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The map label for this gene is relA [H]

Identifier: 116872227

GI number: 116872227

Start: 835623

End: 836165

Strand: Direct

Name: relA [H]

Synonym: lwe0807

Alternate gene names: 116872227

Gene position: 835623-836165 (Clockwise)

Preceding gene: 116872226

Following gene: 116872228

Centisome position: 29.69

GC content: 39.41

Gene sequence:

>543_bases
ATGTATGAAAAAGCGAGACAAATGATGATCGAAGCGCATACTGGACAAGTTCGCAAGATTACTGGCGAGCCTTATTTTTC
GCATCCTTTAAATGTAGCGAGAATATTGCGCCGTGCTGGGTTTCAGGAGGCGGTTGTTATCGCGGGCTTATTACATGATG
CTGTAGAAGATACGGAGATGACCGACCAGGATATTCGCACGACATTTGGCGATAAGGTTGCAGATTTAGTAGCTTCTCAT
ACAGAAAACAAGGCTTTATCATGGGAAGAACGAAAAGCGCATACAATAGAACAAGTGCGCACTGGAAGTTTAGAAGAAAA
AGCGTTAATCGTTGCAGATAAATTAGATAATTTAACCTCTGTCAAATATGCTTTAAGCTCAGAAGGTAAGTCTGTCTGGA
GTTATTTTAACCGTGGCTATGATCAGCAAAAATGGTACAATGAAGGCATTAAAAATAATATGGAGTTTGGTTTAAATCCA
TCGGAAATTCCTGCTTTCTTTGATGAATATGCGCGCTTAGTGAAGTGGATTTTTAAGAAATAA

Upstream 100 bases:

>100_bases
TTAAACGGTCGTGAAATTACTTTTTATAATTAAAAAACTAGAAAGCCTTGCTCGAATCTTGTATAGTATAGACATAGATT
CTGAGTGGAGGCTTCTTTTT

Downstream 100 bases:

>100_bases
AATTTTAACTTAAATTATCTGTCAAATTAGGTATTTAGAATTAAAATAATAAGTTTTTAGAAAACAGCTTCCTTTTCCAA
GGAAAATATTGTAAAATGAA

Product: phosphohydrolase, putative

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MYEKARQMMIEAHTGQVRKITGEPYFSHPLNVARILRRAGFQEAVVIAGLLHDAVEDTEMTDQDIRTTFGDKVADLVASH
TENKALSWEERKAHTIEQVRTGSLEEKALIVADKLDNLTSVKYALSSEGKSVWSYFNRGYDQQKWYNEGIKNNMEFGLNP
SEIPAFFDEYARLVKWIFKK

Sequences:

>Translated_180_residues
MYEKARQMMIEAHTGQVRKITGEPYFSHPLNVARILRRAGFQEAVVIAGLLHDAVEDTEMTDQDIRTTFGDKVADLVASH
TENKALSWEERKAHTIEQVRTGSLEEKALIVADKLDNLTSVKYALSSEGKSVWSYFNRGYDQQKWYNEGIKNNMEFGLNP
SEIPAFFDEYARLVKWIFKK
>Mature_180_residues
MYEKARQMMIEAHTGQVRKITGEPYFSHPLNVARILRRAGFQEAVVIAGLLHDAVEDTEMTDQDIRTTFGDKVADLVASH
TENKALSWEERKAHTIEQVRTGSLEEKALIVADKLDNLTSVKYALSSEGKSVWSYFNRGYDQQKWYNEGIKNNMEFGLNP
SEIPAFFDEYARLVKWIFKK

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=109, Percent_Identity=44.954128440367, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1790082, Length=90, Percent_Identity=40, Blast_Score=67, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI25143118, Length=166, Percent_Identity=32.5301204819277, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24650996, Length=113, Percent_Identity=40.7079646017699, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 20707; Mature: 20707

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYEKARQMMIEAHTGQVRKITGEPYFSHPLNVARILRRAGFQEAVVIAGLLHDAVEDTEM
CCHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC
TDQDIRTTFGDKVADLVASHTENKALSWEERKAHTIEQVRTGSLEEKALIVADKLDNLTS
CHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHH
VKYALSSEGKSVWSYFNRGYDQQKWYNEGIKNNMEFGLNPSEIPAFFDEYARLVKWIFKK
HHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYEKARQMMIEAHTGQVRKITGEPYFSHPLNVARILRRAGFQEAVVIAGLLHDAVEDTEM
CCHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC
TDQDIRTTFGDKVADLVASHTENKALSWEERKAHTIEQVRTGSLEEKALIVADKLDNLTS
CHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHH
VKYALSSEGKSVWSYFNRGYDQQKWYNEGIKNNMEFGLNPSEIPAFFDEYARLVKWIFKK
HHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8825780; 8631867; 12000953 [H]