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The map label for this gene is ilvA [H]

Identifier: 117918816

GI number: 117918816

Start: 396057

End: 397700

Strand: Direct

Name: ilvA [H]

Synonym: Shewana3_0359

Alternate gene names: 117918816

Gene position: 396057-397700 (Clockwise)

Preceding gene: 117918815

Following gene: 117918817

Centisome position: 7.97

GC content: 53.77

Gene sequence:

>1644_bases
ATGTTATCTCTCGCATCGTCGCAAACGGAGCAGGCTGAGGCGCAGGCCTCTCAGTCGAAGCCGGGCACTTCTGCCTTAGA
AAAGAGTCAGCTTGCGCAAAGCTACCTGCAAAAAATCCTGCTGTCGTCGGTTTATGACGTTGCGAAAGTGACGCCACTCT
CGAGCCTGAATAAACTTTCGGCGCGTTTGGGCTGCCAAGTATTTTTAAAGCGTGAGGATATGCAGCCAGTGCATTCCTTC
AAGTTGCGCGGCGCCTATAACCGTATCGCCCAGTTAAGCCAAGCCGAATGTCAACGCGGCGTAGTGTGCGCCTCGGCGGG
TAACCATGCTCAAGGCGTGGCCATGTCGGCGGCCAGTCGTGGTGTGGATGCTGTGATTGTGATGCCCGAAACTACGCCGG
ATATCAAAGTCGATGCTGTGCGCCGCTTGGGCGGCAACGTAGTGTTGCACGGCCAAGCCTTCGATCAGGCCAATGGCTTT
GCGATGGAGATGGCAAAGCTGGAGGGTCGGGTGTATATCGCCCCCTTCGATGACGAAGCCGTTATCGCAGGCCAAGGCAC
TATCGCCCAAGAAATGCTGCAACAGCAGCGCGACCTTGAAGTGGTATTTGTGCCCGTGGGCGGCGGTGGCTTAATTGCTG
GGATTGCGGCCTATTACAAGGCGGTGATGCCACAGGTCAAAATTGTTGGGGTGGAGCCTGAAGATGCGGCTTGCTTAAAA
GCGGCGATGGAGGCGGGCGAGCCTGTCACACTTGCGCAAGTTGGCTTGTTTGCCGATGGGGTCGCGGTTAAACGTATCGG
CACAGAGCCATTTCGCTTAGCTAAGTGGTTTGTGGATGAAGTGGTGACGGTAACGTCCGACGAAATCTGCGCTGCTGTAA
AAGATATTTTTGAGGATACCCGCGCCATTGCCGAACCTGCTGGCGCCTTATCCCTTGCGGGGCTTAAAAAATACGTCAGC
ACCAATGCCGCAGGCGAGAGTGGCAAGGGGGAAAAAGTCGCGGCGATATTAAGTGGCGCGAATGTGAACTTCCATAGCCT
ACGTTATGTATCGGAGCGCTGCGAGTTGGGTGAGCAAAAAGAAGCCGTGCTGGCGGTTAAAGTGCCCGAGCGTCCCGGCA
GCTTCCTGCGTTTTTGTGAGTTGCTCGAAAAGCGGGTGATGACCGAATTTAACTATCGCTTTAGTAGCCGCGATATGGCG
GTGGTGTTTGCGGGTATTCGTCTGACCAAAGGCCATGGCGAATTAGAGCAGATCATCAATACCTTAGAAGATAATGGCTT
CGAGGTGCAGGACTTATCCGGTGACGAAACCGCGAAATTGCATGTGCGTTATATGGTCGGTGGTCATCCGCCAGAGCCGT
TAGAGGAGCGCCTATTTAGCTTCGAGTTTCCCGAGCATCCGGGGGCGCTGCTGAAGTTTTTAACTACCCTGCAGAGCAAG
TGGAATATCAGTTTATTCCATTACCGTAATCACGGCGCGGCCTTTGGGCGAGTGCTGGCGGGGTTCGAAGTTCCCGAGGG
CGATGCCTTGCCGTTTCAGCAGTTTTTAACTGAGCTGGGATTTGTCTATCAAGAAGAGACGCAAAGCCCTGCTTATCAAC
TATTTTTGAATGCTGGAAAAGGAAAAAAGAGCCTGCCTTTGTAA

Upstream 100 bases:

>100_bases
CGTCAGCGTTATGTGTCGATGGCGCTCAAAGCCTACGCCATGCTTGCCACCAGTGCCGATAAGGGCGCGGTGCGCGATCG
CAGTAAGTTGGAGGACTGAT

Downstream 100 bases:

>100_bases
TCACTTAGCTTTAGGTTACAACTTAGGCTAAAGGAGGGGCGCACAGGCGCCCCTTTTTGTGGTAGTTTGGTTTAACAAGT
TAAGAGTGAATGCTCTAGTC

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MLSLASSQTEQAEAQASQSKPGTSALEKSQLAQSYLQKILLSSVYDVAKVTPLSSLNKLSARLGCQVFLKREDMQPVHSF
KLRGAYNRIAQLSQAECQRGVVCASAGNHAQGVAMSAASRGVDAVIVMPETTPDIKVDAVRRLGGNVVLHGQAFDQANGF
AMEMAKLEGRVYIAPFDDEAVIAGQGTIAQEMLQQQRDLEVVFVPVGGGGLIAGIAAYYKAVMPQVKIVGVEPEDAACLK
AAMEAGEPVTLAQVGLFADGVAVKRIGTEPFRLAKWFVDEVVTVTSDEICAAVKDIFEDTRAIAEPAGALSLAGLKKYVS
TNAAGESGKGEKVAAILSGANVNFHSLRYVSERCELGEQKEAVLAVKVPERPGSFLRFCELLEKRVMTEFNYRFSSRDMA
VVFAGIRLTKGHGELEQIINTLEDNGFEVQDLSGDETAKLHVRYMVGGHPPEPLEERLFSFEFPEHPGALLKFLTTLQSK
WNISLFHYRNHGAAFGRVLAGFEVPEGDALPFQQFLTELGFVYQEETQSPAYQLFLNAGKGKKSLPL

Sequences:

>Translated_547_residues
MLSLASSQTEQAEAQASQSKPGTSALEKSQLAQSYLQKILLSSVYDVAKVTPLSSLNKLSARLGCQVFLKREDMQPVHSF
KLRGAYNRIAQLSQAECQRGVVCASAGNHAQGVAMSAASRGVDAVIVMPETTPDIKVDAVRRLGGNVVLHGQAFDQANGF
AMEMAKLEGRVYIAPFDDEAVIAGQGTIAQEMLQQQRDLEVVFVPVGGGGLIAGIAAYYKAVMPQVKIVGVEPEDAACLK
AAMEAGEPVTLAQVGLFADGVAVKRIGTEPFRLAKWFVDEVVTVTSDEICAAVKDIFEDTRAIAEPAGALSLAGLKKYVS
TNAAGESGKGEKVAAILSGANVNFHSLRYVSERCELGEQKEAVLAVKVPERPGSFLRFCELLEKRVMTEFNYRFSSRDMA
VVFAGIRLTKGHGELEQIINTLEDNGFEVQDLSGDETAKLHVRYMVGGHPPEPLEERLFSFEFPEHPGALLKFLTTLQSK
WNISLFHYRNHGAAFGRVLAGFEVPEGDALPFQQFLTELGFVYQEETQSPAYQLFLNAGKGKKSLPL
>Mature_547_residues
MLSLASSQTEQAEAQASQSKPGTSALEKSQLAQSYLQKILLSSVYDVAKVTPLSSLNKLSARLGCQVFLKREDMQPVHSF
KLRGAYNRIAQLSQAECQRGVVCASAGNHAQGVAMSAASRGVDAVIVMPETTPDIKVDAVRRLGGNVVLHGQAFDQANGF
AMEMAKLEGRVYIAPFDDEAVIAGQGTIAQEMLQQQRDLEVVFVPVGGGGLIAGIAAYYKAVMPQVKIVGVEPEDAACLK
AAMEAGEPVTLAQVGLFADGVAVKRIGTEPFRLAKWFVDEVVTVTSDEICAAVKDIFEDTRAIAEPAGALSLAGLKKYVS
TNAAGESGKGEKVAAILSGANVNFHSLRYVSERCELGEQKEAVLAVKVPERPGSFLRFCELLEKRVMTEFNYRFSSRDMA
VVFAGIRLTKGHGELEQIINTLEDNGFEVQDLSGDETAKLHVRYMVGGHPPEPLEERLFSFEFPEHPGALLKFLTTLQSK
WNISLFHYRNHGAAFGRVLAGFEVPEGDALPFQQFLTELGFVYQEETQSPAYQLFLNAGKGKKSLPL

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=340, Percent_Identity=32.3529411764706, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI19923959, Length=308, Percent_Identity=30.8441558441558, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI33469958, Length=310, Percent_Identity=28.0645161290323, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI295821202, Length=338, Percent_Identity=27.810650887574, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI295821200, Length=338, Percent_Identity=27.810650887574, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI4557415, Length=338, Percent_Identity=27.810650887574, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1790207, Length=521, Percent_Identity=58.3493282149712, Blast_Score=596, Evalue=1e-171,
Organism=Escherichia coli, GI1789505, Length=306, Percent_Identity=37.9084967320261, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1789235, Length=257, Percent_Identity=25.2918287937743, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI2367138, Length=206, Percent_Identity=28.1553398058252, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71991565, Length=327, Percent_Identity=35.474006116208, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17537387, Length=328, Percent_Identity=31.0975609756098, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17508781, Length=255, Percent_Identity=29.4117647058824, Blast_Score=115, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6320930, Length=513, Percent_Identity=50.682261208577, Blast_Score=474, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6322631, Length=303, Percent_Identity=35.973597359736, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6319788, Length=297, Percent_Identity=25.9259259259259, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21355833, Length=319, Percent_Identity=33.8557993730408, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24645328, Length=255, Percent_Identity=34.1176470588235, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24643623, Length=207, Percent_Identity=28.9855072463768, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI20129101, Length=207, Percent_Identity=28.9855072463768, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 59268; Mature: 59268

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSLASSQTEQAEAQASQSKPGTSALEKSQLAQSYLQKILLSSVYDVAKVTPLSSLNKLS
CCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ARLGCQVFLKREDMQPVHSFKLRGAYNRIAQLSQAECQRGVVCASAGNHAQGVAMSAASR
HHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHCC
GVDAVIVMPETTPDIKVDAVRRLGGNVVLHGQAFDQANGFAMEMAKLEGRVYIAPFDDEA
CCCEEEEECCCCCCCHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHCCEEEEEECCCCE
VIAGQGTIAQEMLQQQRDLEVVFVPVGGGGLIAGIAAYYKAVMPQVKIVGVEPEDAACLK
EEECCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHH
AAMEAGEPVTLAQVGLFADGVAVKRIGTEPFRLAKWFVDEVVTVTSDEICAAVKDIFEDT
HHHHCCCCEEHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
RAIAEPAGALSLAGLKKYVSTNAAGESGKGEKVAAILSGANVNFHSLRYVSERCELGEQK
HHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCC
EAVLAVKVPERPGSFLRFCELLEKRVMTEFNYRFSSRDMAVVFAGIRLTKGHGELEQIIN
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEECCCCHHHHHHH
TLEDNGFEVQDLSGDETAKLHVRYMVGGHPPEPLEERLFSFEFPEHPGALLKFLTTLQSK
HHHCCCEEEEECCCCCEEEEEEEEEECCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCC
WNISLFHYRNHGAAFGRVLAGFEVPEGDALPFQQFLTELGFVYQEETQSPAYQLFLNAGK
CCEEEEEEECCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHCCCCCEEEEEEECCC
GKKSLPL
CCCCCCC
>Mature Secondary Structure
MLSLASSQTEQAEAQASQSKPGTSALEKSQLAQSYLQKILLSSVYDVAKVTPLSSLNKLS
CCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ARLGCQVFLKREDMQPVHSFKLRGAYNRIAQLSQAECQRGVVCASAGNHAQGVAMSAASR
HHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHCC
GVDAVIVMPETTPDIKVDAVRRLGGNVVLHGQAFDQANGFAMEMAKLEGRVYIAPFDDEA
CCCEEEEECCCCCCCHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHCCEEEEEECCCCE
VIAGQGTIAQEMLQQQRDLEVVFVPVGGGGLIAGIAAYYKAVMPQVKIVGVEPEDAACLK
EEECCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHH
AAMEAGEPVTLAQVGLFADGVAVKRIGTEPFRLAKWFVDEVVTVTSDEICAAVKDIFEDT
HHHHCCCCEEHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
RAIAEPAGALSLAGLKKYVSTNAAGESGKGEKVAAILSGANVNFHSLRYVSERCELGEQK
HHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCC
EAVLAVKVPERPGSFLRFCELLEKRVMTEFNYRFSSRDMAVVFAGIRLTKGHGELEQIIN
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEECCCCHHHHHHH
TLEDNGFEVQDLSGDETAKLHVRYMVGGHPPEPLEERLFSFEFPEHPGALLKFLTTLQSK
HHHCCCEEEEECCCCCEEEEEEEEEECCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCC
WNISLFHYRNHGAAFGRVLAGFEVPEGDALPFQQFLTELGFVYQEETQSPAYQLFLNAGK
CCEEEEEEECCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHCCCCCEEEEEEECCC
GKKSLPL
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]