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The map label for this gene is ilvD [H]

Identifier: 117918815

GI number: 117918815

Start: 394196

End: 396055

Strand: Direct

Name: ilvD [H]

Synonym: Shewana3_0358

Alternate gene names: 117918815

Gene position: 394196-396055 (Clockwise)

Preceding gene: 117918814

Following gene: 117918816

Centisome position: 7.93

GC content: 55.86

Gene sequence:

>1860_bases
ATGCCAAAGTTACGTTCAGCAACCAGTACCGAAGGCCGCAATATGGCGGGTGCCCGTGCGCTATGGCGCGCCACAGGGGT
GAAAGACAATGATTTTGGTAAGCCGATTATTGCGATTGCCAACTCCTTTACTCAGTTTGTTCCCGGCCATGTGCACTTAA
AAGATATGGGCTCTCTGGTGGCGGACGCCATCGAAGAGGCGGGCGGTATCGCCAAGGAATTCAACACCATCGCTGTGGAT
GATGGTATCGCCATGGGCCACGGTGGCATGCTCTACAGTCTGCCTTCGCGGGAGCTTATCGCCGATAGCGTTGAGTATAT
GGTCAATGCCCACTGCGCCGATGCGCTGGTCTGTATATCTAACTGCGACAAAATCACCCCCGGCATGTTGATGGCGGCGC
TGCGCCTCAATATCCCCGTGGTGTTTGTGTCGGGTGGGCCGATGGAGGCGGGTAAAACCAAACTGTCGGACAAGCTTATC
AAGCTCGATTTAGTCGATGCTATGGTGGCGGCGGCCGACTCGAGTGTGAGCGATGAAGATAGCGCCAAAATTGAACGCAG
TGCTTGCCCTACATGTGGTTCCTGTTCGGGCATGTTTACCGCCAACTCGATGAACTGTTTAACCGAAGCTTTAGGTCTGT
CGCTGCCGGGCAACGGCTCCATGCTCGCGACCCATGCCGATCGCCGTGAGTTGTTTTTAGAAGCGGGCCGCCGCGTAATG
GCGCTGACCAAACGTTACTACGAACAAGATGATGCCTCTGCACTGCCACGCAACATCGCCAGCTTTAAAGCCTTTGAAAA
CGCCATGGCGCTAGATATCGCCATGGGTGGCTCCTCTAATACAGTGTTGCACTTATTGGCTGCGGCGCAGGAGGCGGACG
TGGCATTCACTATGGACGATATCGACCGTATGTCGCGCCAAGTGCCGCATCTGTGTAAGGTGGCGCCGTCGACCGCTAAA
TACCATATGGAAGATGTGCACCGCGCCGGTGGTGTGATGGGTATCTTAGGCGAGCTAGACCGCGCCGGACTGCTACATAC
CGATGTGCCACACGTTGCCGCCGATGCGGGGGGCAACCTCAAGTCGGTGCTCGCCAAGTACGATGTCATGCAAACCCAAG
ATGACAAAGTAAAACAATTCTTTATGGCGGGACCTGCGGGTATTCCTACCACTAAAGCCTTTAGCCAAGACTGCCGCTGG
CCATCGCTGGACGATGACAGACGTGAAGGTTGTATCCGCAGCCGCGAATTTGCCTTCAGCCAAGAGGGCGGTTTGGCCGT
GTTATCGGGTAATCTGGCCGACAATGGCTGTATTGTTAAAACGGCGGGTGTGGATGAATCGAATCTGACCTTTATCGGCA
GCGCTCGGGTGTACGAAAGCCAAGACGATGCAGTCGCTGGTATCTTAGGTGGCGAAGTGGTGGCGGGTGATGTGGTGGTG
ATTCGTTACGAAGGGCCAAAAGGCGGCCCAGGCATGCAAGAAATGTTGTATCCCACCAGTTACTTAAAATCCCGCGGTTT
AGGCAAGGCCTGCGCACTGATCACCGACGGCCGTTTCTCTGGTGGAACTTCCGGTTTATCCATCGGCCATGTGTCGCCTG
AGGCGGCGGCGGGCGGCACGATTGCCTTGATTGAAAACGGCGATCGCATCGAAATCGATATTCCTAAACGCAGTATCAAG
CTTGCGGTGAGTGATGCCGAGTTAGCGGCGCGCCGTGAAACCATGCTCGCCCGTGGGCCAATGGCGTGGAAACCGCTTTC
GCGTCAGCGTTATGTGTCGATGGCGCTCAAAGCCTACGCCATGCTTGCCACCAGTGCCGATAAGGGCGCGGTGCGCGATC
GCAGTAAGTTGGAGGACTGA

Upstream 100 bases:

>100_bases
CAACAAAAAGTACACGCATAAGCATCCAGTGGCAGCGGTATTAGCACTGCAGCAACGCCCTAAGGGCACGATTTTCGATT
TGAGATAAGGGATAGAGTCA

Downstream 100 bases:

>100_bases
TATGTTATCTCTCGCATCGTCGCAAACGGAGCAGGCTGAGGCGCAGGCCTCTCAGTCGAAGCCGGGCACTTCTGCCTTAG
AAAAGAGTCAGCTTGCGCAA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 619; Mature: 618

Protein sequence:

>619_residues
MPKLRSATSTEGRNMAGARALWRATGVKDNDFGKPIIAIANSFTQFVPGHVHLKDMGSLVADAIEEAGGIAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKLI
KLDLVDAMVAAADSSVSDEDSAKIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRVM
ALTKRYYEQDDASALPRNIASFKAFENAMALDIAMGGSSNTVLHLLAAAQEADVAFTMDDIDRMSRQVPHLCKVAPSTAK
YHMEDVHRAGGVMGILGELDRAGLLHTDVPHVAADAGGNLKSVLAKYDVMQTQDDKVKQFFMAGPAGIPTTKAFSQDCRW
PSLDDDRREGCIRSREFAFSQEGGLAVLSGNLADNGCIVKTAGVDESNLTFIGSARVYESQDDAVAGILGGEVVAGDVVV
IRYEGPKGGPGMQEMLYPTSYLKSRGLGKACALITDGRFSGGTSGLSIGHVSPEAAAGGTIALIENGDRIEIDIPKRSIK
LAVSDAELAARRETMLARGPMAWKPLSRQRYVSMALKAYAMLATSADKGAVRDRSKLED

Sequences:

>Translated_619_residues
MPKLRSATSTEGRNMAGARALWRATGVKDNDFGKPIIAIANSFTQFVPGHVHLKDMGSLVADAIEEAGGIAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKLI
KLDLVDAMVAAADSSVSDEDSAKIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRVM
ALTKRYYEQDDASALPRNIASFKAFENAMALDIAMGGSSNTVLHLLAAAQEADVAFTMDDIDRMSRQVPHLCKVAPSTAK
YHMEDVHRAGGVMGILGELDRAGLLHTDVPHVAADAGGNLKSVLAKYDVMQTQDDKVKQFFMAGPAGIPTTKAFSQDCRW
PSLDDDRREGCIRSREFAFSQEGGLAVLSGNLADNGCIVKTAGVDESNLTFIGSARVYESQDDAVAGILGGEVVAGDVVV
IRYEGPKGGPGMQEMLYPTSYLKSRGLGKACALITDGRFSGGTSGLSIGHVSPEAAAGGTIALIENGDRIEIDIPKRSIK
LAVSDAELAARRETMLARGPMAWKPLSRQRYVSMALKAYAMLATSADKGAVRDRSKLED
>Mature_618_residues
PKLRSATSTEGRNMAGARALWRATGVKDNDFGKPIIAIANSFTQFVPGHVHLKDMGSLVADAIEEAGGIAKEFNTIAVDD
GIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKLIK
LDLVDAMVAAADSSVSDEDSAKIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRVMA
LTKRYYEQDDASALPRNIASFKAFENAMALDIAMGGSSNTVLHLLAAAQEADVAFTMDDIDRMSRQVPHLCKVAPSTAKY
HMEDVHRAGGVMGILGELDRAGLLHTDVPHVAADAGGNLKSVLAKYDVMQTQDDKVKQFFMAGPAGIPTTKAFSQDCRWP
SLDDDRREGCIRSREFAFSQEGGLAVLSGNLADNGCIVKTAGVDESNLTFIGSARVYESQDDAVAGILGGEVVAGDVVVI
RYEGPKGGPGMQEMLYPTSYLKSRGLGKACALITDGRFSGGTSGLSIGHVSPEAAAGGTIALIENGDRIEIDIPKRSIKL
AVSDAELAARRETMLARGPMAWKPLSRQRYVSMALKAYAMLATSADKGAVRDRSKLED

