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The map label for this gene is cobQ

Identifier: 119356937

GI number: 119356937

Start: 1263439

End: 1264956

Strand: Direct

Name: cobQ

Synonym: Cpha266_1117

Alternate gene names: 119356937

Gene position: 1263439-1264956 (Clockwise)

Preceding gene: 119356936

Following gene: 119356938

Centisome position: 40.32

GC content: 52.31

Gene sequence:

>1518_bases
ATGGTAAATTCCTCTCCAGTACCAGGCGCTCTTGCCATTTTCGGCACGGCCTCCGATGTCGGCAAAAGCATTGTCGCCAC
GGCGCTCTGCAGGATGTTCAGCAATGCCGGTATCGATGTCGCTCCCTACAAGGCGCAGAACATGTCGAACAACTCCGGTG
TTACCCCTGACGGTTGTGAAATCGGCCGGGCGCAGATCGCCCAGGCCGAAGCTGCCAGAGTAGTGCCAACGGCTGATATG
AATCCGGTTTTATTGAAGCCGAATTCCGATACAGGAGCTCAGATTGTATTGCAGGGAAAAGTCTGCTCGACAGAGACCGC
AAAGGGCTATTTTCTCGATACCTCCCTCTGGGCCGAGGCTGCCCGCAAAAGCCTTGACCAGCTCATGCAACGCCACGAGC
TGGTTGTTATCGAAGGAGCCGGTTCATGTGCGGAGATGAACCTTTACGATCGCGATTTCGTCAATTTCCGAACTGCCAGA
ATTTCCGGAGCTCCGGTTATTCTTGTTGCCGATATTGATCGGGGCGGGGTTTTTGCTCAGGTTGTCGGGACTCTTGCCGT
GCTTCCTCCTGAAGATAGAGCACTGGTTAAAGGGGTTATTATCAACCGTTTTCGCGGGGATATCGATCTGTTCCGTGATG
GCGTCAAACTGATTGAAACGCTTGCCGGGATTCCAGTGCTTGGCGTTATTCCTTATTTTCGCGGTTTTCGTATCGATGCC
GAAGACGCAGTACCCCTCTCTTCAAAGGTTGACCCTTCCGGTGCGCCTGAAAAAGGGAGGATTGCGGTTGCAGCCATCTA
TTTTCCGCATATTTCAAATTTTACCGATCTTTCGCCGCTTGAACTTGATCCGAAGGTTGAACTGCACTATCTGCACTTTC
CCCGTTCGTTACGGGGGTATCAGGCGCTGATTTTGCCTGGTACCAAAAACGTTCGTGGTGATCTCGACTGGCTTACCTCG
CTTGGATGGGCGGAGAAAATCCGTGAGTTCAGGAGAGATGGTGGACTCATTATGGGTATTTGCGGAGGGTATCAGATGCT
CGGCGCGACGATTGCTGATCCCTCCGGAGTGGAAGGTGAGCCCGGCGAAAGCGCCGGACTCGGGATGCTTCCGGTACACA
CCGTGCTTGAAGAGGAAAAATGCCTCAGTAATGCGATCGGGAACATTCAGGGAGAATCCATCGCCGTGTCCGGTTATGAA
ATCCATATGGGAAGAACAACCTCGAATGGCGACTGCTCTTCATTTCTCAGGGTAACGGCACGAAACAACAGACCGGCAGA
TGATGTTGACGGGGTGATAACTCCGGACGGGAAAGTGATCGGCACCTATTTTCACGGGATTATTGATGAACCTGAGGTTC
GGTGCTGGTTTCTTCGGCAAATTGATCCCGCCTATACCCCGGATGCAGAAGAACGTGGGCGGCAAGAGAGTTATGATTTG
CTTGCCGACCATTTTTCAGGGTATCTCGATATTCCGAAACTCTATGAGATCATACAGCGACCATGTCCGAACCCTTGA

Upstream 100 bases:

>100_bases
TCTGCGTGGGCTATGTGAGCTTTTTTCATAAAACGCCCGAGCTTCAGCAGGCCGGATGGCTGCCGCGAATGGAGCTTGAT
TCACTGGTGCACTACGAAAC

Downstream 100 bases:

>100_bases
CCATGAAGAGTATCTATTATCATGAGCACGGAGGCACTCCCGAACGCCGATTTGCTGTGAATCCCGAAGAGCTTCTGGAT
TTCAGTGTCAATATCAGTCC

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MVNSSPVPGALAIFGTASDVGKSIVATALCRMFSNAGIDVAPYKAQNMSNNSGVTPDGCEIGRAQIAQAEAARVVPTADM
NPVLLKPNSDTGAQIVLQGKVCSTETAKGYFLDTSLWAEAARKSLDQLMQRHELVVIEGAGSCAEMNLYDRDFVNFRTAR
ISGAPVILVADIDRGGVFAQVVGTLAVLPPEDRALVKGVIINRFRGDIDLFRDGVKLIETLAGIPVLGVIPYFRGFRIDA
EDAVPLSSKVDPSGAPEKGRIAVAAIYFPHISNFTDLSPLELDPKVELHYLHFPRSLRGYQALILPGTKNVRGDLDWLTS
LGWAEKIREFRRDGGLIMGICGGYQMLGATIADPSGVEGEPGESAGLGMLPVHTVLEEEKCLSNAIGNIQGESIAVSGYE
IHMGRTTSNGDCSSFLRVTARNNRPADDVDGVITPDGKVIGTYFHGIIDEPEVRCWFLRQIDPAYTPDAEERGRQESYDL
LADHFSGYLDIPKLYEIIQRPCPNP

Sequences:

>Translated_505_residues
MVNSSPVPGALAIFGTASDVGKSIVATALCRMFSNAGIDVAPYKAQNMSNNSGVTPDGCEIGRAQIAQAEAARVVPTADM
NPVLLKPNSDTGAQIVLQGKVCSTETAKGYFLDTSLWAEAARKSLDQLMQRHELVVIEGAGSCAEMNLYDRDFVNFRTAR
ISGAPVILVADIDRGGVFAQVVGTLAVLPPEDRALVKGVIINRFRGDIDLFRDGVKLIETLAGIPVLGVIPYFRGFRIDA
EDAVPLSSKVDPSGAPEKGRIAVAAIYFPHISNFTDLSPLELDPKVELHYLHFPRSLRGYQALILPGTKNVRGDLDWLTS
LGWAEKIREFRRDGGLIMGICGGYQMLGATIADPSGVEGEPGESAGLGMLPVHTVLEEEKCLSNAIGNIQGESIAVSGYE
IHMGRTTSNGDCSSFLRVTARNNRPADDVDGVITPDGKVIGTYFHGIIDEPEVRCWFLRQIDPAYTPDAEERGRQESYDL
LADHFSGYLDIPKLYEIIQRPCPNP
>Mature_505_residues
MVNSSPVPGALAIFGTASDVGKSIVATALCRMFSNAGIDVAPYKAQNMSNNSGVTPDGCEIGRAQIAQAEAARVVPTADM
NPVLLKPNSDTGAQIVLQGKVCSTETAKGYFLDTSLWAEAARKSLDQLMQRHELVVIEGAGSCAEMNLYDRDFVNFRTAR
ISGAPVILVADIDRGGVFAQVVGTLAVLPPEDRALVKGVIINRFRGDIDLFRDGVKLIETLAGIPVLGVIPYFRGFRIDA
EDAVPLSSKVDPSGAPEKGRIAVAAIYFPHISNFTDLSPLELDPKVELHYLHFPRSLRGYQALILPGTKNVRGDLDWLTS
LGWAEKIREFRRDGGLIMGICGGYQMLGATIADPSGVEGEPGESAGLGMLPVHTVLEEEKCLSNAIGNIQGESIAVSGYE
IHMGRTTSNGDCSSFLRVTARNNRPADDVDGVITPDGKVIGTYFHGIIDEPEVRCWFLRQIDPAYTPDAEERGRQESYDL
LADHFSGYLDIPKLYEIIQRPCPNP

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBQ_CHLPD (A1BFI0)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911581.1
- ProteinModelPortal:   A1BFI0
- STRING:   A1BFI0
- GeneID:   4570157
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_1117
- NMPDR:   fig|290317.7.peg.1187
- eggNOG:   COG1492
- HOGENOM:   HBG302271
- OMA:   ESARNIM
- ProtClustDB:   PRK00784
- HAMAP:   MF_00028
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- TIGRFAMs:   TIGR00313

