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The map label for this gene is cadA [H]

Identifier: 118476282

GI number: 118476282

Start: 619605

End: 621971

Strand: Direct

Name: cadA [H]

Synonym: BALH_0536

Alternate gene names: 118476282

Gene position: 619605-621971 (Clockwise)

Preceding gene: 118476281

Following gene: 118476284

Centisome position: 11.79

GC content: 36.46

Gene sequence:

>2367_bases
ATGGCTGAAGCATTAGTGAAAAAGAAACTGATGTTAGAAGGTTTAGATTGTGCGAACTGTGCAATGAAAATTGAAAAAGG
CGTTGGGAATATAGAAGGAGTAAATTCTTGCTCTGTAAATTTCGCAACAAAAACAATGGTTTTAGAAACAGCGCAAAATA
AAGAAAGCGAAGTTGTTACAGAAGCAAAACAGCTCGTTACAAAATTAGAACCGCACATTAAAGTACAAGAAGAAAAAAAC
ACCAAAGTGGCAAAAGAAGTGTTTATATTAGAAGGTTTAGATTGCGCGAACTGTGCGATGAAGATTGAAAATAAAGTTAA
GGAAATGCCGACTGTTTCAGCAGCAACTGTTGATTTCGTATCAAAGAAATTACGAGTTGAAGTAGCGAATAAAAGAGAAT
TAGAAGCGACTGTAGCGAATATAACAAATGTCGTTCAAAAGTTAGAACCAGATGTGAAAGTTGTTCGTGAAGAAAAGGGT
GGTCATGACCACGGACATAGTCACGATCATGGTGAAGCAAATGTGAAAAAGATGGTAGGCCGATTAGTGGTCGGCGGAAT
TTTGACAGCAATTGCTGCGTTAGCGGGCTTACCACAAATGGTAACAATTCCGTTATTCGTCCTTGCTTATTTATTAATAG
GTGGAGATATCGTTTGGAGAGCGGTAAGAAACATAACTCGTGGCCAAGTATTTGATGAAAACTTCTTAATGGCAATTGCA
ACTGTAGGAGCTTTTGCAATTCAACAATACTCAGAAGCTGTAGCAGTAATGCTATTTTATCAAGTAGGAGAACTATTCCA
AAGCATTGCGGTAAACCGTTCTCGAAAATCAATTACTTCATTAATGGATATTCGTCCTGATTACGCGAATGTAAAGATTG
GAAATGAAACGAAACAAGTATCACCAGAAGATGTACAAATCGGCGATTATATTATCGTGAAACCTGGTGAGAAAGTACCA
TTAGACGGAAAAGTAGTTGAAGGAACATCAATGGTAGATACTTCAGCATTGACTGGTGAATCTGTACCACGTGAAGTTGA
AGTTGGAAATGATGTACTAAGTGGTTTTGTGAACCAAAATGGTGTATTAACAATTGAAGTTACAAAAGAATTTGGTGAAT
CAACTGTATCAAAAATTTTAGACTTAGTTCAAAATGCAAGCAGTAAAAAAGCGCCAACAGAAAACTTTATTACGAAGTTC
GCGCGTTACTACACGCCAGTTGTAGTAATTACAGCAGCGATCATGGCGTTTATTCCACCACTTATTTTAGAAGGAGCTAC
ATTCTCTGATTGGATTTATAGAGCTCTAGTGTTCTTAGTAATCTCTTGTCCATGTGCGTTAGTTGTATCTATTCCTCTTG
GATTCTTTGGAGGTATCGGTGGTGCATCTAAAAGTGGTGTGTTAGTAAAAGGAAGTAACTATTTAGAAGCTTTAAATGAT
GTGAAATATATTGTTTTTGATAAAACAGGAACATTAACAAAAGGTGTCTTCAAAGTTACAAAAATGGAACCGAGCGAAGG
CATTACAAATGAAGAATTATTAGAGTATGCAGCATTTGCTGAAGTATATTCTAACCATCCAATTGCACAATCGATTCGAA
ATGCATACCGAAAATCAATTGATGAAAAAATAATTGATGATTATAACGAAATTTCTGGTCACGGTACAGTCGTAAAGGTA
CAAGGGAAAGAAATTTTTGCAGGTAATGCTAAATTAATGAGAAAAGAAAACATTACATTTAAGCAACCAGAAACAGTAGG
TACATTAGTTCACGTTGCTGTAGATGGAAAATATGCAGGTTATATTGTTATCTCTGATGAGGTAAAAGAAGATTCAAAAC
AAGCAATTCAAAAGTTAAAAGAATTAGGTATTAAGAAGACAGTCATGTTAACTGGTGACGCAAAACTAGTTGGTGAAGCT
GTTGGGAAAGAATTAGGTTTAGATGAAGTTCACGCAGAACTATTACCGCAACAAAAAGTAGAAGAGATTGAAAAAATTGA
TGCAGCGAAGCACGGAAAAGAAAAAGTTGCTTTCGTTGGTGATGGTATTAATGACACACCGGTATTAGCAAGAGCAGATG
TTGGTATTGCAATGGGTGGTTTAGGATCAGATGCAGCAATTGAAGCGGCAGATATCGTTATTATGACTGATGAGCCTTCA
AAAATTGCAACAGCTGTACACATTGCAAAACGTACACGACGCATTGTATGGCAAAATATCATCTTTGCATTAGGTGTAAA
AGGATTAGTTTTATTACTTGGTGCTTTCGGTATTGCAACAATGTGGGAAGCTGTCTTCTCAGATGTGGGTGTGACACTAC
TTGCAGTGTTAAATGCAATGCGTGTACTACGAGTGAAAGATTTATAA

Upstream 100 bases:

>100_bases
TTATTATTCGTTAGCTGACCAACACGTCATTCATATCTTCGAGCAAGCGTTTGAACACGTAAACGAGGAAGAATAAAAAA
GAACGCGAGGAGGGAGAACG

Downstream 100 bases:

>100_bases
AAAAGAGGACGCAATCTGCGTCCTCTTTTTTAGGTTATTCTGTTGAAATTGACTCAATAAAATAATAACAAATATTATTT
TATGAATAAATAACTTTATA

Product: cation-transporting ATPase, P-type

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 788; Mature: 787

Protein sequence:

>788_residues
MAEALVKKKLMLEGLDCANCAMKIEKGVGNIEGVNSCSVNFATKTMVLETAQNKESEVVTEAKQLVTKLEPHIKVQEEKN
TKVAKEVFILEGLDCANCAMKIENKVKEMPTVSAATVDFVSKKLRVEVANKRELEATVANITNVVQKLEPDVKVVREEKG
GHDHGHSHDHGEANVKKMVGRLVVGGILTAIAALAGLPQMVTIPLFVLAYLLIGGDIVWRAVRNITRGQVFDENFLMAIA
TVGAFAIQQYSEAVAVMLFYQVGELFQSIAVNRSRKSITSLMDIRPDYANVKIGNETKQVSPEDVQIGDYIIVKPGEKVP
LDGKVVEGTSMVDTSALTGESVPREVEVGNDVLSGFVNQNGVLTIEVTKEFGESTVSKILDLVQNASSKKAPTENFITKF
ARYYTPVVVITAAIMAFIPPLILEGATFSDWIYRALVFLVISCPCALVVSIPLGFFGGIGGASKSGVLVKGSNYLEALND
VKYIVFDKTGTLTKGVFKVTKMEPSEGITNEELLEYAAFAEVYSNHPIAQSIRNAYRKSIDEKIIDDYNEISGHGTVVKV
QGKEIFAGNAKLMRKENITFKQPETVGTLVHVAVDGKYAGYIVISDEVKEDSKQAIQKLKELGIKKTVMLTGDAKLVGEA
VGKELGLDEVHAELLPQQKVEEIEKIDAAKHGKEKVAFVGDGINDTPVLARADVGIAMGGLGSDAAIEAADIVIMTDEPS
KIATAVHIAKRTRRIVWQNIIFALGVKGLVLLLGAFGIATMWEAVFSDVGVTLLAVLNAMRVLRVKDL

Sequences:

>Translated_788_residues
MAEALVKKKLMLEGLDCANCAMKIEKGVGNIEGVNSCSVNFATKTMVLETAQNKESEVVTEAKQLVTKLEPHIKVQEEKN
TKVAKEVFILEGLDCANCAMKIENKVKEMPTVSAATVDFVSKKLRVEVANKRELEATVANITNVVQKLEPDVKVVREEKG
GHDHGHSHDHGEANVKKMVGRLVVGGILTAIAALAGLPQMVTIPLFVLAYLLIGGDIVWRAVRNITRGQVFDENFLMAIA
TVGAFAIQQYSEAVAVMLFYQVGELFQSIAVNRSRKSITSLMDIRPDYANVKIGNETKQVSPEDVQIGDYIIVKPGEKVP
LDGKVVEGTSMVDTSALTGESVPREVEVGNDVLSGFVNQNGVLTIEVTKEFGESTVSKILDLVQNASSKKAPTENFITKF
ARYYTPVVVITAAIMAFIPPLILEGATFSDWIYRALVFLVISCPCALVVSIPLGFFGGIGGASKSGVLVKGSNYLEALND
VKYIVFDKTGTLTKGVFKVTKMEPSEGITNEELLEYAAFAEVYSNHPIAQSIRNAYRKSIDEKIIDDYNEISGHGTVVKV
QGKEIFAGNAKLMRKENITFKQPETVGTLVHVAVDGKYAGYIVISDEVKEDSKQAIQKLKELGIKKTVMLTGDAKLVGEA
VGKELGLDEVHAELLPQQKVEEIEKIDAAKHGKEKVAFVGDGINDTPVLARADVGIAMGGLGSDAAIEAADIVIMTDEPS
KIATAVHIAKRTRRIVWQNIIFALGVKGLVLLLGAFGIATMWEAVFSDVGVTLLAVLNAMRVLRVKDL
>Mature_787_residues
AEALVKKKLMLEGLDCANCAMKIEKGVGNIEGVNSCSVNFATKTMVLETAQNKESEVVTEAKQLVTKLEPHIKVQEEKNT
KVAKEVFILEGLDCANCAMKIENKVKEMPTVSAATVDFVSKKLRVEVANKRELEATVANITNVVQKLEPDVKVVREEKGG
HDHGHSHDHGEANVKKMVGRLVVGGILTAIAALAGLPQMVTIPLFVLAYLLIGGDIVWRAVRNITRGQVFDENFLMAIAT
VGAFAIQQYSEAVAVMLFYQVGELFQSIAVNRSRKSITSLMDIRPDYANVKIGNETKQVSPEDVQIGDYIIVKPGEKVPL
DGKVVEGTSMVDTSALTGESVPREVEVGNDVLSGFVNQNGVLTIEVTKEFGESTVSKILDLVQNASSKKAPTENFITKFA
RYYTPVVVITAAIMAFIPPLILEGATFSDWIYRALVFLVISCPCALVVSIPLGFFGGIGGASKSGVLVKGSNYLEALNDV
KYIVFDKTGTLTKGVFKVTKMEPSEGITNEELLEYAAFAEVYSNHPIAQSIRNAYRKSIDEKIIDDYNEISGHGTVVKVQ
GKEIFAGNAKLMRKENITFKQPETVGTLVHVAVDGKYAGYIVISDEVKEDSKQAIQKLKELGIKKTVMLTGDAKLVGEAV
GKELGLDEVHAELLPQQKVEEIEKIDAAKHGKEKVAFVGDGINDTPVLARADVGIAMGGLGSDAAIEAADIVIMTDEPSK
IATAVHIAKRTRRIVWQNIIFALGVKGLVLLLGAFGIATMWEAVFSDVGVTLLAVLNAMRVLRVKDL

Specific function: Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=869, Percent_Identity=25.3164556962025, Blast_Score=263, Evalue=7e-70,
Organism=Homo sapiens, GI55743073, Length=543, Percent_Identity=28.7292817679558, Blast_Score=226, Evalue=8e-59,
Organism=Homo sapiens, GI115529486, Length=904, Percent_Identity=25.4424778761062, Blast_Score=195, Evalue=2e-49,
Organism=Homo sapiens, GI118498343, Length=212, Percent_Identity=28.7735849056604, Blast_Score=70, Evalue=9e-12,
Organism=Escherichia coli, GI1789879, Length=716, Percent_Identity=33.7988826815642, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1786691, Length=855, Percent_Identity=27.719298245614, Blast_Score=275, Evalue=1e-74,
Organism=Escherichia coli, GI1786914, Length=524, Percent_Identity=28.6259541984733, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI2367363, Length=592, Percent_Identity=24.8310810810811, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17556548, Length=888, Percent_Identity=26.463963963964, Blast_Score=218, Evalue=9e-57,
Organism=Saccharomyces cerevisiae, GI6320475, Length=561, Percent_Identity=30.3030303030303, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6319772, Length=635, Percent_Identity=24.7244094488189, Blast_Score=175, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6321271, Length=220, Percent_Identity=26.8181818181818, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221329854, Length=610, Percent_Identity=27.7049180327869, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24668704, Length=157, Percent_Identity=27.3885350318471, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24668708, Length=157, Percent_Identity=27.3885350318471, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281366617, Length=157, Percent_Identity=27.3885350318471, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161085803, Length=157, Percent_Identity=27.3885350318471, Blast_Score=71, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24668696, Length=157, Percent_Identity=27.3885350318471, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI281366676, Length=267, Percent_Identity=26.5917602996255, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 85334; Mature: 85203

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEALVKKKLMLEGLDCANCAMKIEKGVGNIEGVNSCSVNFATKTMVLETAQNKESEVVT
CCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHEEEHHCCCHHHHHH
EAKQLVTKLEPHIKVQEEKNTKVAKEVFILEGLDCANCAMKIENKVKEMPTVSAATVDFV
HHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
SKKLRVEVANKRELEATVANITNVVQKLEPDVKVVREEKGGHDHGHSHDHGEANVKKMVG
HHHHHEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
RLVVGGILTAIAALAGLPQMVTIPLFVLAYLLIGGDIVWRAVRNITRGQVFDENFLMAIA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCHHHHHHH
TVGAFAIQQYSEAVAVMLFYQVGELFQSIAVNRSRKSITSLMDIRPDYANVKIGNETKQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEECCCCCCC
SPEDVQIGDYIIVKPGEKVPLDGKVVEGTSMVDTSALTGESVPREVEVGNDVLSGFVNQN
CCCCEEECCEEEECCCCCCCCCCEEECCCCCCCCHHCCCCCCCCHHHCCHHHHHHHCCCC
GVLTIEVTKEFGESTVSKILDLVQNASSKKAPTENFITKFARYYTPVVVITAAIMAFIPP
CEEEEEEHHHHCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LILEGATFSDWIYRALVFLVISCPCALVVSIPLGFFGGIGGASKSGVLVKGSNYLEALND
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHCC
VKYIVFDKTGTLTKGVFKVTKMEPSEGITNEELLEYAAFAEVYSNHPIAQSIRNAYRKSI
CEEEEEECCCCHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
DEKIIDDYNEISGHGTVVKVQGKEIFAGNAKLMRKENITFKQPETVGTLVHVAVDGKYAG
HHHHHHHHHHCCCCCCEEEEECCEEEECCHHHHEECCCCCCCCCCCCEEEEEEECCCEEE
YIVISDEVKEDSKQAIQKLKELGIKKTVMLTGDAKLVGEAVGKELGLDEVHAELLPQQKV
EEEEECHHCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHCCHHHH
EEIEKIDAAKHGKEKVAFVGDGINDTPVLARADVGIAMGGLGSDAAIEAADIVIMTDEPS
HHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCCCEEECCCCCCCCEEEEEEEEECCCCH
KIATAVHIAKRTRRIVWQNIIFALGVKGLVLLLGAFGIATMWEAVFSDVGVTLLAVLNAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVLRVKDL
HHHHHCCC
>Mature Secondary Structure 
AEALVKKKLMLEGLDCANCAMKIEKGVGNIEGVNSCSVNFATKTMVLETAQNKESEVVT
CHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHEEEHHCCCHHHHHH
EAKQLVTKLEPHIKVQEEKNTKVAKEVFILEGLDCANCAMKIENKVKEMPTVSAATVDFV
HHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
SKKLRVEVANKRELEATVANITNVVQKLEPDVKVVREEKGGHDHGHSHDHGEANVKKMVG
HHHHHEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
RLVVGGILTAIAALAGLPQMVTIPLFVLAYLLIGGDIVWRAVRNITRGQVFDENFLMAIA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCHHHHHHH
TVGAFAIQQYSEAVAVMLFYQVGELFQSIAVNRSRKSITSLMDIRPDYANVKIGNETKQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEECCCCCCC
SPEDVQIGDYIIVKPGEKVPLDGKVVEGTSMVDTSALTGESVPREVEVGNDVLSGFVNQN
CCCCEEECCEEEECCCCCCCCCCEEECCCCCCCCHHCCCCCCCCHHHCCHHHHHHHCCCC
GVLTIEVTKEFGESTVSKILDLVQNASSKKAPTENFITKFARYYTPVVVITAAIMAFIPP
CEEEEEEHHHHCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LILEGATFSDWIYRALVFLVISCPCALVVSIPLGFFGGIGGASKSGVLVKGSNYLEALND
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHCC
VKYIVFDKTGTLTKGVFKVTKMEPSEGITNEELLEYAAFAEVYSNHPIAQSIRNAYRKSI
CEEEEEECCCCHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
DEKIIDDYNEISGHGTVVKVQGKEIFAGNAKLMRKENITFKQPETVGTLVHVAVDGKYAG
HHHHHHHHHHCCCCCCEEEEECCEEEECCHHHHEECCCCCCCCCCCCEEEEEEECCCEEE
YIVISDEVKEDSKQAIQKLKELGIKKTVMLTGDAKLVGEAVGKELGLDEVHAELLPQQKV
EEEEECHHCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHCCHHHH
EEIEKIDAAKHGKEKVAFVGDGINDTPVLARADVGIAMGGLGSDAAIEAADIVIMTDEPS
HHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCCCEEECCCCCCCCEEEEEEEEECCCCH
KIATAVHIAKRTRRIVWQNIIFALGVKGLVLLLGAFGIATMWEAVFSDVGVTLLAVLNAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVLRVKDL
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]