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The map label for this gene is typA [H]

Identifier: 117918758

GI number: 117918758

Start: 336865

End: 338676

Strand: Direct

Name: typA [H]

Synonym: Shewana3_0301

Alternate gene names: 117918758

Gene position: 336865-338676 (Clockwise)

Preceding gene: 117918752

Following gene: 117918760

Centisome position: 6.77

GC content: 49.72

Gene sequence:

>1812_bases
GTGCTAGAGAATTTACGTAACATCGCCATTATTGCGCACGTTGACCATGGCAAAACGACCCTGGTTGACAAGCTGCTGTC
GCAATCAGGAACCCTTGCAACCCGGGGAGAAGCTACTGAGCGGGTGATGGACTCCAACGATCTTGAAAAGGAACGTGGGA
TCACGATTCTGGCAAAGAATACTGCCATCAAGTGGAACGACTACCGCATTAACATCGTAGACACCCCAGGCCACGCCGAC
TTCGGTGGTGAGGTTGAGCGCGTGCTGTCTATGGTGGACTCAGTATTACTGCTGGTTGACGCCGTTGACGGTCCAATGCC
ACAGACTCGCTTCGTAACCAAGAAAGCGTTCGCCCAAGGCTTAAAGCCAATCGTTGTTATCAACAAGATTGACCGTCCTG
GTGCTCGCCCTGATTGGGTTATCGACCAAGTATTCGACCTGTTCGACAACTTAGGTGCGACTGACGAGCAATTAGATTTC
CCAGTGGTTTACGCTTCTGCGTTAAACGGCTTTGCAACCTTAGATCCGGACGAAGTTGGCACCGACATGACGCCACTGTT
CCAAACTATCGTTGAAAAAGTATCTTCACCTGCAGCTGACGCTGAAGGTCCATTCCAGATGCAAATTTCTCAGCTCGATT
ACAACTCATACGTGGGGGTTATCGGTGTTGGCCGCATCAAGCGTGGTAGCATCAAGACTAACCAACAAGTGACCGTGATC
GGCGCCGATGGTAAGACTCGTAACGGTAAAATGGGCCAAGTATTAGGTTACATGGGCTTAGAGCGTACCGAAGTTGACGT
AGCAAACGCTGGCGACATCGTAGCGATTACTGGTTTAGGTGAGCTGAAGATTTCTGACACTGTGTGTGCCGCAGGTAATG
TTGAAGCGCTGCCACCCCTGTCTGTTGACGAACCAACACTGACCATGACTTTCCAAGTCAACACTTCACCTTTCGCAGGT
AAAGAAGGTAAGTACGTGACTTCACGTAACATTCTTGAGCGTCTGCAACAAGAATTAGTGCACAACGTGGCACTGCGTGT
TGAAGAAACCGACAGCCCAGACCGTTTCGCGGTATCTGGCCGTGGTGAATTACACTTATCTATCCTGATCGAAAACATGC
GTCGTGAAGGTTACGAATTAGCGGTTTCTCGCCCAGAAGTTATCTTAAAAACCATCGATGGCGAACTGTGTGAGCCATAC
GAGACGCTGACCGTTGACGTTGAAGAAGAACATCAAGGTACAGTCATCGAGAAGCTGGGTGTACGTAAGGCTGAGATGAA
AGACATGCAGCTTGACGGTAAAGGCCGCGTGCGCGTTGACTTTATCATCCCAAGCCGTGGCTTAATCGGTTTCCAAACTG
AGTTCTTAACGGCAACTTCTGGTACTGGTCTGATTTACCACTCATTCGATCACTACGGTCCGCACAAAGGTGGCGACATT
GGTCAACGTGCGAACGGCGTATTGATCTCTAACGCGACCGGTAAGGCGCTAACATTCGCACTGTTCGGTCTGCAGGACCG
CGGTCGTCTGTTTATCGGCCACGCTGCCGAAGTTTACGAAGGTCAAGTTGTGGGTATCCACTCACGTTCTAACGACCTGA
CAGTTAACTGTCTGAAAGGTAAGCAGCTGACTAACATGCGTGCTTCTGGTACTGACGAAGCTCAAGTACTGACTACGCCA
ATCACCTTAACTCTTGAGCAAGCACTTGAGTTTATCGATGATGACGAATTAGTTGAAGTAACACCTAAGAGCATCCGTGT
TCGTAAGAAACACTTAACTGAAAACGACCGTAAGCGCGCTAGCCGCGGCTAA

Upstream 100 bases:

