Click here to switch to the map view.

The map label for this gene is recQ [H]

Identifier: 119356946

GI number: 119356946

Start: 1272900

End: 1274975

Strand: Direct

Name: recQ [H]

Synonym: Cpha266_1126

Alternate gene names: 119356946

Gene position: 1272900-1274975 (Clockwise)

Preceding gene: 119356945

Following gene: 119356947

Centisome position: 40.62

GC content: 50.29

Gene sequence:

>2076_bases
ATGATATATAAATCGGCAAGGGCATTGGAGCTTCTGAGGATCGCTTCCTGTAATCCCGATGCAATGTTCCGTGAGAGCCA
GGAGGAAGCAATTCGATACATTGTTGAAGGCCGAGGGCGGTTGCTTGTTGTCCAGAAGACTGGCTGGGGTAAGAGTTTTG
TCTATTTTATTGCGACACGCTTGCTTCGTGAAGGAGGAAGTGGGCCAGCCCTCTTGATTTCACCACTGCTTGCCTTGATG
CGAAACCAGATTGAGGCTGCGGAACGAATGGGGGTGCGTGCTGCTACCATCAACTCAGATAATCCGGATGACTGGGCTGA
GGTGGAACTGAGCATCGCCCGTAATGCGATTGATATTCTGATCATTTCACCTGAACGGCTTGCGAATGAACGTTTCAGTG
CCAATGTTCTGGCTCGAATTGCTTCGCAGATTTCGATATTGGTTATTGATGAAGCACACTGTATTTCTGACTGGGGTCAC
GACTTTCGGCCTTACTATCGATTGCTGGAGCGGATTGTCAAAAGCTTGCCATCAAATCTGAGACTTCTTGCGACCACGGC
GACGGCAAACAATCGCGTTATGGAGGATCTTTCCGAAGTGCTTGGGCCGTATTTGGAGGTATTACGCGGTGATTTGAATC
GTCCATCGCTCACCTTGCAAACCATATTGTTACCTGATCAAGCCCAGCGCCTTGCCTGGCTTTCAGAACAGCTTGCGGCT
CTTCAAGGCCATGGAATTATCTATACCCTCACCGTTCGTGATGCAAACACGGTTGCAGCCTGGCTGAAAAGTCGCGGTTT
CAGTGTTGAAGCTTATACGGGTGAAACCGGTGATCGTCGACCTGAGTTTGAGCAGGCACTGCTCCATAATAAGGTTAAAG
CGCTTGTTGCAACCTCTGCGCTTGGAATGGGCTTCGATAAACCGGATCTGGCATTTGTGATTCACTATCAGATGCCGGGA
TCGGTTGTTGCCTACTATCAGCAGGTAGGGCGTGCCGGGCGTGCTCTTGAATCAGCATATGGCATCTTGCTGAGTGGCAG
GGAAGAGACGGATATCACGGACTGGTTCATCAGGAGTGCCTTTCCGACCAGGCATGAGGTTAATGAGGTCATTAATGCGC
TTGAAAATGAGCTTGCAGGGCTCTCGGTACCCGAACTTCTGGCGAAAGTGAATCTGAGTAAAGGACGTATTGAGAAGACT
ATTGCATTACTTTCGCTGGAATCACCCGCCCCTGTCGCAAAGCAAGGGAGCAAGTGGCAATTGACAGCAGCCACACTTGG
TGAGGGATTTTGGGCTCGTGCGGATCGACTTACCGCGTTACGTCGTGATGATCAACGTCAAATGCAGGAATATCTTGCAT
TGCCCTTTGCTGAACACATGGGTTTTCTTATTCAGGCGCTTGATGGCGATCCAAATACCGTTAGCTTTCCGTTATTGCCT
CCGTTGCCGATACTTGCTGATGCGGCTCTTGTTCTGGAAGCGGTCGCTTTTTTGCGCCGCACCAGTTTGCCCATTGAACC
AAGACTTCAGTGGCCGGGGGGCGGTATGCCACAATATCAGGTAAAAGGAAAAATACCTGTAAATTTGCAGGCCGGGCACG
GTAAAACCCTCTCGGTTTGGGGTGATGCCGGATGGGGCGAACTCGTCAGACAAGGAAAATATCTTGACAACTGTTATTCT
GACAGGTTGGTTACTGCTTGTGTTGAGATGATTCAAAAATGGAATCCGGAACCAGCACCGGCATGGGTGACGTGTGTTCC
ATCATTGCGTCACCCCGATCTCGTTCCGGATTTTGCGCAGCGACTGGCAGATGCGCTGCATCTGCCATTCCAAAAAGTGT
TTGTCAAGAGAGAAGAGAGGCCCGAACAGAAAACGATGGCAAACAGTACCCAACAGGCACGGAATATTGATGGTTCACTT
GCGGTCAATGGACAAACAGTCCCGGAAAGCCCGGTTCTTCTGGTTGATGATGTGGTGGATTCTCGCTGGACATTGACGGT
GTCAGCCTGGCTTTTGAGAAAATACGGAAGCGGCGTGGTTTGGCCTATGGCGCTTGCTCAAACAGGATACGATTAA

Upstream 100 bases:

>100_bases
CGGGGCTGAAGTACCGGAAATGAAATGGTTATGAGCAGTCACCTTTGAGGCAAATTGCTACGATAAGAATCTATCATGAC
AAGTTTCATCAGGAAAGCAG

Downstream 100 bases:

>100_bases
CGATGCAAAAACTCTCTTCGAATACAAAAGCCATTCTCCTTTTGACAGCGCCCTTGATCGCCAGTCACGGCAGTTTGTTG
CCAGACCTTTTGTCGCCTTC

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 691; Mature: 691

Protein sequence:

>691_residues
MIYKSARALELLRIASCNPDAMFRESQEEAIRYIVEGRGRLLVVQKTGWGKSFVYFIATRLLREGGSGPALLISPLLALM
RNQIEAAERMGVRAATINSDNPDDWAEVELSIARNAIDILIISPERLANERFSANVLARIASQISILVIDEAHCISDWGH
DFRPYYRLLERIVKSLPSNLRLLATTATANNRVMEDLSEVLGPYLEVLRGDLNRPSLTLQTILLPDQAQRLAWLSEQLAA
LQGHGIIYTLTVRDANTVAAWLKSRGFSVEAYTGETGDRRPEFEQALLHNKVKALVATSALGMGFDKPDLAFVIHYQMPG
SVVAYYQQVGRAGRALESAYGILLSGREETDITDWFIRSAFPTRHEVNEVINALENELAGLSVPELLAKVNLSKGRIEKT
IALLSLESPAPVAKQGSKWQLTAATLGEGFWARADRLTALRRDDQRQMQEYLALPFAEHMGFLIQALDGDPNTVSFPLLP
PLPILADAALVLEAVAFLRRTSLPIEPRLQWPGGGMPQYQVKGKIPVNLQAGHGKTLSVWGDAGWGELVRQGKYLDNCYS
DRLVTACVEMIQKWNPEPAPAWVTCVPSLRHPDLVPDFAQRLADALHLPFQKVFVKREERPEQKTMANSTQQARNIDGSL
AVNGQTVPESPVLLVDDVVDSRWTLTVSAWLLRKYGSGVVWPMALAQTGYD

Sequences:

>Translated_691_residues
MIYKSARALELLRIASCNPDAMFRESQEEAIRYIVEGRGRLLVVQKTGWGKSFVYFIATRLLREGGSGPALLISPLLALM
RNQIEAAERMGVRAATINSDNPDDWAEVELSIARNAIDILIISPERLANERFSANVLARIASQISILVIDEAHCISDWGH
DFRPYYRLLERIVKSLPSNLRLLATTATANNRVMEDLSEVLGPYLEVLRGDLNRPSLTLQTILLPDQAQRLAWLSEQLAA
LQGHGIIYTLTVRDANTVAAWLKSRGFSVEAYTGETGDRRPEFEQALLHNKVKALVATSALGMGFDKPDLAFVIHYQMPG
SVVAYYQQVGRAGRALESAYGILLSGREETDITDWFIRSAFPTRHEVNEVINALENELAGLSVPELLAKVNLSKGRIEKT
IALLSLESPAPVAKQGSKWQLTAATLGEGFWARADRLTALRRDDQRQMQEYLALPFAEHMGFLIQALDGDPNTVSFPLLP
PLPILADAALVLEAVAFLRRTSLPIEPRLQWPGGGMPQYQVKGKIPVNLQAGHGKTLSVWGDAGWGELVRQGKYLDNCYS
DRLVTACVEMIQKWNPEPAPAWVTCVPSLRHPDLVPDFAQRLADALHLPFQKVFVKREERPEQKTMANSTQQARNIDGSL
AVNGQTVPESPVLLVDDVVDSRWTLTVSAWLLRKYGSGVVWPMALAQTGYD
>Mature_691_residues
MIYKSARALELLRIASCNPDAMFRESQEEAIRYIVEGRGRLLVVQKTGWGKSFVYFIATRLLREGGSGPALLISPLLALM
RNQIEAAERMGVRAATINSDNPDDWAEVELSIARNAIDILIISPERLANERFSANVLARIASQISILVIDEAHCISDWGH
DFRPYYRLLERIVKSLPSNLRLLATTATANNRVMEDLSEVLGPYLEVLRGDLNRPSLTLQTILLPDQAQRLAWLSEQLAA
LQGHGIIYTLTVRDANTVAAWLKSRGFSVEAYTGETGDRRPEFEQALLHNKVKALVATSALGMGFDKPDLAFVIHYQMPG
SVVAYYQQVGRAGRALESAYGILLSGREETDITDWFIRSAFPTRHEVNEVINALENELAGLSVPELLAKVNLSKGRIEKT
IALLSLESPAPVAKQGSKWQLTAATLGEGFWARADRLTALRRDDQRQMQEYLALPFAEHMGFLIQALDGDPNTVSFPLLP
PLPILADAALVLEAVAFLRRTSLPIEPRLQWPGGGMPQYQVKGKIPVNLQAGHGKTLSVWGDAGWGELVRQGKYLDNCYS
DRLVTACVEMIQKWNPEPAPAWVTCVPSLRHPDLVPDFAQRLADALHLPFQKVFVKREERPEQKTMANSTQQARNIDGSL
AVNGQTVPESPVLLVDDVVDSRWTLTVSAWLLRKYGSGVVWPMALAQTGYD

Specific function: Probable DNA helicase. Required for DNA repair and intramolecular recombination; probably has overlapping function with recS (AC P50729). It probably acts to help generate ss-DNA from ds-DNA breaks [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm, nucleoid. Note=Localized throughout the nucleoid in the presence or absence of DNA double- strand breaks [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI14591902, Length=340, Percent_Identity=31.1764705882353, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI14591904, Length=340, Percent_Identity=31.1764705882353, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI4557365, Length=337, Percent_Identity=32.9376854599407, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI148612816, Length=350, Percent_Identity=31.1428571428571, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI51242943, Length=348, Percent_Identity=31.3218390804598, Blast_Score=146, Evalue=8e-35,
Organism=Homo sapiens, GI51242947, Length=348, Percent_Identity=31.3218390804598, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI110735439, Length=334, Percent_Identity=29.3413173652695, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI169218196, Length=334, Percent_Identity=29.3413173652695, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI284005309, Length=352, Percent_Identity=31.8181818181818, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI222352149, Length=369, Percent_Identity=25.4742547425474, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI48994977, Length=321, Percent_Identity=36.4485981308411, Blast_Score=174, Evalue=2e-44,
Organism=Escherichia coli, GI1787016, Length=344, Percent_Identity=26.7441860465116, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71987993, Length=338, Percent_Identity=34.0236686390533, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71987997, Length=338, Percent_Identity=34.0236686390533, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI32564293, Length=322, Percent_Identity=32.9192546583851, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI25145561, Length=334, Percent_Identity=30.8383233532934, Blast_Score=152, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17552866, Length=383, Percent_Identity=27.6762402088773, Blast_Score=138, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6323844, Length=332, Percent_Identity=30.1204819277108, Blast_Score=153, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6325138, Length=338, Percent_Identity=26.3313609467456, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324778, Length=355, Percent_Identity=23.6619718309859, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24646066, Length=334, Percent_Identity=32.9341317365269, Blast_Score=146, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24664230, Length=334, Percent_Identity=31.7365269461078, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI62472181, Length=328, Percent_Identity=32.0121951219512, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24664226, Length=329, Percent_Identity=32.2188449848024, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI21358123, Length=353, Percent_Identity=30.3116147308782, Blast_Score=129, Evalue=1e-29,
Organism=Drosophila melanogaster, GI28574962, Length=358, Percent_Identity=25.9776536312849, Blast_Score=74, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 76696; Mature: 76696

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00690 DEAH_ATP_HELICASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYKSARALELLRIASCNPDAMFRESQEEAIRYIVEGRGRLLVVQKTGWGKSFVYFIATR
CCCCHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHH
LLREGGSGPALLISPLLALMRNQIEAAERMGVRAATINSDNPDDWAEVELSIARNAIDIL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCEEEE
IISPERLANERFSANVLARIASQISILVIDEAHCISDWGHDFRPYYRLLERIVKSLPSNL
EECCHHHHCHHHHHHHHHHHHHCEEEEEEECCHHHHHCCCCCHHHHHHHHHHHHHCCCCC
RLLATTATANNRVMEDLSEVLGPYLEVLRGDLNRPSLTLQTILLPDQAQRLAWLSEQLAA
EEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHH
LQGHGIIYTLTVRDANTVAAWLKSRGFSVEAYTGETGDRRPEFEQALLHNKVKALVATSA
HCCCCEEEEEEECCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
LGMGFDKPDLAFVIHYQMPGSVVAYYQQVGRAGRALESAYGILLSGREETDITDWFIRSA
HCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHC
FPTRHEVNEVINALENELAGLSVPELLAKVNLSKGRIEKTIALLSLESPAPVAKQGSKWQ
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHEEEEECCCCCHHCCCCCEE
LTAATLGEGFWARADRLTALRRDDQRQMQEYLALPFAEHMGFLIQALDGDPNTVSFPLLP
EEHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCCC
PLPILADAALVLEAVAFLRRTSLPIEPRLQWPGGGMPQYQVKGKIPVNLQAGHGKTLSVW
CCHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCEEECCCCEEEEECCCCCEEEEE
GDAGWGELVRQGKYLDNCYSDRLVTACVEMIQKWNPEPAPAWVTCVPSLRHPDLVPDFAQ
CCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCHHHHH
RLADALHLPFQKVFVKREERPEQKTMANSTQQARNIDGSLAVNGQTVPESPVLLVDDVVD
HHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCEEEECCCC
SRWTLTVSAWLLRKYGSGVVWPMALAQTGYD
CCEEEHHHHHHHHHHCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MIYKSARALELLRIASCNPDAMFRESQEEAIRYIVEGRGRLLVVQKTGWGKSFVYFIATR
CCCCHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHH
LLREGGSGPALLISPLLALMRNQIEAAERMGVRAATINSDNPDDWAEVELSIARNAIDIL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCEEEE
IISPERLANERFSANVLARIASQISILVIDEAHCISDWGHDFRPYYRLLERIVKSLPSNL
EECCHHHHCHHHHHHHHHHHHHCEEEEEEECCHHHHHCCCCCHHHHHHHHHHHHHCCCCC
RLLATTATANNRVMEDLSEVLGPYLEVLRGDLNRPSLTLQTILLPDQAQRLAWLSEQLAA
EEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHH
LQGHGIIYTLTVRDANTVAAWLKSRGFSVEAYTGETGDRRPEFEQALLHNKVKALVATSA
HCCCCEEEEEEECCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
LGMGFDKPDLAFVIHYQMPGSVVAYYQQVGRAGRALESAYGILLSGREETDITDWFIRSA
HCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHC
FPTRHEVNEVINALENELAGLSVPELLAKVNLSKGRIEKTIALLSLESPAPVAKQGSKWQ
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHEEEEECCCCCHHCCCCCEE
LTAATLGEGFWARADRLTALRRDDQRQMQEYLALPFAEHMGFLIQALDGDPNTVSFPLLP
EEHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCCC
PLPILADAALVLEAVAFLRRTSLPIEPRLQWPGGGMPQYQVKGKIPVNLQAGHGKTLSVW
CCHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCEEECCCCEEEEECCCCCEEEEE
GDAGWGELVRQGKYLDNCYSDRLVTACVEMIQKWNPEPAPAWVTCVPSLRHPDLVPDFAQ
CCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCHHHHH
RLADALHLPFQKVFVKREERPEQKTMANSTQQARNIDGSLAVNGQTVPESPVLLVDDVVD
HHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCEEEECCCC
SRWTLTVSAWLLRKYGSGVVWPMALAQTGYD
CCEEEHHHHHHHHHHCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9642195 [H]