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The map label for this gene is acoL [H]

Identifier: 118478134

GI number: 118478134

Start: 2654236

End: 2655615

Strand: Reverse

Name: acoL [H]

Synonym: BALH_2491

Alternate gene names: 118478134

Gene position: 2655615-2654236 (Counterclockwise)

Preceding gene: 118478135

Following gene: 118478132

Centisome position: 50.51

GC content: 38.33

Gene sequence:

>1380_bases
ATGAGTAAATTAGTCGTTATTGGAGGCGGACCTGCTGGCTATGTAGCGGCAATTACCGCGGCTCAAAATGGAAAAAATGT
CACTCTTATTGATGAAGCTGATCTTGGCGGGACTTGTTTAAATGTCGGGTGCATGCCTACAAAATCATTGTTAGAAAGTG
CAGAAGTGCATGACATTGTGAGAAAAGCGAATCATTATGGAGTTACACTTAACAAAGAAAGTATATCAGTTGATTGGAAG
CAAATGCAGGTGAGGAAATCACAAATCGTAACGCAGCTCGTCCAAGGAATTCAATATTTAATGAAGAAAAATAAAATAAA
AGTTATACAAGGTAAAGCGAGATTTGAAACGGATCATCGTGTACGAATTACATACGGTGATAAAGAAGATATAGTAGATG
GAGAACAGTTCATTATAGCGACAGGTTCAGAACCAACTGAATTACCTCTTGCTCCATTTGATGGAAAGTGGATTTTAAAT
AGTAGCCATGCAATGTCCATAGATCATATACCGAAATCATTATTAATCGTTGGCGGTGGTGTAATAGGGTGCGAGTTTGC
CAGTATTTATAGTCGTCTTGGAACAAAAGTTACAATTGTTGAAATGGCACCGCAACTATTACTAGGTGAAGATGAAGATA
TCGCACACATTTTAAGAGGAAAACTAGAAACTGATGGCGTAAAAATATTTACAGGGGCAGCTTTAAAAGGATTAAATAGT
TATAAGAAGCAGGCTTTATTTGAATATGAAGGAAGTATCCAAGAAGTTAATCCAGAATTTGTTCTCGTTTCTGTCGGCCG
AAAACCACGTGTACAAAAATTAAATTTAGAAAAAGCAGGCATTCAATATTCAAATAAAGGAATTTCTGTGAATGAACATA
TGCAAACCAATGTATCACATATTTACGCAGCAGGTGATGTGATTGGTGGAATCCAGCTTGCTCACGTTGCATTCCATGAA
GGAACGACGGCAGCATTACACGCGAGCGGAGAAGATGTAAAAGTTAACTATCATGCTGTACCTCGTTGTATGTATACCGC
TCCAGAAATTGCTAGCGTTGGTCTAACAGAAAAAGATGCAAAAGAGCAGTACGGTGACATACAAATTGGAGAATTTCCTT
TTACAGCGAACGGAAAAGCGCTTATTATTGGAGAACAAACGGGGAAAGTAAAAGTTATTGTGGAACCTAAATATCAAGAA
ATTGTTGGGATTTCTATTATCGGTCCACGTGCAACCGAACTAATTGGTCAAGGAACTGTAATGATTCATACGGAAGTTAC
TGCCGATATTATGAGAGATTATATTGCAGCGCATCCGACTTTATCTGAAGCGATTCATGAAGCGCTATTGCAAGCAGTAG
GGCATGCTGTACATGCTTAA

Upstream 100 bases:

>100_bases
TCGTGTACTAGACGGTGCACCAGCAGCTGCATTTTTACGCACAATTAAACGCTATTTAGAAGAACCTGTAACAATTCTTT
TATAAAGAGAAGGTGAGAGA

Downstream 100 bases:

>100_bases
ATGGAATTATAATAAACCACTATTCTCTAAATGAATAAGAGAATAGTGGTTTGAATTTTTACGGAAGAAATTGAATATCC
TATTATTTTTTTACGTCAAT

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of acetoin cleaving system [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSKLVVIGGGPAGYVAAITAAQNGKNVTLIDEADLGGTCLNVGCMPTKSLLESAEVHDIVRKANHYGVTLNKESISVDWK
QMQVRKSQIVTQLVQGIQYLMKKNKIKVIQGKARFETDHRVRITYGDKEDIVDGEQFIIATGSEPTELPLAPFDGKWILN
SSHAMSIDHIPKSLLIVGGGVIGCEFASIYSRLGTKVTIVEMAPQLLLGEDEDIAHILRGKLETDGVKIFTGAALKGLNS
YKKQALFEYEGSIQEVNPEFVLVSVGRKPRVQKLNLEKAGIQYSNKGISVNEHMQTNVSHIYAAGDVIGGIQLAHVAFHE
GTTAALHASGEDVKVNYHAVPRCMYTAPEIASVGLTEKDAKEQYGDIQIGEFPFTANGKALIIGEQTGKVKVIVEPKYQE
IVGISIIGPRATELIGQGTVMIHTEVTADIMRDYIAAHPTLSEAIHEALLQAVGHAVHA

Sequences:

>Translated_459_residues
MSKLVVIGGGPAGYVAAITAAQNGKNVTLIDEADLGGTCLNVGCMPTKSLLESAEVHDIVRKANHYGVTLNKESISVDWK
QMQVRKSQIVTQLVQGIQYLMKKNKIKVIQGKARFETDHRVRITYGDKEDIVDGEQFIIATGSEPTELPLAPFDGKWILN
SSHAMSIDHIPKSLLIVGGGVIGCEFASIYSRLGTKVTIVEMAPQLLLGEDEDIAHILRGKLETDGVKIFTGAALKGLNS
YKKQALFEYEGSIQEVNPEFVLVSVGRKPRVQKLNLEKAGIQYSNKGISVNEHMQTNVSHIYAAGDVIGGIQLAHVAFHE
GTTAALHASGEDVKVNYHAVPRCMYTAPEIASVGLTEKDAKEQYGDIQIGEFPFTANGKALIIGEQTGKVKVIVEPKYQE
IVGISIIGPRATELIGQGTVMIHTEVTADIMRDYIAAHPTLSEAIHEALLQAVGHAVHA
>Mature_458_residues
SKLVVIGGGPAGYVAAITAAQNGKNVTLIDEADLGGTCLNVGCMPTKSLLESAEVHDIVRKANHYGVTLNKESISVDWKQ
MQVRKSQIVTQLVQGIQYLMKKNKIKVIQGKARFETDHRVRITYGDKEDIVDGEQFIIATGSEPTELPLAPFDGKWILNS
SHAMSIDHIPKSLLIVGGGVIGCEFASIYSRLGTKVTIVEMAPQLLLGEDEDIAHILRGKLETDGVKIFTGAALKGLNSY
KKQALFEYEGSIQEVNPEFVLVSVGRKPRVQKLNLEKAGIQYSNKGISVNEHMQTNVSHIYAAGDVIGGIQLAHVAFHEG
TTAALHASGEDVKVNYHAVPRCMYTAPEIASVGLTEKDAKEQYGDIQIGEFPFTANGKALIIGEQTGKVKVIVEPKYQEI
VGISIIGPRATELIGQGTVMIHTEVTADIMRDYIAAHPTLSEAIHEALLQAVGHAVHA

Specific function: Lipoamide Dehydrogenase Is A Component Of The Glycine Cleavage System As Well As Of The Alpha-Ketoacid Dehydrogenase Complexes. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=460, Percent_Identity=34.3478260869565, Blast_Score=258, Evalue=6e-69,
Organism=Homo sapiens, GI50301238, Length=448, Percent_Identity=28.5714285714286, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI148277071, Length=461, Percent_Identity=27.5488069414317, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI148277065, Length=461, Percent_Identity=27.5488069414317, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI33519430, Length=453, Percent_Identity=27.8145695364238, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI33519428, Length=453, Percent_Identity=27.8145695364238, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI33519426, Length=453, Percent_Identity=27.8145695364238, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI22035672, Length=458, Percent_Identity=27.9475982532751, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI291045266, Length=460, Percent_Identity=26.0869565217391, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI291045268, Length=451, Percent_Identity=24.1685144124169, Blast_Score=116, Evalue=5e-26,
Organism=Escherichia coli, GI1786307, Length=449, Percent_Identity=31.6258351893096, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI87081717, Length=452, Percent_Identity=30.7522123893805, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI87082354, Length=465, Percent_Identity=27.9569892473118, Blast_Score=175, Evalue=5e-45,
Organism=Escherichia coli, GI1789915, Length=433, Percent_Identity=28.4064665127021, Blast_Score=166, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI32565766, Length=471, Percent_Identity=37.1549893842887, Blast_Score=271, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI17557007, Length=470, Percent_Identity=28.0851063829787, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI71983429, Length=442, Percent_Identity=26.2443438914027, Blast_Score=121, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI71983419, Length=442, Percent_Identity=26.2443438914027, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71982272, Length=457, Percent_Identity=25.164113785558, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17559934, Length=224, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321091, Length=472, Percent_Identity=38.5593220338983, Blast_Score=277, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6325166, Length=449, Percent_Identity=27.1714922048998, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6325240, Length=480, Percent_Identity=26.875, Blast_Score=163, Evalue=4e-41,
Organism=Drosophila melanogaster, GI21358499, Length=459, Percent_Identity=36.6013071895425, Blast_Score=267, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24640549, Length=465, Percent_Identity=28.3870967741935, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI24640553, Length=465, Percent_Identity=28.3870967741935, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI24640551, Length=465, Percent_Identity=28.3870967741935, Blast_Score=158, Evalue=9e-39,
Organism=Drosophila melanogaster, GI17737741, Length=466, Percent_Identity=27.4678111587983, Blast_Score=142, Evalue=4e-34,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49618; Mature: 49487

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLVVIGGGPAGYVAAITAAQNGKNVTLIDEADLGGTCLNVGCMPTKSLLESAEVHDIV
CCEEEEEECCCCCEEEEEEECCCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHH
RKANHYGVTLNKESISVDWKQMQVRKSQIVTQLVQGIQYLMKKNKIKVIQGKARFETDHR
HHCCCCEEEEECCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEECCCCE
VRITYGDKEDIVDGEQFIIATGSEPTELPLAPFDGKWILNSSHAMSIDHIPKSLLIVGGG
EEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCCEEEHHCCCCEEEEECCC
VIGCEFASIYSRLGTKVTIVEMAPQLLLGEDEDIAHILRGKLETDGVKIFTGAALKGLNS
EEEHHHHHHHHHHCCEEEEEECCCHHHCCCCCHHHHHHCCCCCCCCEEEEECHHHHHHHH
YKKQALFEYEGSIQEVNPEFVLVSVGRKPRVQKLNLEKAGIQYSNKGISVNEHMQTNVSH
HHHHHHHHHCCCCEECCCCEEEEECCCCCCCEEECCHHCCCEECCCCCCCCHHHHCCCCE
IYAAGDVIGGIQLAHVAFHEGTTAALHASGEDVKVNYHAVPRCMYTAPEIASVGLTEKDA
EEECCCHHCCEEEEEEEEECCCEEEEEECCCEEEEEEEECCEEEECCCCHHHCCCCCHHH
KEQYGDIQIGEFPFTANGKALIIGEQTGKVKVIVEPKYQEIVGISIIGPRATELIGQGTV
HHHCCCEEECCCCCCCCCCEEEEECCCCEEEEEECCCHHHEEEEEEECCCHHHHHCCCEE
MIHTEVTADIMRDYIAAHPTLSEAIHEALLQAVGHAVHA
EEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKLVVIGGGPAGYVAAITAAQNGKNVTLIDEADLGGTCLNVGCMPTKSLLESAEVHDIV
CEEEEEECCCCCEEEEEEECCCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHH
RKANHYGVTLNKESISVDWKQMQVRKSQIVTQLVQGIQYLMKKNKIKVIQGKARFETDHR
HHCCCCEEEEECCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEECCCCE
VRITYGDKEDIVDGEQFIIATGSEPTELPLAPFDGKWILNSSHAMSIDHIPKSLLIVGGG
EEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCCEEEHHCCCCEEEEECCC
VIGCEFASIYSRLGTKVTIVEMAPQLLLGEDEDIAHILRGKLETDGVKIFTGAALKGLNS
EEEHHHHHHHHHHCCEEEEEECCCHHHCCCCCHHHHHHCCCCCCCCEEEEECHHHHHHHH
YKKQALFEYEGSIQEVNPEFVLVSVGRKPRVQKLNLEKAGIQYSNKGISVNEHMQTNVSH
HHHHHHHHHCCCCEECCCCEEEEECCCCCCCEEECCHHCCCEECCCCCCCCHHHHCCCCE
IYAAGDVIGGIQLAHVAFHEGTTAALHASGEDVKVNYHAVPRCMYTAPEIASVGLTEKDA
EEECCCHHCCEEEEEEEEECCCEEEEEECCCEEEEEEEECCEEEECCCCHHHCCCCCHHH
KEQYGDIQIGEFPFTANGKALIIGEQTGKVKVIVEPKYQEIVGISIIGPRATELIGQGTV
HHHCCCEEECCCCCCCCCCEEEEECCCCEEEEEECCCHHHEEEEEEECCCHHHHHCCCEE
MIHTEVTADIMRDYIAAHPTLSEAIHEALLQAVGHAVHA
EEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10368162; 8969503; 9384377 [H]