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The map label for this gene is nuoM [H]

Identifier: 119356798

GI number: 119356798

Start: 1110706

End: 1112343

Strand: Direct

Name: nuoM [H]

Synonym: Cpha266_0970

Alternate gene names: 119356798

Gene position: 1110706-1112343 (Clockwise)

Preceding gene: 119356797

Following gene: 119356799

Centisome position: 35.44

GC content: 48.05

Gene sequence:

>1638_bases
ATGCTGAGTTTAATCGTCTTTTTGCCTATTCTTGCCGGTCTTGTGATTCTTGCCGTGCCTTCGTCGCAAAAGCAGATCAT
CAGAATAGTATCGTTGCTTGCGGCGGTTCTCCAGATGGTGCTGGCAGTTATGATCTGGCGAGGGTACGATCCATCGCTGC
CCGGTATTACCGCTTCAGCGGCTGGAATTCCACAGGGATCATTCCAGTTTATTGAGCGTCTGCCATGGATCACGCTTGAT
CTCGGTGGGTTCGGCCCTCTCAATATCGAGTATTTTCTCGGTGTCGATGGTATTTCAATCACTATGGTTATTCTGACAGC
GCTGATCTCGGCCATCGGTGTACTGTCAAGCTGGACAATCCAGAAACAGGTTAAAGGGTATTTTATTCTTTATAACCTGC
TTGCCACAGCAATGATGGGCTGTTTTGTCGCGCTTGATTTCTTTCTTTTCTATGTGTTCTGGGAGCTGATGCTTCTGCCG
ATGTACTTCCTTATTGGTATCTGGGGAGGTCCCAATCGCGAGTATGCCGCAATCAAGTTTTTTCTGTATACGCTGTTCGG
ATCAGTTTTCATGCTGCTTGTCATGATCGGTCTCTATTTCAGCGTTCTTGACCCGGTTACCCATAACCATACTTTCAGTC
TTGTTGCCATGGCAAGCCAGTCTAACTATATCAAGGATGCCATTCTTGGTCCTGATAACGTAATGTGGCGTTACATTGCC
TTTATCGTTCTGTTTATCGGTTTTGCTATCAAGGTTCCGATGTTCCCATTTCACACCTGGCTTCCGGATGCTCACGTCGA
GGCGCCTACACCGATTTCGGTTATTCTTGCCGGCGTGCTTCTCAAGCTGGGCACCTACGGTATGATGCGAATCAACTTCC
CCCTTTTCCCGGAAGTATTTCAGGCATCCATGTATGTCATAGGTGTTTTTGGAGCTATCAATATCATATATGGTGCATTC
TGCGCACTTGCACAGCAGGATCTTAAAAAGATGGTTGCCTATTCGTCAATCAGCCATATGGGCTATGTTCTGCTCGGACT
TGCCGCGGCAAACAGCGAGGGCATGGTTGGCGCTCTTTACCAGATGTTCAACCATGGAACCATTACCGCCATGCTCTTCC
TTCTTGTAGGCGTAATCTATGACAGGGCGCATACCCGACAGATCGACAAATTCGGCGGACTGGCCTCCTATATGCCGGTT
TACGCCGCCCTTGTTACCGTAGCGTGGTTTGCCTCTCTTGGTCTTCCCGGCCTGAGCGGATTTATTTCTGAAGCACTTGT
TTTTGTTGGTGCATTCAGCTCCGTAACAACGAGGCCTATTGCTATCGTCTCTGTGCTTGGTATTGTTTTCGGTGCAGCCT
ATCTCCTGTGGTCGTTACAGAGAATGTTTCTCGGCAAGAGAAAACCTGATGCAGCTTACGATCTTGAAGCTGGTCCGGAT
GGTCACGAACATATTCACTTCCATGACTGGAAAGGAAAACTCGATCTTGATGCACGTGAACTCACCATGCTTGTGCCGCT
TACCGTGATTATCATTTTCCTCGGTATTTATCCGATGCCTGTGCTCGGCATGCTCACGACAAGTATTAACAAACTGGTTG
AAGTGTTGTCTCCTGTCGTGATGACGGCCCTGAATTAA

Upstream 100 bases:

>100_bases
ACTCCTTATGATTGCTGTTTGCGGCTATTTTGTCTATTACTTTACACAACTGGTCTATTAAGAGATTTACTTTTAATCTG
AAAACCTACAGATACGGAAC

Downstream 100 bases:

>100_bases
CCAGACGAAAAGAGCTAAAAAGAATAAACGAAGAGAATTATGTTCGAGCTGCCATCGGGTGCTGAGATCCAGAGTGTCAT
TGCAGGTATAAAAGCAAGTG

Product: proton-translocating NADH-quinone oxidoreductase, chain M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MLSLIVFLPILAGLVILAVPSSQKQIIRIVSLLAAVLQMVLAVMIWRGYDPSLPGITASAAGIPQGSFQFIERLPWITLD
LGGFGPLNIEYFLGVDGISITMVILTALISAIGVLSSWTIQKQVKGYFILYNLLATAMMGCFVALDFFLFYVFWELMLLP
MYFLIGIWGGPNREYAAIKFFLYTLFGSVFMLLVMIGLYFSVLDPVTHNHTFSLVAMASQSNYIKDAILGPDNVMWRYIA
FIVLFIGFAIKVPMFPFHTWLPDAHVEAPTPISVILAGVLLKLGTYGMMRINFPLFPEVFQASMYVIGVFGAINIIYGAF
CALAQQDLKKMVAYSSISHMGYVLLGLAAANSEGMVGALYQMFNHGTITAMLFLLVGVIYDRAHTRQIDKFGGLASYMPV
YAALVTVAWFASLGLPGLSGFISEALVFVGAFSSVTTRPIAIVSVLGIVFGAAYLLWSLQRMFLGKRKPDAAYDLEAGPD
GHEHIHFHDWKGKLDLDARELTMLVPLTVIIIFLGIYPMPVLGMLTTSINKLVEVLSPVVMTALN

Sequences:

>Translated_545_residues
MLSLIVFLPILAGLVILAVPSSQKQIIRIVSLLAAVLQMVLAVMIWRGYDPSLPGITASAAGIPQGSFQFIERLPWITLD
LGGFGPLNIEYFLGVDGISITMVILTALISAIGVLSSWTIQKQVKGYFILYNLLATAMMGCFVALDFFLFYVFWELMLLP
MYFLIGIWGGPNREYAAIKFFLYTLFGSVFMLLVMIGLYFSVLDPVTHNHTFSLVAMASQSNYIKDAILGPDNVMWRYIA
FIVLFIGFAIKVPMFPFHTWLPDAHVEAPTPISVILAGVLLKLGTYGMMRINFPLFPEVFQASMYVIGVFGAINIIYGAF
CALAQQDLKKMVAYSSISHMGYVLLGLAAANSEGMVGALYQMFNHGTITAMLFLLVGVIYDRAHTRQIDKFGGLASYMPV
YAALVTVAWFASLGLPGLSGFISEALVFVGAFSSVTTRPIAIVSVLGIVFGAAYLLWSLQRMFLGKRKPDAAYDLEAGPD
GHEHIHFHDWKGKLDLDARELTMLVPLTVIIIFLGIYPMPVLGMLTTSINKLVEVLSPVVMTALN
>Mature_545_residues
MLSLIVFLPILAGLVILAVPSSQKQIIRIVSLLAAVLQMVLAVMIWRGYDPSLPGITASAAGIPQGSFQFIERLPWITLD
LGGFGPLNIEYFLGVDGISITMVILTALISAIGVLSSWTIQKQVKGYFILYNLLATAMMGCFVALDFFLFYVFWELMLLP
MYFLIGIWGGPNREYAAIKFFLYTLFGSVFMLLVMIGLYFSVLDPVTHNHTFSLVAMASQSNYIKDAILGPDNVMWRYIA
FIVLFIGFAIKVPMFPFHTWLPDAHVEAPTPISVILAGVLLKLGTYGMMRINFPLFPEVFQASMYVIGVFGAINIIYGAF
CALAQQDLKKMVAYSSISHMGYVLLGLAAANSEGMVGALYQMFNHGTITAMLFLLVGVIYDRAHTRQIDKFGGLASYMPV
YAALVTVAWFASLGLPGLSGFISEALVFVGAFSSVTTRPIAIVSVLGIVFGAAYLLWSLQRMFLGKRKPDAAYDLEAGPD
GHEHIHFHDWKGKLDLDARELTMLVPLTVIIIFLGIYPMPVLGMLTTSINKLVEVLSPVVMTALN

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=317, Percent_Identity=33.1230283911672, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI251831117, Length=199, Percent_Identity=30.6532663316583, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788613, Length=541, Percent_Identity=35.3049907578558, Blast_Score=282, Evalue=4e-77,
Organism=Escherichia coli, GI1788827, Length=330, Percent_Identity=30, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788614, Length=444, Percent_Identity=29.5045045045045, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788831, Length=302, Percent_Identity=29.8013245033113, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1788829, Length=288, Percent_Identity=28.125, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI2367154, Length=333, Percent_Identity=27.3273273273273, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI145693160, Length=277, Percent_Identity=27.7978339350181, Blast_Score=82, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 59913; Mature: 59913

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSLIVFLPILAGLVILAVPSSQKQIIRIVSLLAAVLQMVLAVMIWRGYDPSLPGITASA
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
AGIPQGSFQFIERLPWITLDLGGFGPLNIEYFLGVDGISITMVILTALISAIGVLSSWTI
CCCCCHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
QKQVKGYFILYNLLATAMMGCFVALDFFLFYVFWELMLLPMYFLIGIWGGPNREYAAIKF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
FLYTLFGSVFMLLVMIGLYFSVLDPVTHNHTFSLVAMASQSNYIKDAILGPDNVMWRYIA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHCCCHHHHHHHHH
FIVLFIGFAIKVPMFPFHTWLPDAHVEAPTPISVILAGVLLKLGTYGMMRINFPLFPEVF
HHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHH
QASMYVIGVFGAINIIYGAFCALAQQDLKKMVAYSSISHMGYVLLGLAAANSEGMVGALY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
QMFNHGTITAMLFLLVGVIYDRAHTRQIDKFGGLASYMPVYAALVTVAWFASLGLPGLSG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHH
FISEALVFVGAFSSVTTRPIAIVSVLGIVFGAAYLLWSLQRMFLGKRKPDAAYDLEAGPD
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GHEHIHFHDWKGKLDLDARELTMLVPLTVIIIFLGIYPMPVLGMLTTSINKLVEVLSPVV
CCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MTALN
HHHCC
>Mature Secondary Structure
MLSLIVFLPILAGLVILAVPSSQKQIIRIVSLLAAVLQMVLAVMIWRGYDPSLPGITASA
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
AGIPQGSFQFIERLPWITLDLGGFGPLNIEYFLGVDGISITMVILTALISAIGVLSSWTI
CCCCCHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
QKQVKGYFILYNLLATAMMGCFVALDFFLFYVFWELMLLPMYFLIGIWGGPNREYAAIKF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
FLYTLFGSVFMLLVMIGLYFSVLDPVTHNHTFSLVAMASQSNYIKDAILGPDNVMWRYIA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHCCCHHHHHHHHH
FIVLFIGFAIKVPMFPFHTWLPDAHVEAPTPISVILAGVLLKLGTYGMMRINFPLFPEVF
HHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHH
QASMYVIGVFGAINIIYGAFCALAQQDLKKMVAYSSISHMGYVLLGLAAANSEGMVGALY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
QMFNHGTITAMLFLLVGVIYDRAHTRQIDKFGGLASYMPVYAALVTVAWFASLGLPGLSG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHH
FISEALVFVGAFSSVTTRPIAIVSVLGIVFGAAYLLWSLQRMFLGKRKPDAAYDLEAGPD
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GHEHIHFHDWKGKLDLDARELTMLVPLTVIIIFLGIYPMPVLGMLTTSINKLVEVLSPVV
CCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MTALN
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA