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The map label for this gene is mrdA [H]

Identifier: 117919444

GI number: 117919444

Start: 1165327

End: 1167183

Strand: Reverse

Name: mrdA [H]

Synonym: Shewana3_0995

Alternate gene names: 117919444

Gene position: 1167183-1165327 (Counterclockwise)

Preceding gene: 117919445

Following gene: 117919443

Centisome position: 23.47

GC content: 51.16

Gene sequence:

>1857_bases
GTGTCGCCAAAAAAGCGGATAACCATGCACGACCACGCCGCCGAGGCGTCACTGTTTAAGCGCCGTGCGCTGTTCACTTT
TTTTTGTGTAGTCGCCCTCCTGAGCGTGTTGGTGACCAATCTTTATCACCTTCAGGTTGAATCCTATAAAGATTACGCAA
CACGTTCTAATGACAACCGTATTCGTGTCGTGCCCATCGCTCCAAGCCGTGGCCTGATTTACGACAGAAACGGCGTACTC
CTCGCCGAAAACCAACCCTTTTACTCCCTCGATCTGGTGCCTGAGAAAATTGCCAATATGTCCGAGACCTTGGACGAGCT
AGGCAAGTTAATCGAAATCACCCCAGATGAGCGCGAAACCTTTACCGACGCCTTAAAGTTTCACCGCCGCTTTAAGCCGC
TTACCCTTAAAAATCAGCTGACTGAAGAACAAGTGGCGATTTTTAGCGTGAACCAGCATCGCTTTCCCGGTATTTCCGTC
GAGGCGGGTTTAAAGCGTAACTACCCCTATGCGAGCCAGCTCACCCATGTGCTGGGCTATGTAGGCAAAATCAACACCCG
CGATCGCGCCCAATTGGAGCGTAACGATCAATGGAAGAACTATGCCGCCACCAAGGATATTGGTAAGCAAGGCATTGAAA
AGTTTTATGAATCTCTGCTACACGGCACGCCGGGTCACCTCGAAGAAGAAGTGAACAACCGCGGCCGAACTATCCGTACC
CTTAAAATCGTACCGCCGGAGCCGGGGCAAGATATTTACTTAACCCTAGATTTGCAATTGCAGCAAAAGGCGGTGGAATT
ACTCCAAGGTCACCGTGGCTCAATTGTCGCTATCGACCCGAGGGACGGCGGCATCTTAGCCCTAGTCTCAAGCCCTAGTT
ACGACCCGAATCAGTTCGTTCAAGGGATTAACAGCAAAGATTACAGTGATTTATTAAACGATAAATCTCGCCCACTGATT
AACCGCGCGACCCAAGGTCAGTATGCGCCAGCTTCGACGGTCAAACCCATTATCGCCCTACTGGGGTTAGATGAAAAAGC
CGTCACCGAACACACTCGTATTTGGGACCCTGGCTTTTGGCAAATCCCTGGCGTTGAGCGTAAATACCGCGACTGGAAAC
GTTGGGGCCATGGCTGGGTGAACGTCTACAGCGCCATCGTGGAATCCTGCGATACCTACTTCTATGAATTGGCTTATAAA
ATCGGTGTCGATCCTATCGCCCGCTTTATGGAGCAATTCGGCTTTGGACAAAATACCGGTGTCGATATTTTCGAAGAGTC
GGCGGGCAATATGCCGTCGAAGGAATGGAAGCGCTTAAAATACAACCAAGCTTGGTATATTGGTGACACCATTTCTGTCG
GTATCGGCCAAGGTTACTGGACCGCCACGCCATTGCAATTGGCCAGCGCCACCGCCATTCTCGCCAACGATGGCCGCCGC
TTCCCGCCACATTTGTTAAAGTCGATTAAGGATAATACGGCCAAAATTGACTCACCAATTAACGAGTTACCGCCGATTGA
GCTTAAAAATCCGCGCAACTGGAAAATCATTAATGAAGCGATGCGCCAAACGGCTCATAAGTCTCGCTTCACCGACGCCA
GTTACACGGCTGCGATGAAAACCGGTACGGCGCAGGTCATTGGCGTGGCCGAAAACACTAAGTACGATGCCAATAAAATT
GCCGAGCATTTCCGCGATAACGCCCTCGTGGTCGCCTACGCGCCCTTTGAAGATCCTAAAATCGTCCTCGCTGTGGTAAT
GGAAAACGCCGGCTGGGGTGGCGCAAACGCAGGCCCAGTCGCCCGCGCTATGCTCGATGAATACATGCTAAGAGACACTT
GGAAACCAACGCCATGA

Upstream 100 bases:

>100_bases
GTGGAGCGTGAACACCAATCACCCTTATCACAGAGAATAGCGGGATCTTGATGTTAACGAGTGTCAACCACCCGGATGGG
ATCAGCTGGAGATAGCCTAA

Downstream 100 bases:

>100_bases
GTGCCCAACCACGTCAAAATATCTGGCAACGAATGCATATCGACTTGCCCTTACTGCTCGGTCTGTTTGCCGTCATGGGC
TTTGGCCTGTTTGTTATTTA

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 618; Mature: 617

Protein sequence:

>618_residues
MSPKKRITMHDHAAEASLFKRRALFTFFCVVALLSVLVTNLYHLQVESYKDYATRSNDNRIRVVPIAPSRGLIYDRNGVL
LAENQPFYSLDLVPEKIANMSETLDELGKLIEITPDERETFTDALKFHRRFKPLTLKNQLTEEQVAIFSVNQHRFPGISV
EAGLKRNYPYASQLTHVLGYVGKINTRDRAQLERNDQWKNYAATKDIGKQGIEKFYESLLHGTPGHLEEEVNNRGRTIRT
LKIVPPEPGQDIYLTLDLQLQQKAVELLQGHRGSIVAIDPRDGGILALVSSPSYDPNQFVQGINSKDYSDLLNDKSRPLI
NRATQGQYAPASTVKPIIALLGLDEKAVTEHTRIWDPGFWQIPGVERKYRDWKRWGHGWVNVYSAIVESCDTYFYELAYK
IGVDPIARFMEQFGFGQNTGVDIFEESAGNMPSKEWKRLKYNQAWYIGDTISVGIGQGYWTATPLQLASATAILANDGRR
FPPHLLKSIKDNTAKIDSPINELPPIELKNPRNWKIINEAMRQTAHKSRFTDASYTAAMKTGTAQVIGVAENTKYDANKI
AEHFRDNALVVAYAPFEDPKIVLAVVMENAGWGGANAGPVARAMLDEYMLRDTWKPTP

Sequences:

>Translated_618_residues
MSPKKRITMHDHAAEASLFKRRALFTFFCVVALLSVLVTNLYHLQVESYKDYATRSNDNRIRVVPIAPSRGLIYDRNGVL
LAENQPFYSLDLVPEKIANMSETLDELGKLIEITPDERETFTDALKFHRRFKPLTLKNQLTEEQVAIFSVNQHRFPGISV
EAGLKRNYPYASQLTHVLGYVGKINTRDRAQLERNDQWKNYAATKDIGKQGIEKFYESLLHGTPGHLEEEVNNRGRTIRT
LKIVPPEPGQDIYLTLDLQLQQKAVELLQGHRGSIVAIDPRDGGILALVSSPSYDPNQFVQGINSKDYSDLLNDKSRPLI
NRATQGQYAPASTVKPIIALLGLDEKAVTEHTRIWDPGFWQIPGVERKYRDWKRWGHGWVNVYSAIVESCDTYFYELAYK
IGVDPIARFMEQFGFGQNTGVDIFEESAGNMPSKEWKRLKYNQAWYIGDTISVGIGQGYWTATPLQLASATAILANDGRR
FPPHLLKSIKDNTAKIDSPINELPPIELKNPRNWKIINEAMRQTAHKSRFTDASYTAAMKTGTAQVIGVAENTKYDANKI
AEHFRDNALVVAYAPFEDPKIVLAVVMENAGWGGANAGPVARAMLDEYMLRDTWKPTP
>Mature_617_residues
SPKKRITMHDHAAEASLFKRRALFTFFCVVALLSVLVTNLYHLQVESYKDYATRSNDNRIRVVPIAPSRGLIYDRNGVLL
AENQPFYSLDLVPEKIANMSETLDELGKLIEITPDERETFTDALKFHRRFKPLTLKNQLTEEQVAIFSVNQHRFPGISVE
AGLKRNYPYASQLTHVLGYVGKINTRDRAQLERNDQWKNYAATKDIGKQGIEKFYESLLHGTPGHLEEEVNNRGRTIRTL
KIVPPEPGQDIYLTLDLQLQQKAVELLQGHRGSIVAIDPRDGGILALVSSPSYDPNQFVQGINSKDYSDLLNDKSRPLIN
RATQGQYAPASTVKPIIALLGLDEKAVTEHTRIWDPGFWQIPGVERKYRDWKRWGHGWVNVYSAIVESCDTYFYELAYKI
GVDPIARFMEQFGFGQNTGVDIFEESAGNMPSKEWKRLKYNQAWYIGDTISVGIGQGYWTATPLQLASATAILANDGRRF
PPHLLKSIKDNTAKIDSPINELPPIELKNPRNWKIINEAMRQTAHKSRFTDASYTAAMKTGTAQVIGVAENTKYDANKIA
EHFRDNALVVAYAPFEDPKIVLAVVMENAGWGGANAGPVARAMLDEYMLRDTWKPTP

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=612, Percent_Identity=50.8169934640523, Blast_Score=643, Evalue=0.0,
Organism=Escherichia coli, GI1786272, Length=600, Percent_Identity=23.8333333333333, Blast_Score=115, Evalue=9e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 69842; Mature: 69711

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPKKRITMHDHAAEASLFKRRALFTFFCVVALLSVLVTNLYHLQVESYKDYATRSNDNR
CCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHCCCCCE
IRVVPIAPSRGLIYDRNGVLLAENQPFYSLDLVPEKIANMSETLDELGKLIEITPDERET
EEEEEECCCCCEEECCCCEEEECCCCCEEECCCHHHHHHHHHHHHHHHHEEECCCCHHHH
FTDALKFHRRFKPLTLKNQLTEEQVAIFSVNQHRFPGISVEAGLKRNYPYASQLTHVLGY
HHHHHHHHHHCCCCCHHHHHCHHHEEEEEECCCCCCCCEEECCCCCCCCHHHHHHHHHHH
VGKINTRDRAQLERNDQWKNYAATKDIGKQGIEKFYESLLHGTPGHLEEEVNNRGRTIRT
HHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEE
LKIVPPEPGQDIYLTLDLQLQQKAVELLQGHRGSIVAIDPRDGGILALVSSPSYDPNQFV
EEEECCCCCCEEEEEEEHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEECCCCCCHHHHH
QGINSKDYSDLLNDKSRPLINRATQGQYAPASTVKPIIALLGLDEKAVTEHTRIWDPGFW
HCCCCCCHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCE
QIPGVERKYRDWKRWGHGWVNVYSAIVESCDTYFYELAYKIGVDPIARFMEQFGFGQNTG
ECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
VDIFEESAGNMPSKEWKRLKYNQAWYIGDTISVGIGQGYWTATPLQLASATAILANDGRR
CHHHHHCCCCCCHHHHHHCCCCCEEEECCEEEECCCCCCCCCCHHHHHHHEEEEECCCCC
FPPHLLKSIKDNTAKIDSPINELPPIELKNPRNWKIINEAMRQTAHKSRFTDASYTAAMK
CCHHHHHHHCCCCHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHC
TGTAQVIGVAENTKYDANKIAEHFRDNALVVAYAPFEDPKIVLAVVMENAGWGGANAGPV
CCCEEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCCEEEEEEEECCCCCCCCCCHH
ARAMLDEYMLRDTWKPTP
HHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SPKKRITMHDHAAEASLFKRRALFTFFCVVALLSVLVTNLYHLQVESYKDYATRSNDNR
CCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHCCCCCE
IRVVPIAPSRGLIYDRNGVLLAENQPFYSLDLVPEKIANMSETLDELGKLIEITPDERET
EEEEEECCCCCEEECCCCEEEECCCCCEEECCCHHHHHHHHHHHHHHHHEEECCCCHHHH
FTDALKFHRRFKPLTLKNQLTEEQVAIFSVNQHRFPGISVEAGLKRNYPYASQLTHVLGY
HHHHHHHHHHCCCCCHHHHHCHHHEEEEEECCCCCCCCEEECCCCCCCCHHHHHHHHHHH
VGKINTRDRAQLERNDQWKNYAATKDIGKQGIEKFYESLLHGTPGHLEEEVNNRGRTIRT
HHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEE
LKIVPPEPGQDIYLTLDLQLQQKAVELLQGHRGSIVAIDPRDGGILALVSSPSYDPNQFV
EEEECCCCCCEEEEEEEHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEECCCCCCHHHHH
QGINSKDYSDLLNDKSRPLINRATQGQYAPASTVKPIIALLGLDEKAVTEHTRIWDPGFW
HCCCCCCHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCE
QIPGVERKYRDWKRWGHGWVNVYSAIVESCDTYFYELAYKIGVDPIARFMEQFGFGQNTG
ECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
VDIFEESAGNMPSKEWKRLKYNQAWYIGDTISVGIGQGYWTATPLQLASATAILANDGRR
CHHHHHCCCCCCHHHHHHCCCCCEEEECCEEEECCCCCCCCCCHHHHHHHEEEEECCCCC
FPPHLLKSIKDNTAKIDSPINELPPIELKNPRNWKIINEAMRQTAHKSRFTDASYTAAMK
CCHHHHHHHCCCCHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHC
TGTAQVIGVAENTKYDANKIAEHFRDNALVVAYAPFEDPKIVLAVVMENAGWGGANAGPV
CCCEEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCCEEEEEEEECCCCCCCCCCHH
ARAMLDEYMLRDTWKPTP
HHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]