>100_bases
CTGGAGTAGAATGTCACGCTTTTTTATGGCGACTCAACGTAGATTGCTATAACGAATATTGAAATATCCCTATTTTTGTT
TGATGGTAAGAGGTTTATCC

Downstream 100 bases:

>100_bases
TGGTGGTTGTGTAGTCGCGTAAAGTGACTACACAGAGTGAATAAAGCCCCGCTAAGGCAACTTAGCGGGGCTTTTTTATC
AGCCTTCAATCCTCAATTCG

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: Tyrosine phosphorylated protein A [H]

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MLENLRNIAIIAHVDHGKTTLVDKLLSQSGTLATRGEATERVMDSNDLEKERGITILAKNTAIKWNDYRINIVDTPGHAD
FGGEVERVLSMVDSVLLLVDAVDGPMPQTRFVTKKAFAQGLKPIVVINKIDRPGARPDWVIDQVFDLFDNLGATDEQLDF
PVVYASALNGFATLDPDEVGTDMTPLFQTIVEKVSSPAADAEGPFQMQISQLDYNSYVGVIGVGRIKRGSIKTNQQVTVI
GADGKTRNGKMGQVLGYMGLERTEVDVANAGDIVAITGLGELKISDTVCAAGNVEALPPLSVDEPTLTMTFQVNTSPFAG
KEGKYVTSRNILERLQQELVHNVALRVEETDSPDRFAVSGRGELHLSILIENMRREGYELAVSRPEVILKTIDGELCEPY
ETLTVDVEEEHQGTVIEKLGVRKAEMKDMQLDGKGRVRVDFIIPSRGLIGFQTEFLTATSGTGLIYHSFDHYGPHKGGDI
GQRANGVLISNATGKALTFALFGLQDRGRLFIGHAAEVYEGQVVGIHSRSNDLTVNCLKGKQLTNMRASGTDEAQVLTTP
ITLTLEQALEFIDDDELVEVTPKSIRVRKKHLTENDRKRASRG

Sequences:

>Translated_603_residues
MLENLRNIAIIAHVDHGKTTLVDKLLSQSGTLATRGEATERVMDSNDLEKERGITILAKNTAIKWNDYRINIVDTPGHAD
FGGEVERVLSMVDSVLLLVDAVDGPMPQTRFVTKKAFAQGLKPIVVINKIDRPGARPDWVIDQVFDLFDNLGATDEQLDF
PVVYASALNGFATLDPDEVGTDMTPLFQTIVEKVSSPAADAEGPFQMQISQLDYNSYVGVIGVGRIKRGSIKTNQQVTVI
GADGKTRNGKMGQVLGYMGLERTEVDVANAGDIVAITGLGELKISDTVCAAGNVEALPPLSVDEPTLTMTFQVNTSPFAG
KEGKYVTSRNILERLQQELVHNVALRVEETDSPDRFAVSGRGELHLSILIENMRREGYELAVSRPEVILKTIDGELCEPY
ETLTVDVEEEHQGTVIEKLGVRKAEMKDMQLDGKGRVRVDFIIPSRGLIGFQTEFLTATSGTGLIYHSFDHYGPHKGGDI
GQRANGVLISNATGKALTFALFGLQDRGRLFIGHAAEVYEGQVVGIHSRSNDLTVNCLKGKQLTNMRASGTDEAQVLTTP
ITLTLEQALEFIDDDELVEVTPKSIRVRKKHLTENDRKRASRG
>Mature_603_residues
MLENLRNIAIIAHVDHGKTTLVDKLLSQSGTLATRGEATERVMDSNDLEKERGITILAKNTAIKWNDYRINIVDTPGHAD
FGGEVERVLSMVDSVLLLVDAVDGPMPQTRFVTKKAFAQGLKPIVVINKIDRPGARPDWVIDQVFDLFDNLGATDEQLDF
PVVYASALNGFATLDPDEVGTDMTPLFQTIVEKVSSPAADAEGPFQMQISQLDYNSYVGVIGVGRIKRGSIKTNQQVTVI
GADGKTRNGKMGQVLGYMGLERTEVDVANAGDIVAITGLGELKISDTVCAAGNVEALPPLSVDEPTLTMTFQVNTSPFAG
KEGKYVTSRNILERLQQELVHNVALRVEETDSPDRFAVSGRGELHLSILIENMRREGYELAVSRPEVILKTIDGELCEPY
ETLTVDVEEEHQGTVIEKLGVRKAEMKDMQLDGKGRVRVDFIIPSRGLIGFQTEFLTATSGTGLIYHSFDHYGPHKGGDI
GQRANGVLISNATGKALTFALFGLQDRGRLFIGHAAEVYEGQVVGIHSRSNDLTVNCLKGKQLTNMRASGTDEAQVLTTP
ITLTLEQALEFIDDDELVEVTPKSIRVRKKHLTENDRKRASRG

