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The map label for this gene is saeS [H]

Identifier: 117918740

GI number: 117918740

Start: 316368

End: 317603

Strand: Direct

Name: saeS [H]

Synonym: Shewana3_0283

Alternate gene names: 117918740

Gene position: 316368-317603 (Clockwise)

Preceding gene: 117918739

Following gene: 117918741

Centisome position: 6.36

GC content: 50.97

Gene sequence:

>1236_bases
TTGCTGTTTGCCCTTTATCGGCAACTCATTATCGAACAGCAGTACCAAGTGACTCAGTATCTTGAGTCAGAAACCCAACG
CTATCAACAGCTTGCGCTTACAGTTGATCGCCGCAGTTTTGCGGCACAAATTCGTGCAGCCGATCCGCAGACGGCGCTCA
TCGCTTGGCGTAACAGTTATGACATGGTTGGTGCCTTAAGCTTTATGCCTGAAGGCATGCCCATGCTGCCGCAAACCCGG
GATTTCCCGATTTTAACTGGTGGCCCTGATAAGCTGCATATCCTCACCGGCGGCCTAGTGATGACTCGCTATGGCCCTGT
GCTCATCGCCACCCGTACCGATAACTTAGCCACCTTGATCGATAAATTTATCAGTGCGGCGGCCACGGCCGTGATGTTGA
CCATAGTGTTAACCTTAGCGTTGGGCTATTTGTTTTCTAAGGCGATTTTGCGCCGCTTAGTGCAGTACAATCGCTTGAGT
GAGCAAATTGAGCGGGGGCATTACGACACGCGTCTGCCGCTCAGTTGGCGTCAGGACGAGTTCGATATGTTGGCGCTGCA
GTTTAATAACGTGCTGGATATTCTTGAGAATAACCTGATGGCGGTGCGCGGGGTGACAGATAATATTGCGCACGACTTGC
GCACGCCCTTATCCCATATTCGCATCGGTCTTGAGGAGTTGGCGGCCAAATCCCCCGATGAAATCAGCGAAGGTTGCGCG
ATTTTGACCGAAGAGCTCGATCATTGTCTTGCGACCTTCGATGCCATGCTCTCGCTGACACGCATTGAGGAAGGGCAGCA
AACCTTAGATTTGCAGGAGCTGAGTTTGGCGCAGCTATGTACCGATTTGTTGGACATGGCCGACGCGGTCGCCGAGTCGA
ATGAGCAAACCTTGAGTCTGTCGCTCCTATCGGATCATAAGATTTATGGTGACAAGTACTTGTTGTTCCAAGCCTTATAT
AACTTGGTCGACAATGCGATGAAGTACTCAGGTCAAGGCGCTCGCATCGATATTATTCAATCCGGCGCTAAAATTAAGAT
TTGCGATAACGGCCCAGGGATCCCCGATGACAGCAAGGAAAGAGTGTTTGAGCGTCTAGTGCGTCTCGACCCCAGCCGCC
ATTTGCAGGGCACGGGTTTAGGATTATCTATGGTAAAAGCGATTATGTCGCGGCACAATGCGCAAATTACTCTTTCGGAT
AATCATCCCGGCCTAGTGGTGACCATTCAGTTTTAG

Upstream 100 bases:

>100_bases
GCGGGTTATCGCTTACGCCAAAGGCATTAAGCCTTACCAAAGCAGCGTCTGGCGCATCACTATTATCTTCTCGACCTTAG
TGACTGTGATCATAGGCGCT

Downstream 100 bases:

>100_bases
GCCGATATCCGCGTGACACTGTTGAGAACCCCATGTACCGAATCATAGCCGATGAGGCTGATTTTCTTGTTATTTCTAAA
TCGCCGAATGTGCATTTTCA

Product: ATPase domain-containing protein

Products: NA

Alternate protein names: Sensor protein saeS [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MLFALYRQLIIEQQYQVTQYLESETQRYQQLALTVDRRSFAAQIRAADPQTALIAWRNSYDMVGALSFMPEGMPMLPQTR
DFPILTGGPDKLHILTGGLVMTRYGPVLIATRTDNLATLIDKFISAAATAVMLTIVLTLALGYLFSKAILRRLVQYNRLS
EQIERGHYDTRLPLSWRQDEFDMLALQFNNVLDILENNLMAVRGVTDNIAHDLRTPLSHIRIGLEELAAKSPDEISEGCA
ILTEELDHCLATFDAMLSLTRIEEGQQTLDLQELSLAQLCTDLLDMADAVAESNEQTLSLSLLSDHKIYGDKYLLFQALY
NLVDNAMKYSGQGARIDIIQSGAKIKICDNGPGIPDDSKERVFERLVRLDPSRHLQGTGLGLSMVKAIMSRHNAQITLSD
NHPGLVVTIQF

Sequences:

>Translated_411_residues
MLFALYRQLIIEQQYQVTQYLESETQRYQQLALTVDRRSFAAQIRAADPQTALIAWRNSYDMVGALSFMPEGMPMLPQTR
DFPILTGGPDKLHILTGGLVMTRYGPVLIATRTDNLATLIDKFISAAATAVMLTIVLTLALGYLFSKAILRRLVQYNRLS
EQIERGHYDTRLPLSWRQDEFDMLALQFNNVLDILENNLMAVRGVTDNIAHDLRTPLSHIRIGLEELAAKSPDEISEGCA
ILTEELDHCLATFDAMLSLTRIEEGQQTLDLQELSLAQLCTDLLDMADAVAESNEQTLSLSLLSDHKIYGDKYLLFQALY
NLVDNAMKYSGQGARIDIIQSGAKIKICDNGPGIPDDSKERVFERLVRLDPSRHLQGTGLGLSMVKAIMSRHNAQITLSD
NHPGLVVTIQF
>Mature_411_residues
MLFALYRQLIIEQQYQVTQYLESETQRYQQLALTVDRRSFAAQIRAADPQTALIAWRNSYDMVGALSFMPEGMPMLPQTR
DFPILTGGPDKLHILTGGLVMTRYGPVLIATRTDNLATLIDKFISAAATAVMLTIVLTLALGYLFSKAILRRLVQYNRLS
EQIERGHYDTRLPLSWRQDEFDMLALQFNNVLDILENNLMAVRGVTDNIAHDLRTPLSHIRIGLEELAAKSPDEISEGCA
ILTEELDHCLATFDAMLSLTRIEEGQQTLDLQELSLAQLCTDLLDMADAVAESNEQTLSLSLLSDHKIYGDKYLLFQALY
NLVDNAMKYSGQGARIDIIQSGAKIKICDNGPGIPDDSKERVFERLVRLDPSRHLQGTGLGLSMVKAIMSRHNAQITLSD
NHPGLVVTIQF

Specific function: Member of the two-component regulatory system saeR/saeS. Probably functions as a membrane-associated protein kinase that upon sensing the appropriate signal, autophosphorylates and in turn activates the cytosolic response regulator saeR [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788279, Length=274, Percent_Identity=29.1970802919708, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787894, Length=267, Percent_Identity=28.8389513108614, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1786783, Length=331, Percent_Identity=24.773413897281, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788393, Length=279, Percent_Identity=27.2401433691756, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790551, Length=276, Percent_Identity=30.0724637681159, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790346, Length=230, Percent_Identity=26.5217391304348, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786600, Length=209, Percent_Identity=26.7942583732057, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1786912, Length=197, Percent_Identity=30.4568527918782, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1789403, Length=284, Percent_Identity=26.7605633802817, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788713, Length=213, Percent_Identity=26.7605633802817, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790861, Length=205, Percent_Identity=27.8048780487805, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1789808, Length=202, Percent_Identity=25.2475247524752, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789149, Length=207, Percent_Identity=26.5700483091787, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790436, Length=211, Percent_Identity=27.4881516587678, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 46015; Mature: 46015

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFALYRQLIIEQQYQVTQYLESETQRYQQLALTVDRRSFAAQIRAADPQTALIAWRNSY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
DMVGALSFMPEGMPMLPQTRDFPILTGGPDKLHILTGGLVMTRYGPVLIATRTDNLATLI
CHHHHHHHCCCCCCCCCCCCCCCEEECCCCEEEEEECCEEEECCCCEEEEECCCHHHHHH
DKFISAAATAVMLTIVLTLALGYLFSKAILRRLVQYNRLSEQIERGHYDTRLPLSWRQDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
FDMLALQFNNVLDILENNLMAVRGVTDNIAHDLRTPLSHIRIGLEELAAKSPDEISEGCA
HHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCHHHHHHCHHHHCCCCCHHHHHHHH
ILTEELDHCLATFDAMLSLTRIEEGQQTLDLQELSLAQLCTDLLDMADAVAESNEQTLSL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
SLLSDHKIYGDKYLLFQALYNLVDNAMKYSGQGARIDIIQSGAKIKICDNGPGIPDDSKE
EEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCCCCCHHH
RVFERLVRLDPSRHLQGTGLGLSMVKAIMSRHNAQITLSDNHPGLVVTIQF
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCEEEEEEC
>Mature Secondary Structure
MLFALYRQLIIEQQYQVTQYLESETQRYQQLALTVDRRSFAAQIRAADPQTALIAWRNSY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
DMVGALSFMPEGMPMLPQTRDFPILTGGPDKLHILTGGLVMTRYGPVLIATRTDNLATLI
CHHHHHHHCCCCCCCCCCCCCCCEEECCCCEEEEEECCEEEECCCCEEEEECCCHHHHHH
DKFISAAATAVMLTIVLTLALGYLFSKAILRRLVQYNRLSEQIERGHYDTRLPLSWRQDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
FDMLALQFNNVLDILENNLMAVRGVTDNIAHDLRTPLSHIRIGLEELAAKSPDEISEGCA
HHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCHHHHHHCHHHHCCCCCHHHHHHHH
ILTEELDHCLATFDAMLSLTRIEEGQQTLDLQELSLAQLCTDLLDMADAVAESNEQTLSL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
SLLSDHKIYGDKYLLFQALYNLVDNAMKYSGQGARIDIIQSGAKIKICDNGPGIPDDSKE
EEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCCCCCHHH
RVFERLVRLDPSRHLQGTGLGLSMVKAIMSRHNAQITLSDNHPGLVVTIQF
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA