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The map label for this gene is gppA [H]

Identifier: 117918868

GI number: 117918868

Start: 470567

End: 471493

Strand: Direct

Name: gppA [H]

Synonym: Shewana3_0411

Alternate gene names: 117918868

Gene position: 470567-471493 (Clockwise)

Preceding gene: 117918867

Following gene: 117918877

Centisome position: 9.46

GC content: 48.33

Gene sequence:

>927_bases
ATGCCAACACCCGCTTATGCCGCCATTACTTTAGGCTCTAATAGCTTTAATATGCTGATCGCTAAGACAAAAGGCGGTCA
GCCACAGATTATTGCTAAATACAAACGTAAAGTAAGGTTAGCCGAAGGCATTGGCGAAGATGGTCATTTAACCGCAGAAG
TGATGCAGCGTGGCCTAGATTGTCTAGCGATGTTTGCCCAAATGTTGGCGCTGCATAAAATCCATCCTAATCATGTCGCT
GTGATTGCCACCGCGACACTGCGCTGTATCCATAATGCCGATGAGTTTAATCAAAAGGCTATTCCGCTCTTGGGTCATCC
GATTGAGATTATCTCAGGCATGCGTGAGGCTGAGCTTATTTATCAAGGCATGGTGGCGACCACTTGTGGCCAAGGTCGAC
GTTTAGTGATCGATATTGGTGGCGCGAGTACCGAGTTTATAATCGGTGATGGCCACCAAGTTCAGTTTAAGACTAGCTTA
CCCATGGGCAGCGTGACCTTTAACCGTCGCTTCTTTAACAATGCCCCGTTGCAAGAGCTCGATTTTGACGATGCCAAGCA
GGAAGTGTTCGAAGTCTTAGGTGAACATAGGCAAAGGTTAAAAGACTTAGGATGGCACTGTGTGGTGGGGGCTTCTGGCG
CGGTGCAATCTGTAGTCGAAGTCTTAATGCACCGTAAGCAGTCTGAAATCATTACTTTAGCTGTGTTGACACAGCTTAAA
GCGGAAATCCTTGCCGAAGAACATGCCAGCCTTATGGGGATTCTCGGCCTAAGTGCCGAACGCGCACCGACATTTGCTGC
AGGAGTGGCAATTTTACTCGCACTCTTTGAATTCTTGGGCATTGAGCAGTTGGCGCTATCAGGCGGCGCACTGCGTGAAG
GGGTGTTAGTGATGCTGGCGCAGCGAATTTTAGAAGAAGCGATTTAA

Upstream 100 bases:

>100_bases
ACGTAATTTACGTGAACGCTCAGGTGCAGGGCGACCACAAGGTGCCCATCGTAGTGGTGGACGTCCACCTCGCCATGACA
GGACGCGTAGACAGCCTTAA

Downstream 100 bases:

>100_bases
CTTCGGCTCCATTTTAAAAAGATAAAGGCCGCCAAGTGTAGACTTAGCGGCCTTTATTATTTAGCGACTCGAGATTACTT
TAAAATCTCGACTAAATCTT

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MPTPAYAAITLGSNSFNMLIAKTKGGQPQIIAKYKRKVRLAEGIGEDGHLTAEVMQRGLDCLAMFAQMLALHKIHPNHVA
VIATATLRCIHNADEFNQKAIPLLGHPIEIISGMREAELIYQGMVATTCGQGRRLVIDIGGASTEFIIGDGHQVQFKTSL
PMGSVTFNRRFFNNAPLQELDFDDAKQEVFEVLGEHRQRLKDLGWHCVVGASGAVQSVVEVLMHRKQSEIITLAVLTQLK
AEILAEEHASLMGILGLSAERAPTFAAGVAILLALFEFLGIEQLALSGGALREGVLVMLAQRILEEAI

Sequences:

>Translated_308_residues
MPTPAYAAITLGSNSFNMLIAKTKGGQPQIIAKYKRKVRLAEGIGEDGHLTAEVMQRGLDCLAMFAQMLALHKIHPNHVA
VIATATLRCIHNADEFNQKAIPLLGHPIEIISGMREAELIYQGMVATTCGQGRRLVIDIGGASTEFIIGDGHQVQFKTSL
PMGSVTFNRRFFNNAPLQELDFDDAKQEVFEVLGEHRQRLKDLGWHCVVGASGAVQSVVEVLMHRKQSEIITLAVLTQLK
AEILAEEHASLMGILGLSAERAPTFAAGVAILLALFEFLGIEQLALSGGALREGVLVMLAQRILEEAI
>Mature_307_residues
PTPAYAAITLGSNSFNMLIAKTKGGQPQIIAKYKRKVRLAEGIGEDGHLTAEVMQRGLDCLAMFAQMLALHKIHPNHVAV
IATATLRCIHNADEFNQKAIPLLGHPIEIISGMREAELIYQGMVATTCGQGRRLVIDIGGASTEFIIGDGHQVQFKTSLP
MGSVTFNRRFFNNAPLQELDFDDAKQEVFEVLGEHRQRLKDLGWHCVVGASGAVQSVVEVLMHRKQSEIITLAVLTQLKA
EILAEEHASLMGILGLSAERAPTFAAGVAILLALFEFLGIEQLALSGGALREGVLVMLAQRILEEAI

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=303, Percent_Identity=44.8844884488449, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1788848, Length=309, Percent_Identity=39.8058252427184, Blast_Score=209, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 33439; Mature: 33307

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTPAYAAITLGSNSFNMLIAKTKGGQPQIIAKYKRKVRLAEGIGEDGHLTAEVMQRGLD
CCCCCEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEHHHHHCCHH
CLAMFAQMLALHKIHPNHVAVIATATLRCIHNADEFNQKAIPLLGHPIEIISGMREAELI
HHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHCHHHCCCCCCCCCCCCHHHHCCCHHHHHH
YQGMVATTCGQGRRLVIDIGGASTEFIIGDGHQVQFKTSLPMGSVTFNRRFFNNAPLQEL
HHHHHHHHCCCCCEEEEEECCCCEEEEEECCCEEEEEECCCCCCEEECHHHCCCCCCCCC
DFDDAKQEVFEVLGEHRQRLKDLGWHCVVGASGAVQSVVEVLMHRKQSEIITLAVLTQLK
CCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
AEILAEEHASLMGILGLSAERAPTFAAGVAILLALFEFLGIEQLALSGGALREGVLVMLA
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHH
QRILEEAI
HHHHHHCC
>Mature Secondary Structure 
PTPAYAAITLGSNSFNMLIAKTKGGQPQIIAKYKRKVRLAEGIGEDGHLTAEVMQRGLD
CCCCEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEHHHHHCCHH
CLAMFAQMLALHKIHPNHVAVIATATLRCIHNADEFNQKAIPLLGHPIEIISGMREAELI
HHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHCHHHCCCCCCCCCCCCHHHHCCCHHHHHH
YQGMVATTCGQGRRLVIDIGGASTEFIIGDGHQVQFKTSLPMGSVTFNRRFFNNAPLQEL
HHHHHHHHCCCCCEEEEEECCCCEEEEEECCCEEEEEECCCCCCEEECHHHCCCCCCCCC
DFDDAKQEVFEVLGEHRQRLKDLGWHCVVGASGAVQSVVEVLMHRKQSEIITLAVLTQLK
CCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
AEILAEEHASLMGILGLSAERAPTFAAGVAILLALFEFLGIEQLALSGGALREGVLVMLA
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHH
QRILEEAI
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA