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The map label for this gene is emrA [H]

Identifier: 118581046

GI number: 118581046

Start: 2861093

End: 2862220

Strand: Direct

Name: emrA [H]

Synonym: Ppro_2634

Alternate gene names: 118581046

Gene position: 2861093-2862220 (Clockwise)

Preceding gene: 118581045

Following gene: 118581047

Centisome position: 71.38

GC content: 67.46

Gene sequence:

>1128_bases
ATGACGGAAGAGACGCACACGCCGGGCCAGAGCCAGGCGGAGCCGGAAGCGGCCAGGGCGGAACCATTGCCCGACACACC
CAACGGAAACGGGGGCAAGAAGCGCCGCGCCCTGATCATACTGCTGATGGCCGGCCTGGTCTGCCTTGTGCTCGGCCTCG
CCTGGTGGATCCACGGCAAGAGCCACATCGAGACCGACAACGCCTTCATCGAGGCCAAGACCGTGTCCATCTCCTGCAAG
GTAGCCGGCACGGTCAAGCGGGTGCTGGTGGAGGACAACCAGTATGTCGGGAAGGGCGATGCGCTGGTGGAACTGGACCA
GGAGGACTACCGGGTGCAGGTGGCCCAGGCCGAGGCAGGGGTGAGTGTGGCCGAGAACGAGACCGGCGGCGAGCAGTTGC
GGGCCGAGGGGGCACGGGCCACGGTGGAGCTTGCCAGGGCCCGCGCCGAGCAGGCCGATCTGGACCTGCGGCGTGGCGAG
GCGCTCTTTCGGCGTGAGGTGATCCCCCGGGAGCAGTTGGACCGGCTCGGAACCGCCCAGCGGGTGGCGCAGTCCCAGCT
CAGGGAGGCCCGGGAGGGGTTCAAACAGGCACAGGCCGTGGCAGGCCTGGCAGGTCCGGGAGGCAACAGGGCCAGGGTGC
GGCAGCGCCAGGCGCTGCTGAACGAGGCGCGGCTCAGGCTCTCCTATACCCGGGTGCTGGCCCCCACCAACGGCTACATC
ACCCGCAAGGCGGTGGAACCGGGAGCCAACATCCAGGCCGGCCAGCCGCTGATGGCCCTGGTGCCGCTGCAGGACGCCTG
GATCATCGCCAACTACAAGGAAGGGCAGCTCACCCATATCAGGCCCGGCCAGAAGGTGGAGTTTACCGTGGACGCCTATC
CCGACAGGAGCTTCACCGGCAGGGTGAACAGCATCATGGCCGGCACTGGTGCGGCGTTCTCCCTGCTGCCGCCGGAGAAC
GCCACCGGCAACTACGTCAAGGTGGTGCAGCGCATACCGGTCAAGATTTCCATCGACAACAACAGCGACCCGGAACACCT
GCTGCGGGTGGGGATGAGCGTTGTCCCCACCGTGCTGGTGGAGCGCTCCACCGGCGAGATACTGAGGGATCTGGTCCCGT
TCCTGTAG

Upstream 100 bases:

>100_bases
CCCTTTTCGACCGTCAGGTGGCGGCCGCCCGCCTGAGGCGCGCCCTGGGAGAACTGTAGCCAAGAACAGTATTGTACTGT
CCGATGGAGGGACATGAATC

Downstream 100 bases:

>100_bases
GGGCGGCCCCGTGTGGCCGCCCCCCTGCAACATGGATTGCGGCACGACATCCCTTATGCCCGCTGTCGGGCACCCACACA
GGGGTGCCCCTACGGTACAC

Product: secretion protein HlyD family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MTEETHTPGQSQAEPEAARAEPLPDTPNGNGGKKRRALIILLMAGLVCLVLGLAWWIHGKSHIETDNAFIEAKTVSISCK
VAGTVKRVLVEDNQYVGKGDALVELDQEDYRVQVAQAEAGVSVAENETGGEQLRAEGARATVELARARAEQADLDLRRGE
ALFRREVIPREQLDRLGTAQRVAQSQLREAREGFKQAQAVAGLAGPGGNRARVRQRQALLNEARLRLSYTRVLAPTNGYI
TRKAVEPGANIQAGQPLMALVPLQDAWIIANYKEGQLTHIRPGQKVEFTVDAYPDRSFTGRVNSIMAGTGAAFSLLPPEN
ATGNYVKVVQRIPVKISIDNNSDPEHLLRVGMSVVPTVLVERSTGEILRDLVPFL

Sequences:

