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The map label for this gene is pbpA [H]

Identifier: 118477908

GI number: 118477908

Start: 2412266

End: 2414398

Strand: Direct

Name: pbpA [H]

Synonym: BALH_2253

Alternate gene names: 118477908

Gene position: 2412266-2414398 (Clockwise)

Preceding gene: 118477906

Following gene: 118477909

Centisome position: 45.89

GC content: 33.9

Gene sequence:

>2133_bases
ATGAAAGAACAAAAAGGAAAGAAGCAGAAGACATATATATCTATTCGATTAAATATAATGTTCCTTTGCATATTTTTACT
ATTCTCAGCTATTATTATGCAGCTAGGAAAAGTACAAATCGTTGAGGGAGAGGCTTATAAGAATCAAGTGGAAAACAGTC
AAAATGCAACAACTAGCATTCCAGTTCCGCGTGGACAGATTTTAGATCGAGAAGGGAAAACGGTCGTTAATAATAAGTCT
CTTCGTACAATTACGTATACAAGGGTGAAGGGGATTACGAGTGACGATATTTTAAAAACAGCAAAAGACTTGGCAAAAGT
ACTTGAAATGCCTGAACAAGATATAAACAAATTAACAGATATCGATAAAAAAGATTTTTGGATGCAGTTGAATACGAAAC
GTGCGGAAGCAATGATTACGAAAAAAGATATAGAAAAGTTTAAAGAAAAGGGAATAGAGGGAAAAGAGTTAGATAAAAAA
ATAGAAGAATTAAGACGAAGTCGAGTTACAGAAGTAGAATTGGCAGAATTAACAGCACAAGATTTAAAGGTGTTAGCTAT
TAAAAGTAAAATGAATTCAGGTTATCAACTGACACCACAAATTATAAAAAAAGATGTAACAAATCAAGAGTATGCGCAAA
TCAGTGAAAATCTTGCGGAGTTTCCTGGGGTAGATGCAACAGTTGATTGGGAGCGCAATTATGTAAATGGTAATTTATTT
CGTTCCGTGTTAGGTAATATTACGAGTAGCGAAGAAGGTCTGCCAAAAGAAAATTTAGATTTTTATTTAGTACGCGGATA
TAACCGTAATGATCGTGTAGGGAAAAGTTATATTGAACAACGATATGAAGATGTGTTACATGGTACAAAAGAAGAAGTGA
AAAATATTACAGATAAATCAGGAAATATTATAAATACAGAAATAATTTCTAAAGGAAAAAGTGGTAATAGTTTAACATTA
ACGATTGATATGGAATTACAAAAGAAAGTGGAAGAAAGTTTAGAGAAAAATTTGAGAGCTTTTAAGAGTTCAGAGCCACT
ATTGGACCGAGCTTTTGTTGTTATGACAAATCCGAATAACGGACAGATTTTATCTATGGCAGGCAAAAGGATTGTAGAAA
AAGAAGGGAAAATGGAAATCGAGGATTTGGCATTAGGTAATATGACAACTTCGTATGAACTAGGGTCAGCTGTAAAAGGT
GCAACTTTATTAACTGGATATGAGACAGGGGCAATACAACCAGGAGATCAATTTTATGATGCACCGATGAAATTTAAAGG
TACACAAGCTAAGAAATCGTGGAATGTATCCGGATTTGGTAATATTAATGATTTACGAGCTCTACAAGTATCTTCGAATG
TATACATGTTCCAAACAGCTTTAAAAATTGCGGGCGTTAATTACGTACCAAATGGTTCATTGGATATAAAACAAGAAGCA
TTTAATACGATGCGCTATTATTTTAAGCAATTTGGCTTAGGAGTTCCTACGGGTATTGATTTACCGAATGAAATAATTGG
ACAAACTAGAAAAGTAGATAGCCAGCCTGGTTTTTTACTAGATTTTTCTATCGGTCAGTATGATACGTATACGCCATTGC
AATTAGCGCAATATATTTCAACAATTGCTAATGGCGGTTATAGAATGCAACCTCAAATTGTAAAAGAAATACGAGAGCAA
TCAATAAAAGAAGAGGTTGGCAAAGTTATTCGCTCAATAGAGCCTGTCGTATTAAATCGAATTGATATGAAGACAGAACA
TATTAATCGAATAAAAGAAGGCTTTAGATGGGTATTCCAAGAAGGTGATGGAACTGGCGTGAAGTATTTCAAAAATGCTT
CATATAAACCAGCAGGAAAGACAGGAACAGCTCAAACTGTATATGGTGGAGATGATCCAATTGGTAGAAATGCAAAAGGA
GAACGTATGGAATGCTACAACTTAACGTTAGTTGGATATGCTCCATATGATAATCCAGAAGTAGCATTCTCAGTAGTAGT
TCCGTGGCTTCGTAACGATAAAAGTGGAATTAATTCTATAATTGGAAAAGAAGTTTTAGATGTATATTTTGATTTAAAAC
AGCAACGTATAAATGGTGAAACTACTCATACAGATGTTCCGAATCAAAATTAG

Upstream 100 bases:

>100_bases
AAAAAGATAAGACATTATTTATAACCGAATAATGGTTTGTAATATATAGGGAACGTTTAAGTATTAGTGAGAAGTTCCAG
AAGAATTATATGGAGGATTT

Downstream 100 bases:

>100_bases
AAAAACGTATACGCTTTTCTTATGGAAAGACATACTGTTTATATAAAGGTCTTTATAAAAGAAAAATGAGATTGGAAATA
AGAGATAGCGACGATCATTG

Product: penicillin-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 710; Mature: 710

Protein sequence:

>710_residues
MKEQKGKKQKTYISIRLNIMFLCIFLLFSAIIMQLGKVQIVEGEAYKNQVENSQNATTSIPVPRGQILDREGKTVVNNKS
LRTITYTRVKGITSDDILKTAKDLAKVLEMPEQDINKLTDIDKKDFWMQLNTKRAEAMITKKDIEKFKEKGIEGKELDKK
IEELRRSRVTEVELAELTAQDLKVLAIKSKMNSGYQLTPQIIKKDVTNQEYAQISENLAEFPGVDATVDWERNYVNGNLF
RSVLGNITSSEEGLPKENLDFYLVRGYNRNDRVGKSYIEQRYEDVLHGTKEEVKNITDKSGNIINTEIISKGKSGNSLTL
TIDMELQKKVEESLEKNLRAFKSSEPLLDRAFVVMTNPNNGQILSMAGKRIVEKEGKMEIEDLALGNMTTSYELGSAVKG
ATLLTGYETGAIQPGDQFYDAPMKFKGTQAKKSWNVSGFGNINDLRALQVSSNVYMFQTALKIAGVNYVPNGSLDIKQEA
FNTMRYYFKQFGLGVPTGIDLPNEIIGQTRKVDSQPGFLLDFSIGQYDTYTPLQLAQYISTIANGGYRMQPQIVKEIREQ
SIKEEVGKVIRSIEPVVLNRIDMKTEHINRIKEGFRWVFQEGDGTGVKYFKNASYKPAGKTGTAQTVYGGDDPIGRNAKG
ERMECYNLTLVGYAPYDNPEVAFSVVVPWLRNDKSGINSIIGKEVLDVYFDLKQQRINGETTHTDVPNQN

Sequences:

>Translated_710_residues
MKEQKGKKQKTYISIRLNIMFLCIFLLFSAIIMQLGKVQIVEGEAYKNQVENSQNATTSIPVPRGQILDREGKTVVNNKS
LRTITYTRVKGITSDDILKTAKDLAKVLEMPEQDINKLTDIDKKDFWMQLNTKRAEAMITKKDIEKFKEKGIEGKELDKK
IEELRRSRVTEVELAELTAQDLKVLAIKSKMNSGYQLTPQIIKKDVTNQEYAQISENLAEFPGVDATVDWERNYVNGNLF
RSVLGNITSSEEGLPKENLDFYLVRGYNRNDRVGKSYIEQRYEDVLHGTKEEVKNITDKSGNIINTEIISKGKSGNSLTL
TIDMELQKKVEESLEKNLRAFKSSEPLLDRAFVVMTNPNNGQILSMAGKRIVEKEGKMEIEDLALGNMTTSYELGSAVKG
ATLLTGYETGAIQPGDQFYDAPMKFKGTQAKKSWNVSGFGNINDLRALQVSSNVYMFQTALKIAGVNYVPNGSLDIKQEA
FNTMRYYFKQFGLGVPTGIDLPNEIIGQTRKVDSQPGFLLDFSIGQYDTYTPLQLAQYISTIANGGYRMQPQIVKEIREQ
SIKEEVGKVIRSIEPVVLNRIDMKTEHINRIKEGFRWVFQEGDGTGVKYFKNASYKPAGKTGTAQTVYGGDDPIGRNAKG
ERMECYNLTLVGYAPYDNPEVAFSVVVPWLRNDKSGINSIIGKEVLDVYFDLKQQRINGETTHTDVPNQN
>Mature_710_residues
MKEQKGKKQKTYISIRLNIMFLCIFLLFSAIIMQLGKVQIVEGEAYKNQVENSQNATTSIPVPRGQILDREGKTVVNNKS
LRTITYTRVKGITSDDILKTAKDLAKVLEMPEQDINKLTDIDKKDFWMQLNTKRAEAMITKKDIEKFKEKGIEGKELDKK
IEELRRSRVTEVELAELTAQDLKVLAIKSKMNSGYQLTPQIIKKDVTNQEYAQISENLAEFPGVDATVDWERNYVNGNLF
RSVLGNITSSEEGLPKENLDFYLVRGYNRNDRVGKSYIEQRYEDVLHGTKEEVKNITDKSGNIINTEIISKGKSGNSLTL
TIDMELQKKVEESLEKNLRAFKSSEPLLDRAFVVMTNPNNGQILSMAGKRIVEKEGKMEIEDLALGNMTTSYELGSAVKG
ATLLTGYETGAIQPGDQFYDAPMKFKGTQAKKSWNVSGFGNINDLRALQVSSNVYMFQTALKIAGVNYVPNGSLDIKQEA
FNTMRYYFKQFGLGVPTGIDLPNEIIGQTRKVDSQPGFLLDFSIGQYDTYTPLQLAQYISTIANGGYRMQPQIVKEIREQ
SIKEEVGKVIRSIEPVVLNRIDMKTEHINRIKEGFRWVFQEGDGTGVKYFKNASYKPAGKTGTAQTVYGGDDPIGRNAKG
ERMECYNLTLVGYAPYDNPEVAFSVVVPWLRNDKSGINSIIGKEVLDVYFDLKQQRINGETTHTDVPNQN

Specific function: Cell Wall Formation; Pbp-2 Is Responsible For The Determination Of The Rod Shape Of The Cell. Its Synthesize Cross- Linked Peptidoglycan From The Lipid Intermediates. [C]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=719, Percent_Identity=23.643949930459, Blast_Score=135, Evalue=1e-32,
Organism=Escherichia coli, GI1786272, Length=427, Percent_Identity=25.9953161592506, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 80034; Mature: 80034

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEQKGKKQKTYISIRLNIMFLCIFLLFSAIIMQLGKVQIVEGEAYKNQVENSQNATTSI
CCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHCCCCCCCEEC
PVPRGQILDREGKTVVNNKSLRTITYTRVKGITSDDILKTAKDLAKVLEMPEQDINKLTD
CCCCCCEECCCCCEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHC
IDKKDFWMQLNTKRAEAMITKKDIEKFKEKGIEGKELDKKIEELRRSRVTEVELAELTAQ
CCCCHHEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
DLKVLAIKSKMNSGYQLTPQIIKKDVTNQEYAQISENLAEFPGVDATVDWERNYVNGNLF
HHHEEEEEHHCCCCCEECHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHH
RSVLGNITSSEEGLPKENLDFYLVRGYNRNDRVGKSYIEQRYEDVLHGTKEEVKNITDKS
HHHHCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
GNIINTEIISKGKSGNSLTLTIDMELQKKVEESLEKNLRAFKSSEPLLDRAFVVMTNPNN
CCEEEHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
GQILSMAGKRIVEKEGKMEIEDLALGNMTTSYELGSAVKGATLLTGYETGAIQPGDQFYD
CEEEEHHHHHHHHHCCCCCHHHEEECCCCCCHHHCCCCCCCEEEECCCCCCCCCCHHHHC
APMKFKGTQAKKSWNVSGFGNINDLRALQVSSNVYMFQTALKIAGVNYVPNGSLDIKQEA
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEHHHHHHHHCCCCCCCCCCCHHHHH
FNTMRYYFKQFGLGVPTGIDLPNEIIGQTRKVDSQPGFLLDFSIGQYDTYTPLQLAQYIS
HHHHHHHHHHHCCCCCCCCCCCHHHHCCHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHH
TIANGGYRMQPQIVKEIREQSIKEEVGKVIRSIEPVVLNRIDMKTEHINRIKEGFRWVFQ
HHHCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEEEE
EGDGTGVKYFKNASYKPAGKTGTAQTVYGGDDPIGRNAKGERMECYNLTLVGYAPYDNPE
CCCCCCCHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEEEEEEEECCCCCCC
VAFSVVVPWLRNDKSGINSIIGKEVLDVYFDLKQQRINGETTHTDVPNQN
EEEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MKEQKGKKQKTYISIRLNIMFLCIFLLFSAIIMQLGKVQIVEGEAYKNQVENSQNATTSI
CCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHCCCCCCCEEC
PVPRGQILDREGKTVVNNKSLRTITYTRVKGITSDDILKTAKDLAKVLEMPEQDINKLTD
CCCCCCEECCCCCEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHC
IDKKDFWMQLNTKRAEAMITKKDIEKFKEKGIEGKELDKKIEELRRSRVTEVELAELTAQ
CCCCHHEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
DLKVLAIKSKMNSGYQLTPQIIKKDVTNQEYAQISENLAEFPGVDATVDWERNYVNGNLF
HHHEEEEEHHCCCCCEECHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHH
RSVLGNITSSEEGLPKENLDFYLVRGYNRNDRVGKSYIEQRYEDVLHGTKEEVKNITDKS
HHHHCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
GNIINTEIISKGKSGNSLTLTIDMELQKKVEESLEKNLRAFKSSEPLLDRAFVVMTNPNN
CCEEEHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
GQILSMAGKRIVEKEGKMEIEDLALGNMTTSYELGSAVKGATLLTGYETGAIQPGDQFYD
CEEEEHHHHHHHHHCCCCCHHHEEECCCCCCHHHCCCCCCCEEEECCCCCCCCCCHHHHC
APMKFKGTQAKKSWNVSGFGNINDLRALQVSSNVYMFQTALKIAGVNYVPNGSLDIKQEA
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEHHHHHHHHCCCCCCCCCCCHHHHH
FNTMRYYFKQFGLGVPTGIDLPNEIIGQTRKVDSQPGFLLDFSIGQYDTYTPLQLAQYIS
HHHHHHHHHHHCCCCCCCCCCCHHHHCCHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHH
TIANGGYRMQPQIVKEIREQSIKEEVGKVIRSIEPVVLNRIDMKTEHINRIKEGFRWVFQ
HHHCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEEEE
EGDGTGVKYFKNASYKPAGKTGTAQTVYGGDDPIGRNAKGERMECYNLTLVGYAPYDNPE
CCCCCCCHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEEEEEEEECCCCCCC
VAFSVVVPWLRNDKSGINSIIGKEVLDVYFDLKQQRINGETTHTDVPNQN
EEEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]