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The map label for this gene is lysC [H]

Identifier: 118477278

GI number: 118477278

Start: 1735459

End: 1736688

Strand: Reverse

Name: lysC [H]

Synonym: BALH_1589

Alternate gene names: 118477278

Gene position: 1736688-1735459 (Counterclockwise)

Preceding gene: 118477282

Following gene: 118477269

Centisome position: 33.04

GC content: 36.83

Gene sequence:

>1230_bases
ATGGAAACGATTGTACAAAAATTTGGTGGCACTTCTGTCGGAAGCGTTGAACGCATTCAACATGTAGCAAATTTAATTAT
TGAAGAATATGAACGAGGACATAGTATCGTCTCTGTCGTTTCAGCAATGGGGAAAAGTACAGACGAACTTGTAGCACTTG
CTAATGCGATTACAGAAAATCCGAGTAAACGCGAAATGGATATGCTTCTATCAACAGGAGAGCAAGTCACTATTTCATTA
TTAACGATGGCATTACAAGCAAAAGGTTATAACGCGATTTCATTAACAGGATGGCAAGCTGGTATTACGACAGAATCTGT
ACATAGTAGTGCACGGATTACTGACATTCATACAGATCGAATTCAATCTTATCTTACTGAAGGTACGATTGTTATTGTAG
CTGGATTCCAAGGAATGAGTGAAAACCATGAAATTACAACACTTGGACGCGGTGGTTCTGATACAACTGCTGTTGCATTA
GCTGCTGCACTGAACGCAAAAAAATGTGATATTTACACGGATGTAACAGGCGTATATACAACGGACCCACGAGTTGTAAA
AGATGCTTATAAATTAGATGAAATTTCTTATGACGAAATGTTAGAACTTGCAAACCTCGGTGCTGGTGTATTACACCCGC
GTGCTGTTGAGTTTGCTAAAAATCATAATGTCATGTTAGAAGTTCGCTCAAGTATGGAACAAGAAAATGGAACAATTGTA
AAAGGAGAATGTAACATGGAACAACAATCAATCGTTAAAGGTATTGCATTTGAAGATAATATTACACGCATCACAGTGAA
AGGATTGGAACAAGGATCGCTTTCAACTGTTTTCTCTACATTAGCAGCGGCACATATTAATGTAGACATCATCATTCAAA
GTATTACAAATGAAGGAACTGTTCATCTCTCCTTCTCCATCCATTCTAATGATTTAAGAGAAACATTAAAAGTGTTGGAA
CAAAATCAAGAGGCACTTCACTATGAATCAGTAGAATATGAAAATCATTTAGCAAAAGTATCAATTGTAGGATCTGGTAT
GGTCTCTAATCCAGGTGTTGCTGCGAATATGTTCACTACTTTAAAAGAAGAAGATATTCATATTAAAATGGTAAGTACAT
CAGAAATTAAAGTGTCTGTCGTTATTGACCGCCTTCATTTAGTAACAGGTGTCGAGGCGCTGCATCAATCATTTATGGCG
AAAATTGAGCCTTTAGTGCAACTAATTTAA

Upstream 100 bases:

>100_bases
TGAGATGGTGTTTTTTGTTTTTCTCTGGTAACTACAGGAATATTGGGATTTATATATGTCCTAATCTATTCTTAAAAATG
GATGAAAGAAGGAATTCGTA

Downstream 100 bases:

>100_bases
CATTTTTCTTTAAATTTCATAAAAGTCATATCAACCTATTTGCTTCCTATATAAATAAAAAGCTGTTTGTATAGATTTCA
AGACTCTATACAAACAGCTT

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase 2; Aspartokinase II [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
METIVQKFGGTSVGSVERIQHVANLIIEEYERGHSIVSVVSAMGKSTDELVALANAITENPSKREMDMLLSTGEQVTISL
LTMALQAKGYNAISLTGWQAGITTESVHSSARITDIHTDRIQSYLTEGTIVIVAGFQGMSENHEITTLGRGGSDTTAVAL
AAALNAKKCDIYTDVTGVYTTDPRVVKDAYKLDEISYDEMLELANLGAGVLHPRAVEFAKNHNVMLEVRSSMEQENGTIV
KGECNMEQQSIVKGIAFEDNITRITVKGLEQGSLSTVFSTLAAAHINVDIIIQSITNEGTVHLSFSIHSNDLRETLKVLE
QNQEALHYESVEYENHLAKVSIVGSGMVSNPGVAANMFTTLKEEDIHIKMVSTSEIKVSVVIDRLHLVTGVEALHQSFMA
KIEPLVQLI

Sequences:

>Translated_409_residues
METIVQKFGGTSVGSVERIQHVANLIIEEYERGHSIVSVVSAMGKSTDELVALANAITENPSKREMDMLLSTGEQVTISL
LTMALQAKGYNAISLTGWQAGITTESVHSSARITDIHTDRIQSYLTEGTIVIVAGFQGMSENHEITTLGRGGSDTTAVAL
AAALNAKKCDIYTDVTGVYTTDPRVVKDAYKLDEISYDEMLELANLGAGVLHPRAVEFAKNHNVMLEVRSSMEQENGTIV
KGECNMEQQSIVKGIAFEDNITRITVKGLEQGSLSTVFSTLAAAHINVDIIIQSITNEGTVHLSFSIHSNDLRETLKVLE
QNQEALHYESVEYENHLAKVSIVGSGMVSNPGVAANMFTTLKEEDIHIKMVSTSEIKVSVVIDRLHLVTGVEALHQSFMA
KIEPLVQLI
>Mature_409_residues
METIVQKFGGTSVGSVERIQHVANLIIEEYERGHSIVSVVSAMGKSTDELVALANAITENPSKREMDMLLSTGEQVTISL
LTMALQAKGYNAISLTGWQAGITTESVHSSARITDIHTDRIQSYLTEGTIVIVAGFQGMSENHEITTLGRGGSDTTAVAL
AAALNAKKCDIYTDVTGVYTTDPRVVKDAYKLDEISYDEMLELANLGAGVLHPRAVEFAKNHNVMLEVRSSMEQENGTIV
KGECNMEQQSIVKGIAFEDNITRITVKGLEQGSLSTVFSTLAAAHINVDIIIQSITNEGTVHLSFSIHSNDLRETLKVLE
QNQEALHYESVEYENHLAKVSIVGSGMVSNPGVAANMFTTLKEEDIHIKMVSTSEIKVSVVIDRLHLVTGVEALHQSFMA
KIEPLVQLI

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=342, Percent_Identity=32.1637426900585, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1790455, Length=256, Percent_Identity=37.890625, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790376, Length=279, Percent_Identity=27.9569892473118, Blast_Score=88, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6320893, Length=377, Percent_Identity=27.0557029177719, Blast_Score=119, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44456; Mature: 44456

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METIVQKFGGTSVGSVERIQHVANLIIEEYERGHSIVSVVSAMGKSTDELVALANAITEN
CCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHCC
PSKREMDMLLSTGEQVTISLLTMALQAKGYNAISLTGWQAGITTESVHSSARITDIHTDR
CCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHCCCCEEEECHHHH
IQSYLTEGTIVIVAGFQGMSENHEITTLGRGGSDTTAVALAAALNAKKCDIYTDVTGVYT
HHHHHCCCCEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCEEEECCCEEEE
TDPRVVKDAYKLDEISYDEMLELANLGAGVLHPRAVEFAKNHNVMLEVRSSMEQENGTIV
CCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEEHHHHHHCCCCEE
KGECNMEQQSIVKGIAFEDNITRITVKGLEQGSLSTVFSTLAAAHINVDIIIQSITNEGT
EEECCCCHHHHHHCCEECCCCEEEEEECCCCCCHHHHHHHHHHHHCEEEEEEEEECCCCE
VHLSFSIHSNDLRETLKVLEQNQEALHYESVEYENHLAKVSIVGSGMVSNPGVAANMFTT
EEEEEEECCHHHHHHHHHHHCCCHHHHHCCCCHHCCEEEEEEEECCCCCCCCCHHHHHHH
LKEEDIHIKMVSTSEIKVSVVIDRLHLVTGVEALHQSFMAKIEPLVQLI
HCCCCEEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
METIVQKFGGTSVGSVERIQHVANLIIEEYERGHSIVSVVSAMGKSTDELVALANAITEN
CCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHCC
PSKREMDMLLSTGEQVTISLLTMALQAKGYNAISLTGWQAGITTESVHSSARITDIHTDR
CCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHCCCCEEEECHHHH
IQSYLTEGTIVIVAGFQGMSENHEITTLGRGGSDTTAVALAAALNAKKCDIYTDVTGVYT
HHHHHCCCCEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCEEEECCCEEEE
TDPRVVKDAYKLDEISYDEMLELANLGAGVLHPRAVEFAKNHNVMLEVRSSMEQENGTIV
CCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEEHHHHHHCCCCEE
KGECNMEQQSIVKGIAFEDNITRITVKGLEQGSLSTVFSTLAAAHINVDIIIQSITNEGT
EEECCCCHHHHHHCCEECCCCEEEEEECCCCCCHHHHHHHHHHHHCEEEEEEEEECCCCE
VHLSFSIHSNDLRETLKVLEQNQEALHYESVEYENHLAKVSIVGSGMVSNPGVAANMFTT
EEEEEEECCHHHHHHHHHHHCCCHHHHHCCCCHHCCEEEEEEEECCCCCCCCCHHHHHHH
LKEEDIHIKMVSTSEIKVSVVIDRLHLVTGVEALHQSFMAKIEPLVQLI
HCCCCEEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1444390 [H]