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The map label for this gene is kynU [H]

Identifier: 117918752

GI number: 117918752

Start: 328100

End: 329221

Strand: Direct

Name: kynU [H]

Synonym: Shewana3_0295

Alternate gene names: 117918752

Gene position: 328100-329221 (Clockwise)

Preceding gene: 117918751

Following gene: 117918758

Centisome position: 6.6

GC content: 52.23

Gene sequence:

>1122_bases
ATGCTGCTAAATGTAAAACAAGACTTTTGCCTCGCAGGCCCAGGCTATTTGCTTAACCATTCAGTGGGGCGGCCACTCAA
ATCGACCGAACAGGCATTTAAGCAGGCATTTTTTGCGCCCTGGCAAGAGTCTGGCCGCGAGCCTTGGGGTCAATGGTTGG
GCGTCATCGATAACTTTACCGCGGCGCTGGCGAGCCTATTCAATGGTCAACCACAGGATTTTTGCCCGCAGGTGAATCTA
TCGAGCGCATTGACCAAAATTGTGATGTCCCTCGATAGATTAAATCGCGATGGCGCCGTGGTGCTGATGAGCGAGATTGA
TTTTCCCAGCATGGGGTTTGCCCTGAAAAAGGCATTGCCCGCAAGCTGTGAATTGCGCTTTATTCCCAAGGGTTTAGATG
TCACCGACCCCAATGTGTGGGACGCGCATATTTGTGCCGATGTCGATTTAGTCTTTGTTAGCCATGCTTATTCCAATACG
GGTCAGCAGGCGCCATTGGCGCAGATCATTCCCCTTGCCCGTGAGCGTGGCTGCTTGAGCCTAGTGGATGTGGCGCAATC
GGCTGGGGTTTTGCCGCTGGATTTAGCCAAGCTACAGCCGGACTTTATGATTGGTTCGAGTGTGAAATGGTTATGCTCAG
GCCCTGGGGCTGCGTATCTGTGGGTCAATCCGGCGATTTTGCCCCAGTGTCAGCCGCAGGATGTGGGTTGGTTTAGCCAT
GAAAATCCCTTCGACTTTGATATCCATGATTTTCGCTATCACCCAACTGCGCTGCGGTTTTGGGGTGGTACACCTTCTAT
CGCGCCCTATGCGATTGCTGCCCACAGCATTCAATATTTTGCCAATATTGGCTCACAGGCGATGCGTGAACATAACTTGC
AGTTGATGGAGGCAGTTGTACAGACATTAGAGCCTGAGTTGGTCTCGCCGCGGGAAGCCGATAAACGCAGTGGCACCTTG
ATCCTACAATTTGGCGAGCGCCAAGCACCCATCATGGCGGCGTTGGCGGAGGCGAATATCAGTGTCGATGCCCGCAGTTT
AGGAATACGCGTATCGCCGCATATCTATAACGATGAGGCCGATATCGCGAAATTGCTGGAGGTAATAAGAGCCCATCGTT
AA

Upstream 100 bases:

>100_bases
CTCGAGCGCTTAAGGGATAGACGCGCCGCGGTGTTGCGACACGATATTCGCACCCGTTATCACGATCTGAAGAAACTCAA
AGACAGTTTAAGGTAAGGTC

Downstream 100 bases:

>100_bases
CGGATTGAACAGGGCTTGCTCGAAGCGGCTATGAATGGGGTGCGCTAAGTCGACCTAGTTACCCCAATGCCGATATAACA
TCAACCCTTAGTCTCACTGG

Product: aminotransferase, class V

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MLLNVKQDFCLAGPGYLLNHSVGRPLKSTEQAFKQAFFAPWQESGREPWGQWLGVIDNFTAALASLFNGQPQDFCPQVNL
SSALTKIVMSLDRLNRDGAVVLMSEIDFPSMGFALKKALPASCELRFIPKGLDVTDPNVWDAHICADVDLVFVSHAYSNT
GQQAPLAQIIPLARERGCLSLVDVAQSAGVLPLDLAKLQPDFMIGSSVKWLCSGPGAAYLWVNPAILPQCQPQDVGWFSH
ENPFDFDIHDFRYHPTALRFWGGTPSIAPYAIAAHSIQYFANIGSQAMREHNLQLMEAVVQTLEPELVSPREADKRSGTL
ILQFGERQAPIMAALAEANISVDARSLGIRVSPHIYNDEADIAKLLEVIRAHR

Sequences:

>Translated_373_residues
MLLNVKQDFCLAGPGYLLNHSVGRPLKSTEQAFKQAFFAPWQESGREPWGQWLGVIDNFTAALASLFNGQPQDFCPQVNL
SSALTKIVMSLDRLNRDGAVVLMSEIDFPSMGFALKKALPASCELRFIPKGLDVTDPNVWDAHICADVDLVFVSHAYSNT
GQQAPLAQIIPLARERGCLSLVDVAQSAGVLPLDLAKLQPDFMIGSSVKWLCSGPGAAYLWVNPAILPQCQPQDVGWFSH
ENPFDFDIHDFRYHPTALRFWGGTPSIAPYAIAAHSIQYFANIGSQAMREHNLQLMEAVVQTLEPELVSPREADKRSGTL
ILQFGERQAPIMAALAEANISVDARSLGIRVSPHIYNDEADIAKLLEVIRAHR
>Mature_373_residues
MLLNVKQDFCLAGPGYLLNHSVGRPLKSTEQAFKQAFFAPWQESGREPWGQWLGVIDNFTAALASLFNGQPQDFCPQVNL
SSALTKIVMSLDRLNRDGAVVLMSEIDFPSMGFALKKALPASCELRFIPKGLDVTDPNVWDAHICADVDLVFVSHAYSNT
GQQAPLAQIIPLARERGCLSLVDVAQSAGVLPLDLAKLQPDFMIGSSVKWLCSGPGAAYLWVNPAILPQCQPQDVGWFSH
ENPFDFDIHDFRYHPTALRFWGGTPSIAPYAIAAHSIQYFANIGSQAMREHNLQLMEAVVQTLEPELVSPREADKRSGTL
ILQFGERQAPIMAALAEANISVDARSLGIRVSPHIYNDEADIAKLLEVIRAHR

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17550466, Length=394, Percent_Identity=22.5888324873096, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 41060; Mature: 41060

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00591 GLYCOSYL_HYDROL_F10

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLNVKQDFCLAGPGYLLNHSVGRPLKSTEQAFKQAFFAPWQESGREPWGQWLGVIDNFT
CEECCCCCCEECCCCHHCCCCCCCCHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHH
AALASLFNGQPQDFCPQVNLSSALTKIVMSLDRLNRDGAVVLMSEIDFPSMGFALKKALP
HHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHCCC
ASCELRFIPKGLDVTDPNVWDAHICADVDLVFVSHAYSNTGQQAPLAQIIPLARERGCLS
CCCEEEEECCCCCCCCCCCCCHHHHCCCEEEEEEHHHCCCCCCCCHHHHHHHHHCCCCHH
LVDVAQSAGVLPLDLAKLQPDFMIGSSVKWLCSGPGAAYLWVNPAILPQCQPQDVGWFSH
HHHHHHHCCCCEEHHHHCCCCEEECCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCCC
ENPFDFDIHDFRYHPTALRFWGGTPSIAPYAIAAHSIQYFANIGSQAMREHNLQLMEAVV
CCCCCCCCCCCEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QTLEPELVSPREADKRSGTLILQFGERQAPIMAALAEANISVDARSLGIRVSPHIYNDEA
HHCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCEEEHHHCCEEECCCEECCHH
DIAKLLEVIRAHR
HHHHHHHHHHCCC
>Mature Secondary Structure
MLLNVKQDFCLAGPGYLLNHSVGRPLKSTEQAFKQAFFAPWQESGREPWGQWLGVIDNFT
CEECCCCCCEECCCCHHCCCCCCCCHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHH
AALASLFNGQPQDFCPQVNLSSALTKIVMSLDRLNRDGAVVLMSEIDFPSMGFALKKALP
HHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHCCC
ASCELRFIPKGLDVTDPNVWDAHICADVDLVFVSHAYSNTGQQAPLAQIIPLARERGCLS
CCCEEEEECCCCCCCCCCCCCHHHHCCCEEEEEEHHHCCCCCCCCHHHHHHHHHCCCCHH
LVDVAQSAGVLPLDLAKLQPDFMIGSSVKWLCSGPGAAYLWVNPAILPQCQPQDVGWFSH
HHHHHHHCCCCEEHHHHCCCCEEECCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCCC
ENPFDFDIHDFRYHPTALRFWGGTPSIAPYAIAAHSIQYFANIGSQAMREHNLQLMEAVV
CCCCCCCCCCCEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QTLEPELVSPREADKRSGTLILQFGERQAPIMAALAEANISVDARSLGIRVSPHIYNDEA
HHCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCEEEHHHCCEEECCCEECCHH
DIAKLLEVIRAHR
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]