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=617, Percent_Identity=79.902755267423, Blast_Score=1018, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=541, Percent_Identity=30.8687615526802, Blast_Score=189, Evalue=5e-49,
Organism=Escherichia coli, GI2367371, Length=513, Percent_Identity=31.1890838206628, Blast_Score=182, Evalue=8e-47,
Organism=Escherichia coli, GI1786464, Length=533, Percent_Identity=29.8311444652908, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322476, Length=611, Percent_Identity=36.8248772504092, Blast_Score=341, Evalue=2e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65615; Mature: 65483

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKLRSATSTEGRNMAGARALWRATGVKDNDFGKPIIAIANSFTQFVPGHVHLKDMGSLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
ADAIEEAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKLIKLDLVDAMVAAADSSVSDED
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCH
SAKIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRVM
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHCCHHH
ALTKRYYEQDDASALPRNIASFKAFENAMALDIAMGGSSNTVLHLLAAAQEADVAFTMDD
HHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCEEEEHHH
IDRMSRQVPHLCKVAPSTAKYHMEDVHRAGGVMGILGELDRAGLLHTDVPHVAADAGGNL
HHHHHHHCCHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCEECCCCCHHHCCCCCH
KSVLAKYDVMQTQDDKVKQFFMAGPAGIPTTKAFSQDCRWPSLDDDRREGCIRSREFAFS
HHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
QEGGLAVLSGNLADNGCIVKTAGVDESNLTFIGSARVYESQDDAVAGILGGEVVAGDVVV
CCCCEEEEECCCCCCCEEEEECCCCCCCEEEEECCEEECCCCCCEEEEECCCEEECCEEE
IRYEGPKGGPGMQEMLYPTSYLKSRGLGKACALITDGRFSGGTSGLSIGHVSPEAAAGGT
EEECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCE
IALIENGDRIEIDIPKRSIKLAVSDAELAARRETMLARGPMAWKPLSRQRYVSMALKAYA
EEEEECCCEEEEECCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
MLATSADKGAVRDRSKLED
HHHCCCCCCCCCCHHHCCC
>Mature Secondary Structure 
PKLRSATSTEGRNMAGARALWRATGVKDNDFGKPIIAIANSFTQFVPGHVHLKDMGSLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
ADAIEEAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKLIKLDLVDAMVAAADSSVSDED
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCH
SAKIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRVM
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHCCHHH
ALTKRYYEQDDASALPRNIASFKAFENAMALDIAMGGSSNTVLHLLAAAQEADVAFTMDD
HHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCEEEEHHH
IDRMSRQVPHLCKVAPSTAKYHMEDVHRAGGVMGILGELDRAGLLHTDVPHVAADAGGNL
HHHHHHHCCHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCEECCCCCHHHCCCCCH
KSVLAKYDVMQTQDDKVKQFFMAGPAGIPTTKAFSQDCRWPSLDDDRREGCIRSREFAFS
HHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
QEGGLAVLSGNLADNGCIVKTAGVDESNLTFIGSARVYESQDDAVAGILGGEVVAGDVVV
CCCCEEEEECCCCCCCEEEEECCCCCCCEEEEECCEEECCCCCCEEEEECCCEEECCEEE
IRYEGPKGGPGMQEMLYPTSYLKSRGLGKACALITDGRFSGGTSGLSIGHVSPEAAAGGT
EEECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCE
IALIENGDRIEIDIPKRSIKLAVSDAELAARRETMLARGPMAWKPLSRQRYVSMALKAYA
EEEEECCCEEEEECCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
MLATSADKGAVRDRSKLED
HHHCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA