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The map label for this gene is hpt [H]

Identifier: 117919245

GI number: 117919245

Start: 913782

End: 914312

Strand: Direct

Name: hpt [H]

Synonym: Shewana3_0793

Alternate gene names: 117919245

Gene position: 913782-914312 (Clockwise)

Preceding gene: 117919244

Following gene: 117919246

Centisome position: 18.38

GC content: 47.83

Gene sequence:

>531_bases
ATGAAACACACCACCGAAGTGATGATCTCCGCCGAAGAGATCAGCCAAAAATTGGATCAAATGGCCGAGCAAATCAATGC
CCACTATGCCAACAGCGAGCGTTTGCTGATGGTGGGATTGTTAAAAGGTTCAGTCGTATTTATGGCTGATCTGTGCCGCC
GTATTAAAGGCCACGTTGAAATCGATTTTATGTCGGTTTCGAGTTATGGCAATGCCATGACCAGCTCACGGGATGTGAAA
GTGCTGAAGGATGTGCAATCGGATATCGCGGGCCGCGACGTGCTGATTGTCGAAGACTTAATTGACTCGGGCAACACTTT
AAACAAAGTGCGCGAAATGCTGTTATTGCGTGAGCCAAAGAGCTTAGCCCTGTGCACTCTGTTGGATAAACCCGAACGCC
GTGAAGTGGATGTTAAAGTCGACTTTATCGGTTTTACGATCCCAGACGAGTTTATTGTGGGTTACGGCATCGATTATGCG
GAGCAATACCGCAACTTGCCTTATATCGCCAAAGTGGTGCCGCTCGAATAA

Upstream 100 bases:

>100_bases
GTCGCTCGAATCCTCGATCATTTGGGCGTTGACCATGCATTAACGAGTCGCTGGGGCTATGACAAACACTCCCCCAATGA
CATCGACAATTGAGACTGAT

Downstream 100 bases:

>100_bases
GCCCGATGCGTTATGACTCAAACTCCCGCCTAGGCGGGAGTTTTGTTTTGTGCCGAAAGTTGGCTACGCAAATGTTGTTT
GGGGTCACGTATCCGCGTTT

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MKHTTEVMISAEEISQKLDQMAEQINAHYANSERLLMVGLLKGSVVFMADLCRRIKGHVEIDFMSVSSYGNAMTSSRDVK
VLKDVQSDIAGRDVLIVEDLIDSGNTLNKVREMLLLREPKSLALCTLLDKPERREVDVKVDFIGFTIPDEFIVGYGIDYA
EQYRNLPYIAKVVPLE

Sequences:

>Translated_176_residues
MKHTTEVMISAEEISQKLDQMAEQINAHYANSERLLMVGLLKGSVVFMADLCRRIKGHVEIDFMSVSSYGNAMTSSRDVK
VLKDVQSDIAGRDVLIVEDLIDSGNTLNKVREMLLLREPKSLALCTLLDKPERREVDVKVDFIGFTIPDEFIVGYGIDYA
EQYRNLPYIAKVVPLE
>Mature_176_residues
MKHTTEVMISAEEISQKLDQMAEQINAHYANSERLLMVGLLKGSVVFMADLCRRIKGHVEIDFMSVSSYGNAMTSSRDVK
VLKDVQSDIAGRDVLIVEDLIDSGNTLNKVREMLLLREPKSLALCTLLDKPERREVDVKVDFIGFTIPDEFIVGYGIDYA
EQYRNLPYIAKVVPLE

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=150, Percent_Identity=36.6666666666667, Blast_Score=94, Evalue=5e-20,
Organism=Homo sapiens, GI9910262, Length=173, Percent_Identity=29.4797687861272, Blast_Score=81, Evalue=6e-16,
Organism=Escherichia coli, GI87081689, Length=177, Percent_Identity=63.2768361581921, Blast_Score=239, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI17510817, Length=176, Percent_Identity=31.8181818181818, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19883; Mature: 19883

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHTTEVMISAEEISQKLDQMAEQINAHYANSERLLMVGLLKGSVVFMADLCRRIKGHVE
CCCHHHHEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCHHHHHHHHHHHCCCEE
IDFMSVSSYGNAMTSSRDVKVLKDVQSDIAGRDVLIVEDLIDSGNTLNKVREMLLLREPK
EEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEHHHCCCCHHHHHHHHHHHCCCC
SLALCTLLDKPERREVDVKVDFIGFTIPDEFIVGYGIDYAEQYRNLPYIAKVVPLE
HHEEEEECCCCCCCEEEEEEEEEEEECCCHHHEECCCCHHHHHCCCCCEEEEECCC
>Mature Secondary Structure
MKHTTEVMISAEEISQKLDQMAEQINAHYANSERLLMVGLLKGSVVFMADLCRRIKGHVE
CCCHHHHEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCHHHHHHHHHHHCCCEE
IDFMSVSSYGNAMTSSRDVKVLKDVQSDIAGRDVLIVEDLIDSGNTLNKVREMLLLREPK
EEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEHHHCCCCHHHHHHHHHHHCCCC
SLALCTLLDKPERREVDVKVDFIGFTIPDEFIVGYGIDYAEQYRNLPYIAKVVPLE
HHEEEEECCCCCCCEEEEEEEEEEEECCCHHHEECCCCHHHHHCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2388850 [H]