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The map label for this gene is nodT [H]

Identifier: 119386161

GI number: 119386161

Start: 592622

End: 593998

Strand: Direct

Name: nodT [H]

Synonym: Pden_3449

Alternate gene names: 119386161

Gene position: 592622-593998 (Clockwise)

Preceding gene: 119386160

Following gene: 119386163

Centisome position: 34.25

GC content: 72.33

Gene sequence:

>1377_bases
GTGATTTCCCCTTCCCGCTTTTTCGGCCCGGCGCTGCTGCTTCTGGCGGCGGGCTGCGCGGCCGTCGGACCCGATCCCGA
CGCCCGCCCCGCGATCCCCGTGCCCGCGACATTTGTCGAGGGCGAGGCCGCATCGGCCGGCAAGCTGGCCAGCCGCGCCT
TCTGGGCAGAATACCGCGACCCGGTGCTGAACGACCTGATCGCGCGAGGTCTCAAGCAGAACCTGGACGAGGCCGCCGCG
CGCGAGCGCATCCGCGCCGCCGCCGCCGATCTGCGCGGCACCGGCGTGCTTGCCGGCCAGGTCTCGGGCACGGCCAGCGC
CGCGCGCGAACGGGGCGCCAGCGCGGGCGGGGCGGTCCAGACCGCCGGCAATTCGAGCCTTGGCGCGAATTTCGTCTTTG
ACCTGTTCGGCGGTGCGCGGCGTGAAAGACAGGGCGCCGCGGCCAGCCTGGAATCCGCCAAGGCGGGGCTGGGCACGGCG
CGGCTGGCCTGGATCGCCGAGTTGATCGATGCCTATGGCGACGCGCGCTATTACCGGCAGGCGCTGGCCCTGACCCGCAA
GACAGTCTCGACCCGCGAGGAGACCGTCCGCATCACCCGCGACCAGCGCGAGTTCGGCGTGGTCAGCGAGTTCGACATGG
CCCAGGCCGAGGCATTGCTGGCCGCCGCCCGGGCCGAGATACCGGGCTATCAGGCCCAGTATGATGCGCAGGTATTCGCC
ATTGCGACCCTGCTCAATGAACCCGCATCCTCGGTGCAAGCGCAGATGCGGCGCGGTTCGGGTCAGCCCCGCATTCCCGG
TAGCGCTCGCGCAGGCGTCCCGGCGGACCTGCTGCGCAACCGGCCCGACCTGCGCTCGGCCGAATATGATCTGGCAGCGG
CATTGGCGACGGTGGGGGTGGCGACGGCCGACCTGCTGCCCTCGCTTTCGCTCACCGGCTCGGTCAGCGAAAGCGGCGGG
GCGAAGTCCTGGGGCTTCGGGCCGGCGATCTCGTTCCCGGTGCTGAACCAGGGCGCGCTGCAGGCCACGCGCGCGCGCCG
CATCGCCGAGGCGCGCGAGGCCGAGATCGCCTGGCGTGCCGCCGTCTCGCAGGCGGTCGAGGACGTGCAGGTCGCGCAAT
CGAACCTGCGCCGCTATCGCGAGCAGGCCGCGGCCCTGGAAGGCGCGGCCGCAGCCTATGACCGCGCCTATCAGCTGGCC
CGGACGAGCTTTGCCGAGGGTGAGCTGGCGCTGCTGGACCTGCTCGATTCCGACCGCTCGACGGCCAGCGCCCGGCTCTC
GGCCGCGTCGGCCCGCAATCAGGCGGCCAAGGAATGGGCGGCGCTGCAGATCGCGACGGGCGCCGGCGCCGGAGAGGTGG
TGCTGGTCAGCCGCTAG

Upstream 100 bases:

>100_bases
GCATCACGGCCTCGGCGGTGATCGGCATCTTCCTCGTCGCCGTCTTTTACGTCGCGGTCCTCAGGGCCGTGCAGCATTTC
ACCAACAAGAGAGCCAAGAC

Downstream 100 bases:

>100_bases
CGCTGGCGCCGAGGGGGCATCGGCGTCCGGGTCGGGATGGCCAGCGCCGCGAGTGCAAGATGGCCGGTCCTCATTCGTCC
GCCTGCAGAACGGCTTCGAT

Product: RND efflux system outer membrane lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MISPSRFFGPALLLLAAGCAAVGPDPDARPAIPVPATFVEGEAASAGKLASRAFWAEYRDPVLNDLIARGLKQNLDEAAA
RERIRAAAADLRGTGVLAGQVSGTASAARERGASAGGAVQTAGNSSLGANFVFDLFGGARRERQGAAASLESAKAGLGTA
RLAWIAELIDAYGDARYYRQALALTRKTVSTREETVRITRDQREFGVVSEFDMAQAEALLAAARAEIPGYQAQYDAQVFA
IATLLNEPASSVQAQMRRGSGQPRIPGSARAGVPADLLRNRPDLRSAEYDLAAALATVGVATADLLPSLSLTGSVSESGG
AKSWGFGPAISFPVLNQGALQATRARRIAEAREAEIAWRAAVSQAVEDVQVAQSNLRRYREQAAALEGAAAAYDRAYQLA
RTSFAEGELALLDLLDSDRSTASARLSAASARNQAAKEWAALQIATGAGAGEVVLVSR

Sequences:

>Translated_458_residues
MISPSRFFGPALLLLAAGCAAVGPDPDARPAIPVPATFVEGEAASAGKLASRAFWAEYRDPVLNDLIARGLKQNLDEAAA
RERIRAAAADLRGTGVLAGQVSGTASAARERGASAGGAVQTAGNSSLGANFVFDLFGGARRERQGAAASLESAKAGLGTA
RLAWIAELIDAYGDARYYRQALALTRKTVSTREETVRITRDQREFGVVSEFDMAQAEALLAAARAEIPGYQAQYDAQVFA
IATLLNEPASSVQAQMRRGSGQPRIPGSARAGVPADLLRNRPDLRSAEYDLAAALATVGVATADLLPSLSLTGSVSESGG
AKSWGFGPAISFPVLNQGALQATRARRIAEAREAEIAWRAAVSQAVEDVQVAQSNLRRYREQAAALEGAAAAYDRAYQLA
RTSFAEGELALLDLLDSDRSTASARLSAASARNQAAKEWAALQIATGAGAGEVVLVSR
>Mature_458_residues
MISPSRFFGPALLLLAAGCAAVGPDPDARPAIPVPATFVEGEAASAGKLASRAFWAEYRDPVLNDLIARGLKQNLDEAAA
RERIRAAAADLRGTGVLAGQVSGTASAARERGASAGGAVQTAGNSSLGANFVFDLFGGARRERQGAAASLESAKAGLGTA
RLAWIAELIDAYGDARYYRQALALTRKTVSTREETVRITRDQREFGVVSEFDMAQAEALLAAARAEIPGYQAQYDAQVFA
IATLLNEPASSVQAQMRRGSGQPRIPGSARAGVPADLLRNRPDLRSAEYDLAAALATVGVATADLLPSLSLTGSVSESGG
AKSWGFGPAISFPVLNQGALQATRARRIAEAREAEIAWRAAVSQAVEDVQVAQSNLRRYREQAAALEGAAAAYDRAYQLA
RTSFAEGELALLDLLDSDRSTASARLSAASARNQAAKEWAALQIATGAGAGEVVLVSR

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=457, Percent_Identity=24.945295404814, Blast_Score=105, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 47742; Mature: 47742

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISPSRFFGPALLLLAAGCAAVGPDPDARPAIPVPATFVEGEAASAGKLASRAFWAEYRD
CCCCHHHHHHHHHHHHHCHHCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCC
PVLNDLIARGLKQNLDEAAARERIRAAAADLRGTGVLAGQVSGTASAARERGASAGGAVQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCCCCEE
TAGNSSLGANFVFDLFGGARRERQGAAASLESAKAGLGTARLAWIAELIDAYGDARYYRQ
ECCCCCCCHHHHHHHHCCHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHH
ALALTRKTVSTREETVRITRDQREFGVVSEFDMAQAEALLAAARAEIPGYQAQYDAQVFA
HHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
IATLLNEPASSVQAQMRRGSGQPRIPGSARAGVPADLLRNRPDLRSAEYDLAAALATVGV
HHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHH
ATADLLPSLSLTGSVSESGGAKSWGFGPAISFPVLNQGALQATRARRIAEAREAEIAWRA
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AVSQAVEDVQVAQSNLRRYREQAAALEGAAAAYDRAYQLARTSFAEGELALLDLLDSDRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCH
TASARLSAASARNQAAKEWAALQIATGAGAGEVVLVSR
HHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEEC
>Mature Secondary Structure
MISPSRFFGPALLLLAAGCAAVGPDPDARPAIPVPATFVEGEAASAGKLASRAFWAEYRD
CCCCHHHHHHHHHHHHHCHHCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCC
PVLNDLIARGLKQNLDEAAARERIRAAAADLRGTGVLAGQVSGTASAARERGASAGGAVQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCCCCEE
TAGNSSLGANFVFDLFGGARRERQGAAASLESAKAGLGTARLAWIAELIDAYGDARYYRQ
ECCCCCCCHHHHHHHHCCHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHH
ALALTRKTVSTREETVRITRDQREFGVVSEFDMAQAEALLAAARAEIPGYQAQYDAQVFA
HHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
IATLLNEPASSVQAQMRRGSGQPRIPGSARAGVPADLLRNRPDLRSAEYDLAAALATVGV
HHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHH
ATADLLPSLSLTGSVSESGGAKSWGFGPAISFPVLNQGALQATRARRIAEAREAEIAWRA
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AVSQAVEDVQVAQSNLRRYREQAAALEGAAAAYDRAYQLARTSFAEGELALLDLLDSDRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCH
TASARLSAASARNQAAKEWAALQIATGAGAGEVVLVSR
HHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2338917; 2622339 [H]