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The map label for this gene is hflK [H]

Identifier: 116689826

GI number: 116689826

Start: 2005769

End: 2007157

Strand: Reverse

Name: hflK [H]

Synonym: Bcen2424_1805

Alternate gene names: 116689826

Gene position: 2007157-2005769 (Counterclockwise)

Preceding gene: 116689827

Following gene: 116689825

Centisome position: 57.61

GC content: 69.4

Gene sequence:

>1389_bases
GTGAACGAATACAACGAGCGGAGTACCTGGCGGCGGATGCGCGCCTTGCTGTCGATCAACGATCCCCGCTGGGGACGCGG
CGAAGGCAATGGCAAGGACGGGTCCCGCCCGCGCGCGAACGAATCGAAGCGTCCGCAAGGCGGCGACGGCGATGGTCCGC
CCGATCTCGACGAGATGTGGCGCAACTTCAACCGGCGCCTGAGCGGCCTGTTCGGCGGCAAGGGCGGCAACGGCTTCCGT
CCCGACAACGGCCGGGCCGCACGGGTCGGCGTCGGCATCGTGATCGGCGTACTGGTCGCGGTGTATGCGGGCAGCGGGCT
GTTCGTCGTGCAGGAAGGCCAGACGGGCGTCGTGCTGCAGCTCGGCAAGCTGTCGGGCACGGTCGGCCAGGGCGTGCATT
GGCGCGCGCCGTATCCGTTCGCGTCGCACGAGATCGTCGACACGTCGCAGGTGCGCTCGATCGAGATCGGCCGCAACAAC
GTCGTGCGCCTTGCAAACGTGAAGGAAGCCGCGATGCTGACGCGCGATGCCGACATCGTCGACGTGCGCTTCATCGTCCA
GTACCGGATTCGTTCCGCCACCGATTACCTGTTCCGCAGCGTCGATCCCGAACGCAGCGTGTCGCAGGCCGCGCAGGCCG
CGGTGCGCGCGATCGTCGGCACGCGTAGCGCGGCCGACATGCTGAACCAGGATCGCGATGCGCTGCGCGAGCAGCTTTCC
ACCGCGATCCAGCGCGACCTCGACCGCTACCAGTCGGGGCTCGAGGTGACGGCCGTCACGATGCAGAGCGTCGCGGCGCC
CGAGCAGACCCAGGCCGCGTACGCCGAAGTCGCGAAGGCGCGGGACGAGCGCGAGGCCGCGAAGCGCGCCGCGCAGGCGT
ATGCAAGCGACCTGCTGCCGAAGGCGCAGGGCGATGCGGCGAAGCTCATCGACGAAGCGAAGGCGTATGCCGATCGCGTG
GTCACCGAAGCCGAAGGCGACGCGGACCGCTTCAAGCAGGTCTACGCGCAGTATTCGAAGGCGCCGGCGGTCATCCGCGA
GCGGATGTACCTCGAGACGATGCAGGAAATCTATTCGAACGCGACGAAGGTGTTCGTCGGCAACAAGGGCGGCAACAGCG
TCGTGTATCTGCCGCTCGACAAGCTCGTCGAGCAGGGGCGGCAAAACGCCGCGGCGTCGACCGGCGCATCCGCGCCCGAT
GCGGCGTCGGCACCGGCCGCAACGGCGCCCTCGGCAGCCGCTGCCGCGTCGGCACCGGCCGCAACGGCGCCCTCGGCAGC
CGCTGCCGCGCCGGCGAGCGCCGCACCGGCCGCCACCGCGTCGGGTGTCGACGTGCTGCGATCGCGGGACGCGTTTCGCA
GCCGGTCGCGTGAAGACGATACGAAGTAA

Upstream 100 bases:

>100_bases
GCACGTCCGCTGAACCACACGAAGACCACACGATTTCCGAACACGGGCGCTAACCGGTCCCGGCCGGTTCGCCGGCGTCC
AATCTGGTGAACAAACTCTG

Downstream 100 bases:

>100_bases
CGGGGAGCGCAGAACATGAACCGAATCATTGCGCTCGTCGTCGCAATCGTGATCGTTGCCTTCGCGGCATCGTCGACGGT
CCTGACCGTCGATCCGCGCC

Product: HflK protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MNEYNERSTWRRMRALLSINDPRWGRGEGNGKDGSRPRANESKRPQGGDGDGPPDLDEMWRNFNRRLSGLFGGKGGNGFR
PDNGRAARVGVGIVIGVLVAVYAGSGLFVVQEGQTGVVLQLGKLSGTVGQGVHWRAPYPFASHEIVDTSQVRSIEIGRNN
VVRLANVKEAAMLTRDADIVDVRFIVQYRIRSATDYLFRSVDPERSVSQAAQAAVRAIVGTRSAADMLNQDRDALREQLS
TAIQRDLDRYQSGLEVTAVTMQSVAAPEQTQAAYAEVAKARDEREAAKRAAQAYASDLLPKAQGDAAKLIDEAKAYADRV
VTEAEGDADRFKQVYAQYSKAPAVIRERMYLETMQEIYSNATKVFVGNKGGNSVVYLPLDKLVEQGRQNAAASTGASAPD
AASAPAATAPSAAAAASAPAATAPSAAAAAPASAAPAATASGVDVLRSRDAFRSRSREDDTK

Sequences:

>Translated_462_residues
MNEYNERSTWRRMRALLSINDPRWGRGEGNGKDGSRPRANESKRPQGGDGDGPPDLDEMWRNFNRRLSGLFGGKGGNGFR
PDNGRAARVGVGIVIGVLVAVYAGSGLFVVQEGQTGVVLQLGKLSGTVGQGVHWRAPYPFASHEIVDTSQVRSIEIGRNN
VVRLANVKEAAMLTRDADIVDVRFIVQYRIRSATDYLFRSVDPERSVSQAAQAAVRAIVGTRSAADMLNQDRDALREQLS
TAIQRDLDRYQSGLEVTAVTMQSVAAPEQTQAAYAEVAKARDEREAAKRAAQAYASDLLPKAQGDAAKLIDEAKAYADRV
VTEAEGDADRFKQVYAQYSKAPAVIRERMYLETMQEIYSNATKVFVGNKGGNSVVYLPLDKLVEQGRQNAAASTGASAPD
AASAPAATAPSAAAAASAPAATAPSAAAAAPASAAPAATASGVDVLRSRDAFRSRSREDDTK
>Mature_462_residues
MNEYNERSTWRRMRALLSINDPRWGRGEGNGKDGSRPRANESKRPQGGDGDGPPDLDEMWRNFNRRLSGLFGGKGGNGFR
PDNGRAARVGVGIVIGVLVAVYAGSGLFVVQEGQTGVVLQLGKLSGTVGQGVHWRAPYPFASHEIVDTSQVRSIEIGRNN
VVRLANVKEAAMLTRDADIVDVRFIVQYRIRSATDYLFRSVDPERSVSQAAQAAVRAIVGTRSAADMLNQDRDALREQLS
TAIQRDLDRYQSGLEVTAVTMQSVAAPEQTQAAYAEVAKARDEREAAKRAAQAYASDLLPKAQGDAAKLIDEAKAYADRV
VTEAEGDADRFKQVYAQYSKAPAVIRERMYLETMQEIYSNATKVFVGNKGGNSVVYLPLDKLVEQGRQNAAASTGASAPD
AASAPAATAPSAAAAASAPAATAPSAAAAAPASAAPAATASGVDVLRSRDAFRSRSREDDTK

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=386, Percent_Identity=32.1243523316062, Blast_Score=179, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: NA

Molecular weight: Translated: 49303; Mature: 49303

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEYNERSTWRRMRALLSINDPRWGRGEGNGKDGSRPRANESKRPQGGDGDGPPDLDEMW
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
RNFNRRLSGLFGGKGGNGFRPDNGRAARVGVGIVIGVLVAVYAGSGLFVVQEGQTGVVLQ
HHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEE
LGKLSGTVGQGVHWRAPYPFASHEIVDTSQVRSIEIGRNNVVRLANVKEAAMLTRDADIV
ECCCCCCCCCCEECCCCCCCCCCCCCCCHHHEEEEECCCCEEEECCHHHHHHHHCCCCHH
DVRFIVQYRIRSATDYLFRSVDPERSVSQAAQAAVRAIVGTRSAADMLNQDRDALREQLS
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHCHHHHHHHHHH
TAIQRDLDRYQSGLEVTAVTMQSVAAPEQTQAAYAEVAKARDEREAAKRAAQAYASDLLP
HHHHHHHHHHHCCCEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KAQGDAAKLIDEAKAYADRVVTEAEGDADRFKQVYAQYSKAPAVIRERMYLETMQEIYSN
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
ATKVFVGNKGGNSVVYLPLDKLVEQGRQNAAASTGASAPDAASAPAATAPSAAAAASAPA
CEEEEEECCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCC
ATAPSAAAAAPASAAPAATASGVDVLRSRDAFRSRSREDDTK
CCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNEYNERSTWRRMRALLSINDPRWGRGEGNGKDGSRPRANESKRPQGGDGDGPPDLDEMW
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
RNFNRRLSGLFGGKGGNGFRPDNGRAARVGVGIVIGVLVAVYAGSGLFVVQEGQTGVVLQ
HHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEE
LGKLSGTVGQGVHWRAPYPFASHEIVDTSQVRSIEIGRNNVVRLANVKEAAMLTRDADIV
ECCCCCCCCCCEECCCCCCCCCCCCCCCHHHEEEEECCCCEEEECCHHHHHHHHCCCCHH
DVRFIVQYRIRSATDYLFRSVDPERSVSQAAQAAVRAIVGTRSAADMLNQDRDALREQLS
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHCHHHHHHHHHH
TAIQRDLDRYQSGLEVTAVTMQSVAAPEQTQAAYAEVAKARDEREAAKRAAQAYASDLLP
HHHHHHHHHHHCCCEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KAQGDAAKLIDEAKAYADRVVTEAEGDADRFKQVYAQYSKAPAVIRERMYLETMQEIYSN
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
ATKVFVGNKGGNSVVYLPLDKLVEQGRQNAAASTGASAPDAASAPAATAPSAAAAASAPA
CEEEEEECCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCC
ATAPSAAAAAPASAAPAATASGVDVLRSRDAFRSRSREDDTK
CCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]