIAEMAARSHGLGLVPVALF
SSWTQAGRLARPFEAVLAAGDYWLTRLHASPETTGQGALREWLVARCEDVA
>Mature_291_residues
MDRPQLPLNALRAFEVASRHLNLTRAAIELCVTQAALSHQIRGLEERLGVTLFRRVPRGLVLTEEGIMLAPVLTRIFDEM
SGTLDRFSAGHYHETINLGVVNSFATEWLIPRLADFQRLHPSIDLRIHTNNNRVDLAGEGLDLAVRFGDGSWHGVAATRL
MSGAMMVVCSPELAGRLRRVEDLLSVPLLRSYRANEWERWFAGHGLPAPQLRGPVFDTSLAIAEMAARSHGLGLVPVALF
SSWTQAGRLARPFEAVLAAGDYWLTRLHASPETTGQGALREWLVARCEDVA

Specific function: This protein is a positive regulator of gene expression of beta-lactamase (AmpC) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789173, Length=286, Percent_Identity=36.013986013986, Blast_Score=177, Evalue=5e-46,
Organism=Escherichia coli, GI1786448, Length=230, Percent_Identity=36.0869565217391, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI1788706, Length=273, Percent_Identity=33.3333333333333, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1787589, Length=256, Percent_Identity=27.734375, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87081978, Length=187, Percent_Identity=29.9465240641711, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI145693193, Length=190, Percent_Identity=27.8947368421053, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787128, Length=144, Percent_Identity=29.8611111111111, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790262, Length=237, Percent_Identity=25.7383966244726, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI157672245, Length=162, Percent_Identity=29.6296296296296, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32210; Mature: 32210

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRPQLPLNALRAFEVASRHLNLTRAAIELCVTQAALSHQIRGLEERLGVTLFRRVPRGL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VLTEEGIMLAPVLTRIFDEMSGTLDRFSAGHYHETINLGVVNSFATEWLIPRLADFQRLH
EEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCC
PSIDLRIHTNNNRVDLAGEGLDLAVRFGDGSWHGVAATRLMSGAMMVVCSPELAGRLRRV
CCEEEEEEECCCEEEEECCCEEEEEEECCCCCHHHHHHHHHCCCEEEEECHHHHHHHHHH
EDLLSVPLLRSYRANEWERWFAGHGLPAPQLRGPVFDTSLAIAEMAARSHGLGLVPVALF
HHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
SSWTQAGRLARPFEAVLAAGDYWLTRLHASPETTGQGALREWLVARCEDVA
HHHHHHCCCCCHHHHHHHCCHHHHHEEECCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDRPQLPLNALRAFEVASRHLNLTRAAIELCVTQAALSHQIRGLEERLGVTLFRRVPRGL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VLTEEGIMLAPVLTRIFDEMSGTLDRFSAGHYHETINLGVVNSFATEWLIPRLADFQRLH
EEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCC
PSIDLRIHTNNNRVDLAGEGLDLAVRFGDGSWHGVAATRLMSGAMMVVCSPELAGRLRRV
CCEEEEEEECCCEEEEECCCEEEEEEECCCCCHHHHHHHHHCCCEEEEECHHHHHHHHHH
EDLLSVPLLRSYRANEWERWFAGHGLPAPQLRGPVFDTSLAIAEMAARSHGLGLVPVALF
HHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
SSWTQAGRLARPFEAVLAAGDYWLTRLHASPETTGQGALREWLVARCEDVA
HHHHHHCCCCCHHHHHHHCCHHHHHEEECCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8405939; 10984043; 2125210 [H]