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The map label for this gene is ziaR [H]

Identifier: 118476281

GI number: 118476281

Start: 619203

End: 619580

Strand: Direct

Name: ziaR [H]

Synonym: BALH_0535

Alternate gene names: 118476281

Gene position: 619203-619580 (Clockwise)

Preceding gene: 118476280

Following gene: 118476282

Centisome position: 11.78

GC content: 34.92

Gene sequence:

>378_bases
ATGGCTGGAAATAAAGTAGAAACACCACAAGAGACATGTTCTCAAACGATAATCCATGAAGAAGTTGTGGATCAAGTAAA
ACAAACAATTCCAACTGATGAAAGTTTAAGTAAAGTAGCAGAATTATTTAAAGTATTAGGTGATCGTACACGTACGAGAA
TATTACATGCGTTATTTGAAGCTGAAATGTGTGTTTGTGATTTAGCGTATTTATTAGGAATGACACAATCATCCATTTCA
CATCAGCTTCGTGTGTTAAAGCAAGCAAAACTGGTAAAGAATCGTAAAGAAGGAAAAGTCGTTTATTATTCGTTAGCTGA
CCAACACGTCATTCATATCTTCGAGCAAGCGTTTGAACACGTAAACGAGGAAGAATAA

Upstream 100 bases:

>100_bases
GTATGAGATTTCATTGACACATATGAATAGACGCTCATATAATAAAAGTATAAGATATATGAATGATTGTTCATATGTTC
AAATAAAGAGGTGAGCTATA

Downstream 100 bases:

>100_bases
AAAAGAACGCGAGGAGGGAGAACGATGGCTGAAGCATTAGTGAAAAAGAAACTGATGTTAGAAGGTTTAGATTGTGCGAA
CTGTGCAATGAAAATTGAAA

Product: ArsR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 125; Mature: 124

Protein sequence:

>125_residues
MAGNKVETPQETCSQTIIHEEVVDQVKQTIPTDESLSKVAELFKVLGDRTRTRILHALFEAEMCVCDLAYLLGMTQSSIS
HQLRVLKQAKLVKNRKEGKVVYYSLADQHVIHIFEQAFEHVNEEE

Sequences:

>Translated_125_residues
MAGNKVETPQETCSQTIIHEEVVDQVKQTIPTDESLSKVAELFKVLGDRTRTRILHALFEAEMCVCDLAYLLGMTQSSIS
HQLRVLKQAKLVKNRKEGKVVYYSLADQHVIHIFEQAFEHVNEEE
>Mature_124_residues
AGNKVETPQETCSQTIIHEEVVDQVKQTIPTDESLSKVAELFKVLGDRTRTRILHALFEAEMCVCDLAYLLGMTQSSISH
QLRVLKQAKLVKNRKEGKVVYYSLADQHVIHIFEQAFEHVNEEE

Specific function: Transcriptional repressor of the expression of the ziaA gene. Controls zinc homeostasis by triggering ziaA-mediated efflux of excess zinc into the periplasm [H]

COG id: COG0640

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH arsR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001845
- InterPro:   IPR018334
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01022 HTH_5 [H]

EC number: NA

Molecular weight: Translated: 14284; Mature: 14152

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00846 HTH_ARSR_1 ; PS50987 HTH_ARSR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGNKVETPQETCSQTIIHEEVVDQVKQTIPTDESLSKVAELFKVLGDRTRTRILHALFE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHH
AEMCVCDLAYLLGMTQSSISHQLRVLKQAKLVKNRKEGKVVYYSLADQHVIHIFEQAFEH
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHH
VNEEE
CCCCC
>Mature Secondary Structure 
AGNKVETPQETCSQTIIHEEVVDQVKQTIPTDESLSKVAELFKVLGDRTRTRILHALFE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHH
AEMCVCDLAYLLGMTQSSISHQLRVLKQAKLVKNRKEGKVVYYSLADQHVIHIFEQAFEH
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHH
VNEEE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231; 9724772 [H]