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The map label for this gene is mutL

Identifier: 117919048

GI number: 117919048

Start: 697914

End: 699860

Strand: Direct

Name: mutL

Synonym: Shewana3_0595

Alternate gene names: 117919048

Gene position: 697914-699860 (Clockwise)

Preceding gene: 117919047

Following gene: 117919049

Centisome position: 14.04

GC content: 51.57

Gene sequence:

>1947_bases
ATGGGGATCCAGATCCTTCCGCCGCAACTAGCCAACCAAATCGCCGCTGGTGAAGTGGTCGAACGGCCCGCTTCCGTGGT
GAAGGAACTTGTCGAGAACAGCCTAGATGCTGGGGCGACGCGTATCGATATCGAAATCGATAAGGGCGGCAGCAAGCTGA
TTAAGATCCGCGACAATGGTTCGGGGATCCCAAAGGATGAGCTGGCCTTGGCTTTGTCGCGCCATGCTACCTCGAAATTG
CACTCTCTTGACGACCTTGAAGCGATTCTTAGTTTTGGTTTTCGTGGTGAGGCATTGGCGAGTATCAGTTCTGTATCCCG
CTTAACCTTGACCTCGCGCACGGCCGAGCAAACGGAAGCTTGGCAGGCTTATGCCGAAGGTGCCGATATGGCGGTTAAGG
TGATGCCAGCCGCGCATCCTGTTGGTTCAACTATTGAAGTTGTCGATCTGTTTTTTAATACGCCCGCCCGCAGACGTTTT
CTAAAAAGCGATAAAACCGAATTTACCCATATCGATGAATGGTTAAAACGCATTGCATTAGTGCGTGGGGATATTCACTT
TACCTTGACTCACAATGGTAAAATCGTGCGCAACTGTCGTCCGGCGATGAACGAGCCGCAGTATTTACAGCGATTGACTC
AGGTTGCTGGGCGCCAGTTTGCCGATGAGGCGTTGCGGGTCGAATGCCAACACGATGACCTGCGTTTAAGTGGTTATTTA
CAGTCGCCTTGGTCAACGGTGTTAACCGACACCCATTACTTTTATGTGAATGGCCGCTTAGTGCGCGACCGTTTAGTCAA
TCATGCGGTGCGCCAAGCATTTGCCCAAAAAGCCGAGGTCGAACAGCCGGGTTATGTGTTGATGCTGGATATCGATCCCC
ATCAGGTAGATGTGAACGTGCATCCGGCGAAACACGAAGTGCGCTTTCATCAGAGCCGTTATGTGCATGATTATATTCTG
CAGGCACTGCAATCGGCACTCGAAGAAGCGGGTGAGCTGGGTTTTGAGCGTCCTTTCGAGCCGAGCTCGCCACAGATTAG
GGATGAAGCCTCTCTCTCTGAAACTGGGGCGCAGACACAAACTGAGCATCATGCCTTCGAGCTGCAATCGCCTGAATCTA
AAACTCATTCAACTTGGAATGAAGCTTCACGTGTTGATACTTCCCGTGCCGAGACGTCACGGGAAAGCCGAATCGATTCG
CCGCTAGGTGAGCGTACTCGGGATATTGCTAGCGCGCGTCCTTACGCTGGCGTGCAGAGCAATGCCTACGGCAGTATGGC
CGTTCCGCGGGAGTCACGCAGTGGTTCGGCAGGGGAAAGTCGAGCACGAGCCGAGCTTCCTTCTAAGGTGGCTATCGCCA
GTTACGGCGAATTATTGCAAACGCCATCCTACAGCGTGCAGGACAAGCCGTATCAACCCGTGCTTGCAATGCCCGCCATA
CTCAATGGTCAATACTGGGTGTTGGCTCAAGGGCAAAACTTGAGTCTATTGCCGATTCAATCTGTGGCGTTAGCGACCCG
TAGCCATGAGGTTGAAACAAAGCTGGCAACGGGTTTGATAGGTCAGCCATTACTGATGCCAGTGTCGATTGCCGCCGATA
CGGATTGGCCTGCATTACTTGAAGAACATGAGACACTTATCCGGCAATTAGGATTAGAACTAACAATTCGCTATCAGCAG
TTGATAATTAAAAAAGTGCCCCCATATCTCAGGGATAGCCAGTTAGCGAAGGTGATCCCCGAGTGGTTGCAATCGCTACG
TTTTGAAGCGCCAGCACCTAATGCATTGGCTGTGTGGCTGGCAGAGCAGAGTTTGACTGGATTTACCTCGGCCGCGGATA
TTTGGGCGGCCTATTGTCAGTTAACTGAAGAGAAAAGACAGCAAATTGCCGATAAAGCAGTATCCTTACCTTGGCAATCG
TGGCTAGAAGAGCAAGCAAGTGAATAA