Specific function: Probably interacts with the ribosomes in a GTP dependent manner. GTPase that mediates interactions between enteropathogenic E.coli (EPEC) and epithelial cells [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=510, Percent_Identity=26.4705882352941, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=43.609022556391, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI18390331, Length=147, Percent_Identity=42.1768707482993, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI4503483, Length=147, Percent_Identity=40.1360544217687, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI25306287, Length=171, Percent_Identity=33.9181286549708, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI19923640, Length=171, Percent_Identity=33.9181286549708, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI25306283, Length=171, Percent_Identity=33.9181286549708, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI310132016, Length=111, Percent_Identity=40.5405405405405, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI310110807, Length=111, Percent_Identity=40.5405405405405, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI310123363, Length=111, Percent_Identity=40.5405405405405, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI34147630, Length=264, Percent_Identity=29.5454545454545, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI217272892, Length=136, Percent_Identity=36.7647058823529, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI217272894, Length=136, Percent_Identity=36.7647058823529, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI94966752, Length=129, Percent_Identity=31.0077519379845, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI4503471, Length=277, Percent_Identity=25.9927797833935, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI48994988, Length=603, Percent_Identity=77.1144278606965, Blast_Score=975, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=502, Percent_Identity=29.4820717131474, Blast_Score=152, Evalue=7e-38,
Organism=Escherichia coli, GI1789738, Length=152, Percent_Identity=38.1578947368421, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1790835, Length=212, Percent_Identity=29.7169811320755, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1789737, Length=245, Percent_Identity=30.2040816326531, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1790412, Length=245, Percent_Identity=30.2040816326531, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1789559, Length=137, Percent_Identity=36.4963503649635, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17557151, Length=235, Percent_Identity=35.3191489361702, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17556745, Length=445, Percent_Identity=26.9662921348315, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71988819, Length=130, Percent_Identity=40.7692307692308, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI71988811, Length=130, Percent_Identity=40.7692307692308, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17533571, Length=178, Percent_Identity=36.5168539325843, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17506493, Length=159, Percent_Identity=37.7358490566038, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17552882, Length=179, Percent_Identity=34.6368715083799, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17556456, Length=287, Percent_Identity=29.616724738676, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI25141371, Length=247, Percent_Identity=29.1497975708502, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115532067, Length=268, Percent_Identity=25, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI115532065, Length=268, Percent_Identity=25, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323320, Length=583, Percent_Identity=27.1012006861063, Blast_Score=144, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6324707, Length=147, Percent_Identity=40.1360544217687, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320593, Length=147, Percent_Identity=40.1360544217687, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323098, Length=179, Percent_Identity=37.4301675977654, Blast_Score=107, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6322359, Length=151, Percent_Identity=39.0728476821192, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324761, Length=273, Percent_Identity=28.9377289377289, Blast_Score=98, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324166, Length=142, Percent_Identity=37.3239436619718, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI78706572, Length=566, Percent_Identity=27.0318021201413, Blast_Score=142, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24582462, Length=148, Percent_Identity=41.8918918918919, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28574573, Length=139, Percent_Identity=39.568345323741, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24585709, Length=151, Percent_Identity=39.0728476821192, Blast_Score=106, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24585711, Length=151, Percent_Identity=39.0728476821192, Blast_Score=106, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24585713, Length=151, Percent_Identity=39.0728476821192, Blast_Score=106, Evalue=5e-23,
Organism=Drosophila melanogaster, GI221458488, Length=160, Percent_Identity=40, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI281363316, Length=322, Percent_Identity=29.1925465838509, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17864358, Length=322, Percent_Identity=29.1925465838509, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI21357743, Length=190, Percent_Identity=33.6842105263158, Blast_Score=93, Evalue=6e-19,
Organism=Drosophila melanogaster, GI19921738, Length=309, Percent_Identity=30.42071197411, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28572034, Length=166, Percent_Identity=34.9397590361446, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 65954; Mature: 65954

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLENLRNIAIIAHVDHGKTTLVDKLLSQSGTLATRGEATERVMDSNDLEKERGITILAKN
CCCCCCEEEEEEEECCCCHHHHHHHHHCCCCEEECCCHHHHHHCCCCCHHHCCEEEEEEC
TAIKWNDYRINIVDTPGHADFGGEVERVLSMVDSVLLLVDAVDGPMPQTRFVTKKAFAQG
CEEEECCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCC
LKPIVVINKIDRPGARPDWVIDQVFDLFDNLGATDEQLDFPVVYASALNGFATLDPDEVG
CCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEECCHHHCC
TDMTPLFQTIVEKVSSPAADAEGPFQMQISQLDYNSYVGVIGVGRIKRGSIKTNQQVTVI
CCHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCEEEEEEECEEECCCCCCCCEEEEE
GADGKTRNGKMGQVLGYMGLERTEVDVANAGDIVAITGLGELKISDTVCAAGNVEALPPL
ECCCCCCCCCHHHHHHHCCCCCCEEEECCCCCEEEEECCCCEEECCEEECCCCCCCCCCC
SVDEPTLTMTFQVNTSPFAGKEGKYVTSRNILERLQQELVHNVALRVEETDSPDRFAVSG
CCCCCEEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEECC
RGELHLSILIENMRREGYELAVSRPEVILKTIDGELCEPYETLTVDVEEEHQGTVIEKLG
CCCEEEEEEEHHHHCCCEEEEECCCCEEEEECCCCCCCCCEEEEEEECCCCCCCHHHHHC
VRKAEMKDMQLDGKGRVRVDFIIPSRGLIGFQTEFLTATSGTGLIYHSFDHYGPHKGGDI
CCHHHHHCCEECCCCCEEEEEEECCCCCEEEEEEEEEECCCCEEEEECCCCCCCCCCCCC
GQRANGVLISNATGKALTFALFGLQDRGRLFIGHAAEVYEGQVVGIHSRSNDLTVNCLKG
CCCCCCEEEECCCCCEEEEEEEEECCCCCEEEECCHHHHCCEEEEEEECCCCEEEEEECC
KQLTNMRASGTDEAQVLTTPITLTLEQALEFIDDDELVEVTPKSIRVRKKHLTENDRKRA
CEECCCCCCCCCCCEEEEECEEEEHHHHHHHCCCCCEEEECCHHHHHHHHHCCCCHHHHC
SRG
CCC
>Mature Secondary Structure
MLENLRNIAIIAHVDHGKTTLVDKLLSQSGTLATRGEATERVMDSNDLEKERGITILAKN
CCCCCCEEEEEEEECCCCHHHHHHHHHCCCCEEECCCHHHHHHCCCCCHHHCCEEEEEEC
TAIKWNDYRINIVDTPGHADFGGEVERVLSMVDSVLLLVDAVDGPMPQTRFVTKKAFAQG
CEEEECCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCC
LKPIVVINKIDRPGARPDWVIDQVFDLFDNLGATDEQLDFPVVYASALNGFATLDPDEVG
CCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEECCHHHCC
TDMTPLFQTIVEKVSSPAADAEGPFQMQISQLDYNSYVGVIGVGRIKRGSIKTNQQVTVI
CCHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCEEEEEEECEEECCCCCCCCEEEEE
GADGKTRNGKMGQVLGYMGLERTEVDVANAGDIVAITGLGELKISDTVCAAGNVEALPPL
ECCCCCCCCCHHHHHHHCCCCCCEEEECCCCCEEEEECCCCEEECCEEECCCCCCCCCCC
SVDEPTLTMTFQVNTSPFAGKEGKYVTSRNILERLQQELVHNVALRVEETDSPDRFAVSG
CCCCCEEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEECC
RGELHLSILIENMRREGYELAVSRPEVILKTIDGELCEPYETLTVDVEEEHQGTVIEKLG
CCCEEEEEEEHHHHCCCEEEEECCCCEEEEECCCCCCCCCEEEEEEECCCCCCCHHHHHC
VRKAEMKDMQLDGKGRVRVDFIIPSRGLIGFQTEFLTATSGTGLIYHSFDHYGPHKGGDI
CCHHHHHCCEECCCCCEEEEEEECCCCCEEEEEEEEEECCCCEEEEECCCCCCCCCCCCC
GQRANGVLISNATGKALTFALFGLQDRGRLFIGHAAEVYEGQVVGIHSRSNDLTVNCLKG
CCCCCCEEEECCCCCEEEEEEEEECCCCCEEEECCHHHHCCEEEEEEECCCCEEEEEECC
KQLTNMRASGTDEAQVLTTPITLTLEQALEFIDDDELVEVTPKSIRVRKKHLTENDRKRA
CEECCCCCCCCCCCEEEEECEEEEHHHHHHHCCCCCEEEECCHHHHHHHHHCCCCHHHHC
SRG
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9622352 [H]