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3

EC number: 6.3.5.10

Molecular weight: Translated: 54533; Mature: 54533

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS51274 GATASE_COBBQ

Important sites: ACT_SITE 341-341 ACT_SITE 445-445

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNSSPVPGALAIFGTASDVGKSIVATALCRMFSNAGIDVAPYKAQNMSNNSGVTPDGCE
CCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCC
IGRAQIAQAEAARVVPTADMNPVLLKPNSDTGAQIVLQGKVCSTETAKGYFLDTSLWAEA
CCHHHHHHHHHCEECCCCCCCCEEECCCCCCCCEEEEECCCCCCCCCCCEEEEHHHHHHH
ARKSLDQLMQRHELVVIEGAGSCAEMNLYDRDFVNFRTARISGAPVILVADIDRGGVFAQ
HHHHHHHHHHHCCEEEEECCCCEEECCCCCCHHHCEEEEEECCCCEEEEEECCCCCHHHH
VVGTLAVLPPEDRALVKGVIINRFRGDIDLFRDGVKLIETLAGIPVLGVIPYFRGFRIDA
HHHHHEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCEEECC
EDAVPLSSKVDPSGAPEKGRIAVAAIYFPHISNFTDLSPLELDPKVELHYLHFPRSLRGY
CCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCC
QALILPGTKNVRGDLDWLTSLGWAEKIREFRRDGGLIMGICGGYQMLGATIADPSGVEGE
EEEEECCCCCCCCCHHHHHHCCHHHHHHHHHHCCCEEEEECCCHHHHCCEECCCCCCCCC
PGESAGLGMLPVHTVLEEEKCLSNAIGNIQGESIAVSGYEIHMGRTTSNGDCSSFLRVTA
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCCCCCHHEEEEE
RNNRPADDVDGVITPDGKVIGTYFHGIIDEPEVRCWFLRQIDPAYTPDAEERGRQESYDL
CCCCCCCCCCCEECCCCCEEEEEHHCCCCCCCCEEEEEECCCCCCCCCHHHHCCHHHHHH
LADHFSGYLDIPKLYEIIQRPCPNP
HHHHHCCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MVNSSPVPGALAIFGTASDVGKSIVATALCRMFSNAGIDVAPYKAQNMSNNSGVTPDGCE
CCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCC
IGRAQIAQAEAARVVPTADMNPVLLKPNSDTGAQIVLQGKVCSTETAKGYFLDTSLWAEA
CCHHHHHHHHHCEECCCCCCCCEEECCCCCCCCEEEEECCCCCCCCCCCEEEEHHHHHHH
ARKSLDQLMQRHELVVIEGAGSCAEMNLYDRDFVNFRTARISGAPVILVADIDRGGVFAQ
HHHHHHHHHHHCCEEEEECCCCEEECCCCCCHHHCEEEEEECCCCEEEEEECCCCCHHHH
VVGTLAVLPPEDRALVKGVIINRFRGDIDLFRDGVKLIETLAGIPVLGVIPYFRGFRIDA
HHHHHEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCEEECC
EDAVPLSSKVDPSGAPEKGRIAVAAIYFPHISNFTDLSPLELDPKVELHYLHFPRSLRGY
CCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCC
QALILPGTKNVRGDLDWLTSLGWAEKIREFRRDGGLIMGICGGYQMLGATIADPSGVEGE
EEEEECCCCCCCCCHHHHHHCCHHHHHHHHHHCCCEEEEECCCHHHHCCEECCCCCCCCC
PGESAGLGMLPVHTVLEEEKCLSNAIGNIQGESIAVSGYEIHMGRTTSNGDCSSFLRVTA
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCCCCCHHEEEEE
RNNRPADDVDGVITPDGKVIGTYFHGIIDEPEVRCWFLRQIDPAYTPDAEERGRQESYDL
CCCCCCCCCCCEECCCCCEEEEEHHCCCCCCCCEEEEEECCCCCCCCCHHHHCCHHHHHH
LADHFSGYLDIPKLYEIIQRPCPNP
HHHHHCCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA