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The map label for this gene is cah [H]

Identifier: 116872226

GI number: 116872226

Start: 834854

End: 835555

Strand: Direct

Name: cah [H]

Synonym: lwe0806

Alternate gene names: 116872226

Gene position: 834854-835555 (Clockwise)

Preceding gene: 116872225

Following gene: 116872227

Centisome position: 29.67

GC content: 37.18

Gene sequence:

>702_bases
ATGACTAAGGAGAAAGTGTTATGGGGTTACGATGAGAAGACTGGGCCAGAAATGTGGGGGCATATCTGCTCTGACTTTGA
AATCGCACATACTGGGAAAGCACAATCGCCAGTAAATATTGAACAAGCTGATGTGGTAAAATTAAAGCCATCAACAATGA
AATTCTACTATAAAGAAACAGATTATACGATTAGAAGAATTGAACAGTCTGTACATGTTTTTCCGCATGATAAAGAACAA
GGGTTACGCTTTAATGGCGAATATTATCCACTTGTATCATTCCATGCCCATATTCCGGCGGAGCATTTGTTAGATGGGTA
TATTTATCCAATTGAATGGCATTTCGTTCATGAAAAACCAGATGGTACAACGCTTGTAATGAGTGCTTGGATGGAAATTG
ATAACACTAATAATGTGGAATTTAAAGATTTACCGACGTATTTCCCAGAAGTGTTTGCAGATTTTGAGACAGAACGGGAA
ATTACTTTAGATGTGAATGAATTTATGCCAGAAGAACGTGTTTTCTATACATATCAAGGTTCGCGTACAACACCACCTAC
TGTAGAGGGTGTAACGTGGATTGTATTAAAAAATGCGAAGACACTTGGCCAAGAAGATTTCACTGAATTTGAAAAAGCCA
TTGGCAATACAAGTCGACCAGTACAAGACTTAAACGGTCGTGAAATTACTTTTTATAATTAA

Upstream 100 bases:

>100_bases
CTAAAGTCGAAACACGAACATTAAGCAAATAACTTGTGGAATTGATTAGCTATCCGCTAAAATAATGTTACGCAATTTTT
TTCGAAAAGGAGAAATGGTT

Downstream 100 bases:

>100_bases
AAAACTAGAAAGCCTTGCTCGAATCTTGTATAGTATAGACATAGATTCTGAGTGGAGGCTTCTTTTTATGTATGAAAAAG
CGAGACAAATGATGATCGAA

Product: carbonic anhydrase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MTKEKVLWGYDEKTGPEMWGHICSDFEIAHTGKAQSPVNIEQADVVKLKPSTMKFYYKETDYTIRRIEQSVHVFPHDKEQ
GLRFNGEYYPLVSFHAHIPAEHLLDGYIYPIEWHFVHEKPDGTTLVMSAWMEIDNTNNVEFKDLPTYFPEVFADFETERE
ITLDVNEFMPEERVFYTYQGSRTTPPTVEGVTWIVLKNAKTLGQEDFTEFEKAIGNTSRPVQDLNGREITFYN

Sequences:

>Translated_233_residues
MTKEKVLWGYDEKTGPEMWGHICSDFEIAHTGKAQSPVNIEQADVVKLKPSTMKFYYKETDYTIRRIEQSVHVFPHDKEQ
GLRFNGEYYPLVSFHAHIPAEHLLDGYIYPIEWHFVHEKPDGTTLVMSAWMEIDNTNNVEFKDLPTYFPEVFADFETERE
ITLDVNEFMPEERVFYTYQGSRTTPPTVEGVTWIVLKNAKTLGQEDFTEFEKAIGNTSRPVQDLNGREITFYN
>Mature_232_residues
TKEKVLWGYDEKTGPEMWGHICSDFEIAHTGKAQSPVNIEQADVVKLKPSTMKFYYKETDYTIRRIEQSVHVFPHDKEQG
LRFNGEYYPLVSFHAHIPAEHLLDGYIYPIEWHFVHEKPDGTTLVMSAWMEIDNTNNVEFKDLPTYFPEVFADFETEREI
TLDVNEFMPEERVFYTYQGSRTTPPTVEGVTWIVLKNAKTLGQEDFTEFEKAIGNTSRPVQDLNGREITFYN

Specific function: Reversible hydration of carbon dioxide [H]

COG id: COG3338

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha-carbonic anhydrase family [H]

Homologues:

Organism=Homo sapiens, GI258679498, Length=259, Percent_Identity=27.7992277992278, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI192447434, Length=259, Percent_Identity=27.7992277992278, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI192447432, Length=259, Percent_Identity=27.7992277992278, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI192447430, Length=259, Percent_Identity=27.7992277992278, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4502517, Length=259, Percent_Identity=27.7992277992278, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4557395, Length=259, Percent_Identity=28.957528957529, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI38348436, Length=267, Percent_Identity=26.2172284644195, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI4885101, Length=262, Percent_Identity=27.4809160305344, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI4885099, Length=263, Percent_Identity=23.9543726235741, Blast_Score=68, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17568715, Length=251, Percent_Identity=28.2868525896414, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24645604, Length=256, Percent_Identity=26.953125, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001148
- InterPro:   IPR018338
- InterPro:   IPR018340 [H]

Pfam domain/function: PF00194 Carb_anhydrase [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 27250; Mature: 27119

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS51144 ALPHA_CA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKEKVLWGYDEKTGPEMWGHICSDFEIAHTGKAQSPVNIEQADVVKLKPSTMKFYYKET
CCCCCEEECCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCCCEEEEECCCEEEEEEECC
DYTIRRIEQSVHVFPHDKEQGLRFNGEYYPLVSFHAHIPAEHLLDGYIYPIEWHFVHEKP
CHHHHHHHHHHEECCCCCCCCCEECCEEEEEEEEECCCCHHHHHCCEEEEEEEEEEEECC
DGTTLVMSAWMEIDNTNNVEFKDLPTYFPEVFADFETEREITLDVNEFMPEERVFYTYQG
CCCEEEEEEEEEECCCCCEEECCCCHHHHHHHHCCCCCCEEEEEHHHCCCCCEEEEEECC
SRTTPPTVEGVTWIVLKNAKTLGQEDFTEFEKAIGNTSRPVQDLNGREITFYN
CCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHCCCCEEEEEC
>Mature Secondary Structure 
TKEKVLWGYDEKTGPEMWGHICSDFEIAHTGKAQSPVNIEQADVVKLKPSTMKFYYKET
CCCCEEECCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCCCEEEEECCCEEEEEEECC
DYTIRRIEQSVHVFPHDKEQGLRFNGEYYPLVSFHAHIPAEHLLDGYIYPIEWHFVHEKP
CHHHHHHHHHHEECCCCCCCCCEECCEEEEEEEEECCCCHHHHHCCEEEEEEEEEEEECC
DGTTLVMSAWMEIDNTNNVEFKDLPTYFPEVFADFETEREITLDVNEFMPEERVFYTYQG
CCCEEEEEEEEEECCCCCEEECCCCHHHHHHHHCCCCCCEEEEEHHHCCCCCEEEEEECC
SRTTPPTVEGVTWIVLKNAKTLGQEDFTEFEKAIGNTSRPVQDLNGREITFYN
CCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9108244; 7721686; 9761692 [H]