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The map label for this gene is drrB [H]

Identifier: 116872381

GI number: 116872381

Start: 986169

End: 986921

Strand: Direct

Name: drrB [H]

Synonym: lwe0963

Alternate gene names: 116872381

Gene position: 986169-986921 (Clockwise)

Preceding gene: 116872380

Following gene: 116872383

Centisome position: 35.04

GC content: 37.85

Gene sequence:

>753_bases
ATGAAAGCAGTTCGCGATACTAGTATATTATTTGGTCGATCTATGCGTCACATTTTGCGTAGTCCTGATACAATTATCAC
GGTGGCAATTATTCCGATTATGATTATGTTAATGTTTGTGTATGTCTTAGGTGGGGCGATTCAAACAGGGACCGACAATT
ATGTTGATTACTTGTTACCGGGTATTATTTTAATGGCTATAGCAAGTGGAATTGCTTATACAGCAGTACGATTATTTACA
GATGTACAAAAAGGTTTATTTCAACGATTTCACTCTATGCCAATTAGTCGTTCTTCGGTATTATGGGGACATGTTTTAAC
TTCGCTTGTTTCGAATGCAATTTCAGTAGTATTAATTATTCTTGTTGCGCTTTTAATTGGTTTTCGTTCTTCTGCTGGTT
TGATGGAGTGGCTCGCTGTTGCGGGGATATTACTGTTATTTACATTAGCGCTAACATGGGTCGCTGTTATTCCAGGTTTA
ACTGCAAAATCAGTGGATGGCGCGAGTGCATTTTCATATCCACTCATTTTTTTACCATTTATCAGTTCAGCTTTTGTTCC
TACCGATACAATGCCCACAGTGGTTCGTGCATTTGCTGAAAATCAACCGGTAACCTCTATTGTTAATACGATTCGAGCAT
TGCTTTATTCAGGAGAAGTGGGGAGTGAAATATGGGTCGCACTAGCTTGGTGTATAGGAATTACAGTCGTCGCCTATGTT
TTTGCTGTACTAAAATATAAAAAAACAATTTAA

Upstream 100 bases:

>100_bases
TAAAAAAATTATTCCCGCCTGCTGAAATTGAATACGTCGAAAAGCAACCATCTCTAGAAGAAATTTTTCTAGCAATTATT
AATGAGAAGGAGGAAGTAAA

Downstream 100 bases:

>100_bases
ATAAAAAAGATTGACTCCGAGGAGCCAATCTTTTTTTAATTTTCACCAGAAATATGTTTTTTCGGTAAGATAAAATGAAT
GAAATAACTAACAATACAAC

Product: ABC transporter, permease protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MKAVRDTSILFGRSMRHILRSPDTIITVAIIPIMIMLMFVYVLGGAIQTGTDNYVDYLLPGIILMAIASGIAYTAVRLFT
DVQKGLFQRFHSMPISRSSVLWGHVLTSLVSNAISVVLIILVALLIGFRSSAGLMEWLAVAGILLLFTLALTWVAVIPGL
TAKSVDGASAFSYPLIFLPFISSAFVPTDTMPTVVRAFAENQPVTSIVNTIRALLYSGEVGSEIWVALAWCIGITVVAYV
FAVLKYKKTI

Sequences:

>Translated_250_residues
MKAVRDTSILFGRSMRHILRSPDTIITVAIIPIMIMLMFVYVLGGAIQTGTDNYVDYLLPGIILMAIASGIAYTAVRLFT
DVQKGLFQRFHSMPISRSSVLWGHVLTSLVSNAISVVLIILVALLIGFRSSAGLMEWLAVAGILLLFTLALTWVAVIPGL
TAKSVDGASAFSYPLIFLPFISSAFVPTDTMPTVVRAFAENQPVTSIVNTIRALLYSGEVGSEIWVALAWCIGITVVAYV
FAVLKYKKTI
>Mature_250_residues
MKAVRDTSILFGRSMRHILRSPDTIITVAIIPIMIMLMFVYVLGGAIQTGTDNYVDYLLPGIILMAIASGIAYTAVRLFT
DVQKGLFQRFHSMPISRSSVLWGHVLTSLVSNAISVVLIILVALLIGFRSSAGLMEWLAVAGILLLFTLALTWVAVIPGL
TAKSVDGASAFSYPLIFLPFISSAFVPTDTMPTVVRAFAENQPVTSIVNTIRALLYSGEVGSEIWVALAWCIGITVVAYV
FAVLKYKKTI

Specific function: Part of the ABC transporter complex drrAB involved in daunorubicin and doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000412
- InterPro:   IPR013525 [H]

Pfam domain/function: PF01061 ABC2_membrane [H]

EC number: NA

Molecular weight: Translated: 27134; Mature: 27134

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: PS51012 ABC_TM2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCC
>Mature Secondary Structure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HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1924314 [H]