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The map label for this gene is cusR [H]

Identifier: 117918739

GI number: 117918739

Start: 315620

End: 316297

Strand: Direct

Name: cusR [H]

Synonym: Shewana3_0282

Alternate gene names: 117918739

Gene position: 315620-316297 (Clockwise)

Preceding gene: 117918738

Following gene: 117918740

Centisome position: 6.35

GC content: 51.03

Gene sequence:

>678_bases
ATGAAAATACTTTTAGTTGAAGATGATGCGACAACGATCGACTACATCGTTAAAGGATTTCTTGAGCAGGGGCATAATAT
TGAGACCGCCAGCGACGGCCATCAAGGCCTGCTGCAAGCCACCAGTGGTCAGTACGACCTCTTGATACTCGACCGCATGT
TGCCCCAACTCGATGGTTTGAAGCTGCTAGCCGCCCTCAGAGCCACGGGTAACCAAACCCCAGTGCTTATCCTGTCGGCG
CTTGCCCATGTGGATGAAAGGGTGAAAGGTCTGCGTGCGGGCGGCGATGATTACATGACTAAGCCCTTTGCCTTTTCGGA
GCTGCTGGTGCGTGCCGAAAAACTGATGCAACGGGGCCAATCCGTGCCAATTACCACAGATCTGGTAGTCGGTGGCTTAA
AAATGGAGCTGCTCACCCGCAACGTGACCTTAGATGGCCACGATTTAATGCTGCAACCCAAAGAATTCCAACTGCTTAAG
TATCTGATGGAGCACGCCAATCAGGTGATTAGCCGCACGCTATTATTCGAAGCTGTATGGGATTATCACTTCGATCCCCG
CACCAATGTGATCGACGTGCATATCGCCAAGTTACGTCGCAAGTTTGAAGAGTTAGGCCACGGTGAATTGATTGAAACCG
TAAGGGGAGCGGGTTATCGCTTACGCCAAAGGCATTAA

Upstream 100 bases:

>100_bases
TTGGCATTCGATATTGAAAATTTACGGCAACTACCTTTACTTAAGTGGGATTAGCACTGAGCATCACCGCTAAGTGAAGA
CAGGGGAGCGCAGCATACAG

Downstream 100 bases:

>100_bases
GCCTTACCAAAGCAGCGTCTGGCGCATCACTATTATCTTCTCGACCTTAGTGACTGTGATCATAGGCGCTTTGCTGTTTG
CCCTTTATCGGCAACTCATT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKILLVEDDATTIDYIVKGFLEQGHNIETASDGHQGLLQATSGQYDLLILDRMLPQLDGLKLLAALRATGNQTPVLILSA
LAHVDERVKGLRAGGDDYMTKPFAFSELLVRAEKLMQRGQSVPITTDLVVGGLKMELLTRNVTLDGHDLMLQPKEFQLLK
YLMEHANQVISRTLLFEAVWDYHFDPRTNVIDVHIAKLRRKFEELGHGELIETVRGAGYRLRQRH

Sequences:

>Translated_225_residues
MKILLVEDDATTIDYIVKGFLEQGHNIETASDGHQGLLQATSGQYDLLILDRMLPQLDGLKLLAALRATGNQTPVLILSA
LAHVDERVKGLRAGGDDYMTKPFAFSELLVRAEKLMQRGQSVPITTDLVVGGLKMELLTRNVTLDGHDLMLQPKEFQLLK
YLMEHANQVISRTLLFEAVWDYHFDPRTNVIDVHIAKLRRKFEELGHGELIETVRGAGYRLRQRH
>Mature_225_residues
MKILLVEDDATTIDYIVKGFLEQGHNIETASDGHQGLLQATSGQYDLLILDRMLPQLDGLKLLAALRATGNQTPVLILSA
LAHVDERVKGLRAGGDDYMTKPFAFSELLVRAEKLMQRGQSVPITTDLVVGGLKMELLTRNVTLDGHDLMLQPKEFQLLK
YLMEHANQVISRTLLFEAVWDYHFDPRTNVIDVHIAKLRRKFEELGHGELIETVRGAGYRLRQRH

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=43.4389140271493, Blast_Score=191, Evalue=3e-50,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=42.9223744292237, Blast_Score=177, Evalue=6e-46,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=40.2654867256637, Blast_Score=150, Evalue=7e-38,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=36.1990950226244, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=32.8888888888889, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=32.4444444444444, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=36.1233480176211, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787375, Length=219, Percent_Identity=28.310502283105, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=31.5315315315315, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=28.8288288288288, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=28.695652173913, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=30.5309734513274, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=29.3333333333333, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1790437, Length=135, Percent_Identity=30.3703703703704, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788550, Length=116, Percent_Identity=31.0344827586207, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=28.2608695652174, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788191, Length=119, Percent_Identity=33.6134453781513, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788713, Length=134, Percent_Identity=30.5970149253731, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=36.6336633663366, Blast_Score=63, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=106, Percent_Identity=30.188679245283, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25409; Mature: 25409

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILLVEDDATTIDYIVKGFLEQGHNIETASDGHQGLLQATSGQYDLLILDRMLPQLDGL
CEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCEEHHHHHCCHHCHH
KLLAALRATGNQTPVLILSALAHVDERVKGLRAGGDDYMTKPFAFSELLVRAEKLMQRGQ
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCC
SVPITTDLVVGGLKMELLTRNVTLDGHDLMLQPKEFQLLKYLMEHANQVISRTLLFEAVW
CCCCCHHHHHCCHHEEHHHHCCEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYHFDPRTNVIDVHIAKLRRKFEELGHGELIETVRGAGYRLRQRH
HCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHCCCC
>Mature Secondary Structure
MKILLVEDDATTIDYIVKGFLEQGHNIETASDGHQGLLQATSGQYDLLILDRMLPQLDGL
CEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCEEHHHHHCCHHCHH
KLLAALRATGNQTPVLILSALAHVDERVKGLRAGGDDYMTKPFAFSELLVRAEKLMQRGQ
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCC
SVPITTDLVVGGLKMELLTRNVTLDGHDLMLQPKEFQLLKYLMEHANQVISRTLLFEAVW
CCCCCHHHHHCCHHEEHHHHCCEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYHFDPRTNVIDVHIAKLRRKFEELGHGELIETVRGAGYRLRQRH
HCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]