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The map label for this gene is argF [H]

Identifier: 119357134

GI number: 119357134

Start: 1515776

End: 1516792

Strand: Direct

Name: argF [H]

Synonym: Cpha266_1323

Alternate gene names: 119357134

Gene position: 1515776-1516792 (Clockwise)

Preceding gene: 119357133

Following gene: 119357135

Centisome position: 48.37

GC content: 52.02

Gene sequence:

>1017_bases
ATGCAACACACACCACAACAACAGCCGGCAAAAAAACGAGACTTTCTCGGATTCAGGCCACTTGATGCCGCTAAAATCAT
CGAACTTTTCGATTTCTCGCTGTTTATCAAGGGAAAGAGAAAAGAGAACGCCTCTGAAGAACCCTTTTTGCCGTTACGGC
AAAAAACCGTAGCGATGATTTTCAGCAAACCCTCGCTTCGAACAAGAGTGTCGTTTGAACTCGGCATTCACGAACTCGGC
GGTTACTCAATCAATCTCGACGGAAAATCCATCGGCATGGGCTCACGAGAGTCCGTCGAAGACATTGCGAGGCTTCTTTC
GCGATACAACGACGCTATCGTCGCCCGACTGCACGACCATGCCGTTATCGAAACCCTTGCGGAGCACGCAACCATTCCGG
TTGTCAATGCGCTCACCGATCTCTCGCACCCCTGTCAGGTGCTGGCCGACGCCTTTACCCTCTATGAGAAAAAGCTCTGG
CATGATGAAATAAAAATCGTTTTCGTCGGCGACGGCAATAACGTTGCCAACTCATGGGTTGAGCTTGCAGGCATCCTCCC
CTTTCACTTCGTTCTCGCCTGTCCTGAAGGGTACATGCCGGATGAACGGCTTCTCGACGAAGCAAGAGCGGCAGGGGTAA
GCCGGATCGACATCACCCATGACCCGAAAGAGGCCGCAACTGATGCCGATGTGCTCTATACCGATGTCTGGACAAGCATG
GGACAGGAAGACGAAATAGAGGAGCGCGTTAAAATATTCAGCCCCTTCCAGATCAACAGCACTCTCCTCCGGCTTGCCAA
ACCCTCCGCTGTGGTGATGCACTGCATGCCCGCCCACAGAGGTCAGGAGATTACCGCGGAGGTTATGGATGGAGCGCAAT
CCATCGTGCTTGACGAGGCGGAAAACCGCCTGCACGTTCAAAAAGCGCTGCTGGTAAAACTGTTGAGCCATGATGTGTAC
AGAAAATTCCATCTGACTCACCGCCTGATGAATGCGGCGAAAAACATCAAGGTATAA

Upstream 100 bases:

>100_bases
TTTACCCACTCCCTGCTGCTTGAAATATTTACCCATGAAGGTGTCGGAACGCAGTTCATCGCAGAGCAGGATAACGATAA
CCCCGGAAAACGGTAACGGT

Downstream 100 bases:

>100_bases
GGAGCATTGAACAACATGAACAAGCAGTTACGGCAGTTGAAGGTCAGGGAGATCCTGTGCCAGCATGATGTTGGCAATCA
GCACGACCTGATGCGGCTTC

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MQHTPQQQPAKKRDFLGFRPLDAAKIIELFDFSLFIKGKRKENASEEPFLPLRQKTVAMIFSKPSLRTRVSFELGIHELG
GYSINLDGKSIGMGSRESVEDIARLLSRYNDAIVARLHDHAVIETLAEHATIPVVNALTDLSHPCQVLADAFTLYEKKLW
HDEIKIVFVGDGNNVANSWVELAGILPFHFVLACPEGYMPDERLLDEARAAGVSRIDITHDPKEAATDADVLYTDVWTSM
GQEDEIEERVKIFSPFQINSTLLRLAKPSAVVMHCMPAHRGQEITAEVMDGAQSIVLDEAENRLHVQKALLVKLLSHDVY
RKFHLTHRLMNAAKNIKV

Sequences:

>Translated_338_residues
MQHTPQQQPAKKRDFLGFRPLDAAKIIELFDFSLFIKGKRKENASEEPFLPLRQKTVAMIFSKPSLRTRVSFELGIHELG
GYSINLDGKSIGMGSRESVEDIARLLSRYNDAIVARLHDHAVIETLAEHATIPVVNALTDLSHPCQVLADAFTLYEKKLW
HDEIKIVFVGDGNNVANSWVELAGILPFHFVLACPEGYMPDERLLDEARAAGVSRIDITHDPKEAATDADVLYTDVWTSM
GQEDEIEERVKIFSPFQINSTLLRLAKPSAVVMHCMPAHRGQEITAEVMDGAQSIVLDEAENRLHVQKALLVKLLSHDVY
RKFHLTHRLMNAAKNIKV
>Mature_338_residues
MQHTPQQQPAKKRDFLGFRPLDAAKIIELFDFSLFIKGKRKENASEEPFLPLRQKTVAMIFSKPSLRTRVSFELGIHELG
GYSINLDGKSIGMGSRESVEDIARLLSRYNDAIVARLHDHAVIETLAEHATIPVVNALTDLSHPCQVLADAFTLYEKKLW
HDEIKIVFVGDGNNVANSWVELAGILPFHFVLACPEGYMPDERLLDEARAAGVSRIDITHDPKEAATDADVLYTDVWTSM
GQEDEIEERVKIFSPFQINSTLLRLAKPSAVVMHCMPAHRGQEITAEVMDGAQSIVLDEAENRLHVQKALLVKLLSHDVY
RKFHLTHRLMNAAKNIKV

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=310, Percent_Identity=36.4516129032258, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI18105007, Length=276, Percent_Identity=30.0724637681159, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1790703, Length=330, Percent_Identity=34.8484848484849, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1786469, Length=331, Percent_Identity=34.7432024169184, Blast_Score=183, Evalue=1e-47,
Organism=Escherichia coli, GI2367364, Length=314, Percent_Identity=28.343949044586, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI193204318, Length=340, Percent_Identity=25.2941176470588, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322373, Length=278, Percent_Identity=32.7338129496403, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6322331, Length=279, Percent_Identity=26.8817204301075, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24642586, Length=295, Percent_Identity=26.4406779661017, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 38022; Mature: 38022

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHTPQQQPAKKRDFLGFRPLDAAKIIELFDFSLFIKGKRKENASEEPFLPLRQKTVAMI
CCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCCCHHHHHHHHH
FSKPSLRTRVSFELGIHELGGYSINLDGKSIGMGSRESVEDIARLLSRYNDAIVARLHDH
CCCCCCCEEEEEEECHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHH
AVIETLAEHATIPVVNALTDLSHPCQVLADAFTLYEKKLWHDEIKIVFVGDGNNVANSWV
HHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHH
ELAGILPFHFVLACPEGYMPDERLLDEARAAGVSRIDITHDPKEAATDADVLYTDVWTSM
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEECCCCCHHHCCCHHHHHHHHHHHC
GQEDEIEERVKIFSPFQINSTLLRLAKPSAVVMHCMPAHRGQEITAEVMDGAQSIVLDEA
CCHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHCCHHHEEHHHH
ENRLHVQKALLVKLLSHDVYRKFHLTHRLMNAAKNIKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQHTPQQQPAKKRDFLGFRPLDAAKIIELFDFSLFIKGKRKENASEEPFLPLRQKTVAMI
CCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCCCHHHHHHHHH
FSKPSLRTRVSFELGIHELGGYSINLDGKSIGMGSRESVEDIARLLSRYNDAIVARLHDH
CCCCCCCEEEEEEECHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHH
AVIETLAEHATIPVVNALTDLSHPCQVLADAFTLYEKKLWHDEIKIVFVGDGNNVANSWV
HHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHH
ELAGILPFHFVLACPEGYMPDERLLDEARAAGVSRIDITHDPKEAATDADVLYTDVWTSM
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEECCCCCHHHCCCHHHHHHHHHHHC
GQEDEIEERVKIFSPFQINSTLLRLAKPSAVVMHCMPAHRGQEITAEVMDGAQSIVLDEA
CCHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHCCHHHEEHHHH
ENRLHVQKALLVKLLSHDVYRKFHLTHRLMNAAKNIKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]