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The map label for this gene is emrB [H]

Identifier: 118479716

GI number: 118479716

Start: 4371909

End: 4373708

Strand: Reverse

Name: emrB [H]

Synonym: BALH_4152

Alternate gene names: 118479716

Gene position: 4373708-4371909 (Counterclockwise)

Preceding gene: 118479717

Following gene: 118479709

Centisome position: 83.2

GC content: 37.78

Gene sequence:

>1800_bases
ATGTCCTCAATCGTAATTGCAGGATATGCACTATTTTGTATAATCGTCTTCTTCCTTGTAAATCGTCTTTTACGAAAGAA
AAAAACGAAAATGGGAGAAGAACAAGTCCCAGCCGTAAGTAAAATAGAAGTAAGTAAAGTAGAAACAGAAGAGAAAGACA
TTGAACACAAGCAAGAACCAGAAATTTCTAATGTAGTTGAGTTAGAAACAGGAAAGCAAGAAGAAGTAAAACAAGAAAAA
GAAGTGCCGAAAAAACAAATGTCTATGCCTGTAGAGAATGTGAACGTAAAAGCAGTTGTAGCTGTATTAATTCTCGGCAT
GTTCGTTTCTATTTTAAACCAAACAATCATTAACGTTGCATTGCCGCCGTTAATGAATGAATTTAACGTATCAACTTCAA
CAGCACAATGGTTAATTACAGGTTTCATGCTTGTAAATGGTATTTTAGTACCGATTAGTGCCTTTTTAGTTTCACGATTT
ACGTATCGTAAATTATTCGTAGCCGCAATGTTATTCTTCACGGTAGGTTCTATCATTTGTGCTACTTCAGGAAACTTTAC
AATGATGATGACAGGCCGCGTAATTCAAGCGGTTGGTGCGGGTATTTTAATGCCGGTTGGTATGAATATCTTCATGACGT
TATTCCCACCTCATAAACGCGGAGCAGCGATGGGATTACTAGGTGTAGCAATGATTTTAGCTCCAGCTATCGGACCAACT
GTAACAGGTTGGGTGATTGAAAACTATAGCTGGAACTTAATGTTCTATGCGATGTTTATTATTGGTTTAATTATTACGTT
CCTATCTTTAAAATTCTTTACACTAGCTCAGCCGGTGTCTAACACGAAATTAGATGTATTCGGTGTGGTTAGTTCAAGTA
TTGGACTAGGAAGCTTATTGTACGGATTTAGTGAAGCTGGAAACAATAGTTGGACTAGTGCAGAAGTCATTATTTCACTT
GTGATCGGTGTAATTGGTTTAGCGTTATTTATTTGGAGAGAGTTAACAACGGACAATAAAATGCTTGATTTACAAGTGTT
TAAATATCCAGTATTTACTTTTACTTTAGTAATTAACGCAATCGTTACGATGGCATTATTCGGAGGTATGTTATTGCTTC
CGGTATATCTGCAAAACATTCGTGGCTTTACGCCAATTGAATCTGGTTTACTACTTCTTCCAGGATCATTAATTATGGGG
ATCATGGGACCAGTAGCGGGTAAATTATTCGATAAATATGGCATTCGTCCATTAGCGATAATTGGATTGGCAATTACGAC
GTATGCGACATATGAATTTACAAAATTATCGATGGATACGCCGTATAGCGTTATTATGACGGATTATATTATACGCTCAA
TTGGTATGTCATTCATTATGATGCCAATTATGACAGCTGGTATGAACGCGCTACCGATGAAATTAATTTCTCACGGTACA
GCAACGCAAAATACGTCAAGACAAGTAGCTGGTTCAATTGGAACAGCGATATTAATCACGCTTATGACGCAACAAACGAC
TGCTCACGTAGCAGATTATGGAAACATGTTAACAACGTCAAATCCGATTTTAGTTGATAAAGTGCATGGCATGGGGCAAA
GCTTAGCTGCCTTAGCCGGCTCAGCGCAAGCAGGAGATGCGATGAGCACGCAGCTATTATTTGGACAAATTTCGAAGTTA
TCTGCAATTAACGGTATTAACGATGCCTTCTTAATTGCGACAATACTCGCAGGGATTGCTTGGGTGTTATCGTTCTTCTT
ACCATCAGGCAATAAACCAAATAGAAAAGCTGGGAATTAA

Upstream 100 bases:

>100_bases
AGTAGTACCAGTTAAAATTTCTTTAGATCATAGCAAATCAGTAAATATTGTTCCTGGCATGAATGTGACAGTTCGTATTC
ATAAGTAAGGGGGAGATGAG

Downstream 100 bases:

>100_bases
TTTCCCTGCTTTTCTACTTTTAACCATTAAATTTCACACTAATATAGTCCAAACAATACTCTTCTCTAATATCAGTAGAA
ACTGTACGTATCTTAACAGT

Product: multidrug resistance protein B

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 599; Mature: 598

Protein sequence:

>599_residues
MSSIVIAGYALFCIIVFFLVNRLLRKKKTKMGEEQVPAVSKIEVSKVETEEKDIEHKQEPEISNVVELETGKQEEVKQEK
EVPKKQMSMPVENVNVKAVVAVLILGMFVSILNQTIINVALPPLMNEFNVSTSTAQWLITGFMLVNGILVPISAFLVSRF
TYRKLFVAAMLFFTVGSIICATSGNFTMMMTGRVIQAVGAGILMPVGMNIFMTLFPPHKRGAAMGLLGVAMILAPAIGPT
VTGWVIENYSWNLMFYAMFIIGLIITFLSLKFFTLAQPVSNTKLDVFGVVSSSIGLGSLLYGFSEAGNNSWTSAEVIISL
VIGVIGLALFIWRELTTDNKMLDLQVFKYPVFTFTLVINAIVTMALFGGMLLLPVYLQNIRGFTPIESGLLLLPGSLIMG
IMGPVAGKLFDKYGIRPLAIIGLAITTYATYEFTKLSMDTPYSVIMTDYIIRSIGMSFIMMPIMTAGMNALPMKLISHGT
ATQNTSRQVAGSIGTAILITLMTQQTTAHVADYGNMLTTSNPILVDKVHGMGQSLAALAGSAQAGDAMSTQLLFGQISKL
SAINGINDAFLIATILAGIAWVLSFFLPSGNKPNRKAGN

Sequences:

>Translated_599_residues
MSSIVIAGYALFCIIVFFLVNRLLRKKKTKMGEEQVPAVSKIEVSKVETEEKDIEHKQEPEISNVVELETGKQEEVKQEK
EVPKKQMSMPVENVNVKAVVAVLILGMFVSILNQTIINVALPPLMNEFNVSTSTAQWLITGFMLVNGILVPISAFLVSRF
TYRKLFVAAMLFFTVGSIICATSGNFTMMMTGRVIQAVGAGILMPVGMNIFMTLFPPHKRGAAMGLLGVAMILAPAIGPT
VTGWVIENYSWNLMFYAMFIIGLIITFLSLKFFTLAQPVSNTKLDVFGVVSSSIGLGSLLYGFSEAGNNSWTSAEVIISL
VIGVIGLALFIWRELTTDNKMLDLQVFKYPVFTFTLVINAIVTMALFGGMLLLPVYLQNIRGFTPIESGLLLLPGSLIMG
IMGPVAGKLFDKYGIRPLAIIGLAITTYATYEFTKLSMDTPYSVIMTDYIIRSIGMSFIMMPIMTAGMNALPMKLISHGT
ATQNTSRQVAGSIGTAILITLMTQQTTAHVADYGNMLTTSNPILVDKVHGMGQSLAALAGSAQAGDAMSTQLLFGQISKL
SAINGINDAFLIATILAGIAWVLSFFLPSGNKPNRKAGN
>Mature_598_residues
SSIVIAGYALFCIIVFFLVNRLLRKKKTKMGEEQVPAVSKIEVSKVETEEKDIEHKQEPEISNVVELETGKQEEVKQEKE
VPKKQMSMPVENVNVKAVVAVLILGMFVSILNQTIINVALPPLMNEFNVSTSTAQWLITGFMLVNGILVPISAFLVSRFT
YRKLFVAAMLFFTVGSIICATSGNFTMMMTGRVIQAVGAGILMPVGMNIFMTLFPPHKRGAAMGLLGVAMILAPAIGPTV
TGWVIENYSWNLMFYAMFIIGLIITFLSLKFFTLAQPVSNTKLDVFGVVSSSIGLGSLLYGFSEAGNNSWTSAEVIISLV
IGVIGLALFIWRELTTDNKMLDLQVFKYPVFTFTLVINAIVTMALFGGMLLLPVYLQNIRGFTPIESGLLLLPGSLIMGI
MGPVAGKLFDKYGIRPLAIIGLAITTYATYEFTKLSMDTPYSVIMTDYIIRSIGMSFIMMPIMTAGMNALPMKLISHGTA
TQNTSRQVAGSIGTAILITLMTQQTTAHVADYGNMLTTSNPILVDKVHGMGQSLAALAGSAQAGDAMSTQLLFGQISKLS
AINGINDAFLIATILAGIAWVLSFFLPSGNKPNRKAGN

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=505, Percent_Identity=28.5148514851485, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1788710, Length=504, Percent_Identity=26.5873015873016, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI87081983, Length=407, Percent_Identity=25.0614250614251, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1790195, Length=338, Percent_Identity=26.6272189349112, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI1788392, Length=422, Percent_Identity=24.8815165876777, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322958, Length=374, Percent_Identity=27.2727272727273, Blast_Score=81, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6325455, Length=285, Percent_Identity=24.2105263157895, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323735, Length=318, Percent_Identity=24.5283018867925, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 64886; Mature: 64755

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSIVIAGYALFCIIVFFLVNRLLRKKKTKMGEEQVPAVSKIEVSKVETEEKDIEHKQEP
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHEEHHHHHCHHHHCCCCCCC
EISNVVELETGKQEEVKQEKEVPKKQMSMPVENVNVKAVVAVLILGMFVSILNQTIINVA
CHHCEEEECCCCHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LPPLMNEFNVSTSTAQWLITGFMLVNGILVPISAFLVSRFTYRKLFVAAMLFFTVGSIIC
CCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
ATSGNFTMMMTGRVIQAVGAGILMPVGMNIFMTLFPPHKRGAAMGLLGVAMILAPAIGPT
ECCCCEEEEEHHHHHHHHCCCHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCC
VTGWVIENYSWNLMFYAMFIIGLIITFLSLKFFTLAQPVSNTKLDVFGVVSSSIGLGSLL
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHCCCCHHHHH
YGFSEAGNNSWTSAEVIISLVIGVIGLALFIWRELTTDNKMLDLQVFKYPVFTFTLVINA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHH
IVTMALFGGMLLLPVYLQNIRGFTPIESGLLLLPGSLIMGIMGPVAGKLFDKYGIRPLAI
HHHHHHHHHHHHHHHHHHHCCCCCCHHCCCEECCHHHHHHHHHHHHHHHHHHHCCCHHHH
IGLAITTYATYEFTKLSMDTPYSVIMTDYIIRSIGMSFIMMPIMTAGMNALPMKLISHGT
HHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCC
ATQNTSRQVAGSIGTAILITLMTQQTTAHVADYGNMLTTSNPILVDKVHGMGQSLAALAG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEECHHCCCHHHHHHHC
SAQAGDAMSTQLLFGQISKLSAINGINDAFLIATILAGIAWVLSFFLPSGNKPNRKAGN
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SSIVIAGYALFCIIVFFLVNRLLRKKKTKMGEEQVPAVSKIEVSKVETEEKDIEHKQEP
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHEEHHHHHCHHHHCCCCCCC
EISNVVELETGKQEEVKQEKEVPKKQMSMPVENVNVKAVVAVLILGMFVSILNQTIINVA
CHHCEEEECCCCHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LPPLMNEFNVSTSTAQWLITGFMLVNGILVPISAFLVSRFTYRKLFVAAMLFFTVGSIIC
CCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
ATSGNFTMMMTGRVIQAVGAGILMPVGMNIFMTLFPPHKRGAAMGLLGVAMILAPAIGPT
ECCCCEEEEEHHHHHHHHCCCHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCC
VTGWVIENYSWNLMFYAMFIIGLIITFLSLKFFTLAQPVSNTKLDVFGVVSSSIGLGSLL
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHCCCCHHHHH
YGFSEAGNNSWTSAEVIISLVIGVIGLALFIWRELTTDNKMLDLQVFKYPVFTFTLVINA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHH
IVTMALFGGMLLLPVYLQNIRGFTPIESGLLLLPGSLIMGIMGPVAGKLFDKYGIRPLAI
HHHHHHHHHHHHHHHHHHHCCCCCCHHCCCEECCHHHHHHHHHHHHHHHHHHHCCCHHHH
IGLAITTYATYEFTKLSMDTPYSVIMTDYIIRSIGMSFIMMPIMTAGMNALPMKLISHGT
HHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCC
ATQNTSRQVAGSIGTAILITLMTQQTTAHVADYGNMLTTSNPILVDKVHGMGQSLAALAG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEECHHCCCHHHHHHHC
SAQAGDAMSTQLLFGQISKLSAINGINDAFLIATILAGIAWVLSFFLPSGNKPNRKAGN
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]