>Translated_375_residues
MTEETHTPGQSQAEPEAARAEPLPDTPNGNGGKKRRALIILLMAGLVCLVLGLAWWIHGKSHIETDNAFIEAKTVSISCK
VAGTVKRVLVEDNQYVGKGDALVELDQEDYRVQVAQAEAGVSVAENETGGEQLRAEGARATVELARARAEQADLDLRRGE
ALFRREVIPREQLDRLGTAQRVAQSQLREAREGFKQAQAVAGLAGPGGNRARVRQRQALLNEARLRLSYTRVLAPTNGYI
TRKAVEPGANIQAGQPLMALVPLQDAWIIANYKEGQLTHIRPGQKVEFTVDAYPDRSFTGRVNSIMAGTGAAFSLLPPEN
ATGNYVKVVQRIPVKISIDNNSDPEHLLRVGMSVVPTVLVERSTGEILRDLVPFL
>Mature_374_residues
TEETHTPGQSQAEPEAARAEPLPDTPNGNGGKKRRALIILLMAGLVCLVLGLAWWIHGKSHIETDNAFIEAKTVSISCKV
AGTVKRVLVEDNQYVGKGDALVELDQEDYRVQVAQAEAGVSVAENETGGEQLRAEGARATVELARARAEQADLDLRRGEA
LFRREVIPREQLDRLGTAQRVAQSQLREAREGFKQAQAVAGLAGPGGNRARVRQRQALLNEARLRLSYTRVLAPTNGYIT
RKAVEPGANIQAGQPLMALVPLQDAWIIANYKEGQLTHIRPGQKVEFTVDAYPDRSFTGRVNSIMAGTGAAFSLLPPENA
TGNYVKVVQRIPVKISIDNNSDPEHLLRVGMSVVPTVLVERSTGEILRDLVPFL

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=351, Percent_Identity=34.1880341880342, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI1788711, Length=333, Percent_Identity=33.6336336336336, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1790519, Length=304, Percent_Identity=32.5657894736842, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI87081951, Length=304, Percent_Identity=25.3289473684211, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1790024, Length=282, Percent_Identity=25.177304964539, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789637, Length=316, Percent_Identity=27.2151898734177, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1787013, Length=261, Percent_Identity=26.8199233716475, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790012, Length=269, Percent_Identity=23.4200743494424, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081796, Length=237, Percent_Identity=24.8945147679325, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1789900, Length=333, Percent_Identity=24.3243243243243, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40840; Mature: 40709

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEETHTPGQSQAEPEAARAEPLPDTPNGNGGKKRRALIILLMAGLVCLVLGLAWWIHGK
CCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
SHIETDNAFIEAKTVSISCKVAGTVKRVLVEDNQYVGKGDALVELDQEDYRVQVAQAEAG
CCCCCCCEEEEEEEEEEEEEEHHHHEEHHCCCCCEECCCCCEEEECCCCCEEEEEECCCC
VSVAENETGGEQLRAEGARATVELARARAEQADLDLRRGEALFRREVIPREQLDRLGTAQ
CEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHCCHHH
RVAQSQLREAREGFKQAQAVAGLAGPGGNRARVRQRQALLNEARLRLSYTRVLAPTNGYI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEECCCCCE
TRKAVEPGANIQAGQPLMALVPLQDAWIIANYKEGQLTHIRPGQKVEFTVDAYPDRSFTG
EEEECCCCCCCCCCCCEEEEEECCCEEEEEECCCCCEEEECCCCEEEEEEECCCCCCCCC
RVNSIMAGTGAAFSLLPPENATGNYVKVVQRIPVKISIDNNSDPEHLLRVGMSVVPTVLV
CHHHHEECCCCEEEECCCCCCCCHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHE
ERSTGEILRDLVPFL
ECCHHHHHHHHHCCC
>Mature Secondary Structure 
TEETHTPGQSQAEPEAARAEPLPDTPNGNGGKKRRALIILLMAGLVCLVLGLAWWIHGK
CCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
SHIETDNAFIEAKTVSISCKVAGTVKRVLVEDNQYVGKGDALVELDQEDYRVQVAQAEAG
CCCCCCCEEEEEEEEEEEEEEHHHHEEHHCCCCCEECCCCCEEEECCCCCEEEEEECCCC
VSVAENETGGEQLRAEGARATVELARARAEQADLDLRRGEALFRREVIPREQLDRLGTAQ
CEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHCCHHH
RVAQSQLREAREGFKQAQAVAGLAGPGGNRARVRQRQALLNEARLRLSYTRVLAPTNGYI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEECCCCCE
TRKAVEPGANIQAGQPLMALVPLQDAWIIANYKEGQLTHIRPGQKVEFTVDAYPDRSFTG
EEEECCCCCCCCCCCCEEEEEECCCEEEEEECCCCCEEEECCCCEEEEEEECCCCCCCCC
RVNSIMAGTGAAFSLLPPENATGNYVKVVQRIPVKISIDNNSDPEHLLRVGMSVVPTVLV
CHHHHEECCCCEEEECCCCCCCCHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHE
ERSTGEILRDLVPFL
ECCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1409590; 9205837; 9278503; 8203018 [H]