Upstream 100 bases:

>100_bases
GTGCCTATGGCTAGCATTAAGCGCGCCAATGGCATGAAGACGGATGTGGTACAACTCGGGCAAACACTCGTTATTCCTGA
GAGTTAATAGGATGAAGTCT

Downstream 100 bases:

>100_bases
AGAATTACAGCCAAAAGTGGTTTTTTTGATGGGACCAACGGCGTCCGGAAAAACCGCTTTAGCACTCGAATTAGCCGAAA
AGCATAATTGCGAGATTATC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 648; Mature: 647

Protein sequence:

>648_residues
MGIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIEIDKGGSKLIKIRDNGSGIPKDELALALSRHATSKL
HSLDDLEAILSFGFRGEALASISSVSRLTLTSRTAEQTEAWQAYAEGADMAVKVMPAAHPVGSTIEVVDLFFNTPARRRF
LKSDKTEFTHIDEWLKRIALVRGDIHFTLTHNGKIVRNCRPAMNEPQYLQRLTQVAGRQFADEALRVECQHDDLRLSGYL
QSPWSTVLTDTHYFYVNGRLVRDRLVNHAVRQAFAQKAEVEQPGYVLMLDIDPHQVDVNVHPAKHEVRFHQSRYVHDYIL
QALQSALEEAGELGFERPFEPSSPQIRDEASLSETGAQTQTEHHAFELQSPESKTHSTWNEASRVDTSRAETSRESRIDS
PLGERTRDIASARPYAGVQSNAYGSMAVPRESRSGSAGESRARAELPSKVAIASYGELLQTPSYSVQDKPYQPVLAMPAI
LNGQYWVLAQGQNLSLLPIQSVALATRSHEVETKLATGLIGQPLLMPVSIAADTDWPALLEEHETLIRQLGLELTIRYQQ
LIIKKVPPYLRDSQLAKVIPEWLQSLRFEAPAPNALAVWLAEQSLTGFTSAADIWAAYCQLTEEKRQQIADKAVSLPWQS
WLEEQASE

Sequences:

>Translated_648_residues
MGIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIEIDKGGSKLIKIRDNGSGIPKDELALALSRHATSKL
HSLDDLEAILSFGFRGEALASISSVSRLTLTSRTAEQTEAWQAYAEGADMAVKVMPAAHPVGSTIEVVDLFFNTPARRRF
LKSDKTEFTHIDEWLKRIALVRGDIHFTLTHNGKIVRNCRPAMNEPQYLQRLTQVAGRQFADEALRVECQHDDLRLSGYL
QSPWSTVLTDTHYFYVNGRLVRDRLVNHAVRQAFAQKAEVEQPGYVLMLDIDPHQVDVNVHPAKHEVRFHQSRYVHDYIL
QALQSALEEAGELGFERPFEPSSPQIRDEASLSETGAQTQTEHHAFELQSPESKTHSTWNEASRVDTSRAETSRESRIDS
PLGERTRDIASARPYAGVQSNAYGSMAVPRESRSGSAGESRARAELPSKVAIASYGELLQTPSYSVQDKPYQPVLAMPAI
LNGQYWVLAQGQNLSLLPIQSVALATRSHEVETKLATGLIGQPLLMPVSIAADTDWPALLEEHETLIRQLGLELTIRYQQ
LIIKKVPPYLRDSQLAKVIPEWLQSLRFEAPAPNALAVWLAEQSLTGFTSAADIWAAYCQLTEEKRQQIADKAVSLPWQS
WLEEQASE
>Mature_647_residues
GIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIEIDKGGSKLIKIRDNGSGIPKDELALALSRHATSKLH
SLDDLEAILSFGFRGEALASISSVSRLTLTSRTAEQTEAWQAYAEGADMAVKVMPAAHPVGSTIEVVDLFFNTPARRRFL
KSDKTEFTHIDEWLKRIALVRGDIHFTLTHNGKIVRNCRPAMNEPQYLQRLTQVAGRQFADEALRVECQHDDLRLSGYLQ
SPWSTVLTDTHYFYVNGRLVRDRLVNHAVRQAFAQKAEVEQPGYVLMLDIDPHQVDVNVHPAKHEVRFHQSRYVHDYILQ
ALQSALEEAGELGFERPFEPSSPQIRDEASLSETGAQTQTEHHAFELQSPESKTHSTWNEASRVDTSRAETSRESRIDSP
LGERTRDIASARPYAGVQSNAYGSMAVPRESRSGSAGESRARAELPSKVAIASYGELLQTPSYSVQDKPYQPVLAMPAIL
NGQYWVLAQGQNLSLLPIQSVALATRSHEVETKLATGLIGQPLLMPVSIAADTDWPALLEEHETLIRQLGLELTIRYQQL
IIKKVPPYLRDSQLAKVIPEWLQSLRFEAPAPNALAVWLAEQSLTGFTSAADIWAAYCQLTEEKRQQIADKAVSLPWQSW
LEEQASE

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=328, Percent_Identity=35.6707317073171, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI4505911, Length=326, Percent_Identity=28.5276073619632, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI189458898, Length=318, Percent_Identity=28.9308176100629, Blast_Score=143, Evalue=5e-34,
Organism=Homo sapiens, GI189458896, Length=317, Percent_Identity=27.7602523659306, Blast_Score=133, Evalue=6e-31,
Organism=Homo sapiens, GI4505913, Length=341, Percent_Identity=27.5659824046921, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI310128478, Length=340, Percent_Identity=27.6470588235294, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI263191589, Length=234, Percent_Identity=29.9145299145299, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI310128480, Length=302, Percent_Identity=24.1721854304636, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI91992160, Length=264, Percent_Identity=25.7575757575758, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI91992162, Length=264, Percent_Identity=25.7575757575758, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI1790612, Length=621, Percent_Identity=47.6650563607085, Blast_Score=478, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI71991825, Length=324, Percent_Identity=35.4938271604938, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17562796, Length=345, Percent_Identity=26.6666666666667, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323819, Length=440, Percent_Identity=32.0454545454545, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6324247, Length=422, Percent_Identity=26.5402843601896, Blast_Score=110, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6325093, Length=458, Percent_Identity=25.3275109170306, Blast_Score=104, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6323063, Length=366, Percent_Identity=25.1366120218579, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI17136968, Length=439, Percent_Identity=33.2574031890661, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI17136970, Length=355, Percent_Identity=26.1971830985915, Blast_Score=112, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_SHESA (A0KSR5)

Other databases:

- EMBL:   CP000469
- RefSeq:   YP_868240.1
- ProteinModelPortal:   A0KSR5
- STRING:   A0KSR5
- GeneID:   4476630
- GenomeReviews:   CP000469_GR
- KEGG:   shn:Shewana3_0595
- NMPDR:   fig|94122.5.peg.740
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   FTHIDEW
- PhylomeDB:   A0KSR5
- ProtClustDB:   PRK00095
- BioCyc:   SSP94122:SHEWANA3_0595-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 72089; Mature: 71958

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIEIDKGGSKLIKIRDNG
CCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECCC
SGIPKDELALALSRHATSKLHSLDDLEAILSFGFRGEALASISSVSRLTLTSRTAEQTEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEECCCHHHHHH
WQAYAEGADMAVKVMPAAHPVGSTIEVVDLFFNTPARRRFLKSDKTEFTHIDEWLKRIAL
HHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHH
VRGDIHFTLTHNGKIVRNCRPAMNEPQYLQRLTQVAGRQFADEALRVECQHDDLRLSGYL
HCCCEEEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEECEE
QSPWSTVLTDTHYFYVNGRLVRDRLVNHAVRQAFAQKAEVEQPGYVLMLDIDPHQVDVNV
CCCHHHHHCCCEEEEECCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEE
HPAKHEVRFHQSRYVHDYILQALQSALEEAGELGFERPFEPSSPQIRDEASLSETGAQTQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCC
TEHHAFELQSPESKTHSTWNEASRVDTSRAETSRESRIDSPLGERTRDIASARPYAGVQS
HHHCEEEECCCCCHHCCCHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCC
NAYGSMAVPRESRSGSAGESRARAELPSKVAIASYGELLQTPSYSVQDKPYQPVLAMPAI
CCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHCHHH
LNGQYWVLAQGQNLSLLPIQSVALATRSHEVETKLATGLIGQPLLMPVSIAADTDWPALL
CCCCEEEEECCCCCEEEEHHHHHHHHHCHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHH
EEHETLIRQLGLELTIRYQQLIIKKVPPYLRDSQLAKVIPEWLQSLRFEAPAPNALAVWL
HHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
AEQSLTGFTSAADIWAAYCQLTEEKRQQIADKAVSLPWQSWLEEQASE
EHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
>Mature Secondary Structure 
GIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIEIDKGGSKLIKIRDNG
CCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECCC
SGIPKDELALALSRHATSKLHSLDDLEAILSFGFRGEALASISSVSRLTLTSRTAEQTEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEECCCHHHHHH
WQAYAEGADMAVKVMPAAHPVGSTIEVVDLFFNTPARRRFLKSDKTEFTHIDEWLKRIAL
HHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHH
VRGDIHFTLTHNGKIVRNCRPAMNEPQYLQRLTQVAGRQFADEALRVECQHDDLRLSGYL
HCCCEEEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEECEE
QSPWSTVLTDTHYFYVNGRLVRDRLVNHAVRQAFAQKAEVEQPGYVLMLDIDPHQVDVNV
CCCHHHHHCCCEEEEECCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEE
HPAKHEVRFHQSRYVHDYILQALQSALEEAGELGFERPFEPSSPQIRDEASLSETGAQTQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCC
TEHHAFELQSPESKTHSTWNEASRVDTSRAETSRESRIDSPLGERTRDIASARPYAGVQS
HHHCEEEECCCCCHHCCCHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCC
NAYGSMAVPRESRSGSAGESRARAELPSKVAIASYGELLQTPSYSVQDKPYQPVLAMPAI
CCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHCHHH
LNGQYWVLAQGQNLSLLPIQSVALATRSHEVETKLATGLIGQPLLMPVSIAADTDWPALL
CCCCEEEEECCCCCEEEEHHHHHHHHHCHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHH
EEHETLIRQLGLELTIRYQQLIIKKVPPYLRDSQLAKVIPEWLQSLRFEAPAPNALAVWL
HHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
AEQSLTGFTSAADIWAAYCQLTEEKRQQIADKAVSLPWQSWLEEQASE